Sheep model for fracture treatment in osteoporotic bone: A pilot study about different induction regimens

Journal of Orthopaedic Trauma

Volumn 14, Issue 8, 2000, Pages 559-566

  Lill, Christoph Alexander ^a,b   Fluegel, Alexa Katrin ^b   Schneider, Erich ^a  

^a AO RESEARCH INSTITUTE   (Switzerland)

^b Dept of Orthoped Surgery Freiburg ^*

Author keywords

Animal model; Osteoporosis; Osteoporosis induction; Sheep

Indexed keywords

CALCIUM DERIVATIVE; STEROID; VITAMIN D;

ANIMAL; ARTICLE; BONE DENSITY; BONE REGENERATION; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DIET; DISEASE MODEL; FEMALE; ILIAC BONE; MALE; METHODOLOGY; MULTIMODALITY CANCER THERAPY; OSTEOPOROSIS; OVARIECTOMY; PATHOLOGIC FRACTURE; PHYSIOLOGY; PILOT STUDY; PROSPECTIVE STUDY; RADIODENSITOMETRY; RADIOGRAPHY; RANDOMIZATION; REFERENCE VALUE; SHEEP; TREATMENT OUTCOME;

ANIMALS; BONE DENSITY; BONE REGENERATION; CALCIUM COMPOUNDS; COMBINED MODALITY THERAPY; DENSITOMETRY, X-RAY; DIET; DISEASE MODELS, ANIMAL; FEMALE; FRACTURES, SPONTANEOUS; ILIUM; MALE; OSTEOPOROSIS; OVARIECTOMY; PILOT PROJECTS; PROSPECTIVE STUDIES; RANDOM ALLOCATION; REFERENCE VALUES; SHEEP; STEROIDS; TREATMENT OUTCOME; VITAMIN D;

EID: 0034327227     PISSN: 08905339     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005131-200011000-00007     Document Type: Article

References (42)

