Assessing the risks of persistent organic pollutants to top predators: A review of approaches

Integrated Environmental Assessment and Management

Volumn 4, Issue 4, 2008, Pages 386-398

  Leonards, Pim E G ^a   Van Hattum, Bert ^a   Leslie, Heather ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Dietary intake; POPs; Risk assessment; Tissue residue; Top predators

Indexed keywords

POLYCHLORINATED BIPHENYL;

ANIMAL; ENVIRONMENTAL MONITORING; METHODOLOGY; POLLUTANT; REVIEW; RISK ASSESSMENT;

ANIMALS; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; POLYCHLORINATED BIPHENYLS; RISK ASSESSMENT;

EID: 59149103559     PISSN: 15513793     EISSN: None     Source Type: Journal    
DOI: 10.1897/IEAM_2008-008.1     Document Type: Review

References (111)

1. Aguilar A. 1985. Compartmentation and reliability of sampling procedures in organochlorine pollution surveys of cetaceans. Res Rev 95:91-114.
2. [AMAP] Arctic Monitoring and Assessment Programme. 2004. AMAP assessment 2002: Persistent organic pollutants (POPs) in the Arctic. Oslo (NO): AMAP. 310 p.
3. Aulerich RJ, Bursian SJ, Breslin WJ, Olson BA, Ringer RK. 1985. Toxicological manifestations of 2, 4, 5-hexachlorobiphenyl, 20, 40, 50-hexachlorobiphenyl, 2, 3, 6, 20, 30, 60-hexachlorobiphenyl, and 3, 4, 5, 30, 40, 50-hexachlorobiphenyl and aroclor 1254 in mink. J Toxicol Environ Health 15:63-79.
4. Aulerich RJ, Bursian SJ, Evans MG, Hochstein JR, Koudele KA, Olson BA, Napolitano AC. 1987. Toxicity of 3, 4, 5, 30, 40, 50-hexachlorobiphenyl to mink. Arch Environ Contam Toxicol 16:53-60.
5. Aulerich RJ, Ringer RK. 1977. Current status of PCB toxicity to mink, and effect on their reproduction. Arch Environ Contam Toxicol 6:279-292.
6. Aulerich RJ, Ringer RK, Seagran HL, Youatt WG. 1971. Effects of feeding coho salmon and other Great Lakes fish on mink reproduction. Can J Zool 49:611- 616.
7. Bäcklin BM, Persson E, Jones CJP, Dantzer V. 1998. Polychlorinated biphenyl (PCB) exposure produces placental vascular and trophoblastic lesions in the mink (Mustela vison): A light and electron microscopic study. APMIS 106:785-799.
8. Basu N, Scheuhammer AM, Bursian SJ, Elliott J, Rouvinen-Watt K, Chan HM. 2007. Mink as a sentinel species in environmental health. Environ Res 103:130-144.
9. Bekker DL, Nolet BA. 1990. The diet of otters Lutra lutra in the Netherlands in winter and early spring. Lutra 33:134-144.
10. Bergman A, Backlin BM, Jarplid B, Grimelius L, Wilander E. 1992. Influence of commercial polychlorinated-biphenyls and fractions thereof on liver histology in female mink (Mustela vison). Ambio 21:591-595.
11. Bernhoft A, Skaare JU, Wiig Ø, Derocher AE, Larsen HJS. 2000. Possible immunotoxic effects of organochlorines in polar bears (Ursus maritimus) at Svalbard. J Toxicol Environ Health Part A 59:561-574.
12. Bernhoft A, Skaare JU. 1994. Levels of selected individual polychlorinatedbiphenyls in different tissues of harbor seals (Phoca vitulina) from the southern coast of Norway. Environ Poll 86:99-107.
