메뉴 건너뛰기




Volumn 8, Issue 2, 2009, Pages 147-160

Mutational analysis of the Candida albicans ammonium permease Mep2p reveals residues required for ammonium transport and signaling

Author keywords

[No Author keywords available]

Indexed keywords

CATION TRANSPORT PROTEIN; FUNGAL PROTEIN; QUATERNARY AMMONIUM DERIVATIVE;

EID: 59249090398     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00229-08     Document Type: Article
Times cited : (13)

References (39)
  • 1
    • 17644386151 scopus 로고    scopus 로고
    • The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans
    • Biswas, K., and J. Morschhäuser. 2005. The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans. Mol. Microbiol. 56:649-669.
    • (2005) Mol. Microbiol , vol.56 , pp. 649-669
    • Biswas, K.1    Morschhäuser, J.2
  • 2
    • 52049107109 scopus 로고    scopus 로고
    • Distinct transport mechanisms in yeast ammonium transport/sensor proteins of the Mep/Amt/Rh family and impact on filamentation
    • Boeckstaens, M., B. Andre, and A. M. Marini. 2008. Distinct transport mechanisms in yeast ammonium transport/sensor proteins of the Mep/Amt/Rh family and impact on filamentation. J. Biol. Chem. 283:21362-21370.
    • (2008) J. Biol. Chem , vol.283 , pp. 21362-21370
    • Boeckstaens, M.1    Andre, B.2    Marini, A.M.3
  • 3
    • 34247338962 scopus 로고    scopus 로고
    • The yeast ammonium transport protein Mep2 and its positive regulator, the Npr1 kinase, play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium
    • Boeckstaens, M., B. Andre, and A. M. Marini. 2007. The yeast ammonium transport protein Mep2 and its positive regulator, the Npr1 kinase, play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium. Mol. Microbiol. 64:534-546.
    • (2007) Mol. Microbiol , vol.64 , pp. 534-546
    • Boeckstaens, M.1    Andre, B.2    Marini, A.M.3
  • 4
    • 0031963197 scopus 로고    scopus 로고
    • The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae
    • Didion, T., B. Regenberg, M. U. Jorgensen, M. C. Kielland-Brandt, and H. A. Andersen. 1998. The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae. Mol. Microbiol. 27:643-650.
    • (1998) Mol. Microbiol , vol.27 , pp. 643-650
    • Didion, T.1    Regenberg, B.2    Jorgensen, M.U.3    Kielland-Brandt, M.C.4    Andersen, H.A.5
  • 5
    • 0242437856 scopus 로고    scopus 로고
    • The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae
    • Donaton, M. C., I. Holsbeeks, O. Lagatie, G. Van Zeebroeck, M. Crauwels, J. Winderickx, and J. M. Thevelein. 2003. The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 50:911-929.
    • (2003) Mol. Microbiol , vol.50 , pp. 911-929
    • Donaton, M.C.1    Holsbeeks, I.2    Lagatie, O.3    Van Zeebroeck, G.4    Crauwels, M.5    Winderickx, J.6    Thevelein, J.M.7
  • 6
    • 36749060099 scopus 로고    scopus 로고
    • The W148L substitution in the Escherichia coli ammonium channel AmtB increases flux and indicates that the substrate is an ion
    • Fong, R. N., K. S. Kim, C. Yoshihara, W. B. Inwood, and S. Kustu. 2007. The W148L substitution in the Escherichia coli ammonium channel AmtB increases flux and indicates that the substrate is an ion. Proc. Natl. Acad. Sci. USA 104:18706-18711.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 18706-18711
    • Fong, R.N.1    Kim, K.S.2    Yoshihara, C.3    Inwood, W.B.4    Kustu, S.5
  • 7
    • 0027192868 scopus 로고
    • Isogenic strain construction and gene mapping in Candida albicans
    • Fonzi, W. A., and M. Y. Irwin. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728.
