The Canine Model of Human Brain Aging: Cognition, Behavior, and Neuropathology

Handbook of Models for Human Aging

Volumn , Issue , 2006, Pages 415-4

  Tapp, P Dwight ^a   Siwak, Christina T ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33847760962     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012369391-4/50036-9     Document Type: Chapter

References (84)

1. Adams B., Chan A., Callahan H., Milgram N.W. The canine as a model of human cognitive aging: recent developments. Prog. Neuropsychopharmacol. Biol. Psychiatry 2000, 24(5):675-692.
2. Adams B., Chan A., Callahan H., Siwak C., Tapp D., Ikeda-Douglas C., et al. Use of a delayed nonmatching to position task to model age-dependent cognitive decline in the dog. Behav. Brain Res. 2000, 108:47-56.
3. Almkvist O. Neuropsychological features of early Alzheimer's disease: Preclinical and clinical stages. Acta Neurol. Stand. Suppl. 1996, 165:165-171.
4. Baddeley A.D. Levels of working memory. Perspectives on human and Cognitive Aging: Essays in honor of Fergus Craik 2001, 11-123. Psychology Press. M. Naveh-Benjamin, M. Moscovitch, H.L. Roediger (Eds.).
5. Ball M.J., MacGregor J., Fyfe I.M., Rapoport S.I., London E.D. Paucity of morphological changes in the brains of ageing beagle dogs: Further evidence that Alzheimer lesions are unique for primate central nervous system. Neurobiol. Aging 1983, 4:127-131.
6. Belleville S., Rouleau N., Van der Linden M., Collette F. Effect of manipulation and irrelevant noise on working memory capacity of patients with Alzhemer's dementia. Neuropsychology 2003, 17:69-81.
7. Bennett KM. Gender and longitudinal changes in physical activities in later life. Age Ageing 1998, 27(Suppl 3):24-28.
8. Berg E.A. Simple objective technique for measuring flexibility in thinking. J. Gen. Psychol. 1948, 39:15-22.
9. Bussière T., Friend P.D., Sadeghi N., Wicinski B., Lin G.L., Bouras C., et al. Stereological assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease. Neuroscience 2002, 112:75-91.
10. Callahan H., Ikeda-Douglas C., Head E., Cotman C.W., Milgram N.W. Development of a protocol for studying object recognition memory in the dog. Prog. Neuropsychopharmacol. Biol. Psychiatry 2000, 24(5):693-707.
11. Castellanos F.X., Giedd J.N., Berquin P.C., Walter J.M., Sharp W., Tran T., et al. Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 2001, 58(3):289-295.
12. Chan A.D., Nippak P.M., Murphey H., Ikeda-Douglas C.J., Muggenburg B., Head E., et al. Visuospatial impairments in aged canines (Canis familiaris): The role of cognitive-behavioral flexibility. Behav. Neurosci. 2002, 116(3):443-454.
13. Christie L.A., Studzinski C.M., Araujo J.A., Leung C.S., Ikeda-Douglas C.J., Head E., et al. A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Prog. Neuropsychopharmacol. Biol. Psychiatry 2005, 29(3):361-369.
14. Committee on Animal Models for Research on Aging Carnivores 1981, 180-242. National Academy Press, New York.
15. Courtney S.M., Ungerleider L.G., Keil K., Haxby J.V. Object and spatial visual working memory activate separate neural systems in human cortex. Cerebral Cortex 1996, 6:39-49.
16. Cummings B.J., Head E., Ruehl W., Milgram N.W., Cotman C.W. The canine as an animal model of human aging and dementia. Neurobiol Aging 1996, 17(2):259-268.
17. Daffner K.R., Scinto L.F., Weintraub S., Guinessey J.E., Mesulam M.M. Diminished curiosity in patients with probable Alzheimer's disease as measured by exploratory eye movements. Neurology 1999, 42(2):320-328.
18. Daffner K.R., Scinto L.F., Weintraub S., Guinessey J., Mesulam M.M. The impact of aging on curiosity as measured by exploratory eye movements. Arch. Neurol. 1994, 51(4):368-376.
19. Dodd C.E., Zicker S.C., Jewell D.E., Fritsch D.A., Lowry S.R., Allen T.A. Can a fortified food affect the behavioral manifestations of age-related cognitive decline in dogs?. Vet. Med. 2003, 396-408. May.
20. Duel R.K., Mishkin M., Semmes J. Interaction between the hemispheres in unimanual somesthetic learning. Experimental Neurology 1971, 30:123-138.
