Abnormal vascular reactivity at rest and exercise in obese boys

European Journal of Clinical Investigation

Volumn 39, Issue 2, 2009, Pages 94-102

  Karpoff, L ^a   Vinet, A ^a   Schuster, I ^b,c,d   Oudot, C ^a   Goret, L ^b,c,d   Dauzat, M ^b,c,d   Obert, P ^a   Perez Martin, A ^b,c,d  

^a UNIVERSITY OF AVIGNON   (France)

^b UNIV MONTPELLIER   (France)

^c Nimes University Hospital Centre   (France)

^d NÎMES UNIVERSITY HOSPITAL   (France)

Author keywords

Blood flow; Children; Exercise; Flow mediated dilation; Obesity

Indexed keywords

FIBRINOGEN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITRATE; TRIACYLGLYCEROL;

ARTERIAL WALL THICKNESS; ARTICLE; BLOOD VESSEL REACTIVITY; BODY MASS; CAROTID ARTERY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; HUMAN; LEG BLOOD FLOW; LIPID BLOOD LEVEL; MALE; OBESITY; PRIORITY JOURNAL; REST; SCHOOL CHILD; VASCULAR DISEASE; VASODILATATION; YOUNG MODULUS;

ADIPOSE TISSUE; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; BRACHIAL ARTERY; CAROTID ARTERIES; CASE-CONTROL STUDIES; CHILD; DILATATION, PATHOLOGIC; EXERCISE; HUMANS; INSULIN; LEG; LIPIDS; MALE; MUSCLE, SMOOTH, VASCULAR; OBESITY; REGIONAL BLOOD FLOW; REST;

EID: 58649087823     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2008.02068.x     Document Type: Article

References (52)