    • (1993) Genetics , vol.134 , pp. 717-728
    • Fonzi, W.A.1    Irwin, M.Y.2
  • 8
    • 0034799351 scopus 로고    scopus 로고
    • Sensors of extracellular nutrients in Saccharomyces cerevisiae
    • Forsberg, H., and P. O. Ljungdahl. 2001. Sensors of extracellular nutrients in Saccharomyces cerevisiae. Curr. Genet. 40:91-109.
    • (2001) Curr. Genet , vol.40 , pp. 91-109
    • Forsberg, H.1    Ljungdahl, P.O.2
  • 9
    • 0026588787 scopus 로고
    • Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: Regulation by starvation and RAS
    • Gimeno, C. J., P. O. Ljungdahl, C. A. Styles, and G. R. Fink. 1992. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68:1077-1090.
    • (1992) Cell , vol.68 , pp. 1077-1090
    • Gimeno, C.J.1    Ljungdahl, P.O.2    Styles, C.A.3    Fink, G.R.4
  • 10
    • 0037328986 scopus 로고    scopus 로고
    • Inorganic phosphate is sensed by specific phosphate carriers and acts in concert with glucose as a nutrient signal for activation of the protein kinase A pathway in the yeast Saccharomyces cerevisiae
    • Giots, F., M. C. Donaton, and J. M. Thevelein. 2003. Inorganic phosphate is sensed by specific phosphate carriers and acts in concert with glucose as a nutrient signal for activation of the protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 47:1163-1181.
    • (2003) Mol. Microbiol , vol.47 , pp. 1163-1181
    • Giots, F.1    Donaton, M.C.2    Thevelein, J.M.3
  • 12
    • 0032962927 scopus 로고    scopus 로고
    • Amino acid signaling in Saccharomyces cerevisiae: A permease-like sensor of external amino acids and F-box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease
    • Iraqui, I., S. Vissers, F. Bernard, J. O. de Craene, E. Boles, A. Urrestarazu, and B. Andre. 1999. Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease. Mol. Cell. Biol. 19:989-1001.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 989-1001
    • Iraqui, I.1    Vissers, S.2    Bernard, F.3    de Craene, J.O.4    Boles, E.5    Urrestarazu, A.6    Andre, B.7
  • 13
    • 0037320060 scopus 로고    scopus 로고
    • High-affinity ammonium transporters and nitrogen sensing in mycorrhizas
    • Javelle, A., B. Andre, A. M. Marini, and M. Chalot. 2003. High-affinity ammonium transporters and nitrogen sensing in mycorrhizas. Trends Microbiol. 11:53-55.
    • (2003) Trends Microbiol , vol.11 , pp. 53-55
    • Javelle, A.1    Andre, B.2    Marini, A.M.3    Chalot, M.4
  • 14
    • 42449099887 scopus 로고    scopus 로고
    • Substrate binding, deprotonation, and selectivity at the periplasmic entrance of the Escherichia coli ammonia channel AmtB
    • Javelle, A., D. Lupo, P. Ripoche, T. Fulford, M. Merrick, and F. K. Winkler. 2008. Substrate binding, deprotonation, and selectivity at the periplasmic entrance of the Escherichia coli ammonia channel AmtB. Proc. Natl. Acad. Sci. USA 105:5040-5045.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 5040-5045
    • Javelle, A.1    Lupo, D.2    Ripoche, P.3    Fulford, T.4    Merrick, M.5    Winkler, F.K.6
  • 15
    • 33845981511 scopus 로고    scopus 로고
    • An unusual twin-His arrangement in the pore of ammonia channels is essential for substrate conductance
    • Javelle, A., D. Lupo, L. Zheng, X. D. Li, F. K. Winkler, and M. Merrick. 2006. An unusual twin-His arrangement in the pore of ammonia channels is essential for substrate conductance. J. Biol. Chem. 281:39492-39498.
