메뉴 건너뛰기




Volumn 19, Issue 3, 2009, Pages 220-224

Why Are So Many Epidemiology Associations Inflated or Wrong? Does Poorly Conducted Animal Research Suggest Implausible Hypotheses?

Author keywords

Animal Studies; Bias; Epidemiology Methods; Randomized Trials; Research Synthesis; Systematic Reviews

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; EPIDEMIOLOGY; HYPOTHESIS; METHODOLOGY; PRIORITY JOURNAL; PUBLISHING; SYSTEMATIC REVIEW;

EID: 59649113468     PISSN: 10472797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.annepidem.2008.11.006     Document Type: Note
Times cited : (21)

References (59)
  • 1
    • 0029049462 scopus 로고
    • Epidemiology faces its limits
    • Taubes G. Epidemiology faces its limits. Science 269 (1995) 164-169
    • (1995) Science , vol.269 , pp. 164-169
    • Taubes, G.1
  • 2
    • 0031886654 scopus 로고    scopus 로고
    • Alarums false, alarums real: challenges and threats to the future of epidemiology
    • Bracken M.B. Alarums false, alarums real: challenges and threats to the future of epidemiology. Ann Epidemiol 8 (1998) 79-82
    • (1998) Ann Epidemiol , vol.8 , pp. 79-82
    • Bracken, M.B.1
  • 3
    • 0035098609 scopus 로고    scopus 로고
    • Epidemiology-is it time to call it a day?
    • Davey Smith G., and Ebrahim S. Epidemiology-is it time to call it a day?. Int J Epidemiol 30 (2001) 1-11
    • (2001) Int J Epidemiol , vol.30 , pp. 1-11
    • Davey Smith, G.1    Ebrahim, S.2
  • 4
    • 5144220037 scopus 로고    scopus 로고
    • The scandal of poor epidemiological research
    • von Elm E., and Egger M. The scandal of poor epidemiological research. BMJ 329 (2004) 868-869
    • (2004) BMJ , vol.329 , pp. 868-869
    • von Elm, E.1    Egger, M.2
  • 5
    • 1942488264 scopus 로고    scopus 로고
    • Looking to the 21st century: have we learned from our mistakes, or are we doomed to compound them?
    • Shapiro S. Looking to the 21st century: have we learned from our mistakes, or are we doomed to compound them?. Pharmacoepidemiol Drug Saf 13 (2004) 257-265
    • (2004) Pharmacoepidemiol Drug Saf , vol.13 , pp. 257-265
    • Shapiro, S.1
  • 6
    • 47049090630 scopus 로고    scopus 로고
    • Statin use and the risk of prostate cancer: a metaanalysis of 6 randomized clinical trials and 13 observational studies
    • Bonovas S., Filioussi K., and Sitaras N.M. Statin use and the risk of prostate cancer: a metaanalysis of 6 randomized clinical trials and 13 observational studies. Int J Cancer 123 (2008) 899-904
    • (2008) Int J Cancer , vol.123 , pp. 899-904
    • Bonovas, S.1    Filioussi, K.2    Sitaras, N.M.3
  • 7
    • 38349143676 scopus 로고    scopus 로고
    • Methodological quality and homogeneity influenced agreement between randomized trials and nonrandomized studies of the same intervention for back pain
    • Furlan A.D., Tomlinson G., Jadad A.A., and Bombardier C. Methodological quality and homogeneity influenced agreement between randomized trials and nonrandomized studies of the same intervention for back pain. J Clin Epidemiol 61 (2008) 209-231
    • (2008) J Clin Epidemiol , vol.61 , pp. 209-231