13. Boon JP, Reijnders PJH, Dols J, Wensvoort P, Hillebrand MTJ. 1987. The kinetics of individual polychlorinated biphenyl congeners in female harbor seals (Phoca vitulina), with evidence for structure related metabolism. Aquat Toxicol 10:307-324.
14. Boon JP, Oostingh I, van der Meer J, Hillebrand MTJ. 1994. A model for the bioaccumulation of chlorobiphenyl congeners in marine mammals. Eur J Pharmacol 270:237-251.
15. Boon JP, van Arnhem E, Jansen S, Kannan N, Petrick G, Schulz DE, Duinker JC, Reijnders PJH, Goksoryr A. 1992. The toxicokinetics of PCBs in marine mammals with special reference to possible interactions of individual congeners with the cytochrome P450-dependent monooxygenase system- An overview. In: Walker CH, Livingstone DR, Lipnick RL, editors. Persistent pollutants in marine ecosystems. Oxford (NY): Pergamon. p 119-159.
16. Boon JP, van der Meer J, Allchin CR, Law RJ, Klunsoyr J, Leonards PEG, Spliid H, Storr Hansen E, McKenzie C, Wells DE. 1997. Concentration-dependent changes of PCB patterns in fish-eating mammals: Structural evidence for induction of cytochrome P450. Arch Environ Contam Toxicol 33:298-311.
17. Bosveld ATC, Gradener J, Murk AJ, Brouwer A, Van Kampen M, Evers EHG, van den Berg M. 1995. Effects of PCDDs, PCDFs and PCBs in Common Tern (Sterna hirundo) breeding in estuarine and coastal colonies in the Netherlands and Belgium. Environ Toxicol Chem 14:99-115.
18. Bosveld ATC, Gradener J, Van Kampen M, Murk AJ, Evers EHG, van den Berg M. 1993. Occurrence and effects of PCBs, PCDDs and PCDFs in hatchlings of the Common Tern (Sterna hirundo). Chemosphere 27:419-427.
19. Bosveld ATC, Van den Berg M. 1994. Biomarkers and bioassays as alternative screening methods for the presence and effects of PCDD, PCDF and PCB. J Anal Chem 348:106-110.
20. Bowen WD. 2000. Reconstruction of pinniped diets: accounting for complete digestion of otoliths and cephalopod beaks. Can J Fish Aquat Sci 57:898-905.
21. Brinkhuizen DC. 1992. Het dieet van de otter (Lutra lutra) in De Deelen en de Oude Venen (Friesland) bepaald door middel van analyse van spraints. Report Stichting Otterstation Nederland, Leeuwarden, The Netherlands; Groningener Stichting voor Archaezölogisch Onderzoek, Groningen, The Netherlands. [in Dutch].
22. Brouwer A, Reijnders PJH, Koeman JH. 1989. Polychlorinated biphenyl (PCB)- contaminated fish induces vitamin-A and thyroid-hormone deficiency in the common seal (Phoca vitulina). Aquat Toxicol 15:99-106.
23. Brunström B. 1992. Induction of cytochrome p-450-dependent enzyme-activities in female mink (Mustela vison) and their kits by technical PCB preparations and fractions thereof. Ambio 21:585-587.
24. Brunström B, Lund BO, Bergman A, Asplund L, Athanassiadis I, Athanasiadou M, Jensen S, Orberg J. 2001. Reproductive toxicity in mink (Mustela vison) chronically exposed to environmentally relevant polychlorinated biphenyl concentrations. Environ Toxicol Chem 20:2318-2327.
25. Bursian SJ, Aulerich RJ, Yamini B, Tillitt DE. 2003. Dietary exposure of mink to fish from the Housatonic River: Effects on reproduction and survival. Revised Final Report to EPA, June 10, 2003. www.epa.gov/NE/ge/thesite/ restofriver-reports2.html. Accessed January 2008.
26. Bursian SJ, Beckett KJ, Yamini B, Martin PA, Kannan K, Shields KL, Mohr FC. 2006. Assessment of effects in mink caused by consumption of carp collected from the Saginaw River, Michigan, USA. Arch Environ Contam Toxicol 50:614-623.
