Validation of the sheep as a large animal model for the study of vertebral osteoporosis

European Spine Journal

Volumn 18, Issue 2, 2009, Pages 244-253

  Zarrinkalam, M R ^a   Beard, H ^a   Schultz, C G ^b   Moore, R J ^a,c  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Animal model; Histology; Lumbar spine; Osteoporosis; Sheep

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; COMPRESSIVE STRENGTH; CONTROLLED STUDY; FEMALE; FEMUR; ILIAC CREST; LUMBAR SPINE; MORPHOMETRICS; NONHUMAN; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; RESEARCH SUBJECT; SHEEP; TRABECULAR BONE; WEIGHT BEARING;

ABSORPTIOMETRY, PHOTON; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; BIOMECHANICS; BONE DENSITY; COLLAGEN TYPE I; COMPRESSIVE STRENGTH; DEXAMETHASONE; DISEASE MODELS, ANIMAL; FEMALE; FEMUR; LUMBAR VERTEBRAE; OSTEOPOROSIS; OVARIECTOMY; PEPTIDES; SHEEP;

EID: 59449090116     PISSN: 09406719     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00586-008-0813-8     Document Type: Article

References (44)

1. Aaron JE, Makins NB, Sagreiya K (1987) The microanatomy of trabecular bone loss in normal aging men and women. Clin Orthop Relat Res 260-271
2. P Augat H Reeb LE Claes 1996 Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell J Bone Miner Res 11 1356 1363
3. DM Black SR Cummings HK Genant 1992 Axial and appendicular bone density predict fractures in older women J Bone Miner Res 7 633 638
4. E Canalis AM Delany 2002 Mechanisms of glucocorticoid action in bone Ann N Y Acad Sci 966 73 81
5. LO Chailurkit B Ongphiphadhanakul N Piaseu 2001 Biochemical markers of bone turnover and response of bone mineral density to intervention in early postmenopausal women: an experience in a clinical laboratory Clin Chem 47 1083 1088
6. D Chappard E Legrand MF Basle 1996 Altered trabecular architecture induced by corticosteroids: a bone histomorphometric study J Bone Miner Res 11 676 685
7. P Chavassieux A Buffet P Vergnaud 1997 Short-term effects of corticosteroids on trabecular bone remodeling in old ewes Bone 20 451 455 10.1016/S8756-3282(97)00016-1
8. P Chavassieux P Garnero F Duboeuf 2001 Effects of a new selective estrogen receptor modulator (MDL 103, 323) on cancellous and cortical bone in ovariectomized ewes: a biochemical, histomorphometric, and densitometric study J Bone Miner Res 16 89 96 10.1359/jbmr.2001.16.1.89
9. P Chavassieux P Pastoureau G Boivin 1991 Dose effects on ewe bone remodeling of short-term sodium fluoride administration-a histomorphometric and biochemical study Bone 12 421 427 10.1016/8756-3282(91)90031-D
10. P Chavassieux P Pastoureau MC Chapuy 1993 Glucocorticoid-induced inhibition of osteoblastic bone formation in ewes: a biochemical and histomorphometric study Osteoporos Int 3 97 102 10.1007/BF01623380
11. RG Erben 1996 Trabecular and endocortical bone surfaces in the rat: modeling or remodeling? Anat Rec 246 39 46 10.1002/(SICI)1097-0185(199609)246: 1<39::AID-AR5>3.0.CO;2-A
12. FDA Division of Metabolism and Endocrine Drug Products (1994) Food and Drug Administration Guidelines for preclinical and clinical evaluation of agents used in the prevention or treatment of postmenopausal osteoporosis, Washington, DC
13. J Goldhahn A Jenet E Schneider 2005 Slow rebound of cancellous bone after mainly steroid-induced osteoporosis in ovariectomized sheep J Orthop Trauma 19 23 28 10.1097/00005131-200501000-00005
14. J Goldhahn D Neuhoff S Schaeren 2006 Osseointegration of hollow cylinder based spinal implants in normal and osteoporotic vertebrae: a sheep study Arch Orthop Trauma Surg 126 554 561 10.1007/s00402-006-0185-7
15. SL Greenspan L Maitland-Ramsey E Myers 1996 Classification of osteoporosis in the elderly is dependent on site-specific analysis Calcif Tissue Int 58 409 414 10.1007/BF02509439
16. SB Hornby SL Ford CA Mase 1995 Skeletal changes in the ovariectomised ewe and subsequent response to treatment with 17 beta oestradiol Bone 17 389S 394S
17. M Li Y Shen TJ Wronski 1997 Time course of femoral neck osteopenia in ovariectomized rats Bone 20 55 61 10.1016/S8756-3282(96)00317-1
18. CA Lill AK Fluegel E Schneider 2002 Effect of ovariectomy, malnutrition and glucocorticoid application on bone properties in sheep: a pilot study Osteoporos Int 13 480 486 10.1007/s001980200058