    • Furlan, A.D.1    Tomlinson, G.2    Jadad, A.A.3    Bombardier, C.4
  • 8
    • 50149095987 scopus 로고    scopus 로고
    • Diet and cancer prevention: the roles of observation and experimentation
    • [Epub ahead of print]
    • Martinez M.E., Marshall J.R., and Giovannucci E. Diet and cancer prevention: the roles of observation and experimentation. Nat Rev Cancer (2008 Aug 7) [Epub ahead of print]
    • (2008) Nat Rev Cancer
    • Martinez, M.E.1    Marshall, J.R.2    Giovannucci, E.3
  • 9
    • 16644379982 scopus 로고    scopus 로고
    • Postmenopausal hormone therapy: lessons from observational and randomized studies
    • Rosano G.M., Vitale C., and Lello S. Postmenopausal hormone therapy: lessons from observational and randomized studies. Endocrine 24 (2004) 251-254
    • (2004) Endocrine , vol.24 , pp. 251-254
    • Rosano, G.M.1    Vitale, C.2    Lello, S.3
  • 10
    • 7044227565 scopus 로고    scopus 로고
    • Why results of clinical trials and observational studies of antitumour necrosis factor (anti-TNF) therapy differ: methodological and interpretive issues
    • Wolfe F., Michaud K., and Dewitt E.M. Why results of clinical trials and observational studies of antitumour necrosis factor (anti-TNF) therapy differ: methodological and interpretive issues. Ann Rheum Dis 63 Suppl 2 (2004) ii13-ii17
    • (2004) Ann Rheum Dis , vol.63 , Issue.SUPPL. 2
    • Wolfe, F.1    Michaud, K.2    Dewitt, E.M.3
  • 11
    • 50549104256 scopus 로고    scopus 로고
    • Why most discovered true associations are inflated
    • Ioannidis J.P. Why most discovered true associations are inflated. Epidemiology 19 (2008) 640-648
    • (2008) Epidemiology , vol.19 , pp. 640-648
    • Ioannidis, J.P.1
  • 12
    • 50549083074 scopus 로고    scopus 로고
    • Curses-winner's and otherwise-in genetic epidemiology
    • discussion 657-668
    • Kraft P. Curses-winner's and otherwise-in genetic epidemiology. Epidemiology 19 (2008) 649-651 discussion 657-668
    • (2008) Epidemiology , vol.19 , pp. 649-651
    • Kraft, P.1
  • 13
    • 50549104473 scopus 로고    scopus 로고
    • Transposed conditionals, shrinkage, and direct and indirect unbiasedness
    • discussion 657-658
    • Senn S. Transposed conditionals, shrinkage, and direct and indirect unbiasedness. Epidemiology 19 (2008) 652-654 discussion 657-658
    • (2008) Epidemiology , vol.19 , pp. 652-654
    • Senn, S.1
  • 14
    • 50549096949 scopus 로고    scopus 로고
    • The search for truth must go beyond statistics
    • discussion 657-658
    • Willett W.C. The search for truth must go beyond statistics. Epidemiology 19 (2008) 655-656 discussion 657-658
    • (2008) Epidemiology , vol.19 , pp. 655-656
    • Willett, W.C.1
  • 15
    • 33846563409 scopus 로고    scopus 로고
    • Why most published research findings are false
    • Ioannidis J.P. Why most published research findings are false. PLoS Med 2 (2005) e124
    • (2005) PLoS Med , vol.2
    • Ioannidis, J.P.1
  • 16
    • 59649098195 scopus 로고    scopus 로고
    • Available at:, Accessed August 2008
    • Ibn Sina from the James Lind Library. Available at: http://www.jameslindlibrary.org/. Accessed August 2008.
