BAFF and BAFF-R of peripheral blood and spleen mononuclear cells in idiopathic thrombocytopenic purpura

Autoimmunity

Volumn 42, Issue 2, 2009, Pages 112-119

  Zhou, Zeping ^a   Chen, Zhenping ^a   Li, Hongqiang ^a   Chen, Xiaoli ^a   Xu, Jianhui ^a   Gu, Dongsheng ^a   Du, Weiting ^a   Zheng, Cuiling ^a   Zhang, Lei ^a   Huang, Ying ^a   Ren, Qian ^a   Yang, Renchi ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

BAFF; BAFF R; Idiopathic thrombocytopenic purpura; Peripheral blood; Spleen

Indexed keywords

B CELL ACTIVATING FACTOR; B CELL ACTIVATING FACTOR RECEPTOR; IMMUNOGLOBULIN; MESSENGER RNA;

ACUTE DISEASE; ADULT; ARTICLE; AUTOIMMUNITY; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE MARKER; FEMALE; GENE EXPRESSION; HEREDITARY SPHEROCYTOSIS; HUMAN; HUMAN CELL; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN CELL; SPLEEN MONONUCLEAR CELL; SPLENECTOMY; THROMBOCYTE COUNT;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; B-CELL ACTIVATING FACTOR; B-CELL ACTIVATION FACTOR RECEPTOR; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CHILD; CHRONIC DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; SPLEEN; YOUNG ADULT;

EID: 58949096803     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930802397848     Document Type: Article

References (42)

