α7 nicotinic acetylcholine receptor expression in Alzheimer's disease: Receptor densities in brain regions of the APP(SWE) mouse model and in human peripheral blood lymphocytes

Journal of Molecular Neuroscience

Volumn 30, Issue 1-2, 2006, Pages 83-84

  Jones, Ian W ^a   Westmacott, Adam ^a   Chan, Elcie ^a   Jones, Roy W ^b   Dineley, Kelly ^c   O'Neill, Michael J ^d   Wonnacott, Susan ^a  

^a University of Bath   (United Kingdom)

^b St Martin's Hospital   (United Kingdom)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BUNGAROTOXIN RECEPTOR; ALPHA-BUNGAROTOXIN RECEPTOR; NICOTINIC RECEPTOR;

ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; BRAIN CORTEX; CONFERENCE PAPER; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; ARTICLE; AUTOPSY; BRAIN; COMPARATIVE STUDY; DISEASE MODEL; ENZYMOLOGY; GENETICS; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; REFERENCE VALUE;

ALZHEIMER DISEASE; ANIMALS; AUTOPSY; BRAIN; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; LYMPHOCYTES; MICE; MUTATION; RECEPTORS, NICOTINIC; REFERENCE VALUES;

EID: 33845919760     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:30:1:83     Document Type: Conference Paper

References (5)

1. Bednar I., Paterson D., Marutle A., Pham T., Svedberg M., Hellstrom E., et al. (2002) Selective nicotinic receptor consequences in APP(SWE) transgenic mice. Mol. Cell. Neurosci. 20, 354-365.
2. Chu L. W., Ma E. S., Lam K. K., Chan M. F., and Lee D. H. (2005) Increased alpha 7 nicotinic acetylcholine receptor protein levels in Alzheimer's disease patients. Dement. Geriatr. Cogn. Disord. 19, 106-112.
3. Dineley K., Westerman M., Bui D., Bell K., Ashe K., and Sweatt J. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21, 4125-4133.
4. Hellstrom E., Court J., Keverne J., Svedberg M., Lee M., Marutle A., et al. (2004) Nicotine reduces Abeta in the brain and cerebral vessels of APPsw mice. Eur. J. Neurosci. 19, 2703-2710.
5. Jones I. W., Barik J., O'Neill M. J., and Wonnacott S. (2004) Alpha bungarotoxin-1.4 nm gold: a novel conjugate for visualising the precise subcellular distribution of alpha 7* nicotinic acetylcholine receptors. J. Neurosci. Methods 134, 65-74.