    • Ibn Sina from the James Lind Library
  • 17
    • 50449131426 scopus 로고
    • The proper study of mankind is the man
    • Gold H. The proper study of mankind is the man. Am J Med 12 (1952) 619-620
    • (1952) Am J Med , vol.12 , pp. 619-620
    • Gold, H.1
  • 18
    • 84873777808 scopus 로고
    • The diseases drugs cause
    • Lasagna L. The diseases drugs cause. Perspect Biol Med 7 (1964) 457-470
    • (1964) Perspect Biol Med , vol.7 , pp. 457-470
    • Lasagna, L.1
  • 19
    • 0344049557 scopus 로고
    • Symposium on clinical drug evaluation and human pharmacology. VI. Difficulties in extrapolating data on metabolism of drugs from animal to man
    • Brodie B.B. Symposium on clinical drug evaluation and human pharmacology. VI. Difficulties in extrapolating data on metabolism of drugs from animal to man. Clin Pharmacol Ther 3 (1962) 374-380
    • (1962) Clin Pharmacol Ther , vol.3 , pp. 374-380
    • Brodie, B.B.1
  • 21
    • 0034757851 scopus 로고    scopus 로고
    • Teratogenicity of isotretinoin revisited: species variation and the role of all-trans-retinoic acid
    • Nau H. Teratogenicity of isotretinoin revisited: species variation and the role of all-trans-retinoic acid. J Am Acad Dermatol 45 (2001) S183-S187
    • (2001) J Am Acad Dermatol , vol.45
    • Nau, H.1
  • 22
    • 0021971697 scopus 로고
    • Antirheumatic medication in pregnancy
    • Needs C.J., and Brooks P.M. Antirheumatic medication in pregnancy. Br J Rheumatol 24 (1985) 282-290
    • (1985) Br J Rheumatol , vol.24 , pp. 282-290
    • Needs, C.J.1    Brooks, P.M.2
  • 24
    • 37749032491 scopus 로고    scopus 로고
    • "Cytokine Storm" in the Phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics
    • Stebbings R., Findlay L., Edwards C., Eastwood D., Bird C., North D., et al. "Cytokine Storm" in the Phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics. J Immunol 179 (2007) 3325-3331
    • (2007) J Immunol , vol.179 , pp. 3325-3331
    • Stebbings, R.1    Findlay, L.2    Edwards, C.3    Eastwood, D.4    Bird, C.5    North, D.6
  • 25
    • 33749615999 scopus 로고    scopus 로고
    • Translation of research evidence from animals to humans
    • Hackam D.G., and Redelmeier D.A. Translation of research evidence from animals to humans. JAMA 296 (2006) 1731-1732
    • (2006) JAMA , vol.296 , pp. 1731-1732
    • Hackam, D.G.1    Redelmeier, D.A.2
  • 26
    • 33846677129 scopus 로고    scopus 로고
    • Comparison of treatment effects between animal experiments and clinical trials: systematic review
    • Perel P., Roberts I., Sena E., Wheble P., Briscoe C., Sandercock P., et al. Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ 334 (2007) 197
    • (2007) BMJ , vol.334 , pp. 197
    • Perel, P.1    Roberts, I.2    Sena, E.3    Wheble, P.4    Briscoe, C.5    Sandercock, P.6
  • 27
    • 0037160695 scopus 로고    scopus 로고
    • Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation
    • Roberts I., Kwan I., Evans P., and Haig S. Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation. BMJ 324 (2002) 474-476
    • (2002) BMJ , vol.324 , pp. 474-476
    • Roberts, I.1    Kwan, I.2    Evans, P.3    Haig, S.4
  • 28
    • 27644468268 scopus 로고    scopus 로고
    • How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men
    • Corpet D.E., and Pierre F. How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men. Eur J Cancer 41 (2005) 1911-1922
    • (2005) Eur J Cancer , vol.41 , pp. 1911-1922
    • Corpet, D.E.1    Pierre, F.2
  • 29
    • 0038075469 scopus 로고    scopus 로고
    • Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system
    • Corpet D.E., and Pierre F. Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. Cancer Epidemiol Biomarkers Prev 12 (2003) 391-400
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , pp. 391-400
    • Corpet, D.E.1    Pierre, F.2
  • 31
    • 0037167245 scopus 로고    scopus 로고
    • Systematic reviews of animal experiments
    • Sandercock P., and Roberts I. Systematic reviews of animal experiments. Lancet 360 (2002) 586
    • (2002) Lancet , vol.360 , pp. 586
    • Sandercock, P.1    Roberts, I.2
  • 32
    • 1442311168 scopus 로고    scopus 로고
    • Where is the evidence that animal research benefits humans?
