A genetic basis of susceptibility to acute pyelonephritis

PLoS ONE

Volumn 2, Issue 9, 2007, Pages

  Lundstedt, Ann Charlotte ^a   McCarthy, Shane ^b   Gustafsson, Mattias C U ^a   Godaly, Gabriela ^a   Jodal, Ulf ^c   Karpman, Diana ^a   Leijonhufvud, Irene ^a   Lindén, Carin ^d   Martinell, Jeanette ^c   Ragnarsdottir, Bryndis ^a   Samuelsson, Martin ^a   Truedsson, Lennart ^a   Andersson, Björn ^b   Svanborg, Catharina ^a  

^a LUND UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR1; INTERLEUKIN 8 RECEPTOR; SUCCIMER TC 99M; MESSENGER RNA; PRIMER DNA;

ACUTE PYELONEPHRITIS; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENOTYPE; HUMAN; IMMUNE DEFICIENCY; INFANT; INFECTION RISK; INNATE IMMUNITY; KIDNEY SCAR; KIDNEY SCINTISCANNING; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; URINARY TRACT INFECTION; ACUTE DISEASE; ANIMAL; CASE CONTROL STUDY; GEL MOBILITY SHIFT ASSAY; GENETIC PREDISPOSITION; GENETICS; MOUSE; MOUSE MUTANT; POLYMERASE CHAIN REACTION; PYELONEPHRITIS; RNA PROCESSING;

MUS;

ACUTE DISEASE; ANIMALS; BASE SEQUENCE; CASE-CONTROL STUDIES; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MICE; MICE, MUTANT STRAINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PYELONEPHRITIS; RECEPTORS, INTERLEUKIN-8A; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER;

EID: 41049104005     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000825     Document Type: Article

References (52)

