Altered DHEA and DHEAS response to exercise in healthy older adults

Journal of Aging and Physical Activity

Volumn 17, Issue 1, 2009, Pages 77-88

  Aldred, Sarah ^a   Rohalu, Manjit ^a   Edwards, Kate ^a   Burns, Victoria ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Hormones; Oxidative stress; Physical activity

Indexed keywords

EID: 58849103505     PISSN: 10638652     EISSN: 1543267X     Source Type: Journal    
DOI: 10.1123/japa.17.1.77     Document Type: Article

References (43)

1. Aldred, S., & Griffiths, H.R. (2004). Oxidation of protein in human low density lipoprotein exposed to peroxyl radicals facilitates uptake by monocytes; protection by antioxidants in vitro. Environmental Toxicology and Pharmacology, 15, 111-117.
2. Aragno, M., Mastrocola, R., Catalano, M.G., Brignardello, E., Danni, O., & Boccuzzi, G. (2004). Oxidative stress impairs skeletal muscle repair in diabetic rats. Diabetes, 53, 1082-1088.
3. Balakrishnan, S.D., & Anuradha, C.V. (1998). Exercise, depletion of antioxidants and antioxidant manipulation. Cell Biochemistry and Function, 16, 269-275.
4. Bastianetto, S., Ramassamy, C., Poirier, J., & Quirion, R. (1999). Dehydroepiandroster-one (DHEA) protects hippocampal cells from oxidative stress-induced damage. Brain Research. Molecular Brain Research, 66, 35-41.
5. Berliner, J.A., & Heinecke, J.W. (1996). The role of oxidized lipoproteins in atherogenesis. Free Radical Biology & Medicine, 20, 707-727.
6. Bonen, A., & Keizer, H.A. (1987). Pituitary, ovarian, and adrenal hormone responses to marathon running. International Journal of Sports Medicine, 8(Suppl. 3), 161-167.
7. Bonnefoy, M., Patricot, M.C., Lacour, J.R., Rahmani, A., Berthouze, S., & Kostka, T. (2002). Relations entre l'activité physique, la fonction musculaire et les concentrations en IGF-1, testostérone et DHEAS lors de l'avancé en âge [Relation between physical activity, muscle function and IGF-1, testosterone and DHEAS concentrations in the elderly]. La Revue de Medecine Interne, 23, 819-827.
8. Boudou, P., de Kerviler, E., Erlich, D., Vexiau, P., & Gautier, J.F. (2001). Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with Type 2 diabetes. International Journal of Obesity and Related Metabolic Disorders, 25, 1108-1112.
9. Caputo, F., Mello, M.T., & Denadai, B.S. (2003). Oxygen uptake kinetics and time to exhaustion in cycling and running: A comparison between trained and untrained subjects. Archives of Physiology and Biochemistry, 111, 461-466.
10. Carty, J.L., Bevan, R., Waller, H., Mistry, N., Cooke, M., Lunec, J., et al. (2000). The effects of vitamin C supplementation on protein oxidation in healthy volunteers. Biochemical and Biophysical Research Communications, 273, 729-735.
11. Chung, B.H., Segrest, J.P., Ray, M.J., Brunell, J.D., Hakanson, J.E., Krauss, R.M., et al. (1986). Single vertical spin density gradient centrifugation. Methods in Enzymology, 128, 181-209.
12. Consitt, L.A., Copeland, J.L., & Tremblay, M.S. (2001). Hormone responses to resistance vs. endurance exercise in premenopausal females. Canadian Journal of Applied Physiology, 26, 574-587.
13. Consitt, L.A., Copeland, J.L., & Tremblay, M.S. (2002). Endogenous anabolic hormone responses to endurance versus resistance exercise and training in women. Sports Medicine (Auckland, N.Z.), 32, 1-22.
14. Copeland, J.L., Chu, S.Y., & Tremblay, M.S. (2004). Aging, physical activity, and hormones in women-A review. Journal of Aging and Physical Activity, 12, 101-116.
15. Copeland, J.L., Consitt, L.A., & Tremblay, M.S. (2002). Hormonal responses to endurance and resistance exercise in females aged 19-69 years. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 57, B158-B165.
16. Corrigan, B. (2002). DHEA and sport. Clinical Journal of Sport Medicine, 12, 236-241.
17. Elosua, R., Molina, L., Fito, M., Arquer, A., Sanchez-Quesada, J.L., Covas, M.I., et al. (2003). Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women. Atherosclerosis, 167, 327-334.
18. Giannopoulou, I., Carhart, R., Sauro, L.M., & Kanaley, J.A. (2003). Adrenocortical responses to submaximal exercise in postmenopausal Black and White women. Metabolism: Clinical and Experimental, 52, 1643-1647.
19. Hammer, F., Subtil, S., Lux, P., Maser-Gluth, C., Stewart, P.M., Allolio, B., et al. (2005). No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: In vivo and in vitro studies. The Journal of Clinical Endocrinology and Metabolism, 90, 3600-3605.
20. Hill, G.E., Miller, J.A., Baxter, B.T., Klassen, L.W., Duryee, M.J., Tuma, D.J., et al. (1998). Association of malondialdehyde-acetaldehyde (MAA) adducted proteins with atherosclerotic-induced vascular inflammatory injury. Atherosclerosis, 141, 107-116.
