Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function

Blood

Volumn 113, Issue 2, 2009, Pages 338-346

  Moreno, Ramon Urrea ^a   Gil, Juana ^a   Rodriguez Sainz, Carmen ^a   Cela, Elena ^a   LaFay, Victor ^b   Oloizia, Brian ^b   Herr, Andrew B ^c   Sumegi, Janos ^b   Jordan, Michael B ^b,c   Risma, Kimberly A ^b,c  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALCIUM; LIPID; LIPOSOME; PERFORIN; MEMBRANE LIPID;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BASOPHIL; BINDING ASSAY; CALCIUM BINDING; CELL MEMBRANE; CONTROLLED STUDY; CYTOTOXICITY; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; INFLAMMATION; LEUKEMIA CELL; MOUSE; MUTANT; NONHUMAN; PATHOGENICITY; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RAT; ANIMAL; CELLULAR IMMUNITY; CYTOTOXIC T LYMPHOCYTE; GENETICS; HOMEOSTASIS; HUMAN; IMMUNOLOGY; MISSENSE MUTATION; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; ANIMALS; CALCIUM; CELL LINE, TUMOR; CELL MEMBRANE; HOMEOSTASIS; HUMANS; IMMUNITY, CELLULAR; MEMBRANE LIPIDS; MICE; MUTATION, MISSENSE; PERFORIN; PROTEIN STRUCTURE, TERTIARY; RATS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 58849106393     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-08-172924     Document Type: Article

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