Protective effects of melatonin on myocardial ischemia-reperfusion induced infarct size and oxidative changes

Physiological Research

Volumn 54, Issue 5, 2005, Pages 491-495

  Sahna, E ^a   Parlakpinar, H ^b   Turkoz, Y ^b   Acet, A ^b  

^a FIRAT UNIVERSITY   (Turkey)

^b INONU UNIVERSITY   (Turkey)

Author keywords

Glutathione; Heart; Infarct size; Malondialdehyde; Melatonin; Reperfusion injury

Indexed keywords

ANTIOXIDANT; GLUTATHIONE; MALONALDEHYDE; MELATONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEART INFARCTION; HEART INFARCTION SIZE; HEART INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY;

ANIMALS; CARDIOTONIC AGENTS; GLUTATHIONE; MALE; MALONDIALDEHYDE; MELATONIN; MYOCARDIAL INFARCTION; OXIDATIVE STRESS; RATS; RATS, WISTAR; REPERFUSION INJURY; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 27644598160     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. DHALLA NS, ELMOSELHI AB, HATA T, MAKINO N: Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res 47: 446-456, 2000.
2. DOBŠÁK P, SIEGELOVÁ J, EICHER JC, JANČÍK J, SVAČINOVÁ H, VAŠKŮ J, KUCHTIČKOVA S, HORKÝ M, WOLF JE: Melatonin protects against ischemia-reperfusion injury and inhibits apoptosis in isolated working rat heart. Pathophysiology 9: 179-187, 2003.
3. HARA M, YOSHIDA M, NISHIJIMA H, YOKOSUKA M, IIGO M, OHTANI-KANEKO R, SHIMADA A, HASEGAWA T, AKAMA Y, HIRATA K: Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats. J Pineal Res 30: 129-138, 2001.
4. KANEKO S, OKUMURA K, NUMAGUCHI Y, MATSUI H, MURASE K, MOKUNO S, MORISHIMA I, HIRA K, TOKI Y, ITO T, HATAKAWA T: Melatonin scavenges hydroxyl radical and protects isolated rat hearts from ischemic reperfusion injury. Life Sci 67: 101-112, 2000.
5. LAGNEUX C, JOYEUX M, DEMENGE P, RIBUOT C, GODIN-RIBUOT D: Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart. Life Sci 66: 503-509, 2000.
6. LEE YM, CHEN HR, HSIAO G, SHEU JR, WANG JJ, YEN MH: Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. J Pineal Res 33: 72-80, 2002.
7. LEFER DJ, GRANGER DN: Oxidative stress and cardiac disease. Am J Med 109: 315-323, 2000.
8. MAXWELL SR, LIP GY: Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options. Int J Cardiol 58: 95-117, 1997.
9. PEI Z, PANG SF, CHEUNG RT: Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. Stroke 34: 770-775, 2003.
10. REITER RJ, TAN DX: Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Cardiovasc Res 58: 10-19, 2003.
11. REITER RJ, TAN DX, OSUNA C, GITTO E: Actions of melatonin in the reduction of oxidative stress. A review. J Biomed Sci 7: 444-458, 2000.
12. REITER RJ, TAN DX, MANCHESTER LC, QI W: Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. Cell Biochem Biophys 34: 237-256, 2001.
13. SAHNA E, ACET A, OZER MK, OLMEZ E: Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin. J Pineal Res 35: 234-238, 2002.
14. SAHNA E, PARLAKPINAR H, OZTURK F, CIGREMIS Y, ACET A: The protective effects of physiological and pharmacological concentrations of melatonin on renal ischemia-reperfusion injury in rats. Urol Res 31: 188-193, 2003a.
15. SAHNA E, PARLAKPINAR H, OZTURK F, OZER MK, OZUǦURLU F, ACET A: Melatonin protects against myocardial doxorubicin toxicity in rats: role of physiological concentrations. J Pineal Res 35: 257-261, 2003b.
16. SENER G, TOSUN O, SEHIRLI AO, KACMAZ A, ARBAK S, ERSOY Y, AYANOGLU-DULGER G: Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci 72: 2707-2718, 2003.
17. SZÁRSZOI O, ASEMU G, VANĚČEK J, OŠŤ ÁDAL B, KOLÁŘ F: Effects of melatonin on ischemia and reperfusion injury of the rat heart. Cardiovasc Drugs Ther 15: 251-257, 2001.
18. TAN DX, MANCHESTER LC, REITER RJ, QI W, KIM SJ, EL-SOKKARY GH: Ischemia/reperfusion-induced arrhythmias in the isolated rat heart: prevention by melatonin. J Pineal Res 25: 184-191, 1998.
19. VANÉČEK J: Melatonin inhibits increase of intracellular calcium and cyclic AMP in neonatal rat pituitary via independent pathways. Mol Cell Endocrinol 107: 149-153, 1995.
20. VERMEULEN NPE, BALDEW GS: The role of lipid peroxidation in the nephrotoxicity of cisplatin. Biochem Pharmacol 44: 1193-1199, 1992.