    • Pound P., Ebrahim S., Sandercock P., Bracken M.B., and Roberts I. Where is the evidence that animal research benefits humans?. BMJ 328 (2004) 514-517
    • (2004) BMJ , vol.328 , pp. 514-517
    • Pound, P.1    Ebrahim, S.2    Sandercock, P.3    Bracken, M.B.4    Roberts, I.5
  • 33
    • 33645834076 scopus 로고    scopus 로고
    • Methodological quality of systematic reviews of animal studies: a survey of reviews of basic research
    • Mignini L.E., and Khan K.S. Methodological quality of systematic reviews of animal studies: a survey of reviews of basic research. BMC Med Res Methodol 6 (2006) 10
    • (2006) BMC Med Res Methodol , vol.6 , pp. 10
    • Mignini, L.E.1    Khan, K.S.2
  • 34
    • 33747644452 scopus 로고    scopus 로고
    • A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting
    • Peters J.L., Sutton A.J., Jones D.R., Rushton L., and Abrams K.R. A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting. J Environ Sci Health B 41 (2006) 1245-1258
    • (2006) J Environ Sci Health B , vol.41 , pp. 1245-1258
    • Peters, J.L.1    Sutton, A.J.2    Jones, D.R.3    Rushton, L.4    Abrams, K.R.5
  • 35
    • 51949106158 scopus 로고    scopus 로고
    • Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
    • Lang I.A., Galloway T.S., Scarlett A., Henley W.E., Depledge M., Wallace R.B., et al. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 300 (2008) 1303-1310
    • (2008) JAMA , vol.300 , pp. 1303-1310
    • Lang, I.A.1    Galloway, T.S.2    Scarlett, A.3    Henley, W.E.4    Depledge, M.5    Wallace, R.B.6
  • 36
    • 33745182884 scopus 로고    scopus 로고
    • An updated weight of the evidence evaluation of reproductive and developmental effects of low doses of bisphenol A
    • Goodman J.E., McConnell E.E., Sipes I.G., Witorsch R.J., Slayton T.M., Yu C.J., et al. An updated weight of the evidence evaluation of reproductive and developmental effects of low doses of bisphenol A. Crit Rev Toxicol 36 (2006) 387-457
    • (2006) Crit Rev Toxicol , vol.36 , pp. 387-457
    • Goodman, J.E.1    McConnell, E.E.2    Sipes, I.G.3    Witorsch, R.J.4    Slayton, T.M.5    Yu, C.J.6
  • 37
    • 34548475597 scopus 로고    scopus 로고
    • How can we improve the pre-clinical development of drugs for stroke?
    • Sena E., van der Worp H.B., Howells D., and Macleod M. How can we improve the pre-clinical development of drugs for stroke?. Trends Neurosci 30 (2007) 433-439
    • (2007) Trends Neurosci , vol.30 , pp. 433-439
    • Sena, E.1    van der Worp, H.B.2    Howells, D.3    Macleod, M.4
  • 39
    • 0038616401 scopus 로고    scopus 로고
    • Emergency medicine animal research: does use of randomization and blinding affect the results?
    • Bebarta V., Luyten D., and Heard K. Emergency medicine animal research: does use of randomization and blinding affect the results?. Acad Emerg Med 10 (2003) 684-687
    • (2003) Acad Emerg Med , vol.10 , pp. 684-687
    • Bebarta, V.1    Luyten, D.2    Heard, K.3
  • 40
    • 33749648484 scopus 로고    scopus 로고
    • Establishing risk of human experimentation with drugs: lessons from TGN1412
    • Kenter M.J., and Cohen A.F. Establishing risk of human experimentation with drugs: lessons from TGN1412. Lancet 368 (2006) 1387-1391
    • (2006) Lancet , vol.368 , pp. 1387-1391
    • Kenter, M.J.1    Cohen, A.F.2
  • 41
    • 34548351274 scopus 로고    scopus 로고
    • Thinking inside the box. To cope with an increasing disease burden, drug discovery needs biologically relevant and predictive testing systems
    • Spec No:S40-43
    • Sundstrom L. Thinking inside the box. To cope with an increasing disease burden, drug discovery needs biologically relevant and predictive testing systems. EMBO Rep 8 (2007) Spec No:S40-43
    • (2007) EMBO Rep , vol.8
    • Sundstrom, L.1
  • 42
    • 31844443695 scopus 로고
    • The environment and disease: association or causation?
