Haemophagocytic syndrome and HIV

Current Opinion in Infectious Diseases

Volumn 22, Issue 1, 2009, Pages 1-6

  Doyle, Tomas ^a   Bhagani, Sanjay ^a   Cwynarski, Kate ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Haemophagocytosis; HIV; Hypercytokinemia; Macrophage; T lymphocyte

Indexed keywords

CYCLOSPORIN A; DEXAMETHASONE; ETOPOSIDE; GAMMA INTERFERON; IMMUNOGLOBULIN; INFLIXIMAB; METHYLPREDNISOLONE;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; CLINICAL FEATURE; DIAGNOSTIC PROCEDURE; DISEASE ASSOCIATION; HEMOPHAGOCYTIC SYNDROME; HERPES VIRUS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; REVIEW; SPLENECTOMY; T LYMPHOCYTE;

HIV INFECTIONS; HUMANS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC;

EID: 58849155108     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/QCO.0b013e32832180b0     Document Type: Review

References (45)

1. Risdall RJ, McKenna RW, Nesbit ME, et al. Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. Cancer 1979; 44:993-1002.
2. Niedt GW, Schinella RA. Acquired immunodeficiency syndrome. Clinico- pathologic study of 56 autopsies. Arch Pathol Lab Med 1985; 109:727-734.
3. Stepp SE, Dufourcq-Lagelouse R, Le Deist F, et al. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science 1999; 286:1957-1959.
4. Verbsky JW, Grossman WJ. Hemophagocytic lymphohistiocytosis: diagnosis, pathophysiology, treatment, and future perspectives. Ann Med 2006; 38:20-31.
5. Kogawa K, Lee SM, Villanueva J, et al. Perforin expression in cytotoxic lymphocytes from patients with hemophagocytic lymphohistiocytosis and their family members. Blood 2002; 99:61 -66.
6. Villanueva J, Lee S, Giannini EH, et al. Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. Arthritis Res Ther 2005; 7:R30-R37.
7. Matloubian M, Suresh M, Glass A, et al. A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol 1999; 73:2527-2536.
8. Larroche C, Mouthon L. Pathogenesis of hemophagocytic syndrome (HPS). Autoimmun Rev 2004; 3:69-75.
9. Takada H, Nomura A, Ohga S, Hara T. lnterleukin-18 in hemophagocytic lymphohistiocytosis. Leuk Lymphoma 2001; 42:21-28.
10. Jordan MB, Hildeman D, Kappler J, Marrack P. An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood 2004; 104:735-743.
11. Bhatia S, Bauer F, Bilgrami SA. Candidiasis-associated hemophagocytic lymphohistiocytosis in a patient infected with human immunodeficiency virus. Clin Infect Dis 2003; 37:e161-e166.
12. Tiab M, Mechinaud Lacroix F, Hamidou M, et al. Reactive haemophagocytic syndrome in AIDS. AIDS 1996; 10:108-111.
13. Gotoh M, Matsuda J, Gohchi K, et al. Successful recovery from human immunodeficiency virus (HIV)-associated haemophagocytic syndrome treated with highly active antiretroviral therapy in a patient with HIV infection. Br J Haematol 2001; 112:1090.
14. Lortholary A, Raffi F, Aubertin P, et al. HIV-associated haemophagocytic syndrome. Lancet 1990; 336:1128.
15. Park KH, Yu HS, Jung SI, et al. Acute human immunodeficiency virus syndrome presenting with hemophagocytic lymphohistiocytosis. Yonsei Med J 2008; 49:325-328. This article reported a case of acute HIV infection presenting with HPS.
16. Sasadeusz J, Buchanan M, Speed B. Reactive haemophagocytic syndrome in human immunodeficiency virus infection. J Infect 1990; 20:65-68.
17. Sproat LO, Pantanowitz L, Lu CM, Dezube BJ. Human immunodeficiency virus-associated hemophagocytosis with iron-deficiency anemia and massive splenomegaly. Clin Infect Dis 2003; 37:e170-e173.
18. Castilletti C, Preziosi R, Bernardini G, et al. Hemophagocytic syndrome in a patient with acute human immunodeficiency virus infection. Clin Infect Dis 2004; 38:1792-1793.
19. Martinez-Escribano JA, Pedro F, Sabater V, et al. Acute exanthem and pancreatic panniculitis in a patient with primary HIV infection and haemophagocytic syndrome. Br J Dermatol 1996; 134:804-807.
20. Sun HY, Chen MY, Fang CT, et al. Hemophagocytic lymphohistiocytosis: an unusual initial presentation of acute HIV infection. J Acquir Immune Defic Syndr 2004; 37:1539-1540.
21. Fardet L, Blum L, Kerob D, et al. Human herpesvirus 8-associated hemophagocytic lymphohistiocytosis in human immunodeficiency virus-infected patients. Clin Infect Dis 2003; 37:285-291.
22. Kasahara Y, Yachie A, Takei K, et al. Differential cellular targets of Epstein- Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection. Blood 2001; 98:1882-1888.