1. Sorensen UB, Blom J (1988) Ultrastructural localization of capsules, cell wall polysacharide, cell wall proteins, and F antigen in pneumococci. Infect Immun.
2. Chotivanich K, Udomsangpetch R, Pattanapanyasat K, Chierakul W, Simpson J, et al. (2002) Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria. Blood 100: 1172-1176.
3. Hagberg L, Briles D, Svanborg-Edén C (1985) Evidence for separate genetic defects in C3H/HeJ and C3HeB/FeJ mice that afrect the susceptibility to Gram-negative infections. J Immunol 134:4118-4122.
4. Hang L, Frendeus B, Godaly G, Svanborg C (2000) Interleukin-B receptor knockout mice have subepithelial neutrophil entrapment and renal scarring following acute pyelonephritis. J Infect Dis 182: 1738-1748.
5. Frendous B, Godaly G, Hang L, Karpmah D, Lundstedt AC, et al. (2000) Interieukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart. J Exp Med 192: 881-890.
6. Kunin C (1997) Urinary Tract Infections: Detection, Prevention, and Management: Lippincott Williams and Wilkins.
7. Stamm WE, McKevitt M, Roberts PL, White NJ (1991) Natural history of recurrent urinary iract infections in women. Rev Infect Dis 13: 77-84.
8. Hodson CJ, Maling TM, McManamon PJ, Lewis MG (1975) The pathogenesis of reflux nephropathy (chronic atrophic pyclonephritis): Br J Radiol Suppl. 13: 1-26.
9. Ransiey P, Risdon R (1978) Reflux and renal scarring. Br J Radiol Suppl 14: 1-38.
10. Lomberg H, Hanson L, Jaccbssbn B, Jodal U, Leffler H, et al. (1989) Correlation. of P blood group phenotype, vesicoureteral reflux and bacterial attachment in patients with recurrent pyclonephritis, N Engl J Med 308: 1189-1192.
11. Svanborg-Edén C, Briles D, Magberg L, McGheé J, Michalec S (1984) Genetic factors in host resistance to urinary tract infection. Infection 12: 118-123.
12. Frendeus B, Godaly G,Hang L, Karpman D, Svanborg C (2001) Interleukin-8 receptor deciency confers susceptibility to acute pyelonephritis. J Infect Dis 183 Suppl 1: 56-60.
13. Bailey M, Wallace M (1978) HLA-B12 as a genetic marker for vesicoureteric reflux? Br Med J 1: 48-49.
14. Hagborg L, Hellstrom M, Jodal U, Lefffer H, Lincoln K, et al. (1984) Difference in susceptibility io gram-negative urinary tract infection between C3H/HcJ and C3H/HeN mice. Infect Immun 46: 839-944.
15. Svanborg C, Bergsten G, Fischer H, Frendeus B, Godaly G, et al. (2001) The 'innate' host response protects d damage the infected urinary tract. Ann Med 3: 563-570.
16. Svensson M, Irjala H, Alm P, Holmqvist B, Lundstedt AC, et al. (2005) Natural history of renal scarring in susceptible mTL-8Rh-/- mice. Kidney Int 67: 103-110.
17. Holmes W, Lee J, Kuang W, Rice C, Wood W (1991) Structure and Functional expression of a human interleukin-8 receptor. Science 253: 1278-1280.
18. Murphy P, Tiffany H (1991) Cloning of complementary DNA encoding a functional human interieukin-8 receptor. Science 253: 1280.
19. Wolf M, Delgado MB, Jones SA, Dewald B, Clark-Lewis I, et al. (1998) Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2. Eur J Immumol 28: 164-170.
20. Lundstedt AC, Leijonhufvud I, Ragnarsdottir B, Karpman D, Andersson B, et al. (2007) Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection. J Infect Dis 195: 1227-1234.
21. Martinell J, Claesson I, Lidin-Janson G, Jodal U (1995) Urinary infection, reflux and renal scarring in females continuously followed for 13-38 years. Pediatr Nephrol 9: 131-136.
22. Nickerson DA, Tobe VO, Taylor SL (1997) PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing. Nucleic Acids Res 25: 2745-2751.
23. Ahuja SK, Shetty A, Tiffany HL, Murphy PM (1994) Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. J Biol Chem 269: 26381-26389.
24. Gordon D, Abajian C, Green P (1998) Consed: a graphical tool for sequence finishing. Genome Res 8: 195-202.
25. Sherry ST, Ward M, Sirotkin K (1999) dbSNP-database for single nucleotide polymorphisms and other classes of minor genetic variation. Genome Res 9: 677-679.
26. Andrews NC, Faller DY (1991) A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nudeic Acids Res 19: 2499.
27. Lennartsson A, Pieters K, Ullmark T, Vidovic K, Gullberg U (2003) AML-1, PU.1, and Sp3 regulate expression of human bactericidal/ permeability-increasing protein. Biochem Biophys Res Commun 311: 853-863.
28. Heinemeyer T, Wingender E, Reuter I, Hermjakob H, Kel AE, et al, (1998) Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL Nucleic Acids Res 26: 362-367.
29. Andersen H (1966) Studies ofurinary trac infections in infancy and childhood. VII. The relation of E.coli antibody in pyelonephritis as measured by homologous and common (Kunin) antigens. J Pediatr 68: 542-550.
30. Jakolosson B, Esbjorner E, Hanason S (1999) Minimum incidence and diagnostic rate of first urinary tract infection. Pediatrics 104: 222-226.
31. Ahuja SK, Ozcelik T, Milatovitch A, Francke U, Murphy PM (1992) Molecular evolution of the human interleukin-8 receptor gene cluster. Nat Genet 2: 31-36.
32. Lloyd A, Modi W, Sprenger H, Cevario S, Oppenheim J, et al. (1993) Assignment of genes for interleukin-8 receptors (IL8R) A and B to human chromosome band 2q35. Cytogenet Cell Genet 63: 238-240.
33. Sprenger H, Lloyd AR, Meyer RG, Johnston JA, Kelvin DJ (1994) Genomic structure, characterization, and identification of the promoter of the human IL-8 receptor A gene. J Immunol 153: 2524-2532.
34. Wilkinson NC, Navarro J (1999) PU.1 regulates the CXCR1 promoter. J Biol Chem 274: 438-443.
35. Meyers S, Lenny N, Hiebert SW (1995) The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol Cell Biol 15: 1974-1982.
36. Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD (1999) Functional and physical interactions between AML1 proteins and an ETS protein, MEF; implications for the pathogenesis of t(8;21)-positive leukemias. Mol Cell Biol 19: 3635-3644.
37. Collins SJ, Ruscetti FW, Gallagher RE, Gallo RC, (1978) Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. Proc Natl Acad Sci U S A 75: 2458-2462.
38. Decker CJ, Parker R (1995) Diversity of cytoplasmic functions for die 3′ untranslated region of eukaryotic transcripts. Curr Opin Cell Biol 7: 386-392.
39. Conne B, Stutz A, Vassalli JD (2000) The 3′ untranslated region of messenger RNA: A molecular 'hotspot for pathology? Nat Med 6: 637-641.
40. Gbadegesin RA, Cotton SA, Watson CJ, Brenchley PE, Webb NJ (2006) Association between ICAM-1 Gly-Arg polymorphism and renal parenchymal scarring following childhood urinary tract infection. Int J Immunogenet 33: 49-53.
41. Sun W, Watanabe Y, Wang ZQ (2006) Expression and significance of ICAM- I and its counter receptors LFA-1 and Mac-1 in experimental acute pancreatitis of rats. World J Gastroenterol 12: 5005-5009.
42. Springer TA (1990) Adhesion receptors of the immune system. Nature 346: 425-434.
43. Agace W, Patarroyo M, Svensson M, Carlemalm E, Svanborg C (1995) Ercherichia coli induce trans-uroepithelial neutrophil migration by an ICAM-1 dependant mechanism. Infect Immun 63: 4045-4062.
44. Pober JS, Cotran RS (1990) The role of endothelial cells in inflammation, Transplantation 50: 537-544.
45. Anderson KL, Smith KA, Pio F, Torbett BE, Maki RA (1998) Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent. Blood 92: 1576-1585.
46. Prokunina L, Castillejo-Lopez C, Oberg F, Gunnarsson I, Berg L, et al. (2002) A regulatory polymorphism in PDCD 1 is associated with susceptibility to systemic lupus crythematosus in humans. Nat Genet 32: 666-669.
47. Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, et al. (2003) An intronic SNP in a RUNXI binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet 35: 341-348.
48. Yamada R, Tokuhiro S, Chang X, Yamamoto K (2004) SLC22A4 and RUNX1: identification of RA susceptible genes. J Mol Med 82: 558-564.
49. Helms C, Cao L, Krueger JG, Wijsman EM, Chamian F, et al. (2003) A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis, Nat Genet 35: 349-356.
50. Gehring NH, Frede U, Neu-Yilik G, Hundsdoerfer P, Vetter B, et al. (2001) Increased efficiency of mRNA 3′ end formation: a new genetic mechanism contributing to hereditary thrombophilia. Nat Genet 28: 389-392.
51. Artifoni L, Negrisolo S, Montini G, Zuccherra P, Molinari PP, et al. (2007) Interleukin-8 and CXCR1 receptor functional polymorphisms and susceptibility to acute pyelonephritis. J Urol 177: 1102-1106.
52. Smithson A, Sarrias MR, Barcelo J, Suarez B, Horcajada JP, et al. (2005) Expression of interleukin-8 receptors (CXGR1 and CXCR2) in premenopausal women with recurrent urinary tract infections. Clin Diagn Lab Immunol 12: 1358-1363.