Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice

Journal of Neuroscience Research

Volumn 86, Issue 16, 2008, Pages 3605-3612

  Ahmad, Muzamil ^a,b   Rose, Marie E ^a,b   Vagni, Vincent ^b   Griffith, Raymond P ^b   Dixon, C Edward ^b   Kochanek, Patrick M ^b   Hickey, Robert W ^b   Graham, Steven H ^a,b  

^a VA Pittsburgh Healthcare System   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Behavior; Cyclooxygenase; Morris water maze; Prostaglandin E2; TUNEL staining

Indexed keywords

CYCLOOXYGENASE 2; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; GENE DISRUPTION; GENE EXPRESSION; HIPPOCAMPUS; INJURY SEVERITY; MAZE TEST; MENTAL PERFORMANCE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROSTAGLANDIN SYNTHESIS; TRAUMATIC BRAIN INJURY; WILD TYPE;

ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; BRAIN INJURIES; CYCLOOXYGENASE 2; CYTOPROTECTION; DINOPROSTONE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENCEPHALITIS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE THERAPY; HIPPOCAMPUS; IN SITU NICK-END LABELING; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, KNOCKOUT; NEURONS; UP-REGULATION;

EID: 59349102320     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21809     Document Type: Article

References (48)

1. Alkayed NJ, Birks EK, Hudetz AG, Roman RJ, Henderson L, Harder DR. 1996. Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow. Am J Physiol 271:H1541-H1546.
2. Alloza I, Baxter A, Chen Q, Matthiesen R, Vandenbroeck K. 2006. Celecoxib inhibits interleukin-12 alphabeta and beta2 folding and secretion by a novel COX2-independent mechanism involving chaperones of the endoplasmic reticulum. Mol Pharmacol 69:1579-1587.
3. Belton O, Fitzgerald DJ. 2003. Cyclooxygenase isoforms and atherosclerosis. Expert Rev Mol Med 5:1-18.
4. Cernak I, O'Connor C, Vink R. 2002. Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats. Exp Brain Res 147: 193-199.
5. Chang JW, Coleman PD, O'Banion MK. 1996. Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease. Neurobiol Aging 17:801-808.
6. Chu K, Jeong SW, Jung KH, Han SY, Lee ST, Kim M, Roh JK. 2004. Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death. J Cereb Blood Flow Metab 24:926-933.
7. Clark RSB, Chen M, Kochanek PM, Watkins SC, Jin KL, Draviam R, Nathaniel PD, Pinto R, Marion DW, Graham SH. 2001. Detection of single- and double-strand DNA breaks after traumatic brain injury in rats: comparison of in situ labeling techniques using DNA polymerase I, the Klenow fragment of DNA polymerase I, and terminal deoxynucleotidyl transferase. J Neurotrauma 18:675-689.
8. Dash PK, Mach SA, Moore AN. 2000. Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury. J Neurotrauma 17:69-81.
9. Drachman DB, Rothstein JD. 2000. Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis. Ann Neurol 48:792-795.
10. Ellis EF, Police RJ, Yancey L, McKinney JS, Amruthesh SC. 1990. Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid. Am J Physiol 259:H1171-H1177.
11. Frick KM, Stillner ET, Berger-Sweeney J. 2000. Mice are not little rats: species differences in a one-day water maze task. Neuroreport 11:3461-3465.
12. Gavrieli Y, Sherman Y, Ben-Sasson SA. 1992. Identi.cation of programmed cell death in situ via speci.c labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
13. Gopez JJ, Yue H, Vasudevan R, Malik AS, Fogelsanger LN, Lewis S, Panikashvili D, Shohami E, Jansen SA, Narayan RK, Strauss KI. 2005. Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury. Neurosurgery 56:590-604.
14. Han S, Roman J. 2006. COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals. Lung Cancer 51:283-296.
15. Hatton J. 2001. Pharmacological treatment of traumatic brain injury: a review of agents in development. CNS Drugs 15:553-581.
16. Hickey RW, Adelson PD, Johnnides MJ, Davis DS, Yu Z, Rose ME, Chang YF, Graham SH. 2007. Cyclooxygenase-2 activity following traumatic brain injury in the developing rat. Pediatric Res 62:271-276.
17. Hurley SD, Olschowka JA, O'Banion MK. 2002. Cyclooxygenase inhibition as a strategy to ameliorate brain injury. J Neurotrauma 19:1-15.
18. Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S, Ross ME. 2001. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc Natl Acad Sci U S A 98:1294-1299.
19. Kaloustian S, Wann BP, Bah TM, Falcao S, Dufort AM, Ryvlin P, Godbout R, Rousseau G. 2007. Celecoxib after the onset of reperfusion reduces apoptosis in the amygdala. Apoptosis 12:1945-1951.
20. Kardosh A, Blumenthal M, Wang WJ, Chen TC, Schonthal AH. 2004. Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines. Cancer Biol Ther 3:55-62.
