Development and validation of an HPLC method for the rapid and simultaneous determination of 6-mercaptopurine and four of its metabolites in plasma and red blood cells

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 2, 2009, Pages 401-409

  Hawwa, Ahmed F ^a   Millership, Jeff S ^a   Collier, Paul S ^a   McElnay, James C ^a  

^a School of Pharmacy   (United Kingdom)

Author keywords

6 Mercaptopurine; 6 Thioguanine nucleotides; HPLC; Inflammatory bowel disease; Leukaemia; Paediatrics

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; AZATHIOPRINE; DRUG METABOLITE; MERCAPTOPURINE; METHYLMERCAPTOPURINE DERIVATIVE; PERCHLORIC ACID; THIOGUANINE DERIVATIVE; THIOURIC ACID DERIVATIVE; THIOXANTHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; CONCENTRATION RESPONSE; DEPROTEINIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ERYTHROCYTE LEVEL; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; PATIENT COMPLIANCE; PHARMACOGENETICS; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY ANALYSIS; VALIDATION STUDY;

6-MERCAPTOPURINE; ANTIMETABOLITES, ANTINEOPLASTIC; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; DRUG STORAGE; ERYTHROCYTES; FREEZING; HUMANS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 59349102294     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.10.045     Document Type: Article

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