Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia: A voxel-based morphometric study

Acta Psychiatrica Scandinavica

Volumn 119, Issue 3, 2009, Pages 199-208

  Herold, R ^a   Feldmann, A ^a   Simon, M ^a   Tenyi T ^a   Kover F ^a   Nagy, F ^a   Varga, E ^a   Fekete, S ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Frontal lobe; Schizophrenia; Temporal lobe; Theory of mind; Voxel based morphometry

Indexed keywords

ADULT; ARTICLE; BASAL GANGLION; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; DISEASE COURSE; FEMALE; FRONTAL CORTEX; GRAY MATTER; HUMAN; MALE; MORPHOMETRICS; ORBITAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; TEMPORAL CORTEX; TEMPORAL LOBE;

ADOLESCENT; ADULT; CEREBELLUM; CEREBRAL CORTEX; DOMINANCE, CEREBRAL; FEMALE; FRONTAL LOBE; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; NEUROPSYCHOLOGICAL TESTS; ORGAN SIZE; PERSONAL CONSTRUCT THEORY; PSYCHIATRIC STATUS RATING SCALES; REFERENCE VALUES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TEMPORAL LOBE; YOUNG ADULT;

EID: 58849103046     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/j.1600-0447.2008.01297.x     Document Type: Article

References (69)