    • (2006) J. Biol. Chem , vol.281 , pp. 39492-39498
    • Javelle, A.1    Lupo, D.2    Zheng, L.3    Li, X.D.4    Winkler, F.K.5    Merrick, M.6
  • 16
    • 14644439901 scopus 로고    scopus 로고
    • Complex formation between AmtB and GlnK: An ancestral role in prokaryotic nitrogen control
    • Javelle, A., and M. Merrick. 2005. Complex formation between AmtB and GlnK: an ancestral role in prokaryotic nitrogen control. Biochem. Soc. Trans. 33:170-172.
    • (2005) Biochem. Soc. Trans , vol.33 , pp. 170-172
    • Javelle, A.1    Merrick, M.2
  • 17
    • 0037242656 scopus 로고    scopus 로고
    • Molecular characterization, function and regulation of ammonium transporters (Amt) and ammonium-metabolizing enzymes (GS, NADP-GDH) in the ectomycorrhizal fungus Hebeloma cylindrosporum
    • Javelle, A., M. Morel, B. R. Rodriguez-Pastrana, B. Botton, B. Andre, A. M. Marini, A. Brun, and M. Chalot. 2003. Molecular characterization, function and regulation of ammonium transporters (Amt) and ammonium-metabolizing enzymes (GS, NADP-GDH) in the ectomycorrhizal fungus Hebeloma cylindrosporum. Mol. Microbiol. 47:411-430.
    • (2003) Mol. Microbiol , vol.47 , pp. 411-430
    • Javelle, A.1    Morel, M.2    Rodriguez-Pastrana, B.R.3    Botton, B.4    Andre, B.5    Marini, A.M.6    Brun, A.7    Chalot, M.8
  • 18
    • 1542275558 scopus 로고    scopus 로고
    • Ammonium sensing in Escherichia coli. Role of the ammonium transporter AmtB and AmtB-GlnK complex formation
    • Javelle, A., E. Severi, J. Thornton, and M. Merrick. 2004. Ammonium sensing in Escherichia coli. Role of the ammonium transporter AmtB and AmtB-GlnK complex formation. J. Biol. Chem. 279:8530-8538.
    • (2004) J. Biol. Chem , vol.279 , pp. 8530-8538
    • Javelle, A.1    Severi, E.2    Thornton, J.3    Merrick, M.4
  • 20
    • 0032778041 scopus 로고    scopus 로고
    • Ssy1p and Ptr3p are plasma membrane components of a yeast system that senses extracellular amino acids
    • Klasson, H., G. R. Fink, and P. O. Ljungdahl. 1999. Ssy1p and Ptr3p are plasma membrane components of a yeast system that senses extracellular amino acids. Mol. Cell. Biol. 19:5405-5416.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 5405-5416
    • Klasson, H.1    Fink, G.R.2    Ljungdahl, P.O.3
  • 21
    • 4644226755 scopus 로고    scopus 로고
    • Structural biology. The atomic architecture of a gas channel
    • Knepper, M. A., and P. Agre. 2004. Structural biology. The atomic architecture of a gas channel. Science 305:1573-1574.
    • (2004) Science , vol.305 , pp. 1573-1574
    • Knepper, M.A.1    Agre, P.2
  • 22
    • 0030938651 scopus 로고    scopus 로고
    • Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid
    • Köhler, G. A., T. C. White, and N. Agabian. 1997. Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. J. Bacteriol. 179:2331-2338.
    • (1997) J. Bacteriol , vol.179 , pp. 2331-2338
    • Köhler, G.A.1    White, T.C.2    Agabian, N.3
  • 23
    • 0016749873 scopus 로고
    • Factors affecting filamentation in Candida albicans: Relationship of the uptake and distribution of proline to morphogenesis
    • Land, G. A., W. C. McDonald, R. L. Stjernholm, and T. L. Friedman. 1975. Factors affecting filamentation in Candida albicans: relationship of the uptake and distribution of proline to morphogenesis. Infect. Immun. 11:1014-1023.
