TAL1/SCL relieves the E2-2-mediated repression of VEGFR2 promoter activity

Journal of Biochemistry

Volumn 145, Issue 2, 2009, Pages 129-135

  Tanaka, Aya ^a   Itoh, Fumiko ^a   Itoh, Susumu ^a   Kato, Mitsuyasu ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Angiogenesis; E2 2; Endothelial cell; SCL TAL1; VEGFR2

Indexed keywords

GLYCOPROTEIN E2; TRANSCRIPTION FACTOR TAL1; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; E BOX ELEMENT; ENDOTHELIUM CELL; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN INTERACTION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOTHELIAL CELLS; MICE; MODELS, BIOLOGICAL; PROMOTER REGIONS, GENETIC; TCF TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 59449090378     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn158     Document Type: Article

References (23)

1. Carmeliet, P. (2005) Angiogenesis in life, disease and medicine. Nature 438, 932-936
2. Adams, R.H. and Alitalo, K. (2007) Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 8, 464-478
3. Finger, L.R., Kagan, J., Christopher, G., Kurtzberg, J., Hershfield, M.S., Nowell, P.C., and Croce, C.M. (1989) Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc. Natl. Acad. Sci. USA 86, 5039-5043
4. Chen, Q., Cheng, J.T., Tasi, L.H., Schneider, N., Buchanan, G., Carrroll, A., Crist, W., Ozanne, B., Siciliano, M.J., and Baer, R. (1990) The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J. 9, 415-424
5. Aplan, P.D., Raimondi, S.C., and Kirsch, I.R. (1992) Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia. J. Exp. Med. 176, 1303-1310
6. Kallianpur, A.R., Jordan, J.E., and Brandt, S.J. (1994) The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis. Blood 83, 1200-1208
7. Mikkola, H.K., Klintman, J., Yang, H., Hock, H., Schlaeger, T.M., Fujiwara, Y., and Orkin, S.H. (2003) Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature 421, 547-551
8. Visvader, J.E., Fujiwara, Y., and Orkin, S.H. (1998) Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes. Dev. 12, 473-479
9. Hsu, H.L., Cheng, J.T., Chen, Q., and Baer, R. (1991) Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. Mol. Cell. Biol. 11, 3037-3042
10. Wadman, I.A., Osada, H., Grütz, G.G., Agulnick, A.D., Westphal, H., Forster, A., and Rabbitts, T.H. (1997) The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 16, 3145-3157
11. Hsu, H.L., Wadman, I., Tsan, J.T., and Baer, R. (1994) Positive and negative transcriptional control by the TAL1 helix-loop-helix protein. Proc. Natl. Acad. Sci. USA 91, 5947-5951
12. Deleuze, V., Chalhoub, E., El-Hajj, R., Dohet, C., Le Clech, M., Couraud, P.-O., Huber, P., and Mathieu, D. (2007) TAL-1/SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells. Mol. Cell. Biol. 27, 2687-2697
13. O'Neil, J., Shank, J., Cusson, N., Murre, C., and Kelliher, M. (2004) TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell. 5, 587-596
14. Porcher, C., Liao, E.C., Fujiwara, Y., Zon, L.I., and Orkin, S.H. (1999) Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development 126, 4603-4615
15. O'Neil, J., Billa, M., Oikemus, S., and Kelliher, M. (2001) The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice. Oncogene 20, 3897-3905
16. Schlaeger, T.M., Schuh, A., Flitter, S., Fisher, A., Mikkola, H., Orkin, S.H., Vyas, P., and Porcher, C. (2004) Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Mol. Cell. Biol. 24, 7491-7502
17. Goldfarb, A.N. and Lewandowska, K. (1995) Inhibition of cellular differentiation by the SCL/tal oncoprotein: Transcriptional repression by an Id-like mechanism. Blood 85, 465-471
18. Goldfarb, A.N., Lewandowska, K., and Shoham, M. (1996) Determinants of helix-loop-helix dimerization affinity. Random mutational analysis of SCL/tal. J. Biol. Chem. 271, 2683-2688
19. Sigvardsson, M. (2000) Overlapping expression of early B-cell factor and basic helix-loop-helix proteins as a mechanism to dictate B-lineage-specific activity of the λ5 promoter. Mol. Cell. Biol. 20, 3640-3654
20. Valdimarsdottir, G., Goumans, M.-J., Rosendahl, A., Brugman, M., Itoh, S., Lebrin, F., Sideras, P., and ten Dijke, P. (2002) Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells. Circulation 106, 2263-2270
21. Jackson, T.A., Taylor, H.E., Sharma, D., Desiderio, S., and Danoff, S.K. (2005) Vascular endothelial growth factor receptor-2. Counter-regulation by the transcription factors, TFII-I and TFII-IRD1. J. Biol. Chem. 280, 29856-29863
22. Goumans, M.-J., Valdimarsdottir, G., Itoh, S., Rosendahl, A., Sideras, P., and ten Dijke, P. (2002) Balancing the activation state of the endothelium via two distinct TGF-β type I receptors. EMBO J. 21, 1743-1753
23. Itoh, S., Ericsson, J., Nishikawa, J., Heldin, C.-H., and ten Dijke, P. (2000) The transcriptional co-activator P/CAF potentiates TGF-β/Smad signaling. Nucl. Acids Res. 28, 4291-4298