1. Gielen S, Hambrecht R. Effects of exercise training on vascular function and myocardial perfusion. Cardiol Clin 2001 19 : 357 68.
2. Serdula MK, Ivery D, Coates RJ, Freedman DS, Williamson DF, Byers T. Do obese children become obese adults? A review of the literature. Prev Med 1993 22 : 167 77.
3. Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH. Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. N Engl J Med 1992 327 : 1350 5.
4. Must A. Morbidity and mortality associated with elevated body weight in children and adolescents. Am J Clin Nutr 1996 63 : 445S 7S.
5. Srinivasan SR, Bao W, Wattigney WA, Berenson GS. Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study. Metabolism 1996 45 : 235 40.
6. Aggoun Y, Szezepanski I, Bonnet D. Noninvasive assessment of arterial stiffness and risk of atherosclerotic events in children. Pediatr Res, 2005 58 : 173 8.
7. Tounian P, Aggoun Y, Dubern B, Varille V, Guy-Grand B, Sidi D et al. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet 2001 358 : 1400 4.
8. Meyer AA, Kundt G, Steiner M, Schuff-Werner P, Kienast W. Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: the impact of cardiovascular risk factors. Pediatrics 2006 117 : 1560 7.
9. Iannuzzi A, Licenziati MR, Acampora C, Salvatore V, Auriemma L, Romano ML et al. Increased carotid intima-media thickness and stiffness in obese children. Diabetes Care 2004 27 : 2506 8.
10. Atabek ME, Pirgon O, Kivrak AS. Evidence for association between insulin resistance and premature carotid atherosclerosis in childhood obesity. Pediatr Res 2007 61 : 345 9.
11. Beauloye V, Zech F, Tran HT, Clapuyt P, Maes M, Brichard SM. Determinants of early atherosclerosis in obese children and adolescents. J Clin Endocrinol Metab 2007 92 : 3025 32.
12. Giannini C, de GT, Scarinci A, Ciampani M, Marcovecchio ML, Chiarelli F et al. Obese related effects of inflammatory markers and insulin resistance on increased carotid intima media thickness in pre-pubertal children. Atherosclerosis 2008 197 : 448 56.
13. Watts K, Beye P, Siafarikas A, O'Driscoll G, Jones TW, Davis EA et al. Effects of exercise training on vascular function in obese children. J Pediatr 2004 144 : 620 5.
14. Aggoun Y, Tounian P, Dabbas-Tyan M, Massih TA, Girardet JP, Ricour C et al. (Arterial rigidity and endothelial dysfunction in obese children). Arch Mal Coeur Vaiss 2002 95 : 631 5.
15. Kapiotis S, Holzer G, Schaller G, Haumer M, Widhalm H, Weghuber D et al. A proinflammatory state is detectable in obese children and is accompanied by functional and morphological vascular changes. Arterioscler Thromb Vasc Biol, 2006 26 : 2541 6.
16. Moens AL, Goovaerts I, Claeys MJ, Vrints CJ. Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool? Chest 2005 127 : 2254 63.
17. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002 39 : 257 65.
18. Aggoun Y, Farpour-Lambert NJ, Marchand LM, Golay E, Maggio AB, Beghetti M. Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure. Eur Heart J 2008 29 : 792 9.
19. Aggoun Y. Obesity, metabolic syndrome, and cardiovascular disease. Pediatr Res 2007 61 : 653 9.
20. Pena AS, Wiltshire E, MacKenzie K, Gent R, Piotto L, Hirte C et al. Vascular endothelial and smooth muscle function relates to body mass index and glucose in obese and nonobese children. J Clin Endocrinol Metab 2006 91 : 4467 71.
21. Hannon TS, Janosky J, Arslanian SA. Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Pediatr Res 2006 60 : 759 63.
22. Woo KS, Chook P, Yu CW, Sung RY, Qiao M, Leung SS et al. Overweight in children is associated with arterial endothelial dysfunction and intima-media thickening. Int J Obes Relat Metab Disord 2004 28 : 852 7.
23. Zhu W, Huang X, He J, Li M, Neubauer H. Arterial intima-media thickening and endothelial dysfunction in obese Chinese children. Eur J Pediatr 2005 164 : 337 44.
24. Kim SI, Kim SJ. Prevalence and risk factors for cataracts in persons with type 2 diabetes mellitus. Korean J Ophthalmol 2006 20 : 201 4.
25. Saltin B, Radegran G, Koskolou MD, Roach RC. Skeletal muscle blood flow in humans and its regulation during exercise. Acta Physiol Scand 1998 162 : 421 36.
26. Kingwell BA, Formosa M, Muhlmann M, Bradley SJ, McConell GK. Type 2 diabetic individuals have impaired leg blood flow responses to exercise: role of endothelium-dependent vasodilation. Diabetes Care 2003 26 : 899 904.
27. Ribeiro MM, Silva AG, Santos NS, Guazzelle I, Matos LN, Trombetta IC et al. Diet and exercise training restore blood pressure and vasodilatory responses during physiological maneuvers in obese children. Circulation 2005 111 : 1915 23.
28. Rolland-Cachera MF, Cole TJ, Sempe M, Tichet J, Rossignol C, Charraud A. Body Mass Index variations: centiles from birth to 87 years. Eur J Clin Nutr 1991 45 : 13 21.
29. Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 1976 51 : 170 9.
30. Conwell LS, Trost SG, Brown WJ, Batch JA. Indexes of insulin resistance and secretion in obese children and adolescents: a validation study. Diabetes Care 2004 27 : 314 9.
31. Atabek ME, Pirgon O. Assessment of insulin sensitivity from measurements in fasting state and during an oral glucose tolerance test in obese children. J Pediatr Endocrinol Metab 2007 20 : 187 95.
32. Walther G, Nottin S, Dauzat M, Obert P. Femoral and axillary ultrasound blood flow during exercise: a methodological study. Med Sci Sports Exerc, 2006 38 : 1353 61.
33. Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N et al. Mannheim carotid intima-media thickness consensus (2004-2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis 2007 23 : 75 80.
34. Jarvisalo MJ, Ronnemaa T, Volanen I, Kaitosaari T, Kallio K, Hartiala JJ et al. Brachial artery dilatation responses in healthy children and adolescents. Am J Physiol Heart Circ Physiol 2002 282 : H 87 92.
35. Pyke KE, Tschakovsky ME. The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function. J Physiol 2005 568 : 357 69.
36. Wray DW, Richardson RS. Aging, exercise, and limb vascular heterogeneity in humans. Med Sci Sports Exerc 2006 38 : 1804 10.
37. Pyke KE, Hartnett JA, Tschakovsky ME. Are the dynamic response characteristics of brachial artery flow-mediated dilation sensitive to the magnitude of increase in shear stimulus? J Appl Physiol 2008 105 : 282 92.
38. Betik AC, Luckham VB, Hughson RL. Flow-mediated dilation in human brachial artery after different circulatory occlusion conditions. Am J Physiol Heart Circ Physiol 2004 286 : H442 8.
39. Watts K, Beye P, Siafarikas A, Davis EA, Jones TW, O'Driscoll G et al. Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents. J Am Coll Cardiol 2004 43 : 1823 7.
40. Pyke KE, Dwyer EM, Tschakovsky ME. Impact of controlling shear rate on flow-mediated dilation responses in the brachial artery of humans. J Appl Physiol 2004 97 : 499 508.
41. Wray DW, Uberoi A, Lawrenson L, Richardson RS. Heterogeneous limb vascular responsiveness to shear stimuli during dynamic exercise in humans. J Appl Physiol 2005 99 : 81 6.
42. Kearney MT, Duncan ER, Kahn M, Wheatcroft SB. Insulin resistance and endothelial cell dysfunction: studies in mammalian models. Exp Physiol 2008 93 : 158 63.
43. Vecchione C, Maffei A, Colella S, Aretini A, Poulet R, Frati G et al. Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway. Diabetes 2002 51 : 168 73.
44. Valle M, Martos R, Gascon F, Canete R, Zafra MA, Morales R. Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome. Diabetes Metab 2005 31 : 55 62.
45. Correia ML, Rahmouni K. Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome. Diabetes Obes Metab 2006 8 : 603 10.
46. Bouloumie A, Marumo T, Lafontan M, Busse R. Leptin induces oxidative stress in human endothelial cells. FASEB J 1999 13 : 1231 8.
47. Chu NF, Chang JB, Shieh SM. Plasma leptin, fatty acids, and tumor necrosis factor-receptor and insulin resistance in children. Obes Res 2003 11 : 532 40.
48. Reinehr T, Kiess W, de SG, Stoffel-Wagner B, Wunsch R. Intima media thickness in childhood obesity: relations to inflammatory marker, glucose metabolism, and blood pressure. Metabolism 2006 55 : 113 8.
49. Reinehr T, Wunsch R, de SG, Toschke AM. Relationship between metabolic syndrome definitions for children and adolescents and intima-media thickness. Atherosclerosis 2008 199 : 193 200.
50. Laurent S, Girerd X, Mourad JJ, Lacolley P, Beck L, Boutouyrie P et al. Elastic modulus of the radial artery wall material is not increased in patients with essential hypertension. Arterioscler Thromb 1994 14 : 1223 31.
51. Walther G, Nottin S, Karpoff L, Perez-Martin A, Dauzat M, Obert P. Flow-mediated dilation and exercise-induced hyperaemia in highly trained athletes: comparison of the upper and lower limb vasculature. Acta Physiol (Oxf) 2008 193 : 139 50.
52. Frisbee JC. Obesity, insulin resistance, and microvessel density. Microcirculation 2007 14 : 289 98.