27. Bustnes JO. 2006. Pinpointing potential causative agents in mixtures of persistent organic pollutants in observational field studies: A review of glaucous gull studies. J Toxicol Environ Health Part A 69:97-108.
28. Cottrell PE, Trites AW, Miller EH. 1996. Assessing the use of hard parts in faeces to identify harbour seal prey: Results of captive-feeding trials. Can J Zool 74:875- 880.
29. Cullon DL, Jeffries SJ, Ross PS. 2005. Persistent organic pollutants in the diet of harbor seals (Phoca vitulina) inhabiting Puget Sound, Washington (USA), and the Strait of Georgia, British Columbia (Canada): A food basket approach. Environ Toxicol Chem 24:2562-2572.
30. De Swart RL, Ross PS, Vedder LJ, Boink PBTJ, Reijnders PJH, Mulder PGH, Osterhaus ADME. 1995. Haematology and clinical chemistry values for harbour seals (Phoca vitulina) fed environmentally contaminated herring remain within normal ranges. Can J Zool 73:2035-2043.
31. De Swart RL, Ross PS, Vedder LJ, Timmerman HH, Heisterkamp SH, van Loveren H. 1994. Impairment of immune function in harbour seals (Phoca vitulina) feeding on fish from polluted waters. Ambio 23:155-159.
32. De Swart RL, Ross PS, Vos JG, Osterhaus ADME. 1996. Impaired immunity in harbour seals (Phoca vitulina) exposed to bioaccumulated environmental contaminants: Review of a long-term feeding study. Health Perspect 104(Suppl 4):823-828.
33. Di Toro DM, McGrath JA, Hansen DJ. 2000. Technical basis for narcotic chemicals and polycyclic aromatic hydrocarbon criteria. I. Water and tissue. Environ Toxicol Chem 19:1951-1970.
34. Elliott JE, Henny CJ, Harris ML, Wilson LK, Norstrom RJ. 1999. Chlorinated hydrocarbons in livers of American mink (Mustela vison) and river otter (Lutra canadensis) from the Columbia and Fraser River basins, 1990-1992. Environ Monit Assess 57:229-252.
35. [EC] Environment Canada. 1998. Canadian tissue residue guidelines for the polychlorinated biphenyls for the protection of wildlife consumers of aquatic life. Final Draft. Hull (PQ): Environment Canada, Water Quality Guidelines Standards Division. 177 p.
36. Escher BI, Hermens JLM. 2004. Internal exposure: Linking bioavailabilty to effects. Environ Sci Technol 38:455A-462A.
37. European Commission. 2003. Technical guidance document on risk assessment, EUR 20418. Ispra (IT): European Commission, Institute for Health and Consumer Protection of the European Chemicals Bureau, Joint Research Centre.
38. Fairbrother A. 2003. Lines of evidence in wildlife risk assessments. Human and Ecological Risk Assessment 9:1475-1491.
39. Fisk AT, de Wit CA, Wayland M, Kuzyk ZZ, Burgess N, Robert R, Braune B, Norstrom R, Blum SP, Sandau C, Lie E, Larsen HJS, Skaare JU, Muir DCG. 2005. An assessment of the toxicological significance of anthropogenic contaminants in Canadian arctic wildlife. Sci Total Environ 351-352:57-93.
40. Foley RE, Jackling SJ, Sloan RJ, Brown MK. 1988. Organochlorine and mercury residues in wild mink and otter-Comparison with fish. Environ Toxicol Chem 7:363-374.
41. Fossi MC, Marsili L, Neri G, Natoli A, Politi E, Panigada S. 2003. The use of a nonlethal tool for evaluating toxicological hazard of organochlorine contaminants in Mediterranean cetaceans: New data 10 years after the first paper published in MPB. Mar Pollut Bull 46:972-982.