21. Huang, Y.J., Chen, M.T., Fang, C.L., Lee, W.C., Yang, S.C., & Kuo, C.H. (2006). A possible link between exercise-training adaptation and dehydroepiandrosterone sulfate-An oldest-old female study. International Journal of Medical Sciences, 3, 141-147.
22. Hunt, P.J., Gurnell, E.M., Huppert, F.A., Richards, C., Prevost, A.T., Wass, J.A., et al. (2000). Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial. The Journal of Clinical Endocrinology and Metabolism, 85, 4650-4656.
23. Issa, B.G., & Hanna, F.W. (2003). Insulin resistance, the metabolic syndrome and risk of cardiovascular disease: A complex story. Current Opinion in Lipidology, 14, 405-407.
24. Jackson, M.J. (1999). Free radicals in skin and muscle: Damaging agents or signals for adaptation? The Proceedings of the Nutrition Society, 58, 673-676.
25. Kemmler, W., Wildt, L., Engelke, K., Pintag, R., Pavel, M., Bracher, B., et al. (2003). Acute hormonal responses of a high impact physical exercise session in early postmeno-pausal women. European Journal of Applied Physiology, 90, 199-209.
26. Khalil, A., Lehoux, J.G., Wagner, R.J., Lesur, O., Cruz, S., Dupont, E., et al. (1998). Dehy-droepiandrosterone protects LDL against peroxidation of free radicals by gamma-radiolysis of ethanol-water mixtures. Atherosclerosis, 136, 99-107.
27. Kindermann, W., Schnabel, A., Schmitt, W.M., Biro, G., Cassens, J., & Weber, F. (1982). Catecholamines, growth hormone, cortisol, insulin, and sex hormones in anaerobic and aerobic exercise. European Journal of Applied Physiology and Occupational Physiology, 49, 389-399.
28. Kraemer, W.J., & Ratamess, N.A. (2005). Hormonal responses and adaptations to resistance exercise and training. Sports Medicine (Auckland, N.Z.), 35, 339-361.
29. Ledochowski, M., Murr, C., Jager, M., & Fuchs, D. (2001). Dehydroepiandrosterone, ageing and immune activation. Experimental Gerontology, 36, 1739-1747.
30. McArdle, A., Pattwell, D., Vasilaki, A., Griffiths, R.D., & Jackson, M.J. (2001). Contractile activity-induced oxidative stress: Cellular origin and adaptive responses. American Journal of Physiology. Cell Physiology, 280, C621-C627.
31. Morales, A.J., Haubrich, R.H., Hwang, J.Y., Asakura, H., & Yen, S.S. (1998). The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clinical Endocrinology, 49, 421-432.
32. Neuman, M.P., Montenero, Y., Neuman, F.J., Bruetman, J., Roccella, M.C., & Neuman, J. (1998). Screening of preformed oxidised low density lipoprotein isolated by a poly-anion precipitation method. Its correlation with serum triglyceride levels. Pharmacological Research, 37, 265-272.
33. Packer, L. (1997). Oxidants, antioxidant nutrients and the athlete. Journal of Sports Sciences, 15, 353-363.
34. Powers, S.K., DeRuisseau, K.C., Quindry, J., & Hamilton, K.L. (2004). Dietary antioxidants and exercise. Journal of Sports Sciences, 22, 81-94.
35. Racchi, M., Balduzzi, C., & Corsini, E. (2003). Dehydroepiandrosterone (DHEA) and the aging brain: Flipping a coin in the "fountain of youth." CNS Drug Reviews, 9, 21-40.
36. Raitakari, O.T., Pitkanen, O.P., Lehtimaki, T., Lahdenpera, S., Iida, H., Yla-Herttuala, S., et al. (1997). In vivo low density lipoprotein oxidation relates to coronary reactivity in young men. Journal of the American College of Cardiology, 30, 97-102.
37. Roberts, C.K., Vaziri, N.D., & Barnard, R.J. (2002). Effect of diet and exercise intervention on blood pressure, insulin, oxidative stress, and nitric oxide availability. Circulation, 106, 2530-2532.
38. Shirtcliff, E., Zahn-Waxler, C., Klimes-Dougan, B., & Slattery, M. (2007). Salivary dehy-droepiandrosterone responsiveness to social challenge in adolescents with internalizing problems. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 48, 580-591.
39. Tanaka, H., Monahan, K.D., & Seals, D.R. (2001). Age-predicted maximal heart rate revisited. Journal of the American College of Cardiology, 37, 153-156.
40. Tremblay, M.S., Copeland, J.L., & Van Helder, W. (2004). Effect of training status and exercise mode on endogenous steroid hormones in men. Journal of Applied Physiology, 96, 531-539.
41. Walberg-Rankin, J., Franke, W.D., & Gwazdauskas, F.C. (1992). Response of beta-endor-phin and estradiol to resistance exercise in females during energy balance and energy restriction. International Journal of Sports Medicine, 13, 542-547.
42. Whitcomb, J.M., & Schwartz, A.G. (1985). Dehydroepiandrosterone and 16 alpha-Br-epiandrosterone inhibit 12-O-tetradecanoylphorbol-13-acetate stimulation of super-oxide radical production by human polymorphonuclear leukocytes. Carcinogenesis, 6, 333-335.
43. Wolkowitz, O.M., Reus, V.I., Roberts, E., Manfredi, F., Chan, T., Raum, W.J., et al. (1997). Dehydroepiandrosterone (DHEA) treatment of depression. Biological Psychiatry, 41, 311-318.