The possible involvement of tensin2 in the expression and extension of nephrin by glomerular podocytes in mice

Biomedical Research

Volumn 29, Issue 6, 2008, Pages 279-287

  Kato, Takashi ^a,b   Mizuno, Shinya ^a   Taketo, Makoto Mark ^b   Kurosawa, Tsutomu Miki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NEPHRIN; SYNAPTOPODIN; TENSIN; TENSIN 2; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; MEMBRANE PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; SYNPO PROTEIN, MOUSE; TENSIN2 PROTEIN, MOUSE;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; GLOMERULUS; HETEROZYGOTE; IN VIVO STUDY; MOUSE; NONHUMAN; PATHOGENESIS; PODOCYTE; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEINURIA; ANIMAL; CYTOLOGY; FEMALE; GENETICS; HUMAN; KIDNEY DISEASE; MALE; METABOLISM; MOUSE STRAIN; PATHOPHYSIOLOGY;

MUS;

ALBUMINURIA; ANIMALS; FEMALE; HUMANS; KIDNEY DISEASES; KIDNEY GLOMERULUS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED STRAINS; MICROFILAMENT PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PODOCYTES;

EID: 59649086521     PISSN: 03886107     EISSN: 1880313X     Source Type: Journal    
DOI: 10.2220/biomedres.29.279     Document Type: Article

References (38)

