Calcitonin gene-related peptide biases langerhans cells toward Th2-type immunity

Journal of Immunology

Volumn 181, Issue 9, 2008, Pages 6020-6026

  Ding, Wanhong ^a   Stohl, Lori L ^a   Wagner, John A ^a   Granstein, Richard D ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 4; MACROPHAGE DERIVED CHEMOKINE; MESSENGER RNA; OVALBUMIN; T LYMPHOCYTE RECEPTOR; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL FUNCTION; CELL LINE; CELL STIMULATION; CELLULAR IMMUNITY; CHICKEN; CYTOKINE PRODUCTION; DENDRITIC CELL; EXPOSURE; FEMALE; LANGERHANS CELL; LYMPHOCYTE CLONE; MOUSE; NERVE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL; TRANSGENIC MOUSE; A J MOUSE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CLONE; COCULTURE; COMPARATIVE STUDY; DRUG ANTAGONISM; HUMAN; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; TH1 CELL;

ANIMALS; ANTIGEN PRESENTATION; CALCITONIN GENE-RELATED PEPTIDE; CELL LINE; CLONE CELLS; COCULTURE TECHNIQUES; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-4; LANGERHANS CELLS; MICE; MICE, INBRED A; MICE, INBRED BALB C; MICE, TRANSGENIC; TH1 CELLS; TH2 CELLS;

EID: 58749108125     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.9.6020     Document Type: Article

References (39)

