IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure

Clinical and Experimental Allergy

Volumn 39, Issue 2, 2009, Pages 290-298

  Onari, Y ^a   Yokoyama, A ^b   Haruta, Y ^a   Nakashima, T ^a   Iwamoto, H ^b   Hattori, N ^a   Kohno, N ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b KOCHI UNIVERSITY   (Japan)

Author keywords

Airway hyperresponsiveness; Airway remodelling; Bronchial asthma; IL 12

Indexed keywords

GAMMA INTERFERON; HYDROXYPROLINE; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 5; OVALBUMIN; PROTEIN P40;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; DOWN REGULATION; EOSINOPHILIA; LUNG LAVAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; EOSINOPHILS; FEMALE; IMMUNE TOLERANCE; INTERLEUKIN-12 SUBUNIT P40; LEUKOCYTES; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVALBUMIN; RESPIRATORY FUNCTION TESTS;

EID: 58849109068     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2008.03131.x     Document Type: Article

References (36)

1. Busse W, Lemanske RF Jr. Asthma. N Engl J Med 2001 344 : 350 62.
2. Walker C, Kaegi MK, Braun P, Blaser K. Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity. J Allergy Clin Immunol 1991 88 : 935 42.
3. + T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1997 158 : 3539 44.
4. Hogan SP, Matthaei KI, Young JM, Koskinen A, Young IG, Foster PS. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J Immunol 1998 161 : 1501 9.
5. Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 1999 103 : 175 83.
6. Elias JA, Zhu Z, Chupp G, Homer RJ. Airway remodeling in asthma. J Clin Invest 1999 104 : 1001 6.
7. Crimi E, Spanevello A, Neri M, Ind PW, Rossi GA, Brusasco V. Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma. Am J Respir Crit Care Med 1998 157 : 4 9.
8. Birrell MA, Battram CH, Woodman P, McCluskie K, Belvisi MG. Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airway. Respir Res 2003 4 : 3.
9. Tournoy KG, Kips JC, Schou C, Pauwels RA. Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness. Clin Exp Allergy 2000 30 : 79 85.
10. Sakai K, Yokoyama A, Kohno N, Hamada H, Hiwada K. Prolonged antigen exposure ameliorates airway inflammation but not remodeling in a mouse model of bronchial asthma. Int Arch Allergy Immunol 2001 126 : 126 34.
11. Schramm CM, Puddington L, Wu C et al. Chronic inhaled ovalbumin exposure induces antigen-dependent but not antigen-specific inhalational tolerance in a murine model of allergic airway disease. Am J Pathol 2004 164 : 295 304.
12. Swirski FK, D'Sa A, Kianpour S, Inman MD, Stampfli MR. Prolonged ovalbumin exposure attenuates airway hyperresponsiveness and T cell function in mice. Int Arch Allergy Immunol 2006 141 : 130 4.
13. Van Hove CL, Maes T, Joos GF, Tournoy KG. Prolonged inhaled allergen exposure can induce persistent tolerance. Am J Respir Cell Mol Biol 2007 36 : 573 84.
14. Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 2007 25 : 221 42.
15. Gavett SH, O'Hearn DJ, Li X, Huang S, Finkelman FD, Wills-Karp M. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 1995 182 : 1527 36.
16. Kips JC, Brusselle GJ, Joos GF et al. Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice. Am J Respir Crit Care Med 1996 153 : 535 9.
17. Kuribayashi K, Kodama T, Okamura H, Sugita M, Matsuyama T. Effects of post-inhalation treatment with interleukin-12 on airway hyper-reactivity, eosinophilia and interleukin-18 receptor expression in a mouse model of asthma. Clin Exp Allergy 2002 32 : 641 9.
18. Rais M, Wild S, Choudhury BK et al. Interleukin-12 inhibits eosinophil differentiation from bone marrow stem cells in an interferon-gamma-dependent manner in a mouse model of asthma. Clin Exp Allergy 2002 32 : 627 32.
19. Zhao LL, Lindén A, Sjöstrand M, Cul ZH, Lötvall J, Jordana M. IL-12 regulates bone marrow eosinophilia and airway eotaxin levels induced by airway allergen exposure. Allergy 2000 55 : 749 56.
20. Sur S, Lam J, Bouchard P, Sigounas A, Holbert D, Metzger WJ. Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses. J Immunol 1996 157 : 4173 80.
21. Sakai K, Yokoyama A, Kohno N, Hiwada K. Effect of different sensitizing doses of antigen in a murine model of atopic asthma. Clin Exp Immunol 1999 118 : 9 15.
22. Hattori N, Degen JL, Sisson TH et al. Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice. J Clin Invest 2000 106 : 1341 50.
23. Wang XM, Zhang Y, Kim HP et al. Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J Exp Med 2006 203 : 2895 906.
24. Belperio JA, Dy M, Burdick MD et al. Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 2002 27 : 419 27.
25. James AL, Pare PD, Hogg JC. The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989 183 : 195 210.
26. Koya T, Kodama T, Takeda K et al. Importance of myeloid dendritic cells in persistent airway disease after repeated allergen exposure. Am J Respir Crit Care Med 2006 173 : 42 55.
27. Jang AS, Choi IS, Lee JH, Park CS, Park C-S Prolonged ozone exposure in an allergic airway disease model: adaptation of airway responsiveness and airway remodeling. Respir Res 2006 7 : 24.
28. Meyts I, Hellings PW, Hens G et al. IL-12 contributes to allergen-induced airway inflammation in experimental asthma. J Immunol 2006 177 : 6460 70.
29. Gavett SH, O'Hearn DJ, Li X, Huang SK, Finkelman FD, Wills-Karp M. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 1995 182 : 1527 36.
30. Wang S, Fan Y, Han X, Yang J, Bilenki L, Yang X. IL-12-dependent vascular cell adhesion molecule-1 expression contributes to airway eosinophilic inflammation in a mouse model of asthma-like reaction. J Immunol 2001 166 : 2741 9.
31. Kumar RK, Herbert C, Foster PS. Expression of growth factors by airway epithelial cells in a model of chronic asthma: regulation and relationship to subepithelial fibrosis. Clin Exp Allergy 2004 34 : 567 75.
32. Minshall EM, Leung DY, Martin RJ et al. Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1997 17 : 326 33.
33. Lee CG, Link H, Baluk P et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 2004 10 : 1095 103.
34. Oh CK, Ariue B, Alban RF, Shaw B, Cho SH. PAI-1 promotes extracellular matrix deposition in the airways of a murine asthma model. Biochem Biophys Res Commun 2002 294 : 1155 60.
35. -/- mice treated with intratracheal bleomycin exhibit decreased pulmonary inflammation and increased fibrosis. Exp Mol Pathol 2002 72 : 1 9.
36. Huaux F, Arras M, Tomasi D et al. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. J Immunol 2002 169 : 2653 61.