메뉴 건너뛰기




Volumn 122, Issue 1, 2009, Pages 44-51

A preliminary and comparative evaluation of a novel Ad5 [E1-, E2b-] recombinant-based vaccine used to induce cell mediated immune responses

Author keywords

Adenovirus 5; Cell mediated immunity; Vaccine

Indexed keywords

ADENOVIRUS VECTOR; GAG PROTEIN; GAMMA INTERFERON; INTERLEUKIN 2; RECOMBINANT VACCINE; VIRUS VACCINE;

EID: 59649119374     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2008.11.003     Document Type: Article
Times cited : (32)

References (48)
  • 1
    • 0242351940 scopus 로고    scopus 로고
    • Adenoviruses as vectors for HIV vaccines
    • Gómez-Román V.R., and Robert-Guroff M. Adenoviruses as vectors for HIV vaccines. AIDS Rev 5 (2003) 178-185
    • (2003) AIDS Rev , vol.5 , pp. 178-185
    • Gómez-Román, V.R.1    Robert-Guroff, M.2
  • 2
    • 0037122719 scopus 로고    scopus 로고
    • Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
    • Shiver J.W., Fu T.M., Chen L., Casimiro D.R., Davies M.E., Evans R.K., et al. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 415 (2002) 331-335
    • (2002) Nature , vol.415 , pp. 331-335
    • Shiver, J.W.1    Fu, T.M.2    Chen, L.3    Casimiro, D.R.4    Davies, M.E.5    Evans, R.K.6
  • 3
    • 31344441132 scopus 로고    scopus 로고
    • Immunization with recombinant adenovirus synthesizing the secretory form of Japanese encephalitis virus envelope protein protects adenovirus-exposed mice against lethal encephalitis
    • Appaiahgari M.B., Saini M., Rauthan M., Jyoti, and Vrati S. Immunization with recombinant adenovirus synthesizing the secretory form of Japanese encephalitis virus envelope protein protects adenovirus-exposed mice against lethal encephalitis. Microbes Infect 8 (2006) 92-104
    • (2006) Microbes Infect , vol.8 , pp. 92-104
    • Appaiahgari, M.B.1    Saini, M.2    Rauthan, M.3    Jyoti4    Vrati, S.5
  • 4
    • 30344484256 scopus 로고    scopus 로고
    • Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5- and 35-based vectors
    • Barratt-Boyes S.M., Soloff A.C., Gao W., Nwanegbo E., Liu X., Rajakumar P.A., et al. Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5- and 35-based vectors. J Gen Virol 87 (2006) 139-149
    • (2006) J Gen Virol , vol.87 , pp. 139-149
    • Barratt-Boyes, S.M.1    Soloff, A.C.2    Gao, W.3    Nwanegbo, E.4    Liu, X.5    Rajakumar, P.A.6
  • 5
    • 33845439080 scopus 로고    scopus 로고
    • Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector
    • Cantanzaro A.T., Koup R.A., Roederrer M., Bailer R.T., Enama M.E., Moodic Z., et al. Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector. J Infect Dis 194 12 (2006) 1638-1649
    • (2006) J Infect Dis , vol.194 , Issue.12 , pp. 1638-1649
    • Cantanzaro, A.T.1    Koup, R.A.2    Roederrer, M.3    Bailer, R.T.4    Enama, M.E.5    Moodic, Z.6
  • 6
    • 0034659615 scopus 로고    scopus 로고
    • Adult dogs receiving a rabies booster dose with a recombinant adenovirus expressing rabies virus glycoprotein develop high titers of neutralizing antibodies
    • Tims T., Briggs D.J., Davis R.D., Xiang Z., Ertl H.C., and Fu Z.F. Adult dogs receiving a rabies booster dose with a recombinant adenovirus expressing rabies virus glycoprotein develop high titers of neutralizing antibodies. Vaccine 18 (2000) 2804-2807
    • (2000) Vaccine , vol.18 , pp. 2804-2807
    • Tims, T.1    Briggs, D.J.2    Davis, R.D.3    Xiang, Z.4    Ertl, H.C.5    Fu, Z.F.6
  • 7
    • 0036187846 scopus 로고    scopus 로고
    • Novel, chimpanzee serotype 68-based adenoviral vaccine carrier for induction of antibodies to a transgene product
    • Xiang Z., Gao G., Reyes-Sandoval A., Cohen C.J., Li Y., Bergelson J.M., et al. Novel, chimpanzee serotype 68-based adenoviral vaccine carrier for induction of antibodies to a transgene product. J Virol 76 (2002) 2667-2675
    • (2002) J Virol , vol.76 , pp. 2667-2675
    • Xiang, Z.1    Gao, G.2    Reyes-Sandoval, A.3    Cohen, C.J.4    Li, Y.5    Bergelson, J.M.6
  • 8
    • 38749096240 scopus 로고    scopus 로고
    • The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development?