42. Giesy JP, Kannan K. 1998. Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (PCBs): Implications for risk assessment. Crit Rev Toxicol 28:511-569.
43. Giesy J, Verbrugge DA, Othout RA, Bowerman WW, Mora MA, Jones PD, Newsted JL, Vandervoort C, Heaton SN, Aulerich RJ, Bursian SJ, Ludwig JP, Dawson GA, Kubiak TJ, Best D, Tillitt DE. 1994. Contaminants in fishes from great lakesinfluenced sections and above dams of three Michigan rivers. II: Implications for health of mink. Arch Environ Contam Toxicol 27:202-212.
44. Haave M, Ropstad E, Derocher AE, Lie E, Dahl E, Wiig Ø, Skaare JU, Jenssen BM. 2003. Polychlorinated biphenyls and reproductive hormones in female polar bears at Svalbard. Environ Health Perspect 111:431-436.
45. Håkansson H, Manzoor E, Ahlborg UG. 1992. Effects of technical PCB preparations and fractions thereof on vitamin-A levels in the mink (Mustela vison). Ambio 21:588-590.
46. Halbrook RS, Aulerich RJ, Bursian SJ, Lewis L. 1999. Ecological risk assessment in a large river-reservoir: 8. Experimental study of the effects of polychlorinated biphenyls on reproductive success in mink. Environ Toxicol Chem 18:649-654.
47. Harding LE, Harris ML, Stephen CR, Elliott JE. 1999. Reproductive and morphological condition of wild mink (Mustela vison) and river otters (Lutra canadensis) in relation to chlorinated hydrocarbon contamination. Environ Health Perspect 107:141-147.
48. Heaton SN, Bursian SJ, Giesy JP, Tillitt DE, Render JA, Jones PD, Verbrugge DA, Kubiak TJ, Aulerich RJ. 1995a. Dietary exposure of mink to carp from Saginaw Bay, Michigan: 1. Effects on reproduction and survival, and the potential risks to wild mink populations. Arch Environ Contam Toxicol 28:334-343.
49. Heaton SN, Bursian SJ, Giesy JP, Tillitt DE, Render JA, Jones PD, Verbrugge DA, Kubiak TJ, Aulerich RJ. 1995b. Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology. Arch Environ Contam Toxicol 29:411-417.
50. Hendriks AJ, Traas TP, Huijbregts MAJ. 2005. Critical body residues linked to octanol-water partitioning, organism composition, and LC50 QSARs: Metaanalysis and model. Environ Sci Technol 39:3226-3236.
51. Hochstein JR, Bursian SJ, Aulerich RJ. 1998. Effects of dietary exposure to 2, 3, 7, 8- tetrachlorodibenzo-p-dioxin in adult female mink (Mustela vison). Arch Environ Contam Toxicol 35:348-353.
52. Holcomb LC. 1963. Reproductive physiology in mink (Mustela vison) [PhD thesis]. East Lansing (MI): Michigan State Univ.
53. Hornshaw TC, Safronoff J, Ringer RK, Aulerich RJ. 1986. LC50 test-results in polychlorinated biphenyl-fed mink-Age, season, and diet comparisons. Arch Environ Contam Toxicol 15:717-723.
54. Hwang H, Fisher SW, Kim K, Landrum PF. 2001. Comparison of the toxicity using body residues of DDE and select PCB congeners to the midge, Chironomus riparius, in partial-life cycle tests. Arch Environ Contam Toxicol 46:32-42.
55. Iverson SJ, Frost KJ, Lowry LF. 1997. Fatty acid signatures reveal fine scale structure of foraging distribution of harbor seals and their prey in Prince William Sound, Alaska. Mar Ecol Prog Ser 151:255-271.
56. Jensen S, Kihlström JE, Olsson M, Lundberg C, Örberg J. 1977. Effects of PCB and DDT on mink (Mustela vison) during reproductive season. Ambio 6:239.