    • (1975) Infect. Immun , vol.11 , pp. 1014-1023
    • Land, G.A.1    McDonald, W.C.2    Stjernholm, R.L.3    Friedman, T.L.4
  • 24
    • 33947155410 scopus 로고    scopus 로고
    • A cytosolic trans-activation domain essential for ammonium uptake
    • Loque, D., S. Lalonde, L. L. Looger, N. von Wiren, and W. B. Frommer. 2007. A cytosolic trans-activation domain essential for ammonium uptake. Nature 446:195-198.
    • (2007) Nature , vol.446 , pp. 195-198
    • Loque, D.1    Lalonde, S.2    Looger, L.L.3    von Wiren, N.4    Frommer, W.B.5
  • 25
    • 0032473497 scopus 로고    scopus 로고
    • The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae
    • Lorenz, M. C., and J. Heitman. 1998. The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. EMBO J. 17:1236-1247.
    • (1998) EMBO J , vol.17 , pp. 1236-1247
    • Lorenz, M.C.1    Heitman, J.2
  • 26
    • 33646702613 scopus 로고    scopus 로고
    • Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters
    • Marini, A. M., M. Boeckstaens, F. Benjelloun, B. Cherif-Zahar, and B. Andre. 2006. Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. Curr. Genet. 49:364-374.
    • (2006) Curr. Genet , vol.49 , pp. 364-374
    • Marini, A.M.1    Boeckstaens, M.2    Benjelloun, F.3    Cherif-Zahar, B.4    Andre, B.5
  • 27
    • 0030791422 scopus 로고    scopus 로고
    • A family of ammonium transporters in Saccharomyces cerevisiae
    • Marini, A. M., S. Soussi-Boudekou, S. Vissers, and B. Andre. 1997. A family of ammonium transporters in Saccharomyces cerevisiae. Mol. Cell. Biol. 17:4282-4293.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 4282-4293
    • Marini, A.M.1    Soussi-Boudekou, S.2    Vissers, S.3    Andre, B.4
  • 28
    • 33744967790 scopus 로고    scopus 로고
    • Ammonium ion transport by the AMT/Rh homologue LeAMT1;1
    • Mayer, M., M. Dynowski, and U. Ludewig. 2006. Ammonium ion transport by the AMT/Rh homologue LeAMT1;1. Biochem. J. 396:431-437.
    • (2006) Biochem. J , vol.396 , pp. 431-437
    • Mayer, M.1    Dynowski, M.2    Ludewig, U.3
  • 29
    • 0028324030 scopus 로고
    • Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: Persistence of Candida albicans strains with the same genotype
    • Millon, L., A. Manteaux, G. Reboux, C. Drobacheff, M. Monod, T. Barale, and Y. Michel-Briand. 1994. Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. J. Clin. Microbiol. 32:1115-1118.
    • (1994) J. Clin. Microbiol , vol.32 , pp. 1115-1118
    • Millon, L.1    Manteaux, A.2    Reboux, G.3    Drobacheff, C.4    Monod, M.5    Barale, T.6    Michel-Briand, Y.7
  • 30
    • 34248144236 scopus 로고    scopus 로고
    • + transport by essential cross talk between AMT monomers through the carboxyl tails
    • + transport by essential cross talk between AMT monomers through the carboxyl tails. Plant Physiol. 143:1651-1659.
