Hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human FTDP-17 Tau and lacking the PARK2 gene

Acta Neuropathologica

Volumn 117, Issue 2, 2009, Pages 159-168

  Guerrero, Rosa ^a   Navarro, Paloma ^a   Gallego, Eva ^a   Garcia Cabrero, Ana M ^a   Avila, Jesus ^b   Sanchez, Marina P ^a  

^a Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

FTDP 17 mutant tau transgenic mice; Hyperphosphorylated tau aggregates; Neurodegeneration; PARK2 gene deletion; Parkin deficient mutant mice; Parkin ubiquitin ligase; Parkinsonism; Tauopathies

Indexed keywords

CELL PROTEIN; FRONTOTEMPORAL DEMENTIA AND PARKINSONISM LINKED TO CHROMOSOME 17 PROTEIN; MONOCLONAL ANTIBODY ALZ 50; PAIRED HELICAL FILAMENT 1; PARKIN; PROTEIN AT8; PROTEIN PARK2; TAU PROTEIN; THIOFLAVINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN ATROPHY; BRAIN CORTEX; CONTROLLED STUDY; DNA FRAGMENTATION; GENE DELETION; GENE INTERACTION; GENE OVEREXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MEMORY DISORDER; MOTONEURON NUCLEUS; MOUSE; MOUSE MUTANT; NEUROPATHOLOGY; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TAUOPATHY; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

AGING; ANIMALS; ANTIGENS; BLOTTING, WESTERN; CEREBRAL CORTEX; DNA-BINDING PROTEINS; GENE DELETION; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MUTATION; NEUROFIBRILLARY TANGLES; NEURONS; NEUROPIL; PHOSPHORYLATION; SPINAL CORD; TAU PROTEINS; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES;

EID: 59249103718     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-008-0470-3     Document Type: Article

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