The neuroprotective effects of benzylideneacetophenone derivatives on excitotoxicity and inflammation via phosphorylated Janus tyrosine kinase 2/phosphorylated signal transducer and activator of transcription 3 and mitogen-activated protein K pathways

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 2, 2009, Pages 435-447

  Jang, Soyong ^a   Jung, Jae Chul ^a   Dong, Hyun Kim ^b   Jong, Hoon Ryu ^b   Lee, Yongnam ^c   Jung, Mankil ^c   Oh, Seikwan ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Kyung Hee University   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 HYDROXY 3 METHOXYPHENYL) 7 PHENYLHEPT 1 EN 3 ONE; 1 (4 HYDROXY 3 METHOXYPHENYL)HEPT 1 EN 3 ONE; 3 (4 HYDROXY 3 METHOXYPHENYL) 5 PHENYLPENT 1 EN 3 ONE; 3 (4 HYDROXY 3 METHOXYPHENYL) 6 PHENYLHEX 1 EN 3 ONE; 4 (4 HYDROXY 3 METHOXYPHENYL)BUT 3 EN 2 ONE; CHALCONE DERIVATIVE; CYTOKINE; JANUS KINASE 2; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; EXCITOTOXICITY; HIPPOCAMPUS; INFLAMMATION; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SCAVENGING SYSTEM;

ANIMALS; BRAIN ISCHEMIA; CHALCONE; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GLUTAMIC ACID; HYDROGEN PEROXIDE; INFLAMMATION; JANUS KINASE 2; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; NITRIC OXIDE; PHOSPHORYLATION; PROPIOPHENONES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 59649107514     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.144014     Document Type: Article

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