1. Roncone R, Falloon IR, Mazza M et al. Is theory of mind in schizophrenia more strongly associated with clinical and social functioning than with neurocognitive deficits? Psychopathology 2002 35 : 280 288.
2. Brüne M. Emotion recognition, 'theory of mind,' and social behavior in schizophrenia. Psychiatry Res 2005 133 : 135 147.
3. Lysaker PH, Carcione A, Dimaggio G et al. Metacognition amidst narratives of self and illness in schizophrenia: associations with neurocognition, symptoms, insight and quality of life. Acta Psychiatr Scand 2005 112 : 64 71.
4. Pinkham AE, Penn DL. Neurocognitive and social cognitive predictors of interpersonal skill in schizophrenia. Psychiatry Res 2006 143 : 167 178.
5. Brüne M, Abdel-Hamid M, Lehmkämper C, Sonntag C. Mental state attribution, neurocognitive functioning, and psychopathology: what predicts poor social competence in schizophrenia best? Schizophr Res 2007 92 : 151 159.
6. Frith U, Frith CD. Development and neurophysiology of mentalizing. Philos Transact Biol Sci 2003 358 : 459 473.
7. Brunet-Gouet E, Decety J. Social brain dysfunctions in schizophrenia: a review of neuroimaging studies. Psychiatry Res 2006 148 : 75 92.
8. Brüne M. "Theory of mind" in schizophrenia: a review of the literature. Schizophr Bull 2005 31 : 21 42.
9. Sprong M, Schothorst P, Vos E, Hox J, van Engeland H. Theory of mind in schizophrenia: meta-analysis. Br J Psychiatry 2007 191 : 5 13.
10. Herold R, Tényi T, Lénárd K, Trixler M. Theory of mind deficit in people with schizophrenia during remission. Psychol Med 2002 32 : 1125 1129.
11. Lieberman JA, Perkins D, Belger A et al. The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches. Biol Psychiatry 2001 50 : 884 897.
12. Langdon R, Coltheart M. Mentalising, schizotypy, and schizophrenia. Cognition 1999 71 : 43 71.
13. Wykes T, Hamid S, Wagstaff K. Theory of mind and executive functions in the non-psychotic siblings of patients with schizophrenia. Schizophr Res 2001 49 : 148.
14. Schiffman J, Lam CW, Jiwatram T, Ekstrom M, Sorensen H, Mednick S. Perspective-taking deficits in people with schizophrenia spectrum disorders: a prospective investigation. Psychol Med 2005 34 : 1581 1586.
15. Schenkel LS, Spaulding WD, Silverstein SM. Poor premorbid social functioning and theory of mind deficit in schizophrenia: evidence of reduced context processing? J Psychiatr Res 2005 39 : 499 508.
16. Janssen I, Krabbendam L, Jolles J, van Os J. Alterations in theory of mind in patients with schizophrenia and non-psychotic relatives. Acta Psychiatr Scand 2003 108 : 110 117.
17. Marjoram D, Job DE, Whalley HC et al. A visual joke fMRI investigation into theory of mind and enhanced risk of schizophrenia. NeuroImage 2006 31 : 1850 1858.
18. Addington J, Penn D, Woods SW, Addington D, Perkins DO. Facial affect recognition in individuals at clinical high risk for psychosis. Br J Psychiatry 2008 192 : 67 68.
19. Hollis C, Taylor E. Schizophrenia: a critique from the developmental perspective. In : Keshavan MS, Murray RM, eds. Neurodevelopment and adult psychopathology. Cambridge : Cambridge University Press, 1997 : 213 234.
20. Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987 44 : 660 669.
21. Job DE, Whalley HC, Johnstone EC, Lawrie SM. Grey matter changes over time in high risk subjects developing schizophrenia. NeuroImage 2005 25 : 1023 1030.
22. DeLisi LE. The concept of progressive brain change in schizophrenia: implications for understanding schizophrenia. Schizophr Bull 2008 34 : 312 321.
23. Thompson PM, Vidal C, Giedd JN et al. Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia. Proc Natl Acad Sci USA 2001 98 : 11650 11655.
24. Salisbury DF, Kuroki N, Kasai K, Shenton ME, McCarley RW. Progressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia. Arch Gen Psychiatry 2007 64 : 521 529.
25. McGlashan TH, Johannessen JO. Early detection and intervention with schizophrenia: rationale. Schizophr Bull 1996 22 : 201 222.
26. Keshavan MS, Berger G, Zipursky RB, Wood SJ, Pantelis C. Neurobiology of early psychosis. Br J Psychiatry Suppl 2005 48 : s8 s18.
27. Lieberman JA, Tollefson GD, Charles C, Zipursky R et al. Antipsychotic drug effects on brain morphology in first-episode psychosis. Arch Gen Psychiatry 2005 62 : 361 370.
28. Mazza M, Costagliola C, Di Michele V et al. Deficit of social cognition in subjects with surgically treated frontal lobe lesions and in subjects affected by schizophrenia. Eur Arch Psychiatry Clin Neurosci 2006 257 : 12 22.
29. Shamay-Tsoory S, Aharon-Peretz J, Levkovitz Y. The neuroanatomical basis of affective mentalizing in schizophrenia: comparison of patients with schizophrenia and patients with localized prefrontal lesions. Schizophr Res 2006 90 : 274 283.
30. Yamada M, Hirao K, Namiki C et al. Social cognition and frontal lobe pathology in schizophrenia: a voxel-based morphometric study. NeuroImage 2007 35 : 292 298.
31. Endicott J, Spitzer RL. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 1978 35 : 837 844.
32. Wechsler D. Wechsler adult intelligence scale, revised. New York : Psychological Corporation, 1986 : 156.
33. Kay SR, Opler LA. The positive-negative dimension in schizophrenia: its validity and significance. Psychiatr Dev 1987 5 : 79 103.
34. Lee L, Harkness KL, Sabbagh MA, Jacobson JA. Mental state decoding abilities in clinical depression. J Affect Disord 2005 86 : 247 258.