21. Duyckaerts C., Bennecib M., Grignon Y., Uchihara T., He Y., Piette F., Hauw J.J. Modeling the relation between neurofibrillary tangles and intellectual status. Neurobiol. Aging 1997, 18(3):267-273.
22. Floyd R.A., West M., Hensley K. Oxidative biochemical markers; clues to understanding aging in long-lived species. Exp. Gerontol. 2001, 36(4-6):619-640.
23. Folstein M.F., Bylsma F.W. Noncognitive symptoms of Alzheimer's disease. Alzheimer's Disease 1999, 25-37. Lippincott Williams & Wilkins, Washington, DC. 2nd ed. R.D. Terry, R. Katzman, K.L. Bick, S.S. Sisodia (Eds.).
24. Fox M.W. Integrative Development of Brain and Behavior in the Dog 1971, The University of Chicago Press, Philadelphia.
25. Freedman M., Oscar-Berman M. Spatial and visual learning deficits in Alzheimer's and Parkinson's disease. Brain Cogn. 1989, 11(1):114-126.
26. Fuster J.M. Cognitive functions of the frontal lobes. The Human Frontal Lobes 1999, 187-195. Guilford Press, Chicago. B.L. Miller, J.L. Cummings (Eds.).
27. Gallup G.G. Mirror-image stimulation. Psychol. Bull. 1968, 70(6):782-793.
28. Harris G.J., Lewis R.F., Satlin A., English C.D., Scott T.M., Yurgelun-Todd D.A., Renshaw P.F. Dynamic susceptibility contrast MR imaging of regional cerebral blood volume in Alzheimer disease: A promising alternative to nuclear medicine. Am. J. Neuroradiol. 1998, 19(9):1727-1732.
29. Hasher L., Zacks R.T. Working Memory, comprehension, and aging: A review and a new view. Psychology of Learning and Motivation 1988, 22:122-149.
30. Head E., Callahan H., Cummings B.J., Cotman C.W., Ruehl W.W., Muggenburg B.A., Milgram N.W. Open field activity and human interaction as a function of age and breed in dogs. Physiol. Behav. 1997, 62(5):963-971.
31. Head E., Callahan H., Muggenburg B.A., Cotman C.W., Milgram N.W. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol. Aging 1998, 19(5):415-425.
32. Head E., Liu J., Hagen T.M., Muggenburg B.A., Milgram N.W., Ames B.N., Cotman C.W. Oxidative damage increases with age in a canine model of human brain aging. J. Neurochem. 2002, 82(2):375-381.
33. Head E., Mehta R., Hartley J., Kameka M., Cummings B.J., Cotman C.W., et al. Spatial learning and memory as a function of age in the dog. Behav. Neurosci. 1995, 109(5):851-858.
34. Head E., Milgram N.W., Cotman C.W. Neurobiological models of aging in the dog and other vertebrate species. Functional Neurobiology of Aging 2001, 457-465. Academic Press, New York. P.R. Hof, C.V. Mobbs (Eds.).
35. Herndon J.G., Killiany R.J., Rosene D.L., Moss M.B. The recognition span memory capacity of intermediate aged (19-24 years old) rhesus monkeys. Society for Neuroscience Abstracts 1993, 19:600.
36. Landsberg G. The most common behavior problems of older dogs. Vet. Med. 1995, S16-S24.
37. McDowd J.M., Oseas-Kreger D.M., Filion D.L. Inhibitory processes in cognition and aging. Interference and Inhibition in Cognition 1995, 363-400. Academic Press, San Diego. F.N. Dempster, C.J. Brainerd (Eds.).
38. Means L.W., Holsten R.D. Individual aged rats are impaired on repeated reversal due to loss of different behavioral patterns. Physiol. Behav. 1992, 52(5):959-963.
39. Milgram N.W., Adams B., Callahan H., Head E., Mackay B., Thirlwell C., Cotman C.W. Landmark discrimination learning in the dog. Learn. Mem. 1999, 6(1):54-61.
40. Milgram N.W., Head E., Muggenburg B., Holowachuk D., Murphey H., Estrada J., et al. Landmark discrimination learning in the dog: Effects of age, an antioxidant fortified food, and cognitive strategy. Neurosci. Biobehav. Rev. 2002, 26(6):679-695.
41. Milgram N.W., Head E., Weiner E., Thomas E. Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks. Behav. Neurosci. 1994, 108(1):57-68.