1. Asanuma K, Yanagida-Asanuma E, Faul C, Tommo Y, Kim K and Mundel P (2006) Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat Cell Biol 8, 485-491.
2. Asanuma K, Yanagida-Asanuma E, Takagi M, Kodama F and Tomino Y (2007) The role of podocytes in proteinuria. Nephrology (Carlton) 12, S15-S20.
3. Barisoni L and Mundel P (2003) Podocyte biology and the emerging understanding of podocyte diseases. Am J Nephrol 23, 353-360.
4. Chen H, Ishii A, Wong WK, Chen LB and Lo SH (2000) Molecular characterization of human tensin. Biochem J 351, 403-411.
5. Chen H, Duncan IC, Bozorgchami H and Lo SH (2002) Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. Proc Natl Acad Sci USA 99, 733-738.
6. Cho AR, Uchio-Yamada K, Torigai T, Miyamoto T, Miyoshi I, Matsuda J, Kurosawa T, Kon Y, Asano A, Sasaki N and Agui T (2006) Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome. Mamm Genome 17, 407-416.
7. Coward RJ, Foster RR, Patton D, Ni L, Lennon R, Bates DO, Harper SJ, Mathieson PW and Saleem MA (2005) Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, podocin, and CD2 associated protein in cultured human podocytes. J Am Soc Nephrol 16, 629-637.
8. Doublier S, Salvidio G, Lupia E, Ruotsalainen V, Verzola D, Deferrari G and Camussi G (2003) Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II, Diabetes 52, 1023-1030.
9. Faul C, Asanuma K, Yanagida-Asanuma E, Kim K and Mundel P (2007) Actin up: regulatian of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 17, 428-437.
10. Floege J, Johnson RJ, Gordon K, Iida H, Pritzl P, Yoshimura A, Campbell C, Alpers CE and Couser WG (1991) Increased synthesis of extracellular matrix in mesangial proliferative nephritis. Kidney Int 40, 477-488.
11. Garovic VD, Wagner SJ, Petrovic LM, Gray CE, Hall P, Sugimoto H, Kalluri R and Grande JP (2007) Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia. Nephrol Dial Transplant 22, 1136-1143.
12. Isaka Y, Takahara S and Imai E (2008) Chronic deteriorating renal function and renal fibrosis. Contrib Nephrol 159, 109-121.
13. Johnstone DB and Holzman LB (2006) Clinical impact of research on the podocyte slit diaphragm. Nat Clin Pract Nephrol 2, 271-282.
14. Jones N, Blasutig IM, Eremina V, Ruston JM, Bladt F, Li H, Huang H, Larose L, Li SS, Takano T, Quaggin SE and Pawson T (2006) Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature 440, 818-823.
15. Kestilä M, Lenkkeri U, Männikkö M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A and Tryggvason K (1998) Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome. Mol Cell 1, 575-582.
16. Koop K, Eikmans M, Baelde HJ, Kawachi H, De Heer E, Paul LC and Bruijn JA (2003) Expression of podocyte-associated molecules in acquired human kidney diseases. J Am Soc Nephrol 14, 2063-2071.
17. Kurosawa T, Okamoto M, Yamada K and Yue BF (1993) Nephrosis (nep): A new mouse mutation which causes albuminuria and other symptoms of nephrosis. Mouse Genome 91, 876-879.
18. Li Y, Kang YS, Dai C, Kiss LP, Wen X and Liu Y (2008) Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria. Am J Pathol 172, 299-308.
19. Lo SH, Yu QC, Degenstein L, Chen LB and Fuchs E (1997) Progressive kidney degeneration in mice lacking tensin. J Cell Biol 136, 1349-1361.
20. Matsusaka T, Xin J, Niwa S, Kobayashi K, Akatsuka A, Hashizume H, Wang QC, Pastan I, Fogo AB and Ichikawa I (2005) Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. J Am Soc Nephrol 16, 1013-1123.
21. Mizuno S, Yue BF, Okamoto M, Horikawa Y and Kurosawa T (1997) Diffuse glomerulosclerosis without tubular injury does not directly manifest renal dysfunction in nephrotic mice (ICGN strain). Exp Nephrol 5, 498-507.
22. Mizuno S, Kurosawa T, Matsumoto K, Mizuno-Horilawa Y, Okamoto M and Nakamura T (1998) Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease. J Clin Invest 101, 1827-1834.
23. Mizuno S, Mizuno-Horikawa Y, Yue BF, Okamoto M and Kurosawa T (1999) Nephrotic mice (ICGN strain): a model of diffuse mesangial sclerosis in infantile nephrotic syndrome. Am J Nephrol 19, 73-82.
24. Mizuno S, Mizuno-Horikawa Y and Kurosawa T (2001) Immunohistochemical analysis of molecular events in tubulo-interstitial fibrosis in a mouse model of diffuse mesangial sclerosis (ICGN strain). J Vet Med Sci 63, 299-307.
25. Mouneimne G and Brugge JS (2007) Tensins: a new switch in cell migration. Dev Cell 13, 317-319.
26. Ogura A, Asano T, Matsuda J, Takano K, Nakagawa M and Fukui M (1989) Characteristics of mutant mice (ICGN) with spontaneous renal lesions: a new model for human nephrotic syndrome. Lab Anim 23, 169-174.
27. Ogura A, Asano T, Matsuda J, Koura M, Nakagawa M, Kawaguchi H and Yamaguchi Y (1990) An electron microscopic study of glomerular lesions in hereditary nephrotic mice (ICGN strain). Virchows Arch A Pathol Anat Histopathol 417, 223-228.
28. Ogura A, Fujimura H, Asano T, Koura M, Naito I and Kobayashi Y (1995) Early ultrasfructural glomerular alterations in neonatal nephrotic mice (ICGN strain). Vet Pathol 32, 321-323.
29. Okamoto M, Yokoi N, Serikawa T, Tajima M and Kurosawa T (2001) Linkage mapping of the mouse nephrosis (nep) gene to chromosome 15. J Vet Med Sci 63, 1347-1350.
30. Putaala H, Soininen R, Kilpeläinen P, Wartiovaara J and Tryggvason K (2001) The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. Hum Mol Genet 10, 1-8.
31. Remuzzi G and Bertani T (1998) Pathophysiology of progressive nephropathies. N Engl J Med 339, 1448-1456.
32. Ruotsalainen V, Ljungberg P, Wartiovaara J, Lenkkeri U, Kestilä M, Jalanko H, Holmberg C and Tryggvason K (1999) Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc Natl Acad Sci USA 96, 7962-7967.
33. Saleem MA, Ni L, Witherden I, Tryggvason K, Ruotsalainen V, Mundel P and Mathieson PW (2002) Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. Am J Pathol 161, 1459-1466.
34. Schiffer M, Bitzer M, Roberts IS, Kopp JB, ten Dijke P, Mundel P and Böttinger EP (2001) Apoptosis in podocytes induced by TGF-beta and Smad7. J Clin Invest 108, 807-816.
35. Schiwek D, Endlich N, Holzman L, Holthöfer H, Kriz Wn and Endlich K (2004) Stable expression of nephrin and localization to cell-cell contacts in novel murine podocyte cell lines. Kidney Int 66, 91-101.
36. Stevens LA, Coresh J, Greene T and Levey AS (2006) Assessing kidney function - measured and estimated glomerular filtration rate. N Engl J Med 354, 2473-2483.
37. Taal MW and Brenner BM (2008) Renal risk scores: progress and prospects. Kidney Int 73, 1216-1219.
38. Topham PS, Kawachi H, Haydar SA, Chugh S, Addona TA, Charron KB, Holzman LB, Shia M, Shimizu F and Salant DJ (1999) Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin. J Clin Invest 104, 1559-1566.