57. Jenssen BM, Skaare JU, Ekker M, Vongraven D, Lorentsen S-H. 1996. Organochlorine compounds in blubber, liver and brain in neonatal grey seal pups. Chemosphere 32:2115-2125.
58. Kakela R, Kakela A, Hyvarinen H, Asikainen J, Dahl SK. 1999. Vitamins A(1), A(2), and E in minks exposed to polychlorinated biphenyls (Acoclor 1242t) and copper, via diet based on freshwater or marine fish. Environ Toxicol Chem 18:2595-2599.
59. Kannan K, Blankenship AL, Jones PD, Giesy JP. 2000. Toxicity reference values for the toxic effects of polychlorinated biphenyls to aquatic mammals. Human and Ecological Risk Assessment 6:181-201.
60. Kannan K, Falandysz J, Tanabe S, Tatsukawa R. 1993. Persistent organochlorines in harbour porpoises from Puck Bay, Poland. Mar Poll Bull 26:162-165.
61. Kannan K, Tanabe S, Tatsukawa R, Sinha RK. 1994. Biodegradation capacity and residue pattern of organochlorines in Ganges River dolphins from India. Toxicol Environ Chem 42:249-261.
62. Kihlström JE, Olsson M, Jensen S, Johansson A, Ahlbom J, Bergman A. 1992. Effects of PCB and different fractions of PCB on the reproduction of the mink (Mustela vison). Ambio 21:563-569.
63. Leonards PEG, Broekhuizen S, de Voogt P, Van Straalen NM, Brinkman UAT, Cofino WP, van Hattum B. 1998. Studies of bioaccumulation and biotransformation of PCBs in mustelids based on concentration and congener patterns in predators and preys. Arch Environ Contam Toxicol 35:654-665.
64. Leonards PEG, de Vries TH, Minnaard W, Stuijfzand S, de Voogt P, Cofino WP, van Straalen NM, van Hattum B. 1995. Assessment of experimental data on PCB induced reproduction inhibition in mink, based on an isomer specific and a congener specific approach using 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin toxic equivalency. Environ Toxicol Chem 14:639-652.
65. Leonards PEG, Zierikzee Y, Brinkman UATh, Cofino WP, van Straalen NM, van Hattum B. 1997. The selective dietary accumulation of planar polychlorinated biphenyls in the otter (Lutra lutra). Environ Toxicol Chem 16:1807-1815.
66. Leslie HA, Kraak MHS, Hermens JLM. 2004. Chronic toxicity and body residues of the nonpolar narcotic 1, 2, 3, 4-tetrachlorobenzene in Chironomus riparius. Environ Toxicol Chem 23:2022-2028.
67. Letcher RJ, Norstrom RJ, Lin S, Ramsay MA, Bandiera SM. 1996. Immunoquantitation and microsomal monooxygenase activities of hepatic cytochromes P4501A and P4502B and chlorinated hydrocarbon contaminant levels in polar bear (Ursus maritimus). Toxicol Appl Pharmacol 137:127-140.
68. Lie E, Larsen HJS, Larsen S, Johansen GM, Derocher AE, Lunn NJ, Norstrom RJ, Wiig Ø, Skaare JU. 2004. Does high organochlorine (OC) exposure impair the resistance to infection in polar bears (Ursus maritimus)? Part 1: Effect of OCs on the humoral immunity. J Toxicol Environ Health Part A 67:555-582.
69. Lie E, Larsen HJS, Larsen S, Johansen GM, Derocher AE, Lunn NJ, Wiig Ø, Skaare JU. 2005. Does high organochlorine (OC) exposure impair the resistance to infection in polar bears (Ursus maritimus)? Part II: Possible effect of OCs on mitogen- and antigen-induced lymphocyte proliferation. J Toxicol Environ Health Part A 68:457-484.
