Vigabatrin extracellular pharmacokinetics and concurrent γ-aminobutyric acid neurotransmitter effects in rat frontal cortex and hippocampus using microdialysis

Epilepsia

Volumn 50, Issue 2, 2009, Pages 174-183

  Tong, Xin ^a,b   Ratnaraj, Neville ^a   Patsalos, Philip N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Aminobutyric acid; Antiepileptic drug; Brain extracellular fluid; Microdialysis; Vigabatrin

Indexed keywords

4 AMINOBUTYRIC ACID; VIGABATRIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG HALF LIFE; EXTRACELLULAR FLUID; FRONTAL CORTEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTICONVULSANTS; BIOLOGICAL AVAILABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR FLUID; FRONTAL LOBE; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; INJECTIONS, INTRAPERITONEAL; MALE; METABOLIC CLEARANCE RATE; MICRODIALYSIS; RATS; RATS, SPRAGUE-DAWLEY; VIGABATRIN;

EID: 58849143825     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01863.x     Document Type: Article

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