Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase-an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine in ALL cell line

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 850, Issue 1-2, 2007, Pages 7-14

  Kalra, Sukirti ^a   Paul, Manash K ^a   Balaram, Hemalatha ^b   Mukhopadhyay, Anup Kumar ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

6 Mercaptopurine; 6 Thiouric acid; Acute lymphoblastic leukemia; Branched bi enzyme system; Reverse phase HPLC; Thioinosine monophosphate

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL); BRANCHED BI-ENZYME SYSTEMS; REVERSE-PHASE HPLC; THIOINOSINE MONOPHOSPHATE; THIOURIC ACID;

BIOCHEMICAL ENGINEERING; CHEMOTHERAPY; DISEASE CONTROL; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TUMORS;

ENZYME KINETICS;

6 THIOURIC ACID; DRUG METABOLITE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MERCAPTOPURINE; THIOINOSINIC MONOPHOSPHATE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHEMICAL ANALYSIS; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

6-MERCAPTOPURINE; ADOLESCENT; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MALE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY; XANTHINE OXIDASE;

EID: 34247470711     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.10.012     Document Type: Article

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