Utility of various non-invasive methods for fibrosis prediction among Basque Country patients with phenotypic hemochromatosis;Utilidad de los diferentes métodos no invasivos de predicción de fibrosis hepática en pacientes del País Vasco con hemocromatosis fenotípica

Revista Espanola de Enfermedades Digestivas

Volumn 100, Issue 10, 2008, Pages 611-614

  Castiella, A ^a,b   Zapata, E ^a   Otazua, P ^a   Fernandez J ^a   Alustiza, J M ^a   Ugarte, M ^a   Legasa, L ^a   Galardi, A ^a   Ugalde, A ^a   Barredo, I ^a   Arriola, J A ^a  

^a Hospitales de Mendaro ^*  (Spain)

^b HOSPITAL DE MENDARO   (Spain)

Author keywords

Hemochromatosis; Iron metabolism; Iron overload; Liver fibrosis; Magnetic resonance imaging

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FERRITIN; IRON;

ADULT; AGED; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; HEMOCHROMATOSIS; HUMAN; LIVER BIOPSY; LIVER FIBROSIS; LIVER LEVEL; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PREDICTIVE VALIDITY; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; THROMBOCYTE COUNT; BIOPSY; BLOOD; CHEMISTRY; COMPARATIVE STUDY; EVALUATION; GENETICS; IRON OVERLOAD; LIVER; LIVER CIRRHOSIS; METABOLISM; MIDDLE AGED; PATHOLOGY; PREDICTION AND FORECASTING; RETROSPECTIVE STUDY; RISK FACTOR; SPAIN;

ADULT; AGED; ASPARTATE AMINOTRANSFERASES; BIOPSY; FEMALE; FERRITINS; HEMOCHROMATOSIS; HUMANS; IRON; IRON OVERLOAD; LIVER; LIVER CIRRHOSIS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PHENOTYPE; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SPAIN;

EID: 58749104388     PISSN: 11300108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Adams PC. Review article: the modern diagnosis and management of hemochromatosis. Alim Pharmacol Ther 2006; 23: 1681-1691
2. Beaton MD, Adams PC. The myths and realities of hemochromatosis. Can J Gastroenterol 2007; 21: 101-104
3. Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996; 13: 399-408.
4. De Juan MD, Reta A, Castiella A, et al. HFE gene mutations analysis in Basque hereditary hemochromatosis patients and controls. Eur J Hum Genet 2001; 9: 961-964
5. O'Neil J, Powell L. Clinical aspects of hemochromatosis. Sem Liv Dis 2005; 25: 381-391
6. Beutler E. Penetrance in hereditary hemochromatosis. The HFE Cys282Tyr mutation as a necessary but not sufficient cause of clinical hereditary hemochromatosis. Blood 2003; 101: 3347-3350
7. Vázquez Romero M, Boixeda de Miquel D, Martin de Argila de Prados C, Vallcorba Gómez del Valle J, Cabello Albendea P, López San Roman A, et al. Familiar penetrancy of HFE gene: four brothers of the same family affected by hereditary hemochromatosis. Rev Esp Enferm Dig 2005; 97: 608-609
8. Pietrangelo A. Hereditary hemochromatosis - A new look to an old disease. N Engl J Med 2004; 350: 2383-2397
9. Guyader D, Jaquelinet C, Moirand R, et al. Noninvasive prediction of fibrosis in C282Y homozygous hemochromatosis. Gastroenterology 1998; 115: 929-936
10. Beaton M, Guyader D, Deugnier Y, Moirand R, Chakrabarti S, Adams P. Noninvasive prediction of cirrhosis in C282Y-linked he- mochromatosis. Hepatology 2002; 36: 673-678
11. Bacon BR, Olynyk JK, Brunt EM, Britton RS, Wolff RK. HFE genotype in patients with hemochromatosis and other liver diseases. Ann Intern Med 1999; 130: 953-962
12. Morrison ED, Brandhagen DJ, Phatak PD, et al. Serum ferritin level predicts advanced hepatic fibrosis among U.S. patients with phenoty- pic hemochromatosis. Ann Intern Med 2003; 138: 627-633
13. Olynyk JK, St Pierre TG, Britton RS, Brunt EM, Bacon BR. Duration of hepatic iron exposure increases the risk of significant fibrosis in hereditary hemochromatosis: A new role for magnetic resonance imaging. Am J Gastroenterol 2005; 100: 837-841
14. Brunt EM. Pathology of hepatic iron overload. Sem Liv Dis 2005; 25: 392-401.
15. Alustiza JM, Artetxe J, Castiella A, et al. MR quantification of hepatic iron concentration. Radiology 2004; 230: 479-484
16. Alustiza JM, Castiella A, De Juan MD, et al. Iron overload in the liver: diagnostic and quantification. Eur J Radiol 2007; 61: 499-506.
17. Castiella A, Emparanza JI. External validation for fibrosis predicting index in hereditary hemochromatosis. Am J Gastroenterol 2005; 100: 2366-2367
18. Bauduer F, Scribans C, Degioanni A, Renoux M, Dutour O. Distribution of the C282Y and H63D polymorphisms in hereditary hemochro- matosis patients from the French Basque Country. Ann Hematol 2005; 84: 99-102.
19. EASL Internacional Consensus Conference on Haemochromatosis. J Hepatol 2000; 33: 485-504.
20. Tavill AS. Diagnosis and management of hemochromatosis. Hepatology 2001; 33: 1321-1328
21. Aguilar-Martinez P, Schved JF, Brissot P. The evaluation of hyperfe-rritinemia: an updated strategy based on advances in detecting genetic abnormalities. Am J Gastroenterol 2005; 100: 1185-1194
22. Castiella A, Alustiza JM, Artetxe J. Hereditary hemochromatosis. N Engl J Med 2004; 35: 1263-1264