1. Romani, N., S. Ebner, C. H. Tripp, V. Flacher, F. Koch, and P. Stoitzner. 2006. Epidermal Langerhans cells: changing views on their function in vivo. Immunol. Lett. 106: 119-125. (Pubitemid 44223748)
2. Granstein, R. D., W. Ding, J. Huang, A. Holzer, R. L. Gallo, A. Di Nardo, and J. A. Wagner. 2005. Augmentation of cutaneous immune responses by ATP γ S: purinergic agonists define a novel class of immunologic adjuvants. J. Immunol. 174: 7725-7731.
3. Merad, M., P. Hoffmann, E. Ranheim, S. Slaymaker, M. G. Manz, S. A. Lira, I. Charo, D. N. Cook, I. L. Weissman, S. Strober, and E. G. Engleman. 2004. Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat. Med. 10: 510-517. (Pubitemid 38667910)
4. Kaplan, D. H., M. C. Jenison, S. Saeland, W. D. Shlomchik, and M. J. Shlomchik. 2005. Epidermal Langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23: 611-620.
5. Hosoi, J., G. F. Murphy, C. L. Egan, E. A. Lerner, S. Grabbe, A. Asahina, and R. D. Granstein. 1993. Regulation of Langerhans cell function by nerves containing CGRP. Nature 363: 159-163.
6. Asahina, A., J. Hosoi, S. Beissert, A. Stratigos, and R. D. Granstein. 1995. Inhibition of the induction of delayed-type and contact hypersensitivity by calcitonin gene-related peptide. J. Immunol. 154: 3056-3061.
7. Asahina, A., O. Moro, J. Hosoi, E. A. Lerner, S. Xu, A. Takashima, and R. D. Granstein. 1995. Specific induction of cAMP in Langerhans cells by calcitonin gene-related peptide: relevance to functional effects. Proc. Natl. Acad. Sci. USA 92: 8323-8327.
8. Nakae, S., Y. Iwakura, H. Suto, and S. J. Galli. 2007. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J. Leukocyte Biol. 81: 1258-1268. (Pubitemid 46702045)
9. Cosmi, L., F. Annunziato, E. Maggi, S. Romagnani, and R. Manetti. 2001. Chemoattractant receptors expressed on type 2 T cells and their role in disease. Int. Arch. Allergy Immunol. 125: 273-279. (Pubitemid 34701505)
10. Fujita, H., A. Asahina, M. Sugaya, K. Nakamura, P. Gao, H. Fujiwara, and K. Tamaki. 2005. Differential production of Th1- and TH2-type chemokines by mouse Langerhans cells and splenic dendritic cells. J. Invest. Dermatol. 124: 343-350. (Pubitemid 40175881)
11. Robertson, M. J. 2002. Role of chemokines in the biology of natural killer cells. J. Leukocyte Biol. 71: 73-83.
12. Lundberg, P., H. Openshaw, M. Wang, H. J. Yang, and E. Cantin. 2007. Effects of CXCR3 signaling on development of fatal encephalitis and corneal and periocular skin disease in HSV-infected mice are mouse-strain dependent. Invest. Ophthalmol. Visual Sci. 48: 4162-4170. (Pubitemid 351261044)
13. Liu, L., M. K. Callahan, D. Huang, and R. M. Ransohoff. 2005. Chemokine receptor CXCR3: an unexpected enigma. Curr. Top. Dev. Biol. 68: 149-181.
14. Garcia, G., V. Godot, and M. Humbert. 2005. New chemokine targets for asthma therapy. Curr. Allergy Asthma Rep. 5: 155-160. (Pubitemid 40331073)
15. Ishida, T., and R. Ueda. 2006. CCR4 as a novel molecular target for immunotherapy of cancer. Cancer Sci. 97: 1139-1146. (Pubitemid 44430638)
16. Xu, S., K. Ariizumi, G. Caceres-Dittmar, D. Edelbaum, K. Hashimoto, P. R. Bergstresser, and A. Takashima. 1995. Successive generation of antigenpresenting, dendritic cell lines from murine epidermis. J. Immunol. 154: 2697-2705.
17. Xu, S., K. Ariizumi, D. Edelbaum, P. R. Bergstresser, and A. Takashima. 1995. Cytokine-dependent regulation of growth and maturation in murine epidermal dendritic cell lines. Eur. J. Immunol. 25: 1018-1024.
18. Schuhmachers, G., S. Xu, P. R. Bergstresser, and A. Takashima. 1995. Identity and functional properties of novel skin-derived fibroblast lines (NS series) that support the growth of epidermal-derived dendritic cell lines. J. Invest. Dermatol. 105: 225-230.
19. + cells of the T helper 2 subset. J. Immunol. 145: 2087-2091.
20. Nakashima, K., T. Kokubo, M. Shichijo, Y. F. Li, T. Yura, and N. Yamamoto. 2004. A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells. Eur. J. Pharmacol. 505: 223-283. (Pubitemid 39535695)
21. Kodali, S., W. Ding, J. Huang, K. Seiffert, J. A. Wagner, and R. D. Granstein. 2004. Vasoactive intestinal peptide modulates Langerhans cell immune function. J. Immunol. 173: 6082-6088. (Pubitemid 39487764)
22. Schinke, T., S. Liese, M. Priemel, M. Haberland, A. F. Schilling, P. Catala-Lehnen, D. Blicharski, J. M. Rueger, R. F. Gagel, R. B. Emeson, and M. Amling. 2004. Decreased bone formation and osteopenia in mice lacking α-calcitonin gene-related peptide. J. Bone Miner. Res. 19: 2049-2056. (Pubitemid 41103420)
23. Park, M. K., K. F. Hoffmann, A. W. Cheever, D. Amichay, T. A. Wynn, and J. M. Farber. 2001. Patterns of chemokine expression in models of Schistosoma mansoni inflammation and infection reveal relationships between type 1 and type 2 responses and chemokines in vivo. Infect. Immun. 69: 6755-6768.
24. Kuroda, E., T. Sugiura, K. Okada, K. Zeki, and U. Yamashita. 2001. Prostaglandin E2 up-regulates macrophage-derived chemokine production but suppresses IFN-inducible protein-10 production by APC. J. Immunol. 166: 1650-1658. (Pubitemid 32114646)
25. Xiao, T., H. Fujita, H. Saeki, H. Mitsui, M. Sugaya, Y. Tada, T. Kakinuma, H. Torii, K. Nakamura, A. Asahina, and K. Tamaki. 2003. Thymus and activation- regulated chemokine (TARC/CCL17) produced by mouse epidermal Langerhans cells is upregulated by TNF-α and IL-4 and downregulated by IFN-γ. Cytokine 23: 126-132. (Pubitemid 37102791)
26. Kuroda, E., T. Sugiura, K. Okada, K. Zeki, and U. Yamashita. 2001. Prostaglandin E2 up-regulates macrophage-derived chemokine production but suppresses IFN-inducible protein-10 production by APC. J. Immunol. 166: 1650-1658. (Pubitemid 32114646)
27. Elliott, K. A., N. A. Osna, M. A. Scofield, and M. M. Khan. 2001. Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells. Int. Immunopharmacol. 1: 1923-1937.
28. Matsue, H., D. Edelbaum, A. C. Hartmann, A. Morita, P. R. Bergstresser, H. Yagita, K. Okumura, and A. Takashima. 1999. Dendritic cells undergo rapid apoptosis in vitro during antigen-specific interaction with CD4+ T cells. J. Immunol. 162: 5287-5298. (Pubitemid 29307135)
29. lo thymocytes in vivo. Science 250: 1720-1723.
30. Hsieh, C. S., A. B. Heimberger, J. S. Gold, A. O'Garra, and K. M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an α β T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA 89: 6065-6069.
31. Nikitenko, L. L., N. Blucher, S. B. Fox, R. Bicknell, D. M. Smith, and M C. Rees. 2006. Adrenomedullin and CGRP interact with endogenous calcitonin-receptorlike receptor in endothelial cells and induce its desensitization by different mechanisms. J. Cell Sci. 119: 910-922.
32. Stingl, G., E C. Wolff-Schreiner, W. J. Pichler, F. Gschnait, W. Knapp, and K. Wolff. 1977. Epidermal Langerhans cells bear Fc and C3 receptors. Nature 268: 245-246. (Pubitemid 8139184)
33. Romani, N., A. Lenz, H. Glassel, H. Stossel, U. Stanzl, O. Majdic, P. Fritsch, and G. Schuler. 1989. Cultured human Langerhans cells resemble lymphoid dendritic cells in phenotype and function. J. Invest. Dermatol. 93: 600-609. (Pubitemid 19262818)
34. Grabbe, S., and R. D. Granstein. 1993. Modulation of antigen-presenting cell function as a potential regulatory mechanism in tumor-host immune reactions. In Vivo 7: 265-270. (Pubitemid 23205704)
35. Lappin, M. B., I. Kimber, and M. Norval. 1996. The role of dendritic cells in cutaneous immunity. Arch. Dermatol. Res. 288: 109-121. (Pubitemid 26093164)
36. Ritter, U., and A. Osterloh. 2007. A new view on cutaneous dendritic cell subsets in experimental leishmaniasis. Med. Microbiol. Immunol. 196: 51-59. (Pubitemid 46197384)
37. Bosnjak, L., M. Miranda-Saksena, D. M. Koelle, R. A. Boadle, C. A. Jones, and A. L. Cunningham. 2005. Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells. J. Immunol. 174: 2220-2227. (Pubitemid 40223968)
38. Zhao, X., E. Deak, K. Soderberg, M. Linehan, D. Spezzano, J. Zhu, D. M. Knipe, and A. Iwasaki. 2003. Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J. Exp. Med. 197: 153-162. (Pubitemid 36152310)
39. Schuler, G., and R. M. Steinman. 1985. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161: 526-546. (Pubitemid 15142803)