    • Sekaly R.P. The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development?. JEM 205 (2008) 7-11
    • (2008) JEM , vol.205 , pp. 7-11
    • Sekaly, R.P.1
  • 9
    • 34249930119 scopus 로고    scopus 로고
    • Effect of preexisting immunity to adenovirus human serotype 5 antigens on the immune responses of nonhuman primates to vaccine regimens based on human- or chimpanzee-derived adenovirus vectors
    • McCoy K., Tatsis N., Korioth-Schmitz B., Lasaro M.O., Hensley S.E., Lin S.W., et al. Effect of preexisting immunity to adenovirus human serotype 5 antigens on the immune responses of nonhuman primates to vaccine regimens based on human- or chimpanzee-derived adenovirus vectors. J Virol 81 12 (2007) 6594-6604
    • (2007) J Virol , vol.81 , Issue.12 , pp. 6594-6604
    • McCoy, K.1    Tatsis, N.2    Korioth-Schmitz, B.3    Lasaro, M.O.4    Hensley, S.E.5    Lin, S.W.6
  • 11
    • 0038664390 scopus 로고    scopus 로고
    • Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene
    • Casimiro D.R., Chen L., Fu T.M., Evans R.K., Caulfield M.J., Davies M.E., et al. Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene. J Virol 77 (2003) 6305-6313
    • (2003) J Virol , vol.77 , pp. 6305-6313
    • Casimiro, D.R.1    Chen, L.2    Fu, T.M.3    Evans, R.K.4    Caulfield, M.J.5    Davies, M.E.6
  • 12
    • 0041707861 scopus 로고    scopus 로고
    • Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines
    • Barouch D.H., McKay P.F., Sumida S.M., Santra S., Jackson S.S., Gorgone D.A., et al. Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines. J Virol 77 (2003) 8729-8735
    • (2003) J Virol , vol.77 , pp. 8729-8735
    • Barouch, D.H.1    McKay, P.F.2    Sumida, S.M.3    Santra, S.4    Jackson, S.S.5    Gorgone, D.A.6
  • 13
    • 33845466958 scopus 로고    scopus 로고
    • Immunogenicity of heterologous recombinant adenovirus prime-boost vaccine regimens is enhanced by circumventing vector cross-reactivity
    • Thorner A.R., Lemckert A.A., Goudsmit J., Lynch D.M., Ewald B.A., Denholtz M., et al. Immunogenicity of heterologous recombinant adenovirus prime-boost vaccine regimens is enhanced by circumventing vector cross-reactivity. J Virol 80 24 (2006) 12009-12016
    • (2006) J Virol , vol.80 , Issue.24 , pp. 12009-12016
    • Thorner, A.R.1    Lemckert, A.A.2    Goudsmit, J.3    Lynch, D.M.4    Ewald, B.A.5    Denholtz, M.6
  • 14
    • 0346366982 scopus 로고    scopus 로고
    • Induction of CD8 + T cells to an HIV-1 antigen through a prime boost regimen with heterologous E1-deleted adenoviral vaccine carriers
    • Pinto A.R., Fitzgerald J.C., Giles-Davis W., Gao G.P., Wilson J.M., and Ertl H.C. Induction of CD8 + T cells to an HIV-1 antigen through a prime boost regimen with heterologous E1-deleted adenoviral vaccine carriers. J Immunol 171 12 (2003) 6774-6779
    • (2003) J Immunol , vol.171 , Issue.12 , pp. 6774-6779
    • Pinto, A.R.1    Fitzgerald, J.C.2    Giles-Davis, W.3    Gao, G.P.4    Wilson, J.M.5    Ertl, H.C.6
  • 15
    • 42649111311 scopus 로고    scopus 로고
    • Replication-attenuated Human Adenoviral type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system
    • Hartman Z.C., Appledorn D.M., Serra D., Glass O., Mendelson T., Clat T., et al. Replication-attenuated Human Adenoviral type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system. Virology 374 2 (2008) 453-467
