Quantitative trait loci associated with susceptibility to bladder and kidney infections induced by Escherichia coli in female C3H/HeJ mice

Journal of Infectious Diseases

Volumn 199, Issue 3, 2009, Pages 355-361

  Hopkins, Walter J ^a,c   Elkahwaji, Johny ^b   Kendziorski, Christina ^a   Moser, Amy R ^a   Briggs, Paulette M ^a   Suhs, Kaleigh A ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c Dept of Urology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL INFECTION; BACTERIAL STRAIN; BAGG ALBINO MOUSE; BLADDER; BLADDER DISEASE; BLADDER INFECTION; C3H MOUSE; CHROMOSOME; CHROMOSOME 19; CHROMOSOME 4; CHROMOSOME 6; COLONY FORMING UNIT; DISEASE SEVERITY; ESCHERICHIA COLI; FEMALE; HOST RESISTANCE; INFECTION SENSITIVITY; INOCULATION; KIDNEY; KIDNEY INFECTION; MALE; MICROSATELLITE MARKER; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; URINARY TRACT INFECTION;

ALLELES; ANIMALS; CHROMOSOME MAPPING; CYSTITIS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; KIDNEY DISEASES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; QUANTITATIVE TRAIT LOCI;

EID: 58849136380     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/595987     Document Type: Article

References (35)

1. Kunin CM. Urinary tract infections in females. Clin Infect Dis 1994; 18:1-12.
2. Johnson JR, Stamm WE. Urinary tract infections in women: diagnosis and treatment. Ann Intern Med 1989; 111:906-17.
3. Foxman B. Recurring urinary tract infections: incidence and risk factors. Am J Public Health 1990; 80:331-3.
4. Foxman B, Brown P. Epidemiology of urinary tract infections: transmission and risk factors, incidence, and costs. Infect Dis Clin North Am 2003; 17:227-41.
5. Hopkins WJ, Uehling DT, Wargowski DS. Evaluation of a familial predisposition to recurrent urinary tract infections in women. Am J Med Genet 1999; 83:422-4.
6. Lundstedt AC, Leijonhufvud I, Ragnarsdottir B, et al. Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection. J Infect Dis 2007; 195:1227-34.
7. Hopkins WJ, Heisey DM, Lorentzen DF, Uehling DT. A comparative study of major histocompatibility and red blood cell antigen phenotypes as risk factors for recurrent urinary tract infections in women. J Infect Dis 1998; 177:1296-1301.
8. Ragnarsdottir B, Samuelsson M, Gustafsson MCU, Leijonhufvud I, Karpman D, Svanborg C. Reduced Toll-like receptor 4 expression in children with asymptomatic bacteriuria. J Infect Dis 2007; 196:475-84.
9. Lundstedt AC, McCarthy S, Gustafsson MCU, et al. A genetic basis of susceptibility to acute pyelonephritis. PloS ONE 2007; 2:e825.
10. Hopkins WJ, Gendron-Fitzpatrick A, Balish E, Uehling DT. Time course and host responses to Escherichia coli urinary tract infection in genetically distinct mouse strains. Infect Immun 1998; 66:2798-2802.
11. Beutler B, Poltorak A. The sole gateway to endotoxin response: how LPS was identified as TLR4, and its role in innate immunity. Drug Metab Dispos 2001; 29:474-8.
12. Hagberg L, Hull R, Hull S, McGhee JR, Michalek SM, Svanborg-Eden C. Difference in susceptibility to gram-negative urinary tract infection between C3H/HeJ and C3H/HeN mice. Infect Immun 1984; 46:839-44.
13. Shahin RD, Engberg I, Hagberg L, Svanborg-Eden C. Neutrophil recruitment and bacterial clearance correlated with LPS responsiveness in local gram-negative infection. J Immunol 1987; 138:3475-80.
14. Haraoka M, Hang L, Frendéus B, et al. Neutrophil recruitment and resistance to urinary tract infection. J Infect Dis 1999; 180:1220-9.
15. Hopkins WJ, Gendron-Fitzpatrick A, McCarthy DO, Haine JE, Uehling DT. Lipopolysaccharide-responder and nonresponder C3H mouse strains are equally susceptible to an induced Escherichia coli urinary tract infection. Infect Immun 1996; 64:1369-72.
16. Marquet S, Schurr E. Genetics of susceptibility to infectious diseases: tuberculosis and leprosy as examples. Drug Metab Dispos 2001; 29:479-83.
17. Silver LM. Mapping in the mouse: an overview. In: Silver LM, ed. Mouse genetics: concepts and applications. New York: Oxford University Press, 1995:133-58.
18. Lengeling A, Pfeffer K, Balling R. The battle of two genomes: genetics of bacterial/host interactions in mice. Mamm Genome 2001; 12:261-71.
19. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 1994; 138:963-71.
20. Dietrich WF. Using mouse genetics to understand infectious diseases. Genome Res 2001; 11:325-31.
21. Georges M. QTL mapping to QTL cloning: mice to the rescue. Genome Res 1997; 7:663-5.
22. Mitos LM, Cardon LR, Fortin A, et al. Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice. Genes Immun 2000; 1:467-77.
23. Sebastiani G, Olien L, Gauthier S, et al. Mapping of genetic modulators of natural resistance to infection with Salmonella typhimurium in wild-derived mice. Genomics 1998; 47:180-6.
24. Roper RJ, Weis JJ, McCracken BA, et al. Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun 2001; 2:388-97.
25. Weis JJ, McCracken BA, Ma Y, et al. Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease. J Immunol 1999; 162:948-56.
26. Hopkins WJ, Elkahwaji JE, Heisey DM, Ott CJ. Inheritance of susceptibility to induced Escherichia coli bladder and kidney infections in female C3H/HeJ mice. J Infect Dis 2003; 187:418-23.
27. Hopkins WJ. Mouse model of ascending urinary tract infection. In: Zak O, Sande MA, eds. Handbook of animal models of infection. London: Academic Press, 1999:435-9.
28. Hopkins WJ, Hall JA, Conway BP, Uehling DT. Induction of urinary tract infection by intraurethral inoculation with Escherichia coli: refining the murine model. J Infect Dis 1995; 171:462-5.
29. Kruglyak L, Lander ES. A nonparametric approach for mapping quantitative trait loci. Genetics 1995; 139:1421-8.
30. Broman KW, Wu H, Sen S, Churchill GA. R/qtl: QTL mapping in experimental crosses. Bioinformatics 2003; 19:889-90.
31. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 1994; 138:963-71.
32. Lan H, Kendziorski CM, Haag JD, Shepel LA, Newton MA, Gould MN. Genetic loci controlling breast cancer susceptibility in the Wistar-Kyoto rat. Genetics 2001; 157:331-9.
33. Schwarz G. Estimating the dimension of a model. Ann Stat 1978; 6:461-4.
34. -/- mice are more susceptible to Escherichia coli urinary tract infection. J Immunol 2007; 178:4717-20.
35. Chomek M, Slamová Z, Bergman P, et al. The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat Med 2006; 12:636-41.