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Volumn 47, Issue 6, 1996, Pages 1567-1571

Human brain GABA levels rise rapidly after initiation of vigabatrin therapy

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; CARBAMAZEPINE; PHENYTOIN; PRIMIDONE; VIGABATRIN;

EID: 0029751102     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.47.6.1567     Document Type: Article
Times cited : (96)

References (45)
  • 1
    • 0024338973 scopus 로고
    • Meta-analysis of European placebo controlled studies of vigabatrin in drug resistant epilepsy
    • Mumford JP, Dam M. Meta-analysis of European placebo controlled studies of vigabatrin in drug resistant epilepsy. Br J Clin Pharmacol 1989;27(suppl 1):101S-107S.
    • (1989) Br J Clin Pharmacol , vol.27 , Issue.1 SUPPL.
    • Mumford, J.P.1    Dam, M.2
  • 4
    • 0017553966 scopus 로고
    • γ-Vinyl-GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: Effects on brain metabolism in mice
    • Jung MJ, Lippert B, Metcalf BW, Böhlen P, Schechter PJ. γ-Vinyl-GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain metabolism in mice. J Neurochem 1977;29:797-802.
    • (1977) J Neurochem , vol.29 , pp. 797-802
    • Jung, M.J.1    Lippert, B.2    Metcalf, B.W.3    Böhlen, P.4    Schechter, P.J.5
  • 5
    • 0024400305 scopus 로고
    • The effect of vigabatrin on brain and platelet GABA-transaminase activities
    • Bolton JB, Rimmer E, Williams J, Richens A. The effect of vigabatrin on brain and platelet GABA-transaminase activities. Br J Clin Pharmacol 1989;27(suppl 1):35S-42S.
    • (1989) Br J Clin Pharmacol , vol.27 , Issue.1 SUPPL.
    • Bolton, J.B.1    Rimmer, E.2    Williams, J.3    Richens, A.4
  • 6
    • 0002984669 scopus 로고
    • Vigabatrin: Mechanisms of action
    • Levy RH, Mattson RH, Meldrum BS, eds. New York: Raven Press
    • Jung MJ, Palfreyman MG. Vigabatrin: mechanisms of action. In: Levy RH, Mattson RH, Meldrum BS, eds. Antiepileptic Drugs, 4th ed. New York: Raven Press, 1995:903-913.
    • (1995) Antiepileptic Drugs, 4th Ed. , pp. 903-913
    • Jung, M.J.1    Palfreyman, M.G.2
  • 7
    • 0021363707 scopus 로고
    • Biochemical and clinical effects of gamma-vinyl-GABA in patients with epilepsy
    • Schechter PJ, Hanke NFJ, Grove J, Huebert N, Sjoerdsma A. Biochemical and clinical effects of gamma-vinyl-GABA in patients with epilepsy. Neurology 1984;34:182-186.
    • (1984) Neurology , vol.34 , pp. 182-186
    • Schechter, P.J.1    Hanke, N.F.J.2    Grove, J.3    Huebert, N.4    Sjoerdsma, A.5
  • 8
    • 0023903928 scopus 로고
    • Inhibitory and excitatory amino acids in CSF of patients suffering with complex partial seizures during chronic treatment with gamma-vinyl GABA (vigabatrin)
    • Halonen T, Lehtinen M, Pitkänen A, Ylinen A, Riekkinen PJ. Inhibitory and excitatory amino acids in CSF of patients suffering with complex partial seizures during chronic treatment with gamma-vinyl GABA (vigabatrin). Epilepsy Res 1988;2:246-252.
    • (1988) Epilepsy Res , vol.2 , pp. 246-252
    • Halonen, T.1    Lehtinen, M.2    Pitkänen, A.3    Ylinen, A.4    Riekkinen, P.J.5
  • 9
    • 0024462921 scopus 로고
    • Specificity of vigabatrin for the GABAergic system in human epilepsy
    • Reikkinen PJ, Pitkänen A, Ylinen A, Sivenius J, Halonen T. Specificity of vigabatrin for the GABAergic system in human epilepsy. Epilepsia 1989;30(suppl 3):S18-S22.
    • (1989) Epilepsia , vol.30 , Issue.3 SUPPL.
    • Reikkinen, P.J.1    Pitkänen, A.2    Ylinen, A.3    Sivenius, J.4    Halonen, T.5
  • 10
    • 0024328385 scopus 로고
    • The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients
    • Ben-Menachem E, Persson LI, Schechter PJ, et al. The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients. Br J Clin Pharmacol 1989;27(suppl 1):79S-85S.
    • (1989) Br J Clin Pharmacol , vol.27 , Issue.1 SUPPL.
    • Ben-Menachem, E.1    Persson, L.I.2    Schechter, P.J.3
  • 12
    • 0024417584 scopus 로고
    • Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans
    • Ben-Menachem E. Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans. Epilepsia 1989; 30(suppl 3):S12-S14.
    • (1989) Epilepsia , vol.30 , Issue.3 SUPPL.
    • Ben-Menachem, E.1
  • 13
    • 0025991584 scopus 로고
    • The effect of long-term vigabatrin therapy on selected neurotransmitter concentrations in cerebrospinal fluid
    • Ben-Menachem E, Persson LI, Mumford JP, Haegele KD, Huebert N. The effect of long-term vigabatrin therapy on selected neurotransmitter concentrations in cerebrospinal fluid. J Child Neurol 1991;6(suppl 2):2S11-2S16.
    • (1991) J Child Neurol , vol.6 , Issue.2 SUPPL.
    • Ben-Menachem, E.1    Persson, L.I.2    Mumford, J.P.3    Haegele, K.D.4    Huebert, N.5
  • 14
    • 0027528939 scopus 로고
    • Amino acid levels in the cerebrospinal fluid of newly diagnosed epileptic patients: Effect of vigabatrin and carbamazepine monotherapies
    • Kälviäinen R, Halonen T, Pitkänen A, Reikkinen PJ. Amino acid levels in the cerebrospinal fluid of newly diagnosed epileptic patients: effect of vigabatrin and carbamazepine monotherapies. J Neurochem 1993;60:1244-1250.
    • (1993) J Neurochem , vol.60 , pp. 1244-1250
    • Kälviäinen, R.1    Halonen, T.2    Pitkänen, A.3    Reikkinen, P.J.4
  • 15
    • 0027753762 scopus 로고
    • Effect of long-term vigabatrin therapy on GABA and other amino acid concentrations in the central nervous system: A case study
    • Ben-Menachem E, Hamberger A, Mumford J. Effect of long-term vigabatrin therapy on GABA and other amino acid concentrations in the central nervous system: a case study. Epilepsy Res 1993;16:241-243.
    • (1993) Epilepsy Res , vol.16 , pp. 241-243
    • Ben-Menachem, E.1    Hamberger, A.2    Mumford, J.3
  • 17
    • 0029609260 scopus 로고
    • Symbiosis between in vivo and in vitro NMR spectroscopy: The creatine, N-acetylaspartate, glutamate, and GABA content of epileptic human brain
    • Petroff OAC, Pleban LA, Spencer DD. Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate, and GABA content of epileptic human brain. Magn Reson Imag 1995;13:1197-1211.
    • (1995) Magn Reson Imag , vol.13 , pp. 1197-1211
    • Petroff, O.A.C.1    Pleban, L.A.2    Spencer, D.D.3
  • 18
    • 0027932402 scopus 로고
    • Vigabatrin: Effects on human brain GABA levels by nuclear magnetic resonance spectroscopy
    • Mattson RH, Petroff O, Rothman D, Behar K. Vigabatrin: effects on human brain GABA levels by nuclear magnetic resonance spectroscopy. Epilepsia 1994;53(suppl 5):S29-S32.
    • (1994) Epilepsia , vol.53 , Issue.5 SUPPL.
    • Mattson, R.H.1    Petroff, O.2    Rothman, D.3    Behar, K.4
  • 20
    • 84989565770 scopus 로고
    • Vigabatrin: Effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy
    • Mattson RH, Petroff OAC, Rothman DL, Behar KL. Vigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy. Acta Neurol Scand 1995; 162(suppl):27-30.
    • (1995) Acta Neurol Scand , vol.162 , Issue.SUPPL. , pp. 27-30
    • Mattson, R.H.1    Petroff, O.A.C.2    Rothman, D.L.3    Behar, K.L.4
  • 21
    • 0029953127 scopus 로고    scopus 로고
    • Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose
    • Petroff OAC, Rothman DL, Behar KL, Mattson RH. Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose. Neurology 1996; 46:1459-1463.
    • (1996) Neurology , vol.46 , pp. 1459-1463
    • Petroff, O.A.C.1    Rothman, D.L.2    Behar, K.L.3    Mattson, R.H.4
  • 22
    • 0022978067 scopus 로고
    • Kinetics of the enantiomers of vigabatrin after an oral dose of the racemate or the active S-enantiomer
    • Haegle KD, Schechter PJ. Kinetics of the enantiomers of vigabatrin after an oral dose of the racemate or the active S-enantiomer. Clin Pharmacol Ther 1986;40:581-586.
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 581-586
    • Haegle, K.D.1    Schechter, P.J.2
  • 23
    • 0024309055 scopus 로고
    • Effect of food on the absorption of vigabatrin
    • Frisk-Holmberg M, Kerth P, Meyer Ph. Effect of food on the absorption of vigabatrin. Br J Clin Pharmac 1989;27(suppl 1):23S-25S.
    • (1989) Br J Clin Pharmac , vol.27 , Issue.1 SUPPL.
    • Frisk-Holmberg, M.1    Kerth, P.2    Meyer, Ph.3
  • 24
    • 0024361868 scopus 로고
    • Clinical pharmacology of vigabatrin
    • Schechter PJ. Clinical pharmacology of vigabatrin. Br J Clin Pharmacol 1989;27(suppl 1):19S-22S.
    • (1989) Br J Clin Pharmacol , vol.27 , Issue.1 SUPPL.
    • Schechter, P.J.1
  • 25
    • 0002463012 scopus 로고
    • Vigabatrin: Chemistry, absorption, distribution, and elimination
    • Levy RH, Mattson RH, Meldrum BS, eds. New York: Raven Press
    • Ben-Menachem E. Vigabatrin: chemistry, absorption, distribution, and elimination. In: Levy RH, Mattson RH, Meldrum BS, eds. Antiepileptic Drugs, 4th ed. New York: Raven Press, 1995:915-923.
    • (1995) Antiepileptic Drugs, 4th Ed. , pp. 915-923
    • Ben-Menachem, E.1
  • 26
    • 0023871465 scopus 로고
    • Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy
    • Ben-Menachem E, Perrson LI, Schechter PJ, et al. Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy. Epilepsy Res 1988;2:96-101.
    • (1988) Epilepsy Res , vol.2 , pp. 96-101
    • Ben-Menachem, E.1    Perrson, L.I.2    Schechter, P.J.3
  • 30
    • 0028798036 scopus 로고
    • Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR
    • Mason GF, Gruetter R, Rothman DL, Behar KL, Shulman RG, Novotny EJ. Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. J Cereb Blood Flow Metab 1995;18:12-25.
    • (1995) J Cereb Blood Flow Metab , vol.18 , pp. 12-25
    • Mason, G.F.1    Gruetter, R.2    Rothman, D.L.3    Behar, K.L.4    Shulman, R.G.5    Novotny, E.J.6
  • 34
    • 0022595158 scopus 로고
    • Failure of GABAergic inhibition: A key to local and global seizures
    • Roberts E. Failure of GABAergic inhibition: a key to local and global seizures. Adv Neurol 1986;44:319-341.
    • (1986) Adv Neurol , vol.44 , pp. 319-341
    • Roberts, E.1
  • 35
    • 0024410491 scopus 로고
    • GABAergic mechanisms in the pathogenesis and treatment of epilepsy
    • Meldrum BS. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br J Clin Pharmacol 1989;27(suppl 1):3S-11S.
    • (1989) Br J Clin Pharmacol , vol.27 , Issue.1 SUPPL.
    • Meldrum, B.S.1
  • 36
    • 0028220347 scopus 로고
    • Strategies in antiepileptic drug development: Is rational drug design superior to random screening and structural variation?
    • Löscher W, Schmidt D. Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation? Epilepsy Res 1994;17:95-134.