23. Wada T, Kurokawa T, Toma T, et al. Immunophenotypic analysis of Epstein - Barr virus (EBV)-infected CD8(+) T cells in a patient with EBV-associated hemophagocytic lymphohistiocytosis. Eur J Haematol 2007; 79:72-75.
24. Rouphael NG, Talati NJ, Vaughan C, et al. Infections associated with nae- mophagocytic syndrome. Lancet Infect Dis 2007; 7:814-822. This is an extensive review outlining the many infections associated with HPS.
25. Tabata YS, Teramura T, Kuriyama K, et al. Molecular analysis of latent membrane protein 1 in patients with Epstein-Barr virus-associated hemo-phagocytic lymphohistiocytosis in Japan. Leuk Lymphoma 2000; 38:373-380.
26. Chiu SS, Chan GC, Loong F. Epstein-Barr virus (EBV) induced hemopha-gocytic syndrome followed by EBV associated T/NK lymphoma in a child with perinatal human immunodeficiency virus (HIV) infection. Med Pediatr Oncol 2001; 36:326-328.
27. Preciado MV, De Matteo E, Fallo A, et al. EBV-associated Hodgkin's disease in an HIV-infected child presenting with a hemophagocytic syndrome. Leuk Lymphoma 2001; 42:231 -234.
28. Wong CK, Wong BC, Chan KC, et al. Cytokine profile in fatal human immunodeficiency virus tuberculosis Epstein-Barr virus associated hemophagocytic syndrome. Arch Intern Med 2007; 167:1901-1903.
29. Navarro WH, Kaplan LD. AiDS-related lymphoproliferative disease. Blood 2006; 107:13-20.
30. Canioni D, Arnulf B, Asso-Bonnet M, et al. Nasal natural killer lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus. Arch Pathol Lab Med 2001; 125:660-662.
31. Grateau G, Bachmeyer C, Blanche P, et al. Haemophagocytic syndrome in patients infected with the human immunodeficiency virus: nine cases and a review. J Infect 1997; 34:219-225.
32. Oh SC, Choi CW, Kim BS, et al. NK/T-cell lymphoma associated with Epstein-Barr vims in a patient infected with human immunodeficiency virus: an autopsy case. Int J Hematol 2004; 79:480-483.
33. Chuang HC, Lay JD, Hsieh WC, Su IJ. Pathogenesis and mechanism of disease progression from hemophagocytic lymphohistiocytosis to Epstein- Barr virus-associated T-cell lymphoma: nuclear factor-kappa B pathway as a potential therapeutic target. Cancer Sci 2007; 98:1281-1287.
34. Baraldes MA, Domingo P, Gonzalez MJ, et al. Tuberculosis- associated hemophagocytic syndrome in patients with acquired immunodeficiency syndrome. Arch Intern Med 1998; 158:194-195.
35. Guillaume MP, Driessens N, Libert M, et al. Hemophagocytic syndrome associated with extracerebral toxoplasmosis in an HIV-infected patient. Eur J Intern Med 2006; 17:503-504.
36. Koduri PR, Chundi V, DeMarais P, et al. Reactive hemophagocytic syndrome: a new presentation of disseminated histoplasmosis in patients with AIDS. Clin Infect Dis 1995; 21:1463-1465.
37. Huang DB, Wu JJ, Hamill RJ. Reactive hemophagocytosis associated with the initiation of highly active antiretroviral therapy (HAART) in a patient with AIDS. Scand J Infect Dis 2004; 36:516-519.
38. Henter Jl, Home A, Arico M, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2007; 48:124-131. This protocol of an ongoing study open to HIV-positive patients with HPS outlines diagnostic guidelines and therapeutic strategies.
39. Wohl DA, McComsey G, Tebas P, et al. Current concepts in the diagnosis and management of metabolic complications of HIV infection and its therapy. Clin Infect Dis 2006; 43:645-653.
40. Kodali S, Kafeel M, Naik S, et al. Conditions associated with hyperferritinemia in HIV positive patients. Blood 2007; 100:678a.
41. Emmenegger U, Schaer DJ, Larroche C, Neftel KA. Haemophagocytic syndromes in adults: current concepts and challenges ahead. Swiss Med Wkly 2005; 135:299-314.
42. Imashuku S, Hibi S, Ohara T, et al. Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society. Blood 1999; 93:1869-1874.
43. Janka G, Imashuku S, Elinder G, et al. Infection- and malignancy-associated hemophagocytic syndromes. Secondary hemophagocytic lymphohistiocytosis. Hematol Oncol Clin North Am 1998; 12:435-444.
44. Larroche C, Bruneel F, Andre MH, et al. Intravenously administered gamma-globulins in reactive hemaphagocytic syndrome. Multicenter study to assess their importance, by the immunoglobulins group of experts of CEDIT of the AP-HP. Ann Med Interne (Paris) 2000; 151:533-539.
45. Tsuda H. The use of cyclosporin-A in the treatment of virus-associated hemophagocytic syndrome in adults. Leuk Lymphoma 1997; 28:73-82.