Serotonin synthesis and presence of tryptophan hydroxylase in lymphocytes of patients with depression treated with fluoxetine and folic acid;Síntesis de serotonina y presencia de hidroxilasa de triptófano en linfocitos de pacientes con depresión mayor tratados con fluoxetina y ácido fólico

Archivos Venezolanos de Farmacologia y Terapeutica

Volumn 27, Issue 2, 2008, Pages 114-120

  Urbina, Mary ^a   Lavie, Renée ^b   Resler, Gustavo ^b   Campos, Julio ^b   Mata, Salvador ^b   Lima, Lucimey ^a,b  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b Hospital Vargas de Caracas   (Venezuela)

Author keywords

Folic acid; Lymphocytes; Major depression; Serotonin; Serotonin synthesis; Tryptophan hydroxylase

Indexed keywords

FLUOXETINE; FOLIC ACID; PLACEBO; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

ADULT; ARTICLE; BLOOD LEVEL; CELL FUNCTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HAMILTON SCALE; HUMAN; LYMPHOCYTE COUNT; MAJOR DEPRESSION; MALE; MEDICAL SOCIETY; SEROTONINERGIC SYSTEM; SUICIDE ATTEMPT;

EID: 59349117775     PISSN: 07980264     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Gisondi P, Fantuzzi F, Malerba M, Girolomoni G. Folic acid in general medicine and dermatology. J Dermatolog Treat 2007; 18:138-146.
2. Bodnar LM, Wisner KL. Nutrition and depression: implications for improving mental health among childbeating-aged women. Biol Psychiatry 2005; 58:679-685.
3. Tiemeier H, Fekkes D, Hofman A, van Tuijl HR, Kiliaan AJ, Breteler MM. Plasma pterins and folate en late life depression: the Rotterdan Study. Psychiatric Res 2006; 145:199-206.
4. Abou-Saleh MT, Coppen A. Folic acid and the treatment of depression. J Psychosom Res 2006; 61:285-287.
5. Young SN: Folate and depression - a neglected problem. J Psychiatry Neurosci 2007; 32:80-82.
6. 12. J Psychopharmacol 2005; 19:59-65.
7. Fraguas R, Papakostas Gl, Mischoulon D, Bottiglieri T, Apert J, Fava M: Anger attacks in major depressive disorder and serum levels of homocysteine. Biol Psychiatric 2006; 60:270-274.
8. Scott TM, Tucker KL, Bhadelia A, Benjamin B, Patz S, Bhadelia R, et al. Homocysteine and B vitamins relate to brain volume and white-matter changes in geriatric patients with psychiatric disorders. Am J Geriatr Psychiatry 2004; 12:631-638.
9. Faraj BA, Olkowski L, Jackson RT. Expression of hich affinity serotonin uptake in human lymphocytes. Int J Immunopharmacol 1994; 16:561-567.
10. Lima L, Mata S, Urbina M. Allelic isophorms and decrease of serotonin transporte mRNA in lymphocytes of major depression patients. NeuroImmunoModulation 2005; 12:299-306.
11. 3H] Paroxetine binding to human peripheral lymphocyte membranes of patients with major depression before and after treatment with fluoxetine. Int Immunopharmacol 1999; 21:631-646.
12. Csaba G, Kovács P. Perinuclear localization of biogenic amines (serotonin and histamine) in rat immune cells. Cell Biol Int 2006; 30:861-865.
13. Betten A, Dahlgren C, Hermodsson S, Hellstrand K. Serotonin protects NK cells against oxidatively induced functional inhibition and apoptosis. J Leukoc Biol 2001; 70:65-72.
14. Lima L, Urbina M, Fazzino F, Carreira I, Mata S: The serotonergic system in peripheral lymphocytes of major depression patients. Res Adv Res Updates 2007; 8:95-105.
15. Carrillo-Vico A, Calvo JR, Abreu P, Lardone PJ, Garcia-Mauriño S, Reiter RJ, et al. Evidence of melatonin synthesis by human lymphocyte and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance. FASEB J 2004; 18:537-539.
16. 1A serotonin receptors, and proliferation of lymphocytes in major depression patients. NeuroImmunoModulation 2007; 14:8-15.
17. Koch JM, Kell S, Hinze-Selch D, Aldenhoff JB. Changes in CREB-phosphorylation during recovery from major depression. J Psychiatr Res 2002; 36:369-375.
18. Mata S, Fazzino F, Urbina M, Morles M, Rojas A, Arocha L et al. Serotonin transporter in lymphocytes of major depression patients treated with venlafaxine and psychotherapy. Congreso Anual de la Asociación Psiquiátrica Americana, Washington, NR3-110, 2008.
19. Vollmayr B, Sulger J, Gabriel P, Aldenhoff JB. Mitogen stimulated rise of intracellular calcium concentration in single T lymphocytes from patients with major depression is reduced. Prog Neuropsychopharmacol Biol Psychiatry 1995; 19:1263-1273.
20. Siegel GJ, Albers RW, Brady ST, Price DL. Basic Neurochemistry. Molecular, Cellular, and Medical Aspects. 7ma. Ed. Canadá: Elsevier, Book Aid International, Sabre Foundation; 2006.
21. Cedeño N, Urbina M, Obregón F, Lima L. Characterization of serotonin transporter in blood lymphochytes of rats. Modulation by in vivo administration of mitogens. J Neuroimmunol. 2005; 159:31-40.
22. Belladonna ML. Paccetti P, Orabona C, Fallarino F, Vacca C, Volpi C, et al. Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes. Transplantation 2007; 84(1 Suppl):17-20.
23. Boasso A, Vaccari M, Hryniewicz A, Fuchs D, Nacsa J, Cecchinato V, et al. Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection. J Virol 2007; 81:11593-11603.
24. Kaper T, Looger LL, Takanaga H, Platten M, Steinman L, Frommer WB. Nanosensor detection of an immunoregulatory tryptophan influx/kynunerine efflux cycle. PloS Biol 2007; 5:257.
25. Romani L, Fallarino F, De Luca A, Montagnoli C, D'Angelo C, Zelante T, et al. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 2008; 451:211-215.
26. Scheler M, Wenzel J, Tüting T, Takikawa O, Bieber T, von Bubnoff D. Indoleamine 2,3-dioxygenase (IDO): the antagonists of type I interferon-driven skin inflammation?. Am J Pathol 2007; 171:1936-1943.
27. American Psychiatric Association: Diagnostic and statistical manual of mental disorders, fourth edition. Washington, DC: American Psychiatric Association 1994
28. Hamilton MA. A rating scale for depression. J Neurol Neurosur Psych 1960; 23:56-62.
29. Ramos-Brieva JA, Cordero A. Validación de la versión castellana de la escala de Hamilton para la depresión. Actas Luso-Esp Neurol Psiquiatr 1986; 14:324-334.
30. Lauge N Behnke K, Sogaard J. Responsiveness of observer rating scale by analysis of number of days until improvement in patient with major depression. Eur Psychiatry 1998; 13:143-145.
31. Butterworth Jr CE, Tamura T: Folic acid safety and toxicity: a brief review. Am J Clin Nutr 1989; 50:353-358.
32. Méndez-Castellanos H, Méndez MC. Fundación centro de estudios sobre crecimiento y desarrollo de la población venezolana (FUNDACREDESA), serie abierta 1994:206.
33. García AJ, Apizt-Castro R. Plasma total homosysteine quantification: an improvement of the classical high-performance liquid chromatographic method with fluorescente detection of the tilol-SBD derivatives. J Chromatogr 2002; 779:359-363.
34. GraphPad Prism, version 4, 2003.
35. Nieto KN, Calvo JM. Acido fólico y depresión. Rev Colomb Psiquiatría 2001; 30:39-49.
36. Guy W. Early clinical drug evaluation (ECDEU). Assessment Manual Rockville: National Institute of Mental Health 1976.
37. 12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression. J Clin Psychiatry 2004; 65:1090-1095.
38. 12, and homocysteine in major depressive disorder, Part 2: predictors of relapse during the continuation phase of pharmacotherapy. J Clin Psychiatry 2004; 65:1096-1098.
39. Coppen A, Bailey J. Enhancement of the antidepressant action of fluoxetine by folic acid: A randomized, placebo-controlled trial. J Affect Disord 2000; 60:121-130.
40. Papakostas GI, Petersen T, Lebowitz BD, Mischoulon D, Ryan JL, Nierenberg AA, et al. The relationship between serum folate, vitamin B12, and homosysteine levels in major depressive disorder and the timing of improvement with fluoxetine. Int J Neuropsychopharmacol 2005; 9:1-6.
41. Taylor MJ, Carney JM, Goodwin GM, Geddes JR. Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. J Psychopharmacol 2004; 18:251-256.
42. 1A receptors and dopamine in blood peripheral lymphocytes of major depression patients. Int Immunopharmacol 2003; 3:1345-1352.
43. Faerber L, Drechsler S, Ladenburger S, Gschaidmeier H, Fisher W. The neuronal 5-HT3 receptor network after 20 years of research-evolving concepts in management of pain and inflammation. Eur J Pharmacol 2007; 560:1-8.
44. Fazzino F, Montes C, Urbina M, Carreira I, Lima L. Serotonin Transporter is Differentially Localized in Subpopulations of Lymphocytes of Major Depression Patients. Effect of Fluoxetine on Proliferation. J. Neuroimmunol 2008; 196:173-180.
45. Yin J, Albert RH, Tretiakova AP, Jameson BA. 5-HT(1B) receptors play a prominent role in the proliferation of T-lymphocytes. J Neuroimmunol 2006; 181:68-81.
46. Lundberg J, Borg J, Halldin C, Farde L. A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain. Psychopharmacology 2007; 195:425-433.
47. Irwin MR, Miller AH. Depressive disorders and immunity: 20 years of progress and discovery. Brain Behav Immun 2007; 21:374-383.
48. Resler G, Lavie R, Campos J, Mata S, García A, Urbina M et al. Acido fólico como posible potenciador de la terapia antidepresiva y variaciones en la concentración de serotonina en linfocitos de pacientes con depresión mayor. Arch Venezolanos Psq Neurol 2007; 51:26-64.
49. Mata S, Urbina M, Manzano E, Ortiz T, Lima L. Noradrenaline transporter is decreased in blood peripheral lymphocytes of patients with major depression. J Neuroimmunol 2005; 170:134-140.
50. + regulatory cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop. Blood 2007; 109:632-641.
51. Yazawa D, Campos J, Urbina M, Mata S, Lima L. Respuesta a la venlafaxina y niveles de serotonina en linfocitos de pacientes distímicos. Arch Vlnos Psq Neurol 2005; 50:20-28.
52. Kawashima K, Fujii T. The lymphocytic cholinergic system and its contribution to the regulation of immune activity. Life Sci 2003; 74:675-696.
53. Scheiber G, Avissar S. Regulators of G-protein-coupled receptor-G-protein coupling: antidepressants mechanism of action. Expert Rev Neurother 2007; 7:75-84. 120