    • (2008) Virology , vol.374 , Issue.2 , pp. 453-467
    • Hartman, Z.C.1    Appledorn, D.M.2    Serra, D.3    Glass, O.4    Mendelson, T.5    Clat, T.6
  • 16
    • 16244407740 scopus 로고    scopus 로고
    • Development and assessment of human adenovirus type 11 as a gene transfer vector
    • Stone D., Ni S., Li Z.Y., Gaggar A., DiPaolo N., Feng Q., et al. Development and assessment of human adenovirus type 11 as a gene transfer vector. J Virol 79 8 (2005) 5090-5104
    • (2005) J Virol , vol.79 , Issue.8 , pp. 5090-5104
    • Stone, D.1    Ni, S.2    Li, Z.Y.3    Gaggar, A.4    DiPaolo, N.5    Feng, Q.6
  • 17
    • 44849140020 scopus 로고    scopus 로고
    • Wild-type Adenoviruses from groups A-F elicit unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent
    • Appledorn D.M., Kiang A., McBride A., Jiang H., Seregin S., Scott J.M., et al. Wild-type Adenoviruses from groups A-F elicit unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent. Gene Ther 15 12 (2008) 885-901
    • (2008) Gene Ther , vol.15 , Issue.12 , pp. 885-901
    • Appledorn, D.M.1    Kiang, A.2    McBride, A.3    Jiang, H.4    Seregin, S.5    Scott, J.M.6
  • 18
    • 0031883829 scopus 로고    scopus 로고
    • Production and characterization of improved adenovirus vectors with the E1, E2b, and E3 genes deleted
    • Amalfitano A., Hauser M.A., Hu H., Serra D., Begy C.R., and Chamberlain J.S. Production and characterization of improved adenovirus vectors with the E1, E2b, and E3 genes deleted. J Virol 72 (1998) 926-933
    • (1998) J Virol , vol.72 , pp. 926-933
    • Amalfitano, A.1    Hauser, M.A.2    Hu, H.3    Serra, D.4    Begy, C.R.5    Chamberlain, J.S.6
  • 19
    • 0030016358 scopus 로고    scopus 로고
    • Encapsidated adenovirus minichromosomes allow delivery and expression of a 14 kb dystrophin cDNA to muscle cells
    • Kumar-Singh R., and Chamberlain J.S. Encapsidated adenovirus minichromosomes allow delivery and expression of a 14 kb dystrophin cDNA to muscle cells. Hum Mol Genet 5 (1996) 913-921
    • (1996) Hum Mol Genet , vol.5 , pp. 913-921
    • Kumar-Singh, R.1    Chamberlain, J.S.2
  • 20
    • 0029918572 scopus 로고    scopus 로고
    • Improved adenovirus packaging cell lines to support the growth of replication-defective gene-delivery vectors
    • Amalfitano A., Begy C.R., and Chamberlain J.S. Improved adenovirus packaging cell lines to support the growth of replication-defective gene-delivery vectors. Proc Natl Acad Sci USA 93 (1996) 3352-3356
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3352-3356
    • Amalfitano, A.1    Begy, C.R.2    Chamberlain, J.S.3
  • 22
    • 0033540652 scopus 로고    scopus 로고
    • Persistence of an [E1-, polymerase-] adenovirus vector despite transduction of a neoantigen into immune-competent mice
    • Hu H., Serra D., and Amalfitano A. Persistence of an [E1-, polymerase-] adenovirus vector despite transduction of a neoantigen into immune-competent mice. Hum Gene Ther 10 (1999) 355-364
    • (1999) Hum Gene Ther , vol.10 , pp. 355-364
    • Hu, H.1    Serra, D.2    Amalfitano, A.3
  • 23
    • 17844402009 scopus 로고    scopus 로고
    • Induction and inhibition of innate inflammatory responses by adenovirus early region proteins
