Vascular effects of acute hyperglycemia in humans are reversed by L- arginine: Evidence for reduced availability of nitric oxide during hyperglycemia

Circulation

Volumn 95, Issue 7, 1997, Pages 1783-1790

  Giugliano, Dario ^a   Marfella, Raffaele ^b   Coppola, Ludovico ^b   Verrazzo, Giovanni ^b   Acampora, Rita ^b   Giunta, Riccardo ^b   Nappo, Francesco ^b   Lucarelli, Carmela ^b   D'Onofrio, Felice ^b  

^a NONE   (Italy)

^b NONE

Author keywords

amino acids; hemodynamics; hyperglycemia; rheology

Indexed keywords

ARGININE; CATECHOLAMINE; DEXTRO ARGININE; LYSINE; N(G) METHYLARGININE; NITRIC OXIDE;

ADULT; ARTICLE; CATECHOLAMINE BLOOD LEVEL; CLINICAL ARTICLE; DIASTOLIC BLOOD PRESSURE; FEMALE; GLUCOSE CLAMP TECHNIQUE; HEART RATE; HEMODYNAMICS; HUMAN; HYPERGLYCEMIA; INTRAVENOUS DRUG ADMINISTRATION; LEG BLOOD FLOW; MALE; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE AGGREGATION;

EID: 0030942586     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.95.7.1783     Document Type: Article

References (40)

1. Colwell JA. Vascular thrombosis in type II diabetes mellitus. Diabetes. 1993;42:8-11.
2. DCCT Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993; 329:977-986.
3. Kuusisto J, Mikkänen L, Pyorälä K, Laakso M. NIDDM and its metabolic control predict coronary artery disease in elderly people. Diabetes. 1994;43:960-967.
4. Klein R. Hyperglycemia and microvascular and macrovascular disease in diabetes. Diabetes Care. 1995;18:269-271.
5. Moss SE, Klein R, Klein BE. The prevalence and incidence of lower extremity amputation in a diabetic population. Arch Intern Med. 1992;152:610-615.
6. Singer DE, Nathan DM, Anderson KM, Wilson WF, Evans JC. Association of HbA1c with prevalent cardiovascular disease in the original cohort of the Framingham Heart Study. Diabetes. 1992;41: 202-208.
7. Haffner SM, Valdez R, Morales PA, Mitchell BD, Hazuda HP, Stern MP. Greater effect of glycemia on incidence of hypertension in women than in men. Diabetes Care. 1992;15:1227-1284.
8. Giugliano D, Ceriello A, Paolisso G. Diabetes mellitus, hypertension and cardiovascular disease: which role for oxidative stress? Metabolism. 1995;44:363-368.
9. Cohen RA. Dysfunction of vascular endothelium in diabetes mellitus. Circulation. 1993;87(suppl V):V-67-V-76.
10. Bohlen HG, Lash JM. Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation in normal rat arterioles. Am J Physiol. 1993;265:H219-H225.
11. Hollenbaugh DC, Pavek TJ, Crampton MJ, Laxson DD. Hyperglycemia impairs coronary microvascular endothelium dependent vasodilation. Circulation. 1995;92(suppl I):I-451. Abstract.
12. Bucala R, Tracey KJ, Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest. 1991;87: 432-438.
13. Tesfamariam B, Cohen RA. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol. 1992;263: H321-H326.
14. Marfella R, Verrazzo G, Acampora R, La Marca C, Giunta R, Lucarelli C, Paolisso G, Ceriello A, Giugliano D. Glutathione reverses systemic hemodynamic changes induced by hyperglycemia in healthy subjects. Am J Physiol. 1995;268:E1167-E1173.
15. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature (Lond). 1988;333: 664-666.
16. Rees DD, Palmer RMJ, Schulz R, Hodson HF, Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol. 1990;101:746-752.
17. Parati G, Casadei R, Groppelli A, Di Rienzo M, Mancia G. Comparison of finger and intra-arterial blood pressure monitoring at rest and during laboratory testing. Hypertension. 1989;13:647-655.
18. Born AV. Aggregation of blood platelets by adenosindiphosphate and its reversal. Nature (Lond). 1962;94:927-929.
19. Paolisso G, Giugliano D, Scheen AJ, D'Onofrio F, Lefebvre PJ. Primary role of glucagon release in the effect of beta-endorphin on glucose homeostasis in normal men. Acta Endocrinol. 1987;115: 161-169.
20. Bouloux P, Perrett D, Besser GM. Methodologic considerations in the determination of plasma catecholamines by high-performance liquid chromatography with electrochemical detection. Ann Clin Biochem. 1985;22:194-203.
21. Baron AD. Hemodynamic actions of insulin. Am J Physiol. 1994; 267:E187-E202.
22. Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy M-A, Simonson DC, Creager MA. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans. Circulation. 1995; 92(suppl I):I-753. Abstract.
23. Paolisso G, Di Maro G, Pizza G, D'Amore A, Sgambato S, Tesauro P, Varricchio M, D'Onofrio F. Plasma GSH/GSSG affects glucose homeostasis in healthy subjects and non-insulin-dependent diabetics. Am J Physiol. 1992;263:E435-E440.
24. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-2012.
25. Bode-Bogër SM, Bogër RH, Creutzig A, Tsikas D, Gutzki F-M, Alexander K, Frölich JC. L-Arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects. Clin Sci. 1994;87:303-310.
26. Smulders RA, Stehouwer CDA, Olthof CG, van Kamp GJ, Teerlink T, de Vries PMJ, Donker AJM. Plasma endothelin levels and vascular effects of intravenous L-arginine infusion in subjects with uncomplicated insulin-dependent diabetes mellitus. Clin Sci. 1994;87:37-43.
27. Kharitonov SA, Lubec G, Lubec B, Hjelm M, Barnes PJ. L-Arginine increases exhaled nitric oxide in normal human subjects. Clin Sci. 1995;88:135-139.
28. Metha S, Stewart DJ, Hussain S, Levy RD. L-Arginine produces systemic vasodilation and increases nitric oxide excretion in expired gas in humans. Circulation. 1994;90(suppl I):I-138. Abstract.
29. White MF. The transport of cationic amino acids across the plasma membrane of mammalian cells. Biochim Biophys Acta. 1985;822: 355-374.
30. Koenig W, Sund M, Lowe AJ, Resch KL, Tunstall-Pedoe H, Keil U, Ernst E. Geographical variations in plasma viscosity and relation to coronary heart rates. Lancet. 1994;344:711-714.
31. Giugliano D, Marfella R, Verrazzo G, Acampora R, Donzella C, Quatraro A, Coppola L, D'Onofrio F. Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants. Ann Intern Med. 1995;123:338-343.
32. Mülsch A, Mordvintcev P, Bassenge E, Jung F, Clement B, Busse R. In vivo spin trapping of glyceryl trinitrate-derived nitric oxide in rabbit blood vessel and organs. Circulation. 1995;92:1876-1882.
33. Radomski MW, Palmer RMJ, Moncada S. An L-arginine:nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci U S A. 1990;87:5193-5197.
34. Best L, Jones PBB, Preston FE. Effect of glucose on platelet thromboxane biosynthesis. Lancet. 1979;2:790. Letter.
35. Gupta S, Tieken K, Ruderman N. Inhibition of nitric oxide synthase activity by hyperglycemia in endothelial cells. Diabetes. 1994; 43(suppl 1):100. Abstract.
36. Rees DD, Palmer RMJ, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A. 1989;86:3375-3378.
37. Hansen J, Jacobsen TN, Victor RG. Is nitric oxide involved in the tonic inhibition of central sympathetic outflow in humans? Hypertension. 1994;24:439-444.
38. Toda N, Okamura T. Role of nitric oxide in neurally induced cerebroarterial relaxation. J Pharmacol Exp Ther. 1991;258: 1027-1032.
39. Owlya R, Vollenweider L, Nicod P, Scherrer U. Inhibition of NO release stimulates sympathetic nerve activity in humans. Circulation. 1995;92(suppl I):I-12. Abstract.
40. Cooke JP, Tsao PS. Cytoprotective effects of nitric oxide. Circulation. 1993;88:2451-2454.