Activation of c-jun N-terminal kinase cascades is involved in part of the neuronal degeneration induced by trimethyltin in cortical neurons of mice

Journal of Pharmacological Sciences

Volumn 109, Issue 1, 2009, Pages 60-70

  Shuto, Makoto ^a,c   Seko, Keiichi ^b   Kuramoto, Nobuyuki ^b   Sugiyama, Chie ^b   Kawada, Koichi ^b   Yoneyama, Masanori ^b   Nagashima, Reiko ^b   Ogita, Kiyokazu ^b  

^a Department of Medical Pharmacy ^*  (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

C jun N terminal kinase; Cortical neuron; Neuronal death; Stress activated protein kinase 1; Trimethyltin

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BETA TUBULIN; C JUN AMINO TERMINAL KINASE P54; C JUN AMINO TERMINAL KINASE P64; DIZOCILPINE; GLIAL FIBRILLARY ACIDIC PROTEIN; LACTATE DEHYDROGENASE; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TRIMETHYLTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXCITOTOXICITY; EXPOSURE; FRONTAL CORTEX; MALE; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PROTEIN PHOSPHORYLATION;

EID: 58649083472     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08211FP     Document Type: Article

References (47)

1. Bouldin TW, Goines ND, Bagnell RC, Krigman MR. Pathogenesis of trimethyltin neuronal toxicity. Ultrastructural and cytochemical observations. Am J Pathol. 1981;104:237-249.
2. Chang LW, Dyer RS. Early effects of trimethyltin on the dentate gyrus basket cells: a morphological study. J Toxicol Environ Health. 1985;16:641-653.
3. Oderfeld-Nowak B, Zaremba M. GM1 ganglioside potentiates trimethyltin-induced expression of interleukin-1 beta and the nerve growth factor in reactive astrocytes in the rat hippocampus: an immunocytochemical study. Neurochem Res. 1998; 23:443-453.
4. Fiedorowicz A, Figiel I, Kaminska B, Zaremba M, Wilk S, Oderfeld-Nowak B. Dentate granule neuron apoptosis and glia activation in murine hippocampus induced by trimethyltin exposure. Brain Res. 2001;912:116-127.
5. Ogita K, Nishiyama N, Sugiyama C, Higuchi K, Yoneyama M, Yoneda Y. Regeneration of granule neurons after lesioning of hippocampal dentate gyrus: evaluation using adult mice treated with trimethyltin chloride as a model. J Neurosci Res. 2005;82:609-621.
6. Yoneyama M, Nishiyama N, Shuto M, Sugiyama C, Kawada K,Seko K, et al. In vivo depletion of endogenous glutathione facilitates trimethyltin-induced neuronal damage in the dentate gyrus of mice by enhancing oxidative stress. Neurochem Int. 2008;52:761-769.
7. Nagashima R, Sugiyama C, Gotoh Y, Yoneyama M, Kuramoto N, Taira T, et al. Altered expression of DJ-1 in the hippocampal cells following in vivo and in vitro neuronal damage induced by trimethyltin. Neurosci Lett. 2008;440:232-236.
8. Yoneyama M, Iwamoto N, Nagashima R, Sugiyama C, Kawada K, Kuramoto N, et al. Altered expression of heat shock protein 110 family members in mouse hippocampal neurons following trimethyltin treatment in vivo and in vitro. Neuropharmacology. 2008;55:693-703.
9. Kawada K, Yoneyama M, Nagashima R, Ogita K. