Noradrenaline transporter and its turnover rate are decreased in blood lymphocytes of patients with major depression

Journal of Neuroimmunology

Volumn 170, Issue 1-2, 2005, Pages 134-140

  Mata, S ^b   Urbina, M ^a   Manzano, E ^b   Ortiz, T ^b   Lima, L ^a,b  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b Hospital Vargas de Caracas   (Venezuela)

Author keywords

Lymphocytes; Major depression; Noradrenaline; Noradrenaline transporter; Noradrenaline turnover; Serotonin turnover

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 5 HYDROXYINDOLEACETIC ACID; NISOXETINE; NORADRENALIN; NORADRENALIN TRANSPORTER; SEROTONIN; TRITIUM;

ADULT; ARTICLE; CATECHOLAMINE METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FEMALE; HAMILTON SCALE; HUMAN; LYMPHOCYTE; MAJOR DEPRESSION; MALE; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; SEROTONIN BLOOD LEVEL; SEROTONIN METABOLISM;

ADULT; BLOOD PLATELETS; CELL MEMBRANE; DEPRESSIVE DISORDER, MAJOR; FEMALE; FLUOXETINE; HUMANS; HYDROXYINDOLEACETIC ACID; LYMPHOCYTES; MALE; METHOXYHYDROXYPHENYLGLYCOL; MIDDLE AGED; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN;

EID: 28444470138     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2005.08.007     Document Type: Article

References (56)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th ed. 1994 American Psychiatric Press Washington, DC
2. V. Andreoli, V. Caillard, R.S. Deo, J.K. Rybakowski, and M. Versiani Reboxetine, a new noradrenaline selective antidepressant, is at least as effective as fluoxetine in the treatment of depression J. Clin. Psychopharmacol. 22 2002 393 399
3. H. Anisman, A.V. Ravindran, J. Griffiths, and Z. Merali Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features Mol. Psychiatry 4 1999 182 188
4. F. Artigas, D.J. Nutt, and R. Shelton Mechanism of action of antidepressants Psychopharmacol. Bull. 2 2002 123 132
5. Baccichet, E., Peña, S., 2001. Transportador de serotonina en linfocitos de pacientes con depresión mayor antes y después del tratamiento con mirtazapina. Tesis de Grado. Universidad Central de Venezuela and Instituto Venezolano de Investigaciones Científicas.
6. P. Barneoud, J.M. Rivet, S. Vitiello, M. Le Moal, P.J. Neveu, and P. Barneound Brain norepinephrine levels after BCG stimulation of the immune system Immunol. Lett. 18 1988 201 204
7. M. Brüss, J. Kunz, B. Lingen, and H. Bonish Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter Hum. Genet. 91 2003 278 280
8. R.G. Coffey, E.M. Hadden, and J.W. Hadden Norepinephrine stimulation of lymphocyte ATPase by an alpha adrenergic receptor mechanism Endocr. Res. Commun. 2 1975 179 198
9. C.L. DeVane Differential pharmacology of newer antidepressants J. Clin. Psychiatry 59 Suppl. 20 1998 85 93
10. A.J. Dunn, A.H. Swiergiel, and R. de Beaurepaire Cytokines as mediators of depression: what can we learn from animal studies? Neurosci. Biobehav. Rev. 29 2005 891 909
11. 1A receptors and dopamine in blood peripheral lymphocytes of major depression patients Int. Immunopharmacol. 3 2003 345 1352
12. B.A. Faraj, L. Olkowski, and R.T. Jackson Expression of high-affinity serotonin transporter in human lymphocytes Int. J. Immunopharmacol. 16 1994 561 567
13. X. Gan, L. Zhang, G.F. Solomon, and B. Bonavida Mechanism of norepinephrine-mediated inhibition of human NK cytotoxic functions: inhibition of cytokine secretion, target binding, and programming for cytotoxicity Brain Behav. Immun. 16 2002 227 246
14. M.L. Gilmor, M.J. Owens, and C.B. Nemeroff Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine Am. J. Psychiatry 159 2002 1702 1710
15. GraphPad, Prisma, Version 4th, 2003.
16. A.J. Grippo, J. Francis, T.G. Beltz, R.B. Felder, and A.K. Johnson Neuroendocrine and cytokine profile of chronic mild stress-induced anhedonia Physiol. Behav. 84 2005 697 706
17. M.A. Hamilton A rating scale of depression J. Neurol. Neurosurg. Psychiatry 23 1960 56 62
18. A. Heils, A. Teufel, S. Petri, G. Stöber, P. Riederer, D. Bengel, and K.P. Lesch Allelic variation of human serotonin transporter gene expression J. Neurochem. 66 1996 2621 2624
19. U. Henning, K. Krieger, S. Loeffler, F. Rivas, G. Orozco, M.G. de Castro, M. Rietschel, M.M. Noethen, and A. Klimbe Increased levels of glucocorticoid receptors and enhanced glucocorticoid receptor auto-regulation after hydrocortisone challenge in B-lymphoblastoids from patients with affective disorders Psychoneuroendocrinology 30 2005 325 332
20. E. Hernández, S. Lastra, M. Urbina, I. Carreira, and L. Lima Serotonin, 5-hydroxyindoleactic acid and serotonin transporter in blood peripheral lymphocytes of patients with generalized anxiety disorder Int. Immunopharmacol. 2 2002 893 900
21. M. Humble Noradrenaline and serotonin reuptake inhibition as clinical principles: a review of antidepressant efficacy Acta Psychiatr. Scand. 402 2000 28 36
22. L. Iversen Neurotransmitter transporters: fruitful targets for CNS drug discovery Mol. Psychiatry 5 2000 357 362
23. M. Kappel, T.D. Poulsen, H. Galbo, and B.K. Pederson Effects of elevated plasma noradrenaline concentration on the immune system in humans Eur. J. Appl. Physiol. Occup. Physiol. 79 1998 93 98
24. V. Klimek, C. Stockmeir, J. Overholser, H.Y. Meltzer, S. Kalka, G. Dilley, and G.A. Ordway Reduced levels of norepinephrine transporters in the locus coeruleus in major depression J. Neurosci. 17 1997 8451 8458
25. A.P. Kohm, and V.M. Sanders Norepinephrine and beta2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo Pharmacol. Rev. 53 2001 487 525
26. I.C. Lai, C.J. Hong, and S.J. Tsai Expression of cAMP response element-binding protein in major depression before and after antidepressant treatment Neuropsychobiology 48 2003 182 185