70. Major AR, Carr KC. 1991. Contaminant concentrations in Connecticut and Massachusetts mink. Report RY91-NEFO-5-EC. US Fish and Wildlife Service, New England Field Office.
71. Martin PA, Mayne GJ, Bursian S, Palace V, Kannan K. 2006a. Changes in thyroid and vitamin A status in mink fed polyhalogenated-aromatic-hydrocarbon- contaminated carp from the Saginaw River, Michigan, USA. Environ Res 101:53-67.
72. Martin PA, McDaniel TV, Hunter B. 2006. Temporal and spatial trends in chlorinated hydrocarbon concentrations of mink in Canadian Lakes Erie and St. Clair. Environ Monit Assess 113:245-263.
73. McCarty LS, Mackay D. 1993. Enhancing ecotoxicological modeling and assessment. Environ Sci Technol 27:1719-1728.
74. Millsap SD, Blankenship AL, Bradley PW, Jones PD, Kay D, Neigh A, Park C, Strause KD, Zwiernik MJ, Giesy JP. 2004. Comparison of risk assessment methodologies for exposure of mink to PCBs on the Kalamazoo River, Michigan. Environ Sci Technol 38:6451-6459.
75. Moore DRJ, Sample BE, Suter GW, Parkhurst BR, Teed RS. 1999. A probabilistic risk assessment of the effects of methylmercury and PCBs on mink and kingfishers along East Fork Poplar Creek, Oak Ridge, Tennessee, USA. Environ Toxicol Chem 18:2941-2953.
76. Murk AJ, Leonards PEG, van Hattum B, Luit R, van der Weiden MEJ, Smit M. 1998. Application of biomarkers for exposure and effect of polyhalogenated aromatic hydrocarbons in naturally exposed European otters (Lutra lutra). Environ Toxicol Pharmacol 6:91-102.
77. Nakata H, Kannan K, Jing L, Thomas N, Tanabe S, Giesy JP. 1998. Accumulation pattern of organochlorine pesticides and polychlorinated biphenyls in southern sea otters (Enhydra lutris nereis) found stranded along coastal California, USA. Environ Pollut 103:45-53.
78. Norris KS. 1977. Whales, dolphins and porpoises. Berkeley (CA): Univ. California Press. 789 p.
79. Norstrom RJ, Belikov SE, Born EW, Garner GW, Malone B, Olpinski S, Ramsay MA, Schliebe S, Stirling I, Stishov MS, Taylor MK, Wiig Ø. 1998. Chlorinated hydrocarbon contaminants in polar bears from eastern Russia, North America, Greenland, and Svalbard: Biomonitoring of Arctic pollution. Arch Environ Contam Toxicol 35:354-367.
80. Olesiuk PF, Bigg MA, Ellis GM, Crockford ST, Wigen RJ. 1990. An assessment of the feeding habits of harbour seals (Phoca vitulina) in the Strait of Georgia, BC, based on scat analysis. Can Tech Rep Fish Aquat Sci 1730:135.
81. O'Shea TJ, Askins TE, Chapman JA. 1981. Polychlorinated biphenyls in a wild mink population. In: Chapman JD, Pursley D, editors. World Furbearer Conference Proceedings. Frostburg (MD): Worldwide Furbearer Conference. 3:1746-1752.
82. Oskam IC, Ropstad E, Dahl E, Lie E, Derocher AE, Wiig Ø, Larsen S, Wiger R, Skaare JU. 2003. Organochlorines affect the major androgenic hormone, testosterone, in male polar bears (Ursus maritimus) at Svalbard. J Toxicol Environ Health Part A 66:2119-2139.
83. Osowski SL, Brewer LW, Baker OE, Cobb GP. 1995. The decline of mink in Georgia, North Carolina, and South Carolina-The role of contaminants. Arch Environ Contam Toxicol 29:418-423.
