Characterisation of the R3/1 cell line as an alveolar epithelial cell model for drug disposition studies

European Journal of Pharmaceutical Sciences

Volumn 36, Issue 4-5, 2009, Pages 444-450

  Horálková, Lenka ^a,b   Radziwon, Aneta ^a   Endter, Sibylle ^a   Andersen, Rikke ^c   Koslowski, Roland ^d   Radomski, Marek W ^a   Doležal, Pavel ^b   Ehrhardt, Carsten ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^c NOVO NORDISK A S   (Denmark)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Alveolar epithelial cells; Drug absorption; Drug disposition; Peptidases; Tight junctions

Indexed keywords

AMINOPEPTIDASE B; AMINOPEPTIDASE P; BOVINE SERUM ALBUMIN; CARBOXYPEPTIDASE M; CAVEOLIN 1; CAVEOLIN 2; CELL PROTEIN; CONNEXIN 43; DEXAMETHASONE; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL PEPTIDASE IV; GAMMA GLUTAMYLTRANSFERASE; GLUTAMYL AMINOPEPTIDASE; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; MICROSOMAL AMINOPEPTIDASE; MONOCLONAL ANTIBODY; OCCLUDIN; PEPTIDASE; PROTEIN ZO1; PROTEIN ZO2; PROTEINASE; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL JUNCTION; CELL LINE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISPOSITION; ELECTRIC RESISTANCE; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOFLUORESCENCE MICROSCOPY; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; MALE; MONOLAYER CULTURE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIGHT JUNCTION;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; DNA PRIMERS; ELECTROPHORESIS, AGAR GEL; MALE; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; PHARMACOKINETICS; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 59349102492     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.11.010     Document Type: Article

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