A high-performance liquid chromatography micromethod for the simultaneous determination of vigabatrin and gabapentin in serum

Therapeutic Drug Monitoring

Volumn 20, Issue 4, 1998, Pages 430-434

  Ratnaraj, Neville ^a   Patsalos, Philip N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antiepileptic drug; Gabapentin; High performance liquid chromatography (HPLC); Micromethod; Vigabatrin

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; ETHOSUXIMIDE; GABAPENTIN; LAMOTRIGINE; LICARBAZEPINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; VALPROIC ACID; VIGABATRIN;

ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MONITORING; EPILEPSY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POLYPHARMACY; PRIORITY JOURNAL;

ACETIC ACIDS; AMINES; ANTICONVULSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOHEXANECARBOXYLIC ACIDS; DRUG INTERACTIONS; GAMMA-AMINOBUTYRIC ACID; HUMANS; MICROCHEMISTRY; SENSITIVITY AND SPECIFICITY; VIGABATRIN;

EID: 0031853846     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199808000-00013     Document Type: Article

References (17)

1. Patsalos PN, Duncan JS. New antiepileptic drugs: a review of their current status and clinical potential. CNS Drugs 1994;2:40-77.
2. 14C] vigabatrin in healthy male volunteers. Drug Metab Dispos 1993;21:480-4.
3. Patsalos PN. Phenobarbitone to gabapentin: a guide to 82 years of anti-epileptic drug pharmacokinetic interactions. Seizure 1994;3: 163-70.
4. Patsalos PN. New antiepileptic drugs. Ann Clin Biochem 1998;in press.
5. Schramm TM, McKinnon GE, Eadie MJ. Gas chromatographic assay of vigabatrin enantiomers in plasma. J Chromatogr Biomed Appl 1993;616:39-44.
6. Grove J, Alken RG, Schechter PJ. Assay of vinyl-aminobutyric-acid (4-amino-hex-5-enoic acid) in plasma and urine by automatic amino-acid analysis. J Chromatogr 1984;306:383-7.
7. Haegele KD, Schoun J, Aiken RG, Huebert J. Determination of R (-) and S (+) enantiomers of vinyl-aminobutyric acid in human body fluids by gas chromatography-mass spectrometry. J Chromatogr 1983;274:103-10.
8. Chen TM, Contario JJ. High performance liquid chromatography resolution of enantimers of vinyl-aminobutyric acid. J Chromatogr 1984;314:495-8.
9. Smithers JA, Lang JF, Okerholm R. Quantitative analysis of vigabatrin in plasma and urine by reversed-phase high performance liquid chromatography. J Chromatogr 1985;341:232-8.
10. Tsanaclis LM, Wicks J, Williams J, Richens A. Determination of vigabatrin in plasma by reversed-phase high performance liquid chromatography. Ther Drug Monit 1991;13:251-3.
11. Forrest G, Sills GJ, Leach JP. Determination of gabapentin in plasma by high-pressure liquid chromatography. J Chromatogr Biomed Appl 1996;681:421-5.
12. Lensmeyer GL, Kempf T, Gidal BE, Wiebe DA. Optimized method for the determination of gabapentin in serum by high-pressure liquid chromatography. Ther Drug Monit 1995;17:251-8.
13. Garcia LL, Shihabi ZK, Oies J. Determination of gabapentin in serum by capillary electrophoresis. J Chromatogr Biomed Appl 1995;669:157-62.
14. Hengy H, Kolle EU. Determination of gabapentin in plasma and urine by high-performance liquid chromatography and precolumn labelling for ultraviolet detection. J Chromatogr 1985;341:473-8.
15. Hooper WD, Kavanagh MC, Dickinson RG. Determination of gabapentin in plasma and urine by capillary column gas chromatography. J Chromatogr Biomed Appl 1990;529:167-74.
16. Fraser AD, MacNeil W. HPLC analysis of gabapentin: a new anticonvulsant drug. In: Sunshine I, ed. Recent Developments in Therapeutic Drug Monitoring and Toxicology. New York: Marcel Dekker; 1992:313-20.
17. Juergens UH, May TW, Rambeck B. Simultaneous HPLC determination of vigabatrin and gabapentin in serum with automated pre-injection derivatization. J Liquid Chromatogr Rel Technol 1996;19:1459-71.