Analysis of red cell parameters on the Sysmex XE 2100 and ADVIA 120 in iron deficiency and in uraemic chronic disease

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 66, Issue 2, 2006, Pages 113-120

  David, O ^a,d   Grillo, A ^b   Ceoloni, B ^a   Cavallo, F ^b   Podda, G ^c   Biancotti, P P ^b   Bergamo, D ^c   Canavese, C ^c  

^a S ANNA HOSPITAL   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

^c UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^d NONE   (Italy)

Author keywords

Anaemia; Hypochromic cell percentage (HYPO); Recombinant human erythropoietin (r HuEPO); Regular dialysis treatment (RDT); Reticulocyte; Reticulocyte haemoglobin content (CHr)

Indexed keywords

BIOLOGICAL MARKER; HEMOGLOBIN; IRON;

ADULT; AGED; ARTICLE; CHRONIC DISEASE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPATHOLOGY; DIAGNOSTIC KIT; DIALYSIS; ERYTHROCYTE; ERYTHROCYTE PARAMETERS; ERYTHROCYTE VOLUME; FEMALE; HUMAN; HUMAN CELL; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; PRIORITY JOURNAL; RETICULOCYTE; SEX RATIO; STATISTICAL SIGNIFICANCE; UREMIA; VALIDITY;

ADULT; AGED; ANEMIA, IRON-DEFICIENCY; BIOLOGICAL MARKERS; ERYTHROCYTE COUNT; ERYTHROCYTE INDICES; ERYTHROCYTES; FEMALE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; RETICULOCYTE COUNT; RETICULOCYTES; UREMIA;

EID: 33644997243     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510500406910     Document Type: Article

References (27)

1. Dallman PR. Diagnosis of anaemia and iron deficiency: analytic and biologic variations of laboratory tests. Am J Clin Nutr 1984;39:937-41.
2. Fishbane S, Kowalsky EA, Imnbriano LJ, Maesaka JK. The evaluation of iron status in hemodialysis patients. J Am Soc Nefrol 1996;7:2654-7.
3. Finc C. Regulation of iron balance in humans. Blood 1994;84:1697-702.
4. De Block CE, Van Campenhout CM, De Leeuw IH, Keenoy BM, Martin M, Van Hoof V, et al. Soluble transferrin receptor level: a new marker of iron deficiency anaemia, a common manifestation of gastric autoimmunity in type 1 diabetes. Diabetes Care 2000;23:1384-8.
5. Brugnara C, Zurakowsky D, DiCanzio J, Boyd T, Platt O. Reticulocyte haemoglobin content to diagnose iron deficiency in children. JAMA 1999;281:2225-30.
6. Mohandas N, Kim JR, Tycko DH, Orlik J, Wyatt J, Groner W. Accurate and independent measurement of volume and haemoglobin concentration of individual red cells by laser light scattering. Blood 1986;68: 506-13.
7. Brugnara C, Colella GM, Cremins J, Langley RC Jr, Schneider TJ, Rutherford CJ, et al. Effects of subcutaneous recombinant human erythropoietin in normal subjects: development of decreased reticulocyte haemoglobin content and iron-deficient erythropoiesis. J Lab Clin Med 1994;123:660-7.
8. Mcdougall IC, Cavill I, Hulme B, Brain B, McGregor E, McKay P, et al. Detection of functional iron deficiency during erythropoietin treatment: a new approach. Br Med J 1992;304:225-6.
9. Cullen P, Söffker J, Höpfl M, Bremer C, Schlaghecker R, Mehrens T, et al. Hypochromic red cells and reticulocyte haemoglobin content as markers of iron-deficient erythropoiesis in patients undergoing chronic haemodialysis. Nephrol Dial Transplant 1999;14:659-65.
10. Brugnara C, Laufer MR, Friedman AJ, Bridges K, Blast O. Reticulocyte haemoglobin content (CHr): early indicator of iron deficiency and response to therapy. Blood 1994;83:3100-101.
11. Tessitore N, Solero GP, Lippi G, Bassi A, Faccini GB, Bedogna V, et al. The role of iron status markers in predicting response to intravenous iron in hemodialysis patients on maintenance erythropoietin. Nephrol Dial Transplant 2001;16:1416-23.
12. David O, Bagna R, Borgione S, Martino C, Fabbris E. Use of reticulocyte parameters to monitor very low birth weight newborns receiving recombinant human erythropoietin. Ital J Pediatr 2002;28:352-8.
13. Parisotto R, Gore C, Hahn A, Ashenden M, Olds T, Martin D, et al. Reticulocyte parameters as potential discriminators of recombinant human erythropoietin abuse in elite athletes. Int J Sports Med 2000;21:471-9.
14. Fishbane S, Shapiro W, Dutka P, Venezuela OF, Faubert J. A randomized trial of iron deficiency testing strategies in hemodialysis patients. Kidney Int 2001;60:2406-11.
15. Schaefer RM, Schaefer L. The hypochromic red cell: a new parameter for monitoring of iron supplementation during rHuEPO therapy. J Perinat Med 1995;23:83-8.
16. Brawn J, Lindner K, Schreiber M, Herdler RA, Horl WH. Percentage hypochronic red cells as a predictor of erythropoietic and iron response after J.W. iron supplementation in maintenance haemodialysis patients. Nephrol Dial Transplant 1997;12:1173-81.
17. Mast AE, Blinder MA, Lu Q, Flax S, Dietzen DJ. Clinical utility of the reticulocyte haemoglobin content in the diagnosis of iron deficiency. Blood 2002;99:1489-91.
18. Franck S, Linssen J, Messinger M, Thomas L. Potential utility of RET-Y in the diagnosis of iron-restricted erythropoiesis. Clin Chem 2004;50:1240-2.
19. Briggs C, Roger R, Thompson B, Machin SJ. New red cell parameters on the Sysmex XE 2100 as potential markers of functional iron deficiency. Infus Ther Transfus Med 2001;28:256-62.
20. Buttarello M, Temporin V, Ceravolo R, Farina G, Bulian P. The new reticulocyte parameter (RET-Y) of the Sysmex XE 2100: its use in the diagnosis and monitoring of posttreatment sideropenic anaemia. Am J Clin Pathol 2004;121:489-95.
21. Beutler E, Lichtman M, Coller B, Kipps T, Seligsohn U. Williams' haematology. 6th ed. New York: McGraw Hill Inc.; 2001.
22. Beilby J, Olynk J, Ching S, Prins A, Swanson N, Reed R, et al. Transferrin index: an alternative method for calculating the iron saturation of transferring. Clin Chem 1992;38:2078-81.
23. D'Onofrio G, Chirillo R, Zini G, Caenaro G, Tommasi M, Micciulli G. Simultaneous measurement of reticulocyte and red cells indices in healthy subjects and patients with microcytic and macrocytic anaemia. Blood 1995;85:818-23.
24. Brugnara C. Use of reticulocyte cellular indices in the diagnosis and treatment of haematological disorders. Int J Clin Lab Res 1998;28:1-11.
25. Thomas C, Thomas L. Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency. Clin Chem 2002;48:1066-76.
26. Breymann C, Bauer C, Major A, Zimmermann R, Gautschi K, Huch A, et al. Optimal timing of repeated rHu-erythropoietin administration improves its effectiveness in stimulating erythropoiesis in healthy volunteers. Br J Haematol 1996;93:295-301.
27. Mitsuiki K, Harada A. Miyata Y. Assessment of iron deficiency in chronic hemodialysis patient investigation of cut-off values for reticulocyte haemoglobin content. Clin Exp Nephrol 2003;7:52-7.