21. Koyfman L, Kaplanski J, Artru AA, Talmor D, Rubin M, Shapira Y. 2000. Inhibition of cyclooxygenase 2 by nimesulide decreases prostaglandin E2 formation but does not alter brain edema or clinical recovery after closed head injury in rats. J Neurosurg Anesthesiol 12:44-50.
22. Kunz T, Oliw EH. 2001. The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus. Eur J Neurosci 13:569-575.
23. Kunz T, Marklund N, Hillered L, Oliw EH. 2002. Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the rat. J Neurotrauma 19:1051-1064.
24. Kunz T, Marklund N, Hillered L, Oliw EH. 2006. Effects of the selective cyclooxygenase-2 inhibitor rofecoxib on cell death following traumatic brain injury in the rat. Restor Neurol Neurosci 24:55-63.
25. Lai Y, Hickey RW, Chen Y, Bayir H, Sullivan ML, Chu CT, Kochanek PM, Dixon CE, Jenkins LW, Graham SH, Watkins SC, Clark RS. 2008. Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab 28:540-550.
26. Larsen BT, Gutterman DD, Hatoum OA. 2006. Emerging role of epoxyeicosatrienoic acids in coronary vascular function. Eur J Clin Invest 36:293-300.
27. Machado FS, Johndrow JE, Esper L, Dias A, Bafica A, Serhan CN, Aliberti J. 2006. Anti-in.ammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Nat Med 12:330-334.
28. Marklund N, Sihver S, Langstrom B, Bergstrom M, Hillered L. 2002. Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats. J Neurotrauma 19:1139-1153.
29. Miyamoto K, Miyake S, Mizuno M, Oka N, Kusunoki S, Yamamura T. 2006. Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2-independent pathway. Brain 129:1984-1992.
30. Morrison B 3rd, Eberwine JH, Meaney DF, McIntosh TK. 2000. Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridization. Neuroscience 96:131-139.
31. Nakayama M, Uchimura K, Zhu RL, Nagayama T, Rose ME, Stetler RA, Isakson PC, Chen J, Graham SH. 1998. Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. Proc Natl Acad Sci U S A 95:10954-10959.
32. Ray SK, Dixon CE, Banik NL. 2002. Molecular mechanisms in the pathogenesis of traumatic brain injury. Histol Histopathol 17:1137-1152.
33. Sasaki T, Nakagomi T, Kirino T, Tamura A, Noguchi M, Saito I, Takakura K. 1988. Indomethacin ameliorates ischemic neuronal damage in the gerbil hippocampal CA1 sector. Stroke 19:1399-1403.
34. Schwab JM, Serhan CN. 2006. Lipoxins and new lipid mediators in the resolution of inflammation. Curr Opin Pharmacol 6:414-420.
35. Serhan CN, Savill J. 2005. Resolution of inflammation: the beginning programs the end. Nat Immunol 6:1191-1197.
36. Sinz EH, Kochanek PM, Dixon CE, Clark RS, Carcillo JA, Schiding JK, Chen M, Wisniewski SR, Carlos TM, Williams D, DeKosky ST, Watkins SC, Marion DW, Billiar TR. 1999. Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice. J Clin Invest 104:647-656.
37. Smith DH, Uryu K, Saatman KE, Trojanowski JQ, McIntosh TK. 2003. Protein accumulation in traumatic brain injury. Neuromol Med 4:59-72.
38. Strauss KI, Barbe MF, Marshall RM, Raghupathi R, Mehta S, Narayan RK. 2000. Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat. J Neurotrauma 17:695-711.
39. Tehranian R, Rose ME, Vagni V, Griffith RP, Wu S, Maits S, Zhang X, Clark RS, Dixon CE, Kochanek PM, Bernard O, Graham SH. 2006. Transgenic mice that overexpress the anti-apoptotic Bcl-2 protein have improved histological outcome but unchanged behavioral outcome after traumatic brain injury. Brain Res 1101:126-135.
40. Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, Vila M, Jackson-Lewis V, Przedborski S. 2003. Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proc Natl Acad Sci U S A 100:5473-5478.
41. Toscano CD, Prabhu VV, Langenbach R, Becker KG, Bosetti F. 2007. Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain. Genome Biol 8:R14.
42. Unterberg AW, Stover J, Kress B, Kiening KL. 2004. Edema and brain trauma. Neuroscience 129:1021-1029.
43. Vane JR, Bakhle YS, Botting RM. 1998. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38:97-120.
44. Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. 2001. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414:212-216.
45. Whalen MJ, Clark RS, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham SH, Virag L, Hasko G, Stachlewitz R, Szabo C, Kochanek PM. 1999. Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab 19:835-842.
46. Yoon JB, Kim SJ, Hwang SG, Chang S, Kang SS, Chun JS. 2003. Non-steroidal anti-inflammatory drugs inhibit nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes independent of cyclooxygenase activity. J Biol Chem 278:15319-15325.
47. Zhang W, Koerner IP, Noppens R, Grafe M, Tsai HJ, Morisseau C, Luria A, Hammock BD, Falck JR, Alkayed NJ. 2007. Soluble epoxide hydrolase: a novel therapeutic target in stroke. J Cereb Blood Flow Metab 27:1931-1940.
48. Zhong H, Willard M, Simons J. 2004. NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms. Int J Cancer 112:585-595.