Glucocorticoid Treatment of Ovariectomized Sheep Affects Mineral Density, Structure, and Mechanical Properties of Cancellous Bone

Journal of Bone and Mineral Research

Volumn 18, Issue 11, 2003, Pages 2010-2015

  Schorlemmer, Sandra ^a   Gohl, Christine ^a   Iwabu, Shohei ^a   Ignatius, Anita ^a   Claes, Lutz ^a   Augat, Peter ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Biomechanics; Bone histomorphometry; Bone quantitative computed tomography; Corticosteroids; Osteoporosis

Indexed keywords

GLUCOCORTICOID; MEDRATESOLUBILE; METHYLPREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE BIOPSY; BONE DENSITY; BONE MINERAL; CANCELLOUS BONE; COMPRESSION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DRUG EFFECT; FEMALE; FEMUR CONDYLE; HISTOPATHOLOGY; LUMBAR SPINE; NONHUMAN; OSSIFICATION; OSTEOID; OSTEOPENIA; OSTEOPOROSIS; OVARIECTOMY; SHEEP; THICKNESS; TIBIA;

ANIMALS; BONE AND BONES; BONE DENSITY; FEMALE; FEMUR; GLUCOCORTICOIDS; MODELS, ANIMAL; OSTEOPOROSIS; OVARIECTOMY; SHEEP; SPINE; TIBIA;

EID: 0242412973     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.11.2010     Document Type: Article

References (29)

1. Manolagas SC, Weinstein RS 1999 New developments in the pathogenesis and treatment of steroid-induced osteoporosis. J Bone Miner Res 14:1061-1066.
2. Martini L, Fini M, Giavaresi G, Giardino R 2001 Sheep model in orthopedic research: A literature review. Comp Med 51:292-299.
3. Newman E, Turner AS, Wark JD 1995 The potential of sheep for the study of osteopenia: Current status and comparison with other animal models. Bone 16(Suppl 4):277S-284S.
4. Chavassieux P, Pastoureau P, Boivin G, Chapuy MC, Delmas PD, Milhaud G, Meunier PJ 1991 Fluoride-induced bone changes in lambs during and after exposure to sodium fluoride. Osteoporos Int 2:26-33.
5. Fini M, Pierini G, Giavaresi G, Biagini G, Mattioli Belmonte MM, Nicoli Aldini N, Rocca M, Martini L, Giardino R 2000 The ovariectomised sheep as a model for testing biomaterials and prosthetic devices in osteopenic bone: A preliminary study on iliac crest biopsies. Int J Artif Organs 23:275-281.
6. Aerssens J, Boonen S, Lowet G, Dequeker J 1998 Interspecies differences in bone composition, density, and quality: Potential implications for in vivo bone research. Endocrinology 139:663-670.
7. Chavassieux P, Garnero P, Duboeuf F, Vergnaud P, Brunner-Ferber F, Delmas PD, Meunier PJ 2001 Effects of a new selective estrogen receptor modulator (MDL 103, 323) on cancellous and cortical bone in ovariectomized ewes: A biochemical, histomorphometric, and densitometric study. J Bone Miner Res 16:89-96.
8. Rodgers JB, Monier-Faugere MC, Malluche H 1993 Animal models for the study of bone loss after cessation of ovarian function. Bone 14:369-377.
9. Turner AS, Alvis M, Myers W, Stevens ML, Lundy MW 1995 Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes. Bone 17(Suppl 4):395S-402S.
10. Turner AS, Mallinckrodt CH, Alvis MR, Bryant HU 1995 Dose-response effects of estradiol implants on bone mineral density in ovariectomized ewes. Bone 17(Suppl 4):421S-427S.
11. Geusens P, Boonen S, Nijs J, Jiang Y, Lowet G, Van Auderkercke R, Huyghe C, Caulin F, Very JM, Dequeker J, Van der Perre G 1996 Effect of salmon calcitonin on femoral bone quality in adult ovariectomized ewes. Calcif Tissue Int 59:315-320.
12. Turner AS 2001 Animal models of osteoporosis - necessity and limitations. Eur Cells Mater 1:66-81.
13. Chavassieux P, Pastoureau P, Chapuy MC, Delmas PD, Meunier PJ 1993 Glucocorticoid-induced inhibition of osteoblastic bone formation in ewes: A biochemical and histomorphometric study. Osteoporos Int 3:97-102.
14. Chavassieux P, Buffet A, Vergnaud P, Garnero P, Meunier PJ 1997 Short-term effects of corticosteroids on trabecular bone remodeling in old ewes. Bone 20:451-455.
15. Lill CA, Gerlach UV, Eckhardt C, Goldhahn J, Schneider E 2002 Bone changes due to glucocorticoid application in an ovariectomized animal model for fracture treatment in osteoporosis. Osteoporos Int 13:407-414.
16. Lill CA, Fluegel AK, Schneider E 2002 Effect of ovariectomy, malnutrition and glucocorticoid application on bone properties in sheep: A pilot study. Osteoporos Int 13:480-486.
17. Augat P, Gordon CL, Lang TF, Iida H, Genant HK 1998 Accuracy of cortical and trabecular bone measurements with peripheral quantitative computed tomography (pQCT). Phys Med Biol 43:2873-2883.
18. Gaertner R, Haen E 2001 Endokrinpharmakologie: Pharmakotherapie mit Hormonen. In: Forth W, Henschler D, Rummel W, Foerstermann U, Starke K (eds.) Allgemeine und spezielle Pharmakologie und Toxikologie fuer Studenten der Medizin, Veterinaermedizin, Pharmazie, Chemi und Biologie sowie fuer Aerzte, Tieraerzte und Apotheker, 8th ed. Urban & Fischer, Munich, Germany, pp. 671-737.
19. Hornby SB, Ford SL, Mase CA, Evans GP 1995 Skeletal changes in the ovariectomised ewe and subsequent response to treatment with 17 beta oestradiol. Bone 17(Suppl 4):389S-394S.
20. Giavaresi G, Fini M, Torricelli P, Martini L, Giardino R 2001 The ovariectomized ewe model in the evaluation of biomaterials for prosthetic devices in spinal fixation. Int J Artif Organs 24:814-820.
21. Deloffre P, Hans D, Rumelhart C, Mitton D, Tsouderos Y, Meunier PJ 1995 Comparison between bone density and bone strength in glucocorticoid-treated aged ewes. Bone 17(Suppl 4): 409S-414S.
22. Reid IR 1997 Glucocorticoid osteoporosis - mechanisms and management. Eur J Endocrinol 137:209-217.
23. Laan RF, Buijs WC, van Erning LJ, Lemmens JA, Corstens FH, Ruijs SH, van de Putte LB, van Riel PL 1993 Differential effects of glucocorticoids on cortical appendicular and cortical vertebral bone mineral content. Calcif Tissue Int 52:5-9.
24. Van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C 2000 Use of oral corticosteroids and risk of fractures. J Bone Miner Res 15:993-1000.
25. Cummings S, Kelsey J, Nevitt M, O'Dowd KJ 1985 Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 1985:178-208.
26. Augat P, Link T, Lang TF, Lin J, Majumdar S, Genant HK 1998 Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations. Med Eng Phys 20:124-131.
27. Parfitt AM 1984 Age-related structural changes in trabecular and cortical bone: Cellular mechanisms and biomechanical consequences. Calcif Tissue Int 36(Suppl 1):S123-S128.
28. Manolagas SC 2000 Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21:115-137.
29. Patschan D, Loddenkemper K, Buttgereit F 2001 Molecular mechanisms of glucocorticoid-induced osteoporosis. Bone 29:498-505.