5,7-dihydroxy-3,4,6-trimethoxyflavone inhibits the inflammatory effects induced by Bacteroides fragilis enterotoxin via dissociating the complex of heat shock protein 90 and IκBα and IκB kinase-γ in intestinal epithelial cell culture

Clinical and Experimental Immunology

Volumn 155, Issue 3, 2009, Pages 541-551

  Kim, J M ^a   Lee, D H ^b,c   Kim, J S ^c   Lee, J Y ^a   Park, H G ^a   Kim, Y J ^d   Oh, Y K ^e   Jung, H C ^c   Kim, S I ^f  

^a Hanyang University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

^d Joongbu University   (South Korea)

^e Korea University   (South Korea)

^f Hanyang University   (South Korea)

Author keywords

Bacteroides fragilis enterotoxin; Eupatilin; Hsp90; I B kinase; NF B

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; EUPATILIN; FRAGILYSIN; HEAT SHOCK PROTEIN 90; I KAPPA B ALPHA; I KAPPA B KINASE GAMMA; INTERLEUKIN 8; PROSTAGLANDIN E2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BACTEROIDES FRAGILIS; CHEMOKINE CXCL2; CYCLOOXYGENASE 2; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENTEROTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FLAVONOIDS; HSP90 HEAT-SHOCK PROTEINS; HT29 CELLS; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; ILEUM; IMMUNOPRECIPITATION; INTERLEUKIN-8; INTESTINAL MUCOSA; MICE; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 59249100492     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03849.x     Document Type: Article

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