    • Hill A.B. The environment and disease: association or causation?. Proc R Soc Med 58 (1965) 295-300
    • (1965) Proc R Soc Med , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 43
    • 0030923529 scopus 로고    scopus 로고
    • Publication bias: evidence of delayed publication in a cohort study of clinical research projects
    • Stern J.M., and Simes R.J. Publication bias: evidence of delayed publication in a cohort study of clinical research projects. BMJ 315 (1997) 640-645
    • (1997) BMJ , vol.315 , pp. 640-645
    • Stern, J.M.1    Simes, R.J.2
  • 44
    • 0032576406 scopus 로고    scopus 로고
    • Reporting of safety data from randomised trials
    • Ioannidis J.P., and Contopoulos-Ioannidis D.G. Reporting of safety data from randomised trials. Lancet 352 (1998) 1752-1753
    • (1998) Lancet , vol.352 , pp. 1752-1753
    • Ioannidis, J.P.1    Contopoulos-Ioannidis, D.G.2
  • 45
    • 40649092301 scopus 로고    scopus 로고
    • Intrauterine growth restriction in a rodent model and developmental programming of the metabolic syndrome: a critical appraisal of the experimental evidence
    • Neitzke U., Harder T., Schellong K., Melchior K., Ziska T., Rodekamp E., et al. Intrauterine growth restriction in a rodent model and developmental programming of the metabolic syndrome: a critical appraisal of the experimental evidence. Placenta 29 (2008) 246-254
    • (2008) Placenta , vol.29 , pp. 246-254
    • Neitzke, U.1    Harder, T.2    Schellong, K.3    Melchior, K.4    Ziska, T.5    Rodekamp, E.6
  • 46
    • 2142768247 scopus 로고    scopus 로고
    • Pooling of animal experimental data reveals influence of study design and publication bias
    • Macleod M.R., O'Collins T., Howells D.W., and Donnan G.A. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke 35 (2004) 1203-1208
    • (2004) Stroke , vol.35 , pp. 1203-1208
    • Macleod, M.R.1    O'Collins, T.2    Howells, D.W.3    Donnan, G.A.4
  • 47
    • 33645161799 scopus 로고    scopus 로고
    • Do extremely low frequency magnetic fields enhance the effects of environmental carcinogens? A meta-analysis of experimental studies
    • Juutilainen J., Kumlin T., and Naarala J. Do extremely low frequency magnetic fields enhance the effects of environmental carcinogens? A meta-analysis of experimental studies. Int J Radiat Biol 82 (2006) 1-12
    • (2006) Int J Radiat Biol , vol.82 , pp. 1-12
    • Juutilainen, J.1    Kumlin, T.2    Naarala, J.3
  • 49
    • 79960965924 scopus 로고    scopus 로고
    • Genome wide association studies
    • Rebbeck TR, Ambrosome C.B., and Shields P.G. (Eds), Taylor & Francis, New York
    • Bracken M.B., DeWan A., and Hoh J. Genome wide association studies. In: Rebbeck TR, Ambrosome C.B., and Shields P.G. (Eds). Fundamentals of molecular epidemiology (2008), Taylor & Francis, New York 225-238
    • (2008) Fundamentals of molecular epidemiology , pp. 225-238
    • Bracken, M.B.1    DeWan, A.2    Hoh, J.3
  • 52
    • 1042268174 scopus 로고    scopus 로고
    • The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?
    • Williams S.M., Haines J.L., and Moore J.H. The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?. Bioessays 26 (2004) 170-179
    • (2004) Bioessays , vol.26 , pp. 170-179
    • Williams, S.M.1    Haines, J.L.2    Moore, J.H.3
  • 55
    • 49649095887 scopus 로고    scopus 로고
    • Neuroscience: standard model
    • Schnabel J. Neuroscience: standard model. Nature 454 (2008) 682-685
    • (2008) Nature , vol.454 , pp. 682-685
    • Schnabel, J.1
  • 56
    • 2442692780 scopus 로고    scopus 로고
    • Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles
    • Chan A.W., Hrobjartsson A., Haahr M.T., Gotzsche P.C., and Altman D.G. Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA 291 (2004) 2457-2465
    • (2004) JAMA , vol.291 , pp. 2457-2465
    • Chan, A.W.1    Hrobjartsson, A.2    Haahr, M.T.3    Gotzsche, P.C.4    Altman, D.G.5
  • 57
    • 17844372209 scopus 로고    scopus 로고
    • Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1)
    • Krleza-Jeric K., Chan A.W., Dickersin K., Sim I., Grimshaw J., and Guud C. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1). BMJ 330 (2005) 956-958
    • (2005) BMJ , vol.330 , pp. 956-958
    • Krleza-Jeric, K.1    Chan, A.W.2    Dickersin, K.3    Sim, I.4    Grimshaw, J.5    Guud, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.