The presence and role of progesterone receptor in the ovaries of postmenopausal women who have not applied hormone replacement therapy

Folia Histochemica et Cytobiologica

Volumn 46, Issue 3, 2008, Pages 277-282

  Starczewski, Andrzej ^a   Brodowska, Agnieszka ^a   Laszczyńska, Maria ^a   Piasecka, Małgorzata ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

Menopause; Ovary; Progesterone receptor; Women

Indexed keywords

ANDROSTENEDIONE; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; PRASTERONE SULFATE; PROGESTERONE RECEPTOR; TESTOSTERONE;

ADULT; ANDROGEN BLOOD LEVEL; ARTICLE; CELL ISOLATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; COLUMNAR EPITHELIUM; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUTEINIZING HORMONE BLOOD LEVEL; OVARY; POSTMENOPAUSE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STROMA CELL; TESTOSTERONE BLOOD LEVEL; BLOOD; CYTOLOGY; METABOLISM; MIDDLE AGED;

ANDROSTENEDIONE; DEHYDROEPIANDROSTERONE SULFATE; ESTRADIOL; FEMALE; FOLLICLE STIMULATING HORMONE; HORMONE REPLACEMENT THERAPY; HUMANS; IMMUNOHISTOCHEMISTRY; LUTEINIZING HORMONE; MIDDLE AGED; OVARY; POSTMENOPAUSE; RECEPTORS, PROGESTERONE;

EID: 58949090089     PISSN: 02398508     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10042-008-0038-z     Document Type: Article

References (35)