27. D. Laifenfeld, E. Klein, and D. Ben-Shachar Norepinephrine alters the expression of genes involved in neuronal sprouting and differentiation: relevance for major depression and antidepressant mechanism J. Neurochem. 83 2002 1054 1064
28. B.E. Leonard Evidence for a biochemical lesion in depression J. Clin. Psychiatry 61 Suppl. 6 2002 12 17
29. G. Levi, and M. Raiteri Carrier-mediated release of neurotransmitter Trends Neurosci. 16 1993 415 419
30. 1A receptors in the hippocampus and the raphe area of rats treated with clonazepam Prog. Neuro-Psychopharmacol. Biol. Psychiatry 17 1993 663 677
31. S. Livnat, S.Y. Felten, S.L. Carlson, D.L. Bellinger, and D.L. Felten Involvement of peripheral and central catecholamine systems in neural-immune interactions J. Neuroimmunol. 10 1985 5 30
32. M. Maes The immunoregulatory effects of antidepressants Hum. Psychopharmacol. 16 2001 95 103
33. M. Maes, E. Bosmans, R. De Jongh, G. Kenis, E. Vandoolaeghe, and H. Neels Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression Cytokine 9 1997 853 858
34. H.L. Miller, R.D. Ekstrom, G.A. Mason, R.B. Lydiard, and R.N. Golden Noradrenergic function and clinical outcome in antidepressant pharmacotherapy Neuropsychopharmacology 24 2001 617 623
35. H.J. Moller Are all antidepressants the same? J. Clin. Psychiatry 6 2000 24 28
36. J. Nakamura, R. Yoshimura, T. Okuno, N. Ueda, M. Hachida, and K. Yasumoto Association of plasma free-3-methoxy-4-hydroxyphenyl(ethylene)glycol, natural killer cell activity and delirium in postoperative patients Int. Clin. Psychopharmacol. 16 2001 339 343
37. S.M. O'Brien, L.V. Scott, and T.G. Dinan Cytokines: abnormalities in major depression and implications for pharmacological treatment Hum. Psychopharmacol. 19 2004 397 403
38. T. Pacholczyk, R.D. Blakely, and S.G. Amara Expression of a cocaine- and antidepressant-sensitive human noradrenaline transporter Nature 350 1991 350 354
39. S. Peña, E. Baccichet, M. Urbina, I. Carreira, and L. Lima Effect of mirtazapine treatment on serotonin transporter in blood peripheral lymphocytes of major depression patients Int. Immunopharmacol. 5 2005 1069 1076
40. Y. Qiu, Y. Peng, and J. Wang Immunoregulatory role of neurotransmitters Adv. Neuroimmunol. 6 1996 223 231
41. S. Ramamoorthy, A.L. Bauman, and K.R. Moore Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization Proc. Natl. Acad. Sci. U. S. A. 90 1993 2542 2546
42. A.V. Ravindran, J. Griffiths, Z. Merali, and H. Anisman Primary dysthymia: a study of several psychosocial, endocrine and immune correlates J. Affect. Disord. 40 1996 73 84
43. G. Rudnik, and J. Clark From synpase to vesicle: the reuptake and storage of biogenic amine neurotransmitters Biochim. Biophys. Acta 1144 1993 249 263
44. O.J. Schiepers, M.C. Wichers, and M. Maes Cytokines and major depression Prog. Neuro-Psychopharmacol. Biol. Psychiatry 29 2005 201 217
45. J. Schlatter, F. Ortuno, and S. Cervera-Enguix Lymphocyte subsets and lymphokine production in patients with melancholic versus nonmelancholic depression Psychiatry Res. 128 2004 259 265
46. 1A and β-adrenergic receptors regulate proliferation of rat blood lymphocytes Neuroimmunomodulation 11 2004 307 315
47. T. Smith, and M.L. Cuzner Neuroendocrine-immune interactions in homeostasis and autoimmunity Neuropathol. Appl. Neurobiol. 20 1994 413 422
48. 3H]Nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding J. Pharmacol. Exp. Ther. 260 1991 427 436
49. G.R. Uhl, and P. Hartig Transporter explosion: update on uptake Trends Pharmacol. Sci. 13 1992 4221 4222
50. 3H]Paroxetine binding to human peripheral lymphocyte membranes of patients with major depression before and after treatment with fluoxetine Int. J. Immunopharmacol. 21 1999 631 646
51. M. Wahle, U. Stachetzki, A. Krause, M. Pierer, H. Hantzschel, and C.G. Baerwald Regulation of beta2-adrenergic receptors on CD4 and CD8 positive lymphocytes by cytokines in vitro Cytokine 16 2001 205 209
52. R.F. Walker, and E.E. Codd Neuroimmunomodulatory interactions of norepinephrine and serotonin J. Neuroimmunol. 10 1985 41 58
53. Y.M. Wang, F. Xu, R.R. Gainetdinov, and M.G. Caron Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene Biol. Psychiatry 46 1999 1124 1130
54. H.G. Westenberg Pharmacology of antidepressants: selectivity or multiplicity? J. Clin. Psychiatry 60 Suppl. 17 1999 4 8
55. 3H]alprenolol binding J. Clin. Invest. 57 1976 149 155
56. P. Zill, R. Engel, T.C. Baghai, G. Juckel, T. Frodi, and F. Müller-Siecheneder Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression Neuropsychopharmacology 26 2002 489 493