    • Schaack J. Induction and inhibition of innate inflammatory responses by adenovirus early region proteins. Viral Immunol 18 (2005) 79-88
    • (2005) Viral Immunol , vol.18 , pp. 79-88
    • Schaack, J.1
  • 25
    • 10644290199 scopus 로고    scopus 로고
    • TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
    • Corey D.P., García-Añoveros J., Holt J.R., Kwan K.Y., Lin S.Y., Vollrath M.A., et al. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432 (2004) 723-730
    • (2004) Nature , vol.432 , pp. 723-730
    • Corey, D.P.1    García-Añoveros, J.2    Holt, J.R.3    Kwan, K.Y.4    Lin, S.Y.5    Vollrath, M.A.6
  • 26
    • 0034984649 scopus 로고    scopus 로고
    • A modified adenovirus can transfect cochlear hair cells in vivo without compromising cochlear function
    • Luebke A.E., Steiger J.D., Hodges B.L., and Amalfitano A. A modified adenovirus can transfect cochlear hair cells in vivo without compromising cochlear function. Gene Ther 8 (2001) 789-794
    • (2001) Gene Ther , vol.8 , pp. 789-794
    • Luebke, A.E.1    Steiger, J.D.2    Hodges, B.L.3    Amalfitano, A.4
  • 27
    • 0346256668 scopus 로고    scopus 로고
    • Liver toxicities typically induced by first-generation adenoviral vectors can be reduced by use of E1, E2b-deleted adenoviral vectors
    • Everett R.S., Hodges B.L., Ding E.Y., Xu F., Serra D., and Amalfitano A. Liver toxicities typically induced by first-generation adenoviral vectors can be reduced by use of E1, E2b-deleted adenoviral vectors. Hum Gene Ther 14 (2003) 1715-1726
    • (2003) Hum Gene Ther , vol.14 , pp. 1715-1726
    • Everett, R.S.1    Hodges, B.L.2    Ding, E.Y.3    Xu, F.4    Serra, D.5    Amalfitano, A.6
  • 28
    • 0034218917 scopus 로고    scopus 로고
    • Multiply deleted [E1, polymerase-, and pTP-] adenovirus vector persists despite deletion of the preterminal protein
    • Hodges B.L., Serra D., Hu H., Begy C.A., Chamberlain J.S., and Amalfitano A. Multiply deleted [E1, polymerase-, and pTP-] adenovirus vector persists despite deletion of the preterminal protein. J Gene Med 2 4 (2000) 250-259
    • (2000) J Gene Med , vol.2 , Issue.4 , pp. 250-259
    • Hodges, B.L.1    Serra, D.2    Hu, H.3    Begy, C.A.4    Chamberlain, J.S.5    Amalfitano, A.6
  • 29
    • 11844306664 scopus 로고    scopus 로고
    • Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence
    • Harari A., Vallelian F., Meylan P.R., and Pantaleo G. Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence. J Immunol 174 (2005) 1037-1145
    • (2005) J Immunol , vol.174 , pp. 1037-1145
    • Harari, A.1    Vallelian, F.2    Meylan, P.R.3    Pantaleo, G.4
  • 30
    • 33646686040 scopus 로고    scopus 로고
    • HIV nonprogressors preferentially maintain highly functional HIV-specific CD8 + T cells
    • Betts M.R., Nason M.C., West S.M., De Rosa S.C., Migueles S.A., Abraham J., et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8 + T cells. Blood 107 (2006) 4781-4789
    • (2006) Blood , vol.107 , pp. 4781-4789
    • Betts, M.R.1    Nason, M.C.2    West, S.M.3    De Rosa, S.C.4    Migueles, S.A.5    Abraham, J.6
  • 31
    • 14844300863 scopus 로고    scopus 로고
    • Adenovirus vector based vaccines for human immunodeficiency virus type 1