42. Milgram N.W., Head E., Zicker S.C., Ikeda-Douglas C.J., Murphey H., Muggenburg B., Cotman C.W., et al. Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Neurobiol. Aging 2005, 26(1):77-90.
43. Milgram N.W., Head E., Zicker S.C., Ikeda-Douglas C., Murphey H., Muggenburg B.A., et al. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp. Gerontol. 2004, 39(5):753-765.
44. Milgram N.W., Zicker S.C., Head E., Muggenburg B.A., Murphey H., Ikeda-Douglas C.J., Cotman C.W. Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol. Aging 2002, 23(5):737-745.
45. Mishkin M., Delacour J. An analysis of short-term visual memory in the monkey. J. Exp. Psychol. Anim. Behav. Process 1975, 1(4):326-334.
46. Morris M.C., Evans D.A., Tangney C.C., Bienias J.L., Wilson R.S., Aggarwal N.T., Scherr P.A. Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am. J. Clin. Nutr. 2005, 81(2):508-514.
47. Morys J., Narkiewicz O., Maciejewska B., Wegiel J., Wisniewski H.M. Amyloid deposits and loss of neurons in the claustrum of the aged dog. Neuroreport 1994, 5:1825-1828.
48. Oscar-Berman M., Bonner R.T. Matching- and delayed matching-to-sample performance as measures of visual processing, selective attention, and memory in aging and alcoholic individuals. Neuropsychologia 1985, 23(5):639-651.
49. Pakkenberg B., Gundersen J.G. Neocortical neuron number in humans: effect of sex and age. J. Comp. Neurol. 1997, 384:312-320.
50. Patronek G.J., Waters D.J., Glickman L.T. Comparative longevity of pet dogs and humans: Implications for gerontology research. J. Gerontol. Biol. Sci. Med. Sci. 1997, 52A(52A):171-178.
51. Pohl W. Dissociation of spatial discrimination deficits following frontal and parietal lesions in monkeys. J. Comp. Physiol. Psychol. 1973, 82(2):227-239.
52. Pop V., Head E., Nistor M., Milgram N.W., Muggenburg B.A., Cotman C.W. Reduced Aβ deposition with long-term antioxidant diet treatment in aged canines. Society for Neuroscience Abstracts 2003, 525.4.
53. Pugliese M., Carrasco J.L., Geloso M.C., Mascort J., Michetti F., Mahy N. Gamma-aminobutyric acidergic interneuron vulnerability to aging in canine prefrontal cortex. J. Neurosci. Res. 2004, 77(6):913-920.
54. Ridderinkhof K.R., Span M.M., van der Molen M.W. Perseverative behavior and adaptive control in older adults: Performance monitoring, rule induction, and set shifting. Brain Cogn. 2002, 49:382-401.
55. Romanes G.J. Mental Evolution in Animals 1884, D. Appleton and Company, San Diego.
56. Sano M., Ernesto C., Thomas R.G., Klauber M.R., Schafer K., Grundman M., et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N. Engl. J. Med. 1997, 336(17):1216-1222.
57. Satlin A., Teicher M.H., Lieberman H.R., Baldessarini R.J., Volicer L., Rheaume Y. Circadian locomotor activity rhythms in Alzheimer's disease. Neuropsychopharmacology 1991, 5(2):115-126.
58. Satou T., Cummings B.J., Head E., Nielson K.A., Hahn F.F., Milgram N.W., et al. The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Res. 1997, 774(1-2):35-43.
59. Simic G., Bexheti S., Kelovic Z., Kos M., Grbic K., Hof P.R., Kostovic I. Hemispheric asymmetry, modular variability and age-related changes in the human entorhinal cortex. Neuroscience 2005, 130:911-925.
60. Siwak C.T., Head E., Muggenburg B.A., Milgram N.W., Cotman C.W. Region specific neuron loss in the aged canine hippocampus and the effects of an antioxidant diet and behavioral enrichment. Society for Neuroscience Abstracts 2005, Program No. 91.
61. Siwak C.T., Murphey H.L., Muggenburg B.A., Milgram N.W. Age-dependent decline in locomotor activity in dogs is environment specific. Physiol. Behav. 2002, 75(1-2):65-70.
62. Siwak C.T., Tapp P.D., Head E., Zicker S.C., Murphey H.L., Muggenburg B.A., et al. Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol. Psychiatry 2005, 29(3):461-469.