1. Mackay, F., Schneider, P., Rennert, P. and Browning, J. (2003) BAFF and APRIL: A tutorial on B-cell survival. Annu Rev Immunol, 21, pp. 231-264.
2. Schneider, P., MacKay, F., Steiner, V., Hofmann, K., Bodmer, JL, Holler, N., Ambrose, C., Lawton, P., Bixler, S., Acha-Orbea, H., Valmori, D., Romero, P., Werner-Favre, C., Zubler, RH, Browning, JL and Tschopp, J. (1999) BAFF, a novel ligand of the tumor necrosis factor family, stimulates B-cell growth. J Exp Med, 189, pp. 1747-1756.
3. Karpusas, M., Cachero, TG, Qian, F., Boriack-Sjodin, A., Mullen, C., Strauch, K., Hsu, YM and Kalled, SL (2002) Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes. J Mol Biol, 315, pp. 1145-1154.
4. Rodig, SJ, Shahsafaei, A., Li, B., Mackay, CR and Dorfman, DM (2005) BAFF-R, the major B-cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders. Hum Pathol, 36, pp. 1113-1119.
5. Schiemann, B., Gommerman, JL, Vora, K., Cachero, TG, Shulga-Morskaya, S., Dobles, M., Frew, E. and Scott, ML (2001) An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science, 293, pp. 2111-2114.
6. Mackay, F. and Browning, JL (2002) BAFF: A fundamental survival factor for B cells. Nat Rev Immunol, 2, pp. 465-475.
7. Thien, M., Phan, TG, Gardam, S., Amesbury, M., Basten, A., Mackay, F. and Brink, R. (2004) Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity, 20, pp. 785-798.
8. Lesley, R., Xu, Y., Kalled, SL, Hess, DM, Schwab, SR, Shu, HB and Cyster, JG (2004) Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity, 20, pp. 441-453.
9. Mackay, F., Woodcock, SA, Lawton, P., Ambrose, C., Baetscher, M., Schneider, P., Tschopp, J. and Browning, JL (1999) Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med, 190, pp. 1697-1710.
10. Cines, DB and Blanchette, VS (2002) Immune thrombocytopenic purpura. N Engl J Med, 346, pp. 995-1008.
11. Zhou, B., Zhao, H., Yang, RC and Han, ZC (2005) Multi-dysfunctional pathophysiology in ITP. Crit Rev Oncol Hematol, 54, pp. 107-116.
12. Panitsas, FP, Theodoropoulou, M., Kouraklis, A., Karakantza, M., Theodorou, GL, Zoumbos, NC, Maniatis, A. and Mouzaki, A. (2004) Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response. Blood, 103, pp. 2645-2647.
13. Wang, T., Zhao, H., Ren, H., Guo, J., Xu, M., Yang, R. and Han, ZC (2005) Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura. Haematologica, 90, pp. 914-923.
14. Siegel, RM and Lenardo, MJ (2001) To B or not to B: TNF family signaling in lymphocytes. Nat Immunol, 2, pp. 577-578.
15. Cheema, GS, Roschke, V., Hilbert, DM and Stohl, W. (2001) Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum, 44, pp. 1313-1319.
16. Mackay, IR, Groom, J. and Mackay, CR (2002) Levels of BAFF in serum in primary biliary cirrhosis andautoimmune diabetes. Autoimmunity, 35, pp. 551-553.
17. Emmerich, F., Bal, G., Barakat, A., Milz, J., Muhle, C., Martinez-Gamboa, L., Dorner, T. and Salama, A. (2007) High-level serum B-cell activating factor and promoter polymorphisms in patients with idiopathic thrombocytopenic purpura. Br J Haematol, 136, pp. 309-314.
18. Kuwana, M., Okazaki, Y., Kaburaki, J., Kawakami, Y. and Ikeda, Y. (2002) Spleen is a primary site for activation of platelet-reactive T and B cells in patients with immune thrombocytopenic purpura. J Immunol, 168, pp. 3675-3682.
19. Becker-Merok, A., Nikolaisen, C. and Nossent, HC (2006) B-lymphocyte activating factor in systemic lupus erythematosus and rheumatoid arthritis in relation to autoantibody levels, disease measures and time. Lupus, 15, pp. 570-576.
20. Krumbholz, M., Specks, U., Wick, M., Kalled, SL, Jenne, D. and Meinl, E. (2005) BAFF is elevated in serum of patients with Wegener's granulomatosis. J Autoimmun, 25, pp. 298-302.
21. Mariette, X., Roux, S., Zhang, J., Bengoufa, D., Lavie, F., Zhou, T. and Kimberly, R. (2003) The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjogren's syndrome. Ann Rheum Dis, 62, pp. 168-171.
22. Jonsson, MV, Szodoray, P., Jellestad, S., Jonsson, R. and Skarstein, K. (2005) Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjogren's syndrome. J Clin Immunol, 25, pp. 189-201.
23. Pers, JO, Daridon, C., Devauchelle, V., Jousse, S., Saraux, A., Jamin, C. and Youinou, P. (2005) BAFFoverexpression is associated with autoantibody production in autoimmune diseases. Ann N Y Acad Sci, 1050, pp. 34-39.
24. Zhang, J., Roschke, V., Baker, KP, Wang, Z., Alarcon, GS, Fessler, BJ, Bastian, H., Kimberly, RP and Zhou, T. (2001) Cutting edge: A role for B lymphocyte stimulator in systemic lupus erythematosus. J Immunol, 166, pp. 6-10.