1. Leonhardt SA, Boonyaratanakornkit V, Edwards DP. Progesterone receptor transcription and non-transcription signaling mechanisms. Steroids, 2003;68:761-770.
2. Aso T, Vasavada HA, Kawaguchi T, Germino FJ, Ganguly S, Kitajima S, Weissman SM, Yasukochi Y. Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF. Nature, 1992;355:461-464.
3. Migliaccio A, Didomenico M, Green S, Defalco A, Kajtaniak EL, Blasi F, Chambon P, Auricchio F. Phosphorylation on tyrosine of in vitro synthesized human estrogen receptor activates its hormone binding. Mol Endocrinol, 1989;3:1061-1069.
4. Fendrick JL, Raafat AM, Haslam SZ. Mammary gland growth and development from the postnatal period to postmenopause: ovarian steroid receptor ontogeny and regulation in the mouse. J Mammary Gland Biol Neoplasia, 1998;3: 7-22.
5. Juengel JL, Heath DA, Laurel DQ, McNatty KP. Oestrogen receptor α and β, androgen receptor and progesterone receptor mRNA and protein localization within the developing ovary and in small growing follicles of sheep. Reprod, 2006; 131:81-92.
6. Saarikoski S, Selander K, Kallio S, Pystynen P. Steroid receptors in normal and neoplastic female reproductive tissues. Gynecol Obstet Invest, 1982;13:206-212.
7. Słomczyńska M, Krok M, Pierśeciński A. Localization of the progesterone receptor in the porcine ovary. Acta Histochem, 2000;102:183-191.
8. Khan MS, Dodson AR, Heatley MK. Ki-67, oestrogen receptor, and progesterone receptor proteins in the human rete ovary and in endometriosis. J Clin Pathol, 1997; 52:517-520.
9. Butnor KJ, Burchette JL, Robboy SJ. Progesterone receptor activity in leiomyomatosis peritonealis disseminata. Int J Gynecol Pathol, 1999;18:259-264.
10. Richer JK, Jacobsen BM, Manning NG, Abel MG, Wolf DM, Horwitz KB. Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. J Biol Chem, 2002;15:5209-5218.
11. Kanajet D, Klarić P, Bolf-Benković L Estrogen and progesterone receptors in ovarian carcinoma. Jugosl Ginekol Perinatol, 1985;25:13-16.
12. Li AJ, Baldwin RL, Karlan BY. Estrogen and progesterone receptor subtype expression in normal and malignant ovarian epithelial cell cultures. Am J Obstet Gynecol, 2003;189:22-27.
13. Marshburn PB, Zhang J, Bahrani-Mostafavi Z, Matthews ML, White J, Hurst BS. Variant progesterone receptor mRNAs are co-expressed with the wild-type progesterone receptor mRNA in human endometrium during all phases of the menstrual cycle. Mol Hum Reprod, 2005;11:809-815.
14. Niwa K, Imai A, Hashimoto M, Yokoyama Y, Mori H, Matsuda Y, Tamaya T. A case-control study of uterine endometrial cancer of pre- and post-menopausal women. Oncol Rep, 2000;7:89-93.
15. Flötotto T, Niederacher D, Hohmann D, Heimerzheim T, Dall P, Djahansouzi S, Bender HG, Hanstein B. Molecular mechanism of estrogen receptor (ER)alpha-specific, estradiol-dependent expression of the progesterone receptor (PR) B-isoform. J Steroid Biochem Mol Biol, 2004;88:131-142.
16. Tung L, Abdel-Hafiz H, Shen T, Harvell DM, Nitao LK, Richer JK, Sartorius CA, Takimoto GS, Horwitz KB. Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B. Mol Endocrinol, 2006;20:2656-2670.
17. Conneely OM, Mulac-Jericevic B, Lydon JP. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids, 2003;68: 771-778.
18. Chakraborty TR, Gore AC. Aging-related changes in ovarian hormones, their receptors, and neuroendocrine function. Exp Biol Med, 2004;229:977-987.
19. Yoshimura Y, Bahr JM. Localization of progesterone receptors in pre-and postovulatory follicles of the domestic hen. Endocrinology, 1991;128:323-330.
20. Ciereszko R, Dusza L. Exogenus prolactin elevates plasma progesterone concetrations and reduces androgen concetrations during early luteal phase of the porcine estrous cycle. Animal Reprod Sci, 1993;31:141-154.
21. Meza-Munoz DE, Fajardo ME, Perez-Luque EL, Malacara JM. Factors associated with estrogen recsptors-alpha (ER-alpha) and -beta (ER-beta) and progesterone receptor abundance in obese and non obese pre- and post-menopausal women. Steroids, 2006;6:498-503.
22. Auersperg N, Wong AS, Choi KC, Kang SK, Leung PC. Ovarian surface epithelium: biology, endocrinology and pathology. Endocr Rev, 2001; 22:255-288.
23. Słomczyńska M. The dynamic of the steroid hormone receptors distibution in the ovary. Post Biol Kom, 2002;29:27-46.
24. Brodowska A, Laszczyńska M, Starczewski A. Apoptosis in ovarian cells in postmenopausal women. Folia Histochem Cytobiol, 2007; 45:99-105.
25. Simpson E, Rubin G, Clyne C, Robertson K, O Donnell L, Davis S, Jones M. Local estrogen biosyntesis in males and females. Endocrine-Related. Cancer, 1999;6:131-137.
26. Wright JW, Stouffer RL, Rodland KD. Hight-dose estrogen and clinical selective estrogen receptor modulators induce growth arrest, p-21, and p-53 in primate ovarian surface epithelial cells. J Clin Endocrinol Metab, 2001;90:3688-3695.
27. Vang R, Gown AM, Barry TS, Wheeler DT, Ronnet BM. Immunohistochemistry for estrogen and progesterone receptors in the distinction of primary and metastatic mucinous tumors in the ovary: an analysis of 124 causes. Modern Pathol, 2006;19:97-105.
28. Vanderhyden BC. Loss of ovarian function and the risk of ovarian cancer. Cell Tissues Res, 2005;322:117-124.
29. Brodowska A, Starczewski A, Laszczyńska M, Szydłowska I. Androgeneza jajnikowa u kobiet po menopauzie. Pol Merk Lek, 2005;19:90-93.
30. Brodowska A, Laszczyńska M, Starczewski A, Karakiewicz B, Brodowski J. Localization and function of the estrogen receptor α in the ovaries of postmenopausal women ovary. Folia Histochem Cytobiol, 2007;45:325-330.
31. Pepe GJ, Billiar RB, Leavitt MG, Zachos NC, Gustafsson JA, Albrecht ED. Expression of estrogen receptors α and β in the baboon fetal ovary. Biol Reprod, 2002;66:1054-1060.
32. Akahira J, Suzuki T, Ito K, Kaneko C, Darnel AD, Moriya T, Okamura K, Yaegashi N, Sasano H. Differential expression of progesterone receptor isoforms A and B in the normal ovary, and in benign, borderline, and malignant ovarian tumors. Jpn J Cancer Resi. 2002;93:807-815.
33. Narayanan R, Edwards DP, Weigel NL. Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. Mol Cell Biol, 2005;25:2885-2898.
34. Romano A, Delvoux B, Fischer DC, Groothuis P. The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone. J Mol Endocrinol, 2007;38:331-350.
35. Hirata S, Shoda T, Kato J, Hoshi K. Novel isoforms of the mRNA for human female sex steroid hormone receptors. J Steroid Biochem Mol Biol, 2002; 83: 25-30