    • Barouch D.H., and Nabel G.J. Adenovirus vector based vaccines for human immunodeficiency virus type 1. Hum Gene Ther 16 (2005) 149-156
    • (2005) Hum Gene Ther , vol.16 , pp. 149-156
    • Barouch, D.H.1    Nabel, G.J.2
  • 32
    • 21644475386 scopus 로고    scopus 로고
    • A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates
    • Barouch D.H., Yang Z.Y., Kong W.P., Korioth-Schmitz B., Sumida S.M., Truitt D.M., et al. A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates. J Virol 79 (2005) 8828-8834
    • (2005) J Virol , vol.79 , pp. 8828-8834
    • Barouch, D.H.1    Yang, Z.Y.2    Kong, W.P.3    Korioth-Schmitz, B.4    Sumida, S.M.5    Truitt, D.M.6
  • 33
    • 0036547263 scopus 로고    scopus 로고
    • New hope for an AIDS vaccine
    • Robinson H.L. New hope for an AIDS vaccine. Nat Rev Immunol 2 (2002) 239-250
    • (2002) Nat Rev Immunol , vol.2 , pp. 239-250
    • Robinson, H.L.1
  • 34
    • 0031969428 scopus 로고    scopus 로고
    • Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers
    • Jooss K., Yang Y., Fisher K.J., and Wilson J.M. Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers. J Virol 72 (1998) 4212-4223
    • (1998) J Virol , vol.72 , pp. 4212-4223
    • Jooss, K.1    Yang, Y.2    Fisher, K.J.3    Wilson, J.M.4
  • 35
    • 0035893749 scopus 로고    scopus 로고
    • The dynamics of the T-cell antitumor response: chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally
    • Kirk C.J., Hartigan-O'Connor D., and Mulé J.J. The dynamics of the T-cell antitumor response: chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally. Cancer Res 61 (2001) 8794-8802
    • (2001) Cancer Res , vol.61 , pp. 8794-8802
    • Kirk, C.J.1    Hartigan-O'Connor, D.2    Mulé, J.J.3
  • 36
    • 0035266293 scopus 로고    scopus 로고
    • T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine: augmentation of dendritic cell-based immunotherapy
    • Kirk C.J., Hartigan-O'Connor D., Nickoloff B.J., Chamberlain J.S., Giedlin M., Aukerman L., et al. T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine: augmentation of dendritic cell-based immunotherapy. Cancer Res 61 (2001) 2062-2070
    • (2001) Cancer Res , vol.61 , pp. 2062-2070
    • Kirk, C.J.1    Hartigan-O'Connor, D.2    Nickoloff, B.J.3    Chamberlain, J.S.4    Giedlin, M.5    Aukerman, L.6
  • 37
    • 0034630499 scopus 로고    scopus 로고
    • Gene-modified dendritic cells for use in tumor vaccines
    • Kirk C.J., and Mulé J.J. Gene-modified dendritic cells for use in tumor vaccines. Hum Gene Ther 11 (2000) 797-806
    • (2000) Hum Gene Ther , vol.11 , pp. 797-806
    • Kirk, C.J.1    Mulé, J.J.2
  • 38
    • 0037213293 scopus 로고    scopus 로고
    • Overcoming immunity to a viral vaccine by DNA priming before vector boosting
    • Yang Z.Y., Wyatt L.S., Kong W.P., Moodie Z., Moss B., and Nabel G.J. Overcoming immunity to a viral vaccine by DNA priming before vector boosting. J Virol 77 (2003) 799-803
    • (2003) J Virol , vol.77 , pp. 799-803
    • Yang, Z.Y.1    Wyatt, L.S.2    Kong, W.P.3    Moodie, Z.4    Moss, B.5    Nabel, G.J.6
  • 39
    • 0032813559 scopus 로고    scopus 로고
    • Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs
    • Harvey B.G., Hackett N.R., El-Sawy T., Rosengart T.K., Hirschowitz E.A., Lieberman M.D., et al. Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs. J Virol 73 (1999) 6729-6742