25. Toubi, E., Kessel, A., Rosner, I., Rozenbaum, M., Paran, D. and Shoenfeld, Y. (2006) The reduction of serum B-lymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus. Scand J Immunol, 63, pp. 299-303.
26. Matsushita, T., Hasegawa, M., Yanaba, K., Kodera, M., Takehara, K. and Sato, S. (2006) Elevated serum BAFFlevels in patients with systemic sclerosis: Enhanced BAFF signaling in systemic sclerosis B lymphocytes. Arthritis Rheum, 54, pp. 192-201.
27. Thangarajh, M., Gomes, A., Masterman, T., Hillert, J. and Hjelmstrom, P. (2004) Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis. J Neuroimmunol, 152, pp. 183-190.
28. Huard, B., Arlettaz, L., Ambrose, C., Kindler, V., Mauri, D., Roosnek, E., Tschopp, J., Schneider, P. and French, LE (2004) BAFF production by antigen-presenting cells provides T-cell co-stimulation. Int Immunol, 16, pp. 467-475.
29. Wang, H., Marsters, SA, Baker, T., Chan, B., Lee, WP, Fu, L., Tumas, D., Yan, M., Dixit, VM, Ashkenazi, A. and Grewal, IS (2001) TACI-ligand interactions are required for T-cell activation and collagen-induced arthritis in mice. Nat Immunol, 2, pp. 632-637.
30. Ye, Q., Wang, L., Wells, AD, Tao, R., Han, R., Davidson, A., Scott, ML and Hancock, WW (2004) BAFF binding to T-cell-expressed BAFF-R costimulates T-cell proliferation and alloresponses. Eur J Immunol, 34, pp. 2750-2759.
31. Sutherland, AP, Ng, LG, Fletcher, CA, Shum, B., Newton, RA, Grey, ST, Rolph, MS, Mackay, F. and Mackay, CR (2005) BAFF augments certain Th1-associated inflammatory responses. J Immunol, 174, pp. 5537-5544.
32. Mackay, F. and Leung, H. (2006) The role of the BAFF/APRIL system on T-cell function. Semin Immunol, 18, pp. 284-289.
33. Huntington, ND, Tomioka, R., Clavarino, C., Chow, AM, Linares, D., Mana, P., Rossjohn, J., Cachero, TG, Qian, F., Kalled, SL, Bernard, CC and Reid, HH (2006) A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses. Int Immunol, 18, pp. 1473-1485.
34. Sellam, J., Miceli-Richard, C., Gottenberg, JE, Ittah, M., Lavie, F., Lacabaratz, C., Gestermann, N., Proust, A., Lambotte, O. and Mariette, X. (2007) Decreased B-cell activating factor receptor expression on peripheral lymphocytes associated with increased disease activity in primary Sjogren's syndrome and systemic lupus erythematosus. Ann Rheum Dis, 66, pp. 790-797.
35. Morimoto, S., Nakano, S., Watanabe, T., Tamayama, Y., Mitsuo, A., Nakiri, Y., Suzuki, J., Nozawa, K., Amano, H., Tokano, Y., Kobata, T. and Takasaki, Y. (2007) Expression of B-cell activating factor of thetumour necrosis factor family (BAFF) in T cells in active systemic lupus erythematosus: The role of BAFF in T-cell-dependent B-cell pathogenic autoantibody production. Rheumatology (Oxford), 46, pp. 1083-1086.
36. Ju, S., Zhang, D., Wang, Y., Ni, H., Kong, X. and Zhong, R. (2006) Correlation of the expression levels of BLyS and its receptors mRNA in patients with systemic lupus erythematosus. Clin Biochem, 39, pp. 1131-1137.
37. Carter, RH, Zhao, H., Liu, X., Pelletier, M., Chatham, W., Kimberly, R. and Zhou, T. (2005) Expression and occupancy of BAFF-R on B cells in systemic lupus erythematosus. Arthritis Rheum, 52, pp. 3943-3954.
38. Provan, D., Newland, AC, Norfolk, D., Bolton-Maggs, P., Lilleyman, J., Greer, I., May, A., Murphy, M., Ouwehand, W. and Watson, S. (2003) Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br J Haematol, 120, pp. 574-596.
39. Wang, T., Xu, M., Ji, L., Han, ZC and Yang, R. (2005) Splenectomy for adult chronic idiopathic thrombocytopenic purpura: Experience from a single center in China. Eur J Haematol, 75, pp. 424-429.
40. Kojouri, K., Vesely, SK, Terrell, DR and George, JN (2004) Splenectomy for adult patients with idiopathic thrombocytopenic purpura: A systematic review to assess long-term platelet count responses, prediction of response, and surgical complications. Blood, 104, pp. 2623-2634.
41. Groom, J., Kalled, SL, Cutler, AH, Olson, C., Woodcock, SA, Schneider, P., Tschopp, J., Cachero, TG, Batten, M., Wheway, J., Mauri, D., Cavill, D., Gordon, TP, Mackay, CR and Mackay, F. (2002) Association of BAFF/ BLyS overexpression and altered B-cell differentiation with Sjogren's syndrome. J Clin Invest, 109, pp. 59-68.
42. Zhou, Z. and Yang, R. (2008) Rituximab treatment for chronic refractory idiopathic thrombocytopenic purpura. Crit Rev Oncol Hematol, 65, pp. 21-31.