19. CA Lill AK Fluegel E Schneider 2000 Sheep model for fracture treatment in osteoporotic bone: a pilot study about different induction regimens J Orthop Trauma 14 559 565 discussion 565-6
20. CA Lill UV Gerlach C Eckhardt 2002 Bone changes due to glucocorticoid application in an ovariectomized animal model for fracture treatment in osteoporosis Osteoporos Int 13 407 414 10.1007/s001980200047
21. JM MacLeay JD Olson RM Enns 2004 Dietary-induced metabolic acidosis decreases bone mineral density in mature ovariectomized ewes Calcif Tissue Int 75 431 437 10.1007/s00223-004-0217-7
22. SC Manolagas RS Weinstein 1999 New developments in the pathogenesis and treatment of steroid-induced osteoporosis J Bone Miner Res 14 1061 1066 10.1359/jbmr.1999.14.7.1061
23. P McDonnell PE McHugh D O'Mahoney 2007 Vertebral osteoporosis and trabecular bone quality Ann Biomed Eng 35 170 189 10.1007/s10439-006-9239-9
24. LJ Melton III EA Chrischilles C Cooper 1992 Perspective. How many women have osteoporosis? J Bone Miner Res 7 1005 1010
25. D Mitton C Rumelhart D Hans 1997 The effects of density and test conditions on measured compression and shear strength of cancellous bone from the lumbar vertebrae of ewes Med Eng Phys 19 464 474 10.1016/S1350-4533(97) 00001-5
26. H Nakamuta T Nitta T Hoshino 1996 Glucocorticoid-induced osteopenia in rats: histomorphometrical and microarchitectural characterization and calcitonin effect Biol Pharm Bull 19 217 219
27. E Newman AS Turner JD Wark 1995 The potential of sheep for the study of osteopenia: current status and comparison with other animal models Bone 16 277S 284S
28. BI Newton RC Cooper JA Gilbert 2004 The ovariectomized sheep as a model for human bone loss J Comp Pathol 130 323 326 10.1016/j.jcpa.2003.12.007
29. O'Connell SL (1999) The sheep as an experimental model for osteoporosis. Department of Medicine. The University of Melbourne, Melbourne
30. G Ortoft H Oxlund 1996 Qualitative alterations of cortical bone in female rats after long-term administration of growth hormone and glucocorticoid Bone 18 581 590 10.1016/8756-3282(96)00077-4
31. IH Parkinson NL Fazzalari 1994 Cancellous bone structure analysis using image analysis Australas Phys Eng Sci Med 17 64 70
32. FM Phillips AS Turner HB Seim III 2006 In vivo BMP-7 (OP-1) enhancement of osteoporotic vertebral bodies in an ovine model Spine J 6 500 506 10.1016/j.spinee.2006.01.014
33. S Schorlemmer C Gohl S Iwabu 2003 Glucocorticoid treatment of ovariectomized sheep affects mineral density, structure, and mechanical properties of cancellous bone J Bone Miner Res 18 2010 2015 10.1359/jbmr.2003. 18.11.2010
34. S Schorlemmer A Ignatius L Claes 2005 Inhibition of cortical and cancellous bone formation in glucocorticoid-treated OVX sheep Bone 37 491 496 10.1016/j.bone.2005.05.002
35. TD Spector EV McCloskey DV Doyle 1993 Prevalence of vertebral fracture in women and the relationship with bone density and symptoms: the Chingford Study J Bone Miner Res 8 817 822
36. Sundstol F, Owen E (1984) Straw and other fibrous by-products as feed. Elsevier, Amsterdam
37. DD Thompson HA Simmons CM Pirie 1995 FDA Guidelines and animal models for osteoporosis Bone 17 125S 133S 10.1016/8756-3282(95)97353-H
38. H Tsugeno T Fujita B Goto 2002 Vertebral fracture and cortical bone changes in corticosteroid-induced osteoporosis Osteoporos Int 13 650 656 10.1007/s001980200088
39. H Tsugeno B Goto T Fujita 2001 Oral glucocorticoid-induced fall in cortical bone volume and density in postmenopausal asthmatic patients Osteoporos Int 12 266 270 10.1007/s001980170115
40. AS Turner 2001 Animal models of osteoporosis-necessity and limitations Eur Cell Mater 1 66 81
41. AS Turner 2002 The sheep as a model for osteoporosis in humans Vet J 163 232 239 10.1053/tvjl.2001.0642
42. AS Turner M Alvis W Myers 1995 Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes Bone 17 395S 402S 10.1016/8756-3282(95)00148-7
43. van Gieson I (1889) Laboratory notes of technical methods for the nervous system. Med J 50:57
44. HJ Wilke A Kettler LE Claes 1997 Are sheep spines a valid biomechanical model for human spines? Spine 22 2365 2374 10.1097/00007632-199710150-00009