    • (1999) J Virol , vol.73 , pp. 6729-6742
    • Harvey, B.G.1    Hackett, N.R.2    El-Sawy, T.3    Rosengart, T.K.4    Hirschowitz, E.A.5    Lieberman, M.D.6
  • 40
    • 17844394733 scopus 로고    scopus 로고
    • Specific depletion of human anti-adenovirus antibodies facilitates transduction in an in vivo model for systemic gene therapy
    • Rahman A., Tsai V., Goudreau A., Shinoda J.Y., Wen S.F., Ramachandra M., et al. Specific depletion of human anti-adenovirus antibodies facilitates transduction in an in vivo model for systemic gene therapy. Mol Ther 3 (2001) 768-778
    • (2001) Mol Ther , vol.3 , pp. 768-778
    • Rahman, A.1    Tsai, V.2    Goudreau, A.3    Shinoda, J.Y.4    Wen, S.F.5    Ramachandra, M.6
  • 41
    • 0032853699 scopus 로고    scopus 로고
    • Immune responses to adenovirus and adeno-associated virus in humans
    • Chirmule N., Propert K., Magosin S., Qian Y., Qian R., and Wilson J. Immune responses to adenovirus and adeno-associated virus in humans. Gene Ther 6 (1999) 1574-1583
    • (1999) Gene Ther , vol.6 , pp. 1574-1583
    • Chirmule, N.1    Propert, K.2    Magosin, S.3    Qian, Y.4    Qian, R.5    Wilson, J.6
  • 42
    • 0035152186 scopus 로고    scopus 로고
    • Rapid assessment of adenovirus serum neutralizing antibody titer based on quantitative, morphometric evaluation of capsid binding and intracellular trafficking: population analysis of adenovirus capsid association with cells is predictive of adenovirus infectivity
    • Vincent T., Harvey B.G., Hogan S.M., Bailey C.J., Crystal R.G., and Leopold P.L. Rapid assessment of adenovirus serum neutralizing antibody titer based on quantitative, morphometric evaluation of capsid binding and intracellular trafficking: population analysis of adenovirus capsid association with cells is predictive of adenovirus infectivity. J Virol 75 (2001) 1516-1521
    • (2001) J Virol , vol.75 , pp. 1516-1521
    • Vincent, T.1    Harvey, B.G.2    Hogan, S.M.3    Bailey, C.J.4    Crystal, R.G.5    Leopold, P.L.6
  • 43
    • 0019801828 scopus 로고
    • Mechanism of activation of early viral transcription by the adenovirus E1a gene product
    • Nevins J.R. Mechanism of activation of early viral transcription by the adenovirus E1a gene product. Cell 26 (1981) 213-220
    • (1981) Cell , vol.26 , pp. 213-220
    • Nevins, J.R.1
  • 45
    • 0028484704 scopus 로고
    • MHC class-I restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
    • Yang Y., Ertl H.C., and Wilson J.M. MHC class-I restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1 (1994) 433-442
    • (1994) Immunity , vol.1 , pp. 433-442
    • Yang, Y.1    Ertl, H.C.2    Wilson, J.M.3
  • 48
    • 0242576821 scopus 로고    scopus 로고
    • Immunogenicity of multiple gene and clade human immunodeficiency virus type 1 DNA vaccines
    • Kong W.P., Huang Y., Yang Z.Y., Chakrabarti B.K., Moodie Z., and Nabel G.J. Immunogenicity of multiple gene and clade human immunodeficiency virus type 1 DNA vaccines. J Virol 77 23 (2003) 12764-12772
    • (2003) J Virol , vol.77 , Issue.23 , pp. 12764-12772
    • Kong, W.P.1    Huang, Y.2    Yang, Z.Y.3    Chakrabarti, B.K.4    Moodie, Z.5    Nabel, G.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.