63. Siwak C.T., Tapp P.D., Milgram N.W. Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the beagle dog. Learn. Mem. 2001, 8(6):317-325.
64. Siwak C.T., Tapp P.D., Zicker S.C., Murphey H.L., Muggenburg B.A., Head E., et al. Locomotor activity rhythms in dogs vary with age and cognitive status. Behav. Neurosci. 2003, 117(4):813-824.
65. Su M.Y., Head E., Brooks W.M., Wang Z., Muggenburg B.A., Adam G.E., et al. Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiol. Aging 1998, 19(5):479-485.
66. Su M.Y., Tapp P.D., Vu L., Chen Y.F., Chu Y., Muggenburg B., et al. A longitudinal study of brain morphometrics using serial magnetic resonance imaging analysis in a canine model of aging. Prog. Neuropsychopharmacol. Biol. Psychiatry 2005, 29(3):389-397.
67. Sutherland N.S., MacKintosh N.J. Mechanisms of Animal Discrimination Learning 1971, Academic Press, New York.
68. Swainson R., Hodges J.R., Galton C.J., Semple J., Michael A., Dunn B.D., et al. Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks. Dement. Geriatr. Cogn. Disord. 2001, 12:265-280.
69. Tapp P.D., Chu Y., Araujo J.A., Chiou J.Y., Head E., Milgram N.W., Su M.Y. Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to assess cerebral blood volume in a canine model of aging. Prog. Neuropsychopharmacol. Biol. Psychiatry 2005, 29(3):399-406.
70. Tapp P.D., Head K., Head E., Milgram N.W., Muggenburg B.A., Su M-Y. Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. Neuroimage 2005, (in press). Available online November 7, 2005.
71. Tapp P.D., Siwak C.T., Estrada J., Head E., Muggenburg B.A., Cotman C.W., Milgram N.W. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn. Mem. 2003, 10(1):64-73.
72. Tapp P.D., Siwak C.T., Estrada J., Holowachuk D., Milgram N.W. Effects of age on measures of complex working memory span in the beagle dog (Canis familiaris) using two versions of a spatial list learning paradigm. Learn. Mem. 2003, 10(2):148-160.
73. Tapp P.D., Siwak C.T., Gao F.Q., Chiou J.Y., Black S.E., Head E., et al. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J. Neurosci. 2004, 24(38):8205-8213.
74. Tapp P.D., Siwak C.T., Head E., Cotman C.W., Murphey H., Muggenburg B.A., et al. Concept abstraction in the aging dog: Development of a protocol using successive discrimination and size concept tasks. Behav. Brain Res. 2004, 153(1):199-210.
75. Tisserand D.J., Boxtel M.P., Pruessner J.C., Hofman P., Evans A.C., Jolles J. A voxel-based morphometric study to determine individual differences in gray matter density associated with age and cognitive change over time. Cerebral Cortex 2004, 14(9):966-973.
76. Uchida K., Okuda R., Yamaguchi R., Tateyama S., Nakayama H., Goto N. Double-labeling immunohistochemical studies on canine senile plaques and cerebral amyloid angiopathy. J. Vet. Med. Sci. 1993, 55:637-642.
77. Vakil E., Agmon-Ashkenazi D. Baseline performance and learning of procedural and declarative memory tasks: Younger versus older adults. J. Gerontol. B. Psychol. Sci. Sot. Sci. 1997, 52(5):220-234.
78. Van Someren E.J. Circadian and sleep disturbances in the elderly. Exp. Gerontol. 2000, 35(9-10):1229-1237.
79. Voytko M.L. Impairments in acquisition and reversal of two-choice discriminations by aged rhesus monkeys. Neurobiol. Aging 1999, 20:617-627.
80. West M.J. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol. Aging 1993, 14:287-293.
81. West M.J., Coleman P.D., Flood D.G., Troncoso J.C. Differences in the pattern of hippocampal neuron loss in normal ageing and Alzheimer's disease. Lancet 1994, 344:769-772.
82. West R.L. An application of prefrontal cortex function theory to cognitive aging. Psychol. Bull. 1996, 120:272-292.
83. Wisniewski H., Johnson A.B., Raine C.S., Kay W.J., Terry R.D. Senile plaques and cerebral amyloidosis in aged dogs: A histochemical and ultrastructural study. Lab. Invest. 1970, 23:287-296.
84. Yamaguchi H., Sugihara S., Ogawa A., Oshima N., Ihara Y. Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects. J. Neuropath. Exp. Neurol. 2001, 60(7):731-739.