35. Lindenmayer JP, Grochowski S, Hyman RB. Five factor model of schizophrenia: replication across samples. Schizophr Res 1995 14 : 229 234.
36. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971 9 : 97 113.
37. Stone VE, Baron-Cohen S, Knight RT. Frontal lobe contributions to theory of mind. J Cogn Neurosci 1998 10 : 640 656.
38. Abu-Akel A, Abushua'leh K. 'Theory of mind' in violent and nonviolent patients with paranoid schizophrenia. Schizophr Res 2004 69 : 45 53.
39. Ashburner J, Friston KJ. Voxel-based morphometry - the methods. NeuroImage 2000 11 : 805 821.
40. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage 2001 14 : 21 36.
41. Hayasaka S, Phan K, Liberzon I, Worsley K, Nichols T. Nonstationary cluster-size inference with random field and permutation methods. NeuroImage 2004 22 : 676 687.
42. Moorhead T, Job D, Spencer M, Whalley H, Johnstone E, Lawrie S. Empirical comparison of maximal voxel and non-isotropic adjusted cluster extent results in a voxel-based morphometry study of comorbid learning disability with schizophrenia. NeuroImage 2005 28 : 544 552.
43. Eickhoff SB, Stephan KE, Mohlberg H et al. A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. Neuroimage 2005 25 : 1325 1335.
44. Brüne M. Theory of mind and the role of IQ in chronic disorganized schizophrenia. Schizophr Res 2003 60 : 57 64.
45. Mo S, Su Y, Chan RC, Liu J. Comprehension of metaphor and irony in schizophrenia during remission: the role of theory of mind and IQ. Psychiatry Res 2008 157 : 21 29.
46. Pickup GJ, Frith CD. Theory of mind impairments in schizophrenia: symptomatology, severity and specificity. Psychol Med 2001 31 : 207 220.
47. Martino DJ, Bucay D, Butman JT, Allegri RF. Neuropsychological frontal impairments and negative symptoms in schizophrenia. Psychiatry Res 2007 152 : 121 128.
48. Zhu CY, Lee TM, Li XS, Jing SC, Wang YG, Wang K. Impairments of social cues recognition and social functioning in Chinese people with schizophrenia. Psychiatry Clin Neurosci 2007 61 : 149 158.
49. Job DE, Whalley HC, McConnell S, Glabus M, Johnstone EC, Lawrie SM. Structural gray matter differences between first-episode schizophrenics and normal controls using voxel-based morphometry. NeuroImage 2002 17 : 880 889.
50. Honea R, Crow TJ, Passingham D, Mackay CE. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am J Psychiatry 2005 162 : 2233 2245.
51. Kuroki N, Shenton ME, Salisbury DF et al. Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study. Am J Psychiatry 2006 163 : 2103 2110.
52. Théberge J, Williamson KE, Aoyama N et al. Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia. Br J Psychiatry 2007 191 : 325 334.
53. Russell TA, Rubia K, Bullmore ET et al. Exploring the social brain in schizophrenia: left prefrontal underactivation during mental state attribution. Am J Psychiatry 2000 157 : 2040 2042.
54. Corcoran R, Frith CD. Autobiographical memory and theory of mind: evidence of a relationship in schizophrenia. Psychol Med 2003 33 : 897 905.
55. Ragland JD, Valdez JN, Loughead J, Gur RC, Gur RE. Functional magnetic resonance imaging of internal source monitoring in schizophrenia: recognition with and without recollection. Schizophr Res 2006 87 : 160 171.
56. Walter H, Vasic N, Höse A, Spitzer M, Wolf RC. Working memory dysfunction in schizophrenia compared to healthy controls and patients with depression: evidence from event-related fMRI. NeuroImage 2007 35 : 1551 1561.
57. Job DE, Whalley HC, McIntosh AM, Owens DG, Johnstone EC, Lawrie SM. Grey matter changes can improve the prediction of schizophrenia in subjects at high risk. BMC Med 2006 4 : 1 4.
58. Abu-Akel A. A neurobiological mapping of theory of mind. Brain Res Rev 2003 43 : 29 40.
59. Hynes CA, Baird AA, Grafton ST. Differential role of the orbital frontal lobe in emotional versus cognitive perspective-taking. Neuropsychologia 2006 44 : 374 383.
60. Brunet E, Sarfati Y, Hardy-Baylé MC, Decety J. Abnormalities of brain function during a nonverbal theory of mind task in schizophrenia. Neuropsychologia 2003 41 : 1574 1582.
61. Shamay-Tsoory SG, Shur S, Harari H, Levkovitz Y. Neurocognitive basis of impaired empathy in schizophrenia. Neuropsychology 2007 21 : 431 438.
62. Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome? Clin Neurosci 1995 3 : 89 97.
63. Schlösser RG, Nenadic I, Wagner G et al. White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI study. Schizophr Res 2007 89 : 1 11.
64. Wolf DH, Gur RC, Valdez JN et al. Alterations of fronto-temporal connectivity during word encoding in schizophrenia. Psychiatry Res 2007 154 : 221 232.
65. Brüne M, Lissek S, Fuchs N et al. An fMRI study of theory of mind in schizophrenic patients with "passivity" symptoms. Neuropsychologia 2008 46 : 1992 2001.
66. Andreasen NC, Calage CA, O'Leary DS. Theory of mind and schizophrenia: a positron emission tomography study of medication-free patients. Schizophr Bull. 2008 doi :.
67. Lee KH, Brown WH, Egleston PN et al. A functional magnetic resonance imaging study of social cognition in schizophrenia during an acute episode and after recovery. Am J Psychiatry 2006 163 : 1926 1933.
68. Mizrahi R, Korostil M, Starkstein SE, Zipursky RB, Kapur S. The effect of antipsychotic treatment on theory of mind. Psychol Med 2006 37 : 595 601.
69. Savina I, Beninger R. Schizophrenic patients treated with clozapine or olanzapine perform better on theory of mind tasks than those treated with risperidone or typical antipsychotic medications. Schizophr Res 2007 94 : 128 138.