Variant progesterone receptor mRNAs are co-expressed with the wild-type progesterone receptor mRNA in human endometrium during all phases of the menstrual cycle

Molecular Human Reproduction

Volumn 11, Issue 11, 2005, Pages 809-815

  Marshburn, Paul B ^a   Zhang, J ^a   Bahrani Mostafavi, Z ^a   Matthews, M L ^a   White, J ^a   Hurst, B S ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

Author keywords

Endometrium; Menstrual cycle; Progesterone receptor; Progesterone receptor splice variants

Indexed keywords

MESSENGER RNA; PROGESTERONE RECEPTOR;

ADULT; ARTICLE; ENDOMETRIUM; ENDOMETRIUM CARCINOMA; EXON; FEMALE; FEMALE INFERTILITY; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SEQUENCE; GYNECOLOGIC DISEASE; HORMONE ACTION; HUMAN; HUMAN TISSUE; HYSTERECTOMY; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; MOLECULAR CLONING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SOUTHERN BLOTTING; WILD TYPE; CONTROLLED STUDY; FEMALE GENITAL TRACT TUMOR; GENE IDENTIFICATION; GENETIC CODE; GENETIC VARIABILITY; HISTOPATHOLOGY; RNA ISOLATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ALTERNATIVE SPLICING; BASE SEQUENCE; DNA PRIMERS; ENDOMETRIUM; EXONS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MENSTRUAL CYCLE; RECEPTORS, PROGESTERONE; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE DELETION; VARIATION (GENETICS);

EID: 32144443092     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/gah244     Document Type: Article

References (25)

1. Ace CI and Okulicz WC (1995) Differential gene regulation by estrogen and progesterone in the primate endometrium. Mol Cell Endocrinol 115,95-103.
2. Arnett-Mansfield RL, DeFazio A, Wain GV, Jaworski RC, Byth K, Mote PA and Clarke CL (2001) Relative expression of progesterone receptors A and B in endometrioid cancers endometrium. Cancer Res 61,4576-4582.
3. Arnett-Mansfield RL, DeFazio A, Mote PA and Clarke CL (2004) Subnuclear distribution of progesterone receptors A and B in normal and malignant endometrium. J Clin Endocrinol Metab 89,1429-1442.
4. Balleine RL, Hunt SM and Clarke CL (1999) Coexpression of alternatively spliced estrogen and progesterone receptor transcripts in human breast cancer. J Clin Endocrinol Metab 84,1370-1377.
5. Boyd-Leinen PA, Fournier D and Thomas CS (1982) Nonfunctioning progesterone receptors in the developed oviducts from estrogen-with-drawn immature chicks and in aged nonlaying hens. Endocrinology 111,30-36.
6. Clarke CL and Sutherland RI (1990) Progestin regulation of cellular proliferation. Endocr Rev 11,266-301.
7. Conneely OM, Maxell BL, Toft DO, Schrader WT and O'Malley BW (1987) The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA. Biochem Biophys Res Commun 149,493-501.
8. Fukuda K, Mori M, Uchiyama M, Iwai K, Iwasaka T and Sugimori H (1998) Prognostic significance of progesterone receptor immunohistochemistry in endometrial carcinoma. Gynecol Oncol 69,220-225.
9. Hisatomi H, Kohno N, Wakita K, Nagao K, Hirata H, Hokiji K and Harada S (2003) Novel alternatively spliced variant with a deletion of 52 BP in exon 6 of the progesterone receptor gene is observed frequently in breast cancer tissues. Int J Cancer 105,182-185.
10. Horwitz KB and Alexander PS (1983) In situ photolinked nuclear progesterone receptors of human breast cancer cells: Subunit molecular weights after transformation and translocation. Endocrinology 113,2195-2201.
11. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H and Chambon P (1990) Two distinct estrogen-regulated promoters generate transcripts encoding the two fractionally different human progesterone receptor forms A and B. EMBO 9,1603-1614.
12. Kato J, Hirata S, Nozawa A and Mouri N (1993) The ontogeny of gene expression of progestin receptors in the female rat brain. J Steroid Biochem Mol Biol 47,173-182.
13. Lessey BA, Killiam AP, Metzger DA, Haney AF, Greene GL and McCarty KS Jr (1988) Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle. J Clin Endocrinol Metab 67,334-340.
14. Levy C, Robel P, Gautray JP, De Bruz J, Verma U, Descomps B and Bailieu EE (1980) Estradiol and progesterone receptors in human endometrium: normal and abnormal cycles and early pregnancy. Am J Obstet Gynecol 136,646-651.
15. Leygue E, Dotzlaw H, Watson PH and Murphy LC (1999) Altered expression of exon deleted progesterone receptor variant mRNA between normal human breast and breast tumor tissues. Br J Cancer 80,379-382.
16. Marshburn PB, Zhang J, Bahrani-Mostafavi Z, Marroum M-C, Mougeot J-L and Rosho MJ (2004) Estrogen receptor-alpha messenger RNA variants that lack exon or exon 7 are coexpressed with wild-type form in human endometrium during all phases of the menstrual cycle. Am J Obstet Gynecol 191,626-634.
17. Misao R, Sun Wen-Shu Iwagaki SI, Fujimoto J and Tamaya T (1998) Identification of various exon-deleted progesterone receptor mRNAs in human endometrium and ovarian endometriosis. Biochem Biophys Res Commun 252,302-306.
18. Misao R, Nakanishi Y, Sun Wen-Shu Iwagaki S, Fujimoto J and Tamaya T (2000) Identification of exon-deleted progesterone receptor mRNAs in human uterine endometrial cancers. Oncology 58,60-65.
19. Mylonas I, Jeschke U, Shabani N, Kuhn C, Balle A, Kriegel S, Krupka MS and Friese K (2004) Immunohistochemical analysis of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in normal human endometrium. Acta Histochem 106,245-252.
20. Nagao K, Kohno N, Wakita K, Hikiji K, Yamamoto S, Hirata H and Hisatomi H (2003) Expression of a novel splicing variant deleting exons 4 and 6 of the progesterone receptor gene is A rate event in breast cancer. Oncol Rep 10,305-308.
21. Noyes RW, Hertig AT and Rock J (1950) Dating the endometrial biopsy. Fertil Steril 1,3-25.
22. Richer JK, Lange CA, Wierman AM, Brooks KM, Tung L, Takimoto GS and Horwitz KB (1998) Progesterone receptor variants found in breast cells repress transcription by wild-type receptors. Breast Cancer Res Treat 48, 231-241.
23. Spelsberg TC and Halberg F (1980) Circannual rhythms in steroid concentration and nuclear binding in the chick oviduct. Endocrinology 107,1234-1244.
24. Wei LL and Miner R (1994) Evidence for the existence of a third progesterone protein in human breast cancer cell line T47D. Cancer Res 54,340-343.
25. Yamanaka T, Hirata S, Shoda T and Hoshi K (2002) Progesterone receptor mRNA variant containing novel exon insertions between exon 4 and exon 5 in human uterine endometrium. Endocr J 49,473-482.