84. Patnode KA, Curtis LR. 1994. 2, 20, 4, 40, 5, 50-Hexachlorobiphenyl and 3, 30, 4, 40, 5, 50-hexachlorobiphenyl alteration of uterine progesterone and estrogen-receptors coincides with embryotoxicity in mink (Mustela vison). Toxicol Appl Pharmacol 127:9-18.
85. Poole KG, Elkin BT, Bethke RW. 1998. Organochlorine and heavy metal contaminants in wild mink in western Northwest Territories, Canada. Arch Environ Contam Toxicol 34:406-413.
86. Ramsay MA, Stirling I. 1988. Reproductive biology and ecology of female polar bears (Ursus maritimus). J Zool 214:601-634.
87. Reddy M, Echols S, Finklea B, Busbee D, Reif J. 1998. PCBs and chlorinated pesticides in clinically healthy Tursiops truncatus: Relationships between levels in blubber and blood. Mar Pollut Bull 36:892-903.
88. Render JA, Aulerich RJ, Bursian SJ, Nachreiner RF. 2000. Proliferation of maxillary and mandibular periodontal squamous cells in mink fed 3, 30, 4, 40, 5- pentachlorobiphenyl (PCB 126). J Vet Diagn Investig 12:477-479.
89. Render JA, Hochstein JR, Aulerich RJ, Bursian SJ. 2000. Proliferation of periodontal squamous epithelium in mink fed 2, 3, 7, 8-tetrachlorodibenzo-p- dioxin (TCDD). Vet Hum Toxicol 42:85-86.
90. Restum JC, Bursian SJ, Giesy JP, Render JA, Helferich WC, Shipp EB, Verbrugge DA. 1998. Multigenerational study of the effects of consumption of PCBcontaminated carp from Saginaw Bay, Lake Huron, on mink. 1. Effects on mink reproduction, kit growth and survival, and selected biological parameters. J Toxicol Environ Health Part A 54:343-375.
91. Ross PS, De Swart R, Addison R, van Loveren H, Vos J, Osterhaus A. 1996. Contaminant-induced immunotoxicity in harbour seals: Wildlife at risk? Toxicology 112:157-169.
92. Ross PS, De Swart RL, Reijnders PJH, van Loveren H, Vos JG, Osterhaus ADME. 1995. Contaminant-related suppression of delayed-type hypersensitivity and antibody responses in harbor seals fed herring from the Baltic Sea. Environ Health Perspect 103:162-167.
93. Sample BE, Opresko DM, Suter GW. 1996. Toxicological benchmarks for wildlife: 1996 revision. Oak Ridge (TN): Risk Assessment Program, Health Sciences Research Division. ES/ER/TM-86/R3.
94. Sandau CD, Meerts IATM, Letcher RJ, McAlees AJ, Chittim B, Brouwer A, Norstrom RJ. 2000. Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transthyretin: A metabolite of octachlorostyrene? Environ Sci Technol 34:3871-3877.
95. Schwacke LH, Voit EO, Hansen LJ, Wells RS, Mitchum GB, Hohn AA, Fair PA. 2002. Probabilistic risk assessment of reproductive effects of polychlorinated biphenyls on bottlenose dolphins (Tursiops truncatus) from the southeast United States coast. Environ Toxicol Chem 21:2752-2764.
96. Shipp EB, Restum JC, Giesy JP, Bursian SJ, Aulerich RJ, Helferich WC. 1998. Multigenerational study of the effects of consumption of PCB-contaminated carp from Saginaw Bay, Lake Huron, on mink. 2. Liver PCB concentration and induction of hepatic cytochrome P-450 activity as a potential biomarker for PCB exposure. J Toxicol Environ Health Part A 54:377-401.
97. Skaare JU, Bernhoft A, Derocher A, Gabrielsen GW, Goksoyr A, Henriksen E, Larsen HJ, Lie E, Wiig Ø. 2000. Organochlorines in top predators at Svalbard- Occurrence, levels and effects. Toxicol Lett 112:103-109.
