Permeability of 5-fluorouracil and its prodrugs in Caco-2 cell monolayers: Evidence for shift from paracellular to transcellular transport by prodrug formation

Journal of Drug Delivery Science and Technology

Volumn 19, Issue 1, 2009, Pages 37-41

  Imoto, M ^a   Azuma, H ^b   Yamamoto, I ^a   Otagiri, M ^b   Imai, Teruko ^b  

^a KYUSHU UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

5 fluorouracil; Caco 2 cell; Paracellular transport; Permeability; Polar surface area; Prodrug; Transcellular transport

Indexed keywords

2 O ALKYLOXY 5 FLUOROPYRIMIDONE DERIVATIVE; FLUOROURACIL; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DIFFUSION; DRUG FORMULATION; DRUG HALF LIFE; DRUG PENETRATION; DRUG STABILITY; DRUG STRUCTURE; DRUG TARGETING; DRUG TRANSPORT; HUMAN; HUMAN CELL; HYDROPHILICITY; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 59849091036     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(09)50005-6     Document Type: Article

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