HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptotic loss of germ cells

Reproductive Toxicology

Volumn 27, Issue 1, 2009, Pages 14-21

  Cai, Li yi ^a,b   Kato, Takako ^a   Nakayama, Michie ^a   Susa, Takao ^a   Murakami, Sanae ^a   Izumi, Shun ichiro ^b   Kato, Yukio ^a  

^a MEIJI UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY   (Japan)

Author keywords

Apoptosis; HSV infection; HSV1 TK; Spermatogenesis; Transgenic rat

Indexed keywords

THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LOSS; CELL MEMBRANE; CONGENITAL MALFORMATION; CONTROLLED STUDY; GERM CELL; HEAD; HERPES SIMPLEX VIRUS 1; MALE; MALE INFERTILITY; NICK END LABELING; NONHUMAN; RAT; SPERMATID; SPERMATOGENESIS; SPERMATOZOON; TAIL; TRANSCRIPTION INITIATION SITE; TRANSGENIC RAT;

ANIMALS; APOPTOSIS; EPIDIDYMIS; HERPESVIRUS 1, HUMAN; IMMUNOHISTOCHEMISTRY; INFERTILITY, MALE; MALE; RATS; RATS, INBRED F344; RATS, TRANSGENIC; SPERMATIDS; SPERMATOGENESIS; SPERMATOZOA; TESTIS; THYMIDINE KINASE; VIRAL STRUCTURAL PROTEINS;

ANIMALIA; RATTUS; RODENTIA; SIMPLEXVIRUS;

EID: 58749088914     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2008.11.052     Document Type: Article

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