98. Skaare JU, Bernhoft A, Wiig Ø, Norum KR, Haug E, Eide DM, Derocher AE. 2001. Relationships between plasma levels of organochlorines, retinol and thyroid hormones from polar bears (Ursus maritimus) at Svalbard. J Toxicol Environ Health Part A 62:227-241.
99. Skaare JU, Larsen HJ, Lie E, Bernhoft A, Derocher AE, Norstrom R, Ropstad E, Lunn NF, Wiig Ø. 2002. Ecological risk assessment of persistent organic pollutants in the arctic. Toxicology 181:193-197.
100. Smit M, Leonards PEG, Murk AJ, de Jongh AWJJ, van Hattum B. 1996. Development of otter-based quality objectives for PCBs (DOQOP). IVM report (R-96/11). Amsterdam/Leeuwarden/Wageningen (NL): Institute for Environmental Studies/VU/SON/DT-WAU.
101. Tillitt DE, Gale RW, Meadows JC, Zajicek JL, Peterman PH, Heaton SN, Jones PD, Bursian SJ, Kubiak TJ, Giesy JP, Aulerich RJ. 1996. Dietary exposure of mink to carp from Saginaw Bay. 3. Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification. Environ Sci Technol 30:283-291.
102. Traas TP, Luttik R, Klepper O, Beurskens JEM, Smit MD, Leonards PEG, van Hattum AGM, Aldenberg T. 2001. Congener-specific model for polychlorinated biphenyl effects on otter (Lutra lutra) and associated sediment quality criteria. Environ Toxicol Chem 20:205-212.
103. Traas TP, van Wezel AP, Hermens JLM, Zorn M, van Hattum B, van Leeuwen CJ. 2004. Environmental quality criteria for organic chemicals predicted from internal effect concentrations and a food web model. Environ Toxicol Chem 23:2518-2527.
104. [USEPA] US Environmental Protection Agency. 1993. Wildlife Exposure Factors Handbook. Vol I. EPA/600/R-93/187a.
105. [USEPA] US Environmental Protection Agency. 1994. Integrated Risk Information System (IRIS). Cincinnati (OH): USEPA, Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment.
106. [USEPA] US Environmental Protection Agency. 1996. Use of uncertainty factors in toxicity extrapolations involving terrestrial wildlife. Technical Basis. Washington DC: USEPA, Office of Research and Development.
107. Van den Berg M, Birnbaum L, Bosveld ATC, Brunström B, Cook P, Feeley M, Giesy JP, Hanberg A, Hasegawa R, Kennedy SW, Kubiak T, Larsen JC, van Leeuwen FXR, Liem AKD, Nolt C, Peterson RE, Poellinger L, Safe S, Schrenk D, Tillitt D, Tysklind M, Younes M, Waern F, Zacharewski T. 1998. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 106:775-792.
108. Van Wezel AP, Opperhuizen A. 1995. Thermodynamics of partitioning of a series of chlorobenzenes to fish storage lipids, in comparison to partitioning to phospholipids. Chemosphere 31:3605-3615.
109. Verreault J, Bech C, Letcher RJ, Ropstad E, Dahl E, Gabrielsen GW. 2007. Organohalogen contamination in breeding glaucous gulls from the Norwegian Arctic: Associations with basal metabolism and circulating thyroid hormones. Environ Pollut 145:138-145.
110. Verreault J, Skaare JU, Jenssen BM, Gabrielsen GW. 2004. Effects of organochlorine contaminants on thyroid hormone levels in arctic breeding glaucous gulls, Larus hyperboreus. Environ Health Perspect 112:532-537.
111. Wren CD. 1991. Cause-effect linkages between chemicals and populations of mink (Mustela vison) and otter (Lutra canadensis) in the Great-Lakes basin. J Toxicol Environ Health 33:549-585.