    • (1994) Epilepsy Res , vol.17 , pp. 95-134
    • Löscher, W.1    Schmidt, D.2
  • 37
    • 0023622272 scopus 로고
    • One to three day dose intervals during subchronic treatment of epileptic gerbils with gamma-vinyl GABA: Anticonvulsant efficacy and alterations in regional brain GABA levels
    • Löscher W, Frey HH. One to three day dose intervals during subchronic treatment of epileptic gerbils with gamma-vinyl GABA: anticonvulsant efficacy and alterations in regional brain GABA levels. Eur J Pharmacol 1987;143:335-342.
    • (1987) Eur J Pharmacol , vol.143 , pp. 335-342
    • Löscher, W.1    Frey, H.H.2
  • 38
    • 0024594555 scopus 로고
    • Anticonvulsant and proconvulsant effects of inhibitors of GABA degradation in the amygdala-kindling model
    • Löscher W, Jäckel R, Müller F. Anticonvulsant and proconvulsant effects of inhibitors of GABA degradation in the amygdala-kindling model. Eur J Pharmacol 1989;163:1-14.
    • (1989) Eur J Pharmacol , vol.163 , pp. 1-14
    • Löscher, W.1    Jäckel, R.2    Müller, F.3
  • 39
    • 0028233334 scopus 로고
    • 31P NMR spectroscopic study of rat brain in vivo
    • 31P NMR spectroscopic study of rat brain in vivo. Magn Reson Med 1994;31:660-667.
    • (1994) Magn Reson Med , vol.31 , pp. 660-667
    • Behar, K.1    Boehm, D.2
  • 40
    • 10544241226 scopus 로고    scopus 로고
    • GABA synthesis in the rat cortex is reduced 24 hours following inhibition of GABA transaminase
    • Manor D, Rothman DL, Mason GF, Hyder F, Petroff OAC, Behar KL. GABA synthesis in the rat cortex is reduced 24 hours following inhibition of GABA transaminase [abstract]. J Neurochem 1996;66(suppl 1):S81.
    • (1996) J Neurochem , vol.66 , Issue.1 SUPPL.
    • Manor, D.1    Rothman, D.L.2    Mason, G.F.3    Hyder, F.4    Petroff, O.A.C.5    Behar, K.L.6
  • 41
    • 0021138821 scopus 로고
    • Is the estimation of the GABA turnover rate in vivo a tool to differentiate between various types of drugs interfering with the GABA/benzodiazapine/ionophore receptor complex?
    • Bernasconi R, Bittiger H, Schmutz M, Martin P, Klein M. Is the estimation of the GABA turnover rate in vivo a tool to differentiate between various types of drugs interfering with the GABA/benzodiazapine/ionophore receptor complex? Neuropharmacology 1984;23:815-816.
    • (1984) Neuropharmacology , vol.23 , pp. 815-816
    • Bernasconi, R.1    Bittiger, H.2    Schmutz, M.3    Martin, P.4    Klein, M.5
  • 42
    • 0018583088 scopus 로고
    • Stimulation by phosphate of the activation of glutamate apodecarboxylase by pyridoxyl-5′-phosphate and its implications for the control of GABA synthesis
    • Martin SB, Martin DL. Stimulation by phosphate of the activation of glutamate apodecarboxylase by pyridoxyl-5′-phosphate and its implications for the control of GABA synthesis. J Neurochem 1979;33:1275-1283.
    • (1979) J Neurochem , vol.33 , pp. 1275-1283
    • Martin, S.B.1    Martin, D.L.2
  • 43
    • 0023475544 scopus 로고
    • Regulatory properties of brain glutamate decarboxylase
    • Martin DL. Regulatory properties of brain glutamate decarboxylase. Cell Mol Neurobiol 1987;7:237-253.
    • (1987) Cell Mol Neurobiol , vol.7 , pp. 237-253
    • Martin, D.L.1
  • 44
    • 0027395911 scopus 로고
    • Regulation of gamma-aminobutyric acid synthesis in the brain
    • Martin DL, Rimvall K. Regulation of gamma-aminobutyric acid synthesis in the brain. J Neurochem 1993;60:395-407.
    • (1993) J Neurochem , vol.60 , pp. 395-407
    • Martin, D.L.1    Rimvall, K.2
  • 45
    • 0028176869 scopus 로고
    • 67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels
    • 67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels. J Neurochem 1994;62:1375-1381.
    • (1994) J Neurochem , vol.62 , pp. 1375-1381
    • Rimvall, K.1    Martin, D.L.2


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