1. Biggemann M, Hilweg D, Brinckmann P. Prediction of compressive strength of vertebral bodies of the lumbar spine by quantitative computed tomography. Skel Radiol 1988;17:264-269.
2. Bressot C, Meunier PJ, Chapuy MC. Histomorphometric profile, pathophysiology and reversibility of corticosteroid-induced osteoporosis. Metab Bone Dis Rel Res 1979;1:303-311.
3. Burstein AH, Frankel VH. A standard test for laboratory animal bone. J Biomech 1971;4:155-158.
4. Chavassieux P. Bone effects of fluoride in animal models in vivo: A review and a recent study. J Bone Miner Res 1990;5(Suppl. 1)-95-99.
5. Chavassieux P, Buffet A, Vergnaud P, Garnero P, Meunier PJ. Short-term effects of corticosteroids on trabecular bone remodeling in old ewes. Bone 1997;20:451-455.
6. Chavassieux P, Pastoureau P, Boivin G, Chapuy C, Delmas PD, Meunier PJ. The effects on ewe bone remodeling of short-term sodium fluoride administration: a histomorphometric and biochemical study. Bone 1991;12:421-427.
7. Chavassieux P, Pastoureau P, Chapuy C, Delmas PD, Meunier PJ. Glucocorticoid-induced inhibition of osteoblastic bone formation in ewes: a biochemical and histomorphometric study. Osteoporosis Int 1993;3:97-102.
8. Currey JD. The mechanical consequence of variation in the mineral content of bone. J Biomech 1969;2:1-11.
9. Currey JD, Brear K, Zioupos P. The effect of ageing and changes in mineral content in degrading the toughness of human femora. J Biomech 1996;29:257-260.
10. Deloffre P, Hans D, Rumelhart C, Mitton D, Tsouderos Y, Meunier PJ. Comparison between bone density and bone strength in glucocorticoid-treated aged ewes. Bone 1995;17:409-414.
11. Dempster DW. Bone histomorphometry in glucocorticoid-induced osteoporosis. J Bone Miner Res 1989;4:137-141.
12. Genant HK, Fuerst T, Engelke K, Glüer CC, Grampp S, Harris ST. Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res 1996;11:707-730.
13. Geusens P, Boonen S, Nijs J, et al. Effect of salmon calcitonin on femoral bone quality in adult ovariectomized ewes. Calcif Tissue Int 1996;59:315-320.
14. Guglielmi G, Glüer CC, Majumdar S, Blunt BA, Genant HK. Current methods and advances in bone densitometry. Eur Radiol 1995;5:129-139.
15. Hahn TJ, Halstead LR, Teitelbaum SL. Altered mineral metabolismin glucocorticoid-induced osteopenia: effect of 25-hydroxyvitamin D administration. J Clin Invest 1979;64:655-665.
16. Hawker GA. The epidemiology of osteoporosis. J Rheumatol 1996;23:2-5.
17. Hodgkinson A, Aaron JE, Horsman A, McLachlan MSF, Nordin BEC. Effect of oophorectomy and calcium deprivation on bone mass in rat. Clin Sci Mol Med 1978;54:439-446.
18. Hornby SB, Ford SL, Mase CA, Evans GP. Skeletal changes in the ovariectomised ewe and subsequent response to treatment with 17β oestradiol. Bone 1995;17:389-394.
19. Ito M, Ohki M, Hayashi K, Yamada M, Uetani M, Nakamura T. Trabecular texture analysis of CT images in the relationship with spinal fracture. Radiology 1995;194:55-59.
20. Jee WSS, Park HZ, Roberts WE, Kenner GH. Cortico-steroids and bone. Am J Anat 1970;129:477-479.
21. Jowsey J, Riggs BL. Bone formation in hypercortisolism. Acta Endocrinol 1970;63:21-28.
22. Kasra M, Grynpas MD. Effect of long-term ovariectomy on bone mechanical properties in young female cynomolgus monkeys. Bone 1994;15:557-561.
23. Klein RG, Arnaud SB, Gallagher JC, DeLuca HF, Riggs BL. Intestinal calcium absorption in exogenous hypercortisolism: role of 25-hydroxyvitamin D and corticosteroid dose. J Clin Invest 1977; 60:253-259.
24. Laitinen K, Valimaki M, Keto P. Bone mineral density measured by dual-energy x-ray absorptiometry in healthy Finnish women. Calcif Tissue Int 1991;48:224-231.
25. Mazess RB, Barden HS. Bone density in premenopausal women: effects of age, dietary intake, physical activity, smoking, and birth control pills. Am J Clin Nutr 1996;54:169-171.
26. McBroom RJ, Hayes WC, Edwards WT, Goldberg RP, White AA. Prediction of vertebral body compressive fracture using quantitative computed tomography. J Bone Joint Surg Am 1985;67:1206-1214.
27. Melton LJI, Chao EYS, Lane J. Biomechanical aspects of fractures. In: Osteoporosis: Etiology, Diagnosis, and Management, ed by Riggs BL, Melton LJI. New York, Raven Press, 1988, pp 111-113.
28. Newman E, Turner AS, Wark JD. The potential of sheep for the study of osteopenia: current status and comparison with other animal models. Bone 1995;16:277-248.
29. Paavolainen P. Studies on mechanical strength of bone. Acta Orthop Scand 1978;49:497-505.
30. Parfitt AM. Implications of architecture in the pathogenesis and prevention of vertebral fracture. Bone 1992;13:41-47.
31. Pastoureau P, Arlot ME, Caulin F, Barier JP, Meunier PJ, Delmas PD. Effects of oophorectomy on biochemical and histological indices of bone turnover in ewes. J Bone Miner Res 1989;4 (suppl. 1):58.
32. Puhl JJ, Pietrowski G, Enneking WF. Biomechanical properties of paired canine fibulas. J Biomech 1972;4:113-117.
33. Rigotti NA, Neer RM, Skates SJ, Herzog DB, Nussbaum SR. The clinical course of osteoporosis in anorexia nervosa: a longitudinal study of cortical bone mass. J Am Med Assoc 1991;265:1133-1138.
34. Riggs BL, Melton LJ III. Medical progress: Involutional osteoporosis. N Engl J Med 1989;314:1676-1686.
35. Rosen CJ, Morrison A, Zhou H, et al. Elderly women in northern New England exhibit seasonal changes in bone mineral density and calciotropic hormones. Bone Miner Res 1994;25:83-92.
36. Ross PD. Osteoporosis. Arch Intern Med 1996;156:1399-1411.
37. Rüegsegger P, Koller B, Müller R. A microtomographic system for the nondestructive evaluation of bone architecture. Calcif Tissue Int 1996;58:24-29.
38. Rüegsegger P. Bone density measurement. In: Osteoporosis: A Guide to Diagnosis and Treatment, ed by Bröll H, Dambacher MA. Basel, Switzerland, Karger, 1996, pp 103-116.
39. Swiontkowski MF, Harrington RM, Keller TS, Van Patten PK. Torsion and bending analysis of internal fixation techniques for femoral neck fractures: the role of implant design and bone density. J Orthop Res 1987;5:433-444.
40. Turner AS, Alvis M, Myers W, Stevens ML, Lundy MW. Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes. Bone 1995;17:395-402.
41. Turner AS, Mallinckrodt CH, Alvis MR, Bryant HU. Dose-response effects of estradiol implants on bone mineral density in ovariectomized ewes. Bone 1995;17:421-427.
42. Yeni YN, Brown CU, Norman TL. Influence of bone composition and apparent densitity on fracture toughness of the human femur and tibia. Bone 1998;22:79-84.