    • (2007) Plant Physiol , vol.143 , pp. 1651-1659
    • Neuhauser, B.1    Dynowski, M.2    Mayer, M.3    Ludewig, U.4
  • 31
    • 0029864499 scopus 로고    scopus 로고
    • Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression
    • Özcan, S., J. Dover, A. G. Rosenwald, S. Wölfl, and M. Johnston. 1996. Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc. Natl. Acad. Sci. USA 93:12428-12432.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 12428-12432
    • Özcan, S.1    Dover, J.2    Rosenwald, A.G.3    Wölfl, S.4    Johnston, M.5
  • 32
    • 51349144690 scopus 로고    scopus 로고
    • A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae
    • Rutherford, J. C., G. Chua, T. Hughes, M. E. Cardenas, and J. Heitman. 2008. A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae. Mol. Biol. Cell 19:3028-3039.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 3028-3039
    • Rutherford, J.C.1    Chua, G.2    Hughes, T.3    Cardenas, M.E.4    Heitman, J.5
  • 33
    • 41449094147 scopus 로고    scopus 로고
    • Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans
    • Rutherford, J. C., X. Lin, K. Nielsen, and J. Heitman. 2008. Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans. Eukaryot. Cell 7:237-246.
    • (2008) Eukaryot. Cell , vol.7 , pp. 237-246
    • Rutherford, J.C.1    Lin, X.2    Nielsen, K.3    Heitman, J.4
  • 34
    • 0141484319 scopus 로고    scopus 로고
    • Isolation and characterization from pathogenic fungi of genes encoding ammonium permeases and their roles in dimorphism
    • Smith, D. G., M. D. Garcia-Pedrajas, S. E. Gold, and M. H. Perlin. 2003. Isolation and characterization from pathogenic fungi of genes encoding ammonium permeases and their roles in dimorphism. Mol. Microbiol. 50:259-275.
    • (2003) Mol. Microbiol , vol.50 , pp. 259-275
    • Smith, D.G.1    Garcia-Pedrajas, M.D.2    Gold, S.E.3    Perlin, M.H.4
  • 35
    • 41449114629 scopus 로고    scopus 로고
    • Impact of ammonium permeases MepA, MepB, and MepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi
    • Teichert, S., J. C. Rutherford, M. Wottawa, J. Heitman, and B. Tudzynski. 2008. Impact of ammonium permeases MepA, MepB, and MepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi. Eukaryot. Cell 7:187-201.
    • (2008) Eukaryot. Cell , vol.7 , pp. 187-201
    • Teichert, S.1    Rutherford, J.C.2    Wottawa, M.3    Heitman, J.4    Tudzynski, B.5
  • 36
    • 0033913267 scopus 로고    scopus 로고
    • Membrane topology of the Mep/Amt family of ammonium transporters
    • Thomas, G. H., J. G. Mullins, and M. Merrick. 2000. Membrane topology of the Mep/Amt family of ammonium transporters. Mol. Microbiol. 37:331-344.
    • (2000) Mol. Microbiol , vol.37 , pp. 331-344
    • Thomas, G.H.1    Mullins, J.G.2    Merrick, M.3
  • 37
    • 39749184089 scopus 로고    scopus 로고
    • Ammonia-induced formation of an AmtB-GlnK complex is not sufficient for nitrogenase regulation in the photosynthetic bacterium Rhodobacter capsulatus
    • Tremblay, P. L., and P. C. Hallenbeck. 2008. Ammonia-induced formation of an AmtB-GlnK complex is not sufficient for nitrogenase regulation in the photosynthetic bacterium Rhodobacter capsulatus. J. Bacteriol. 190:1588-1594.
    • (2008) J. Bacteriol , vol.190 , pp. 1588-1594
    • Tremblay, P.L.1    Hallenbeck, P.C.2
  • 38
    • 58149136355 scopus 로고    scopus 로고
    • Tremblay, P.-L., and P. C. Hallenbeck. 2008. Of blood, brains and bacteria, the Amt/Rh transporter family: emerging role of Amt as a unique microbial sensor. Mol. Microbiol. doi:10.1111/j.1365-2958.2008.06514.x.
    • Tremblay, P.-L., and P. C. Hallenbeck. 2008. Of blood, brains and bacteria, the Amt/Rh transporter family: emerging role of Amt as a unique microbial sensor. Mol. Microbiol. doi:10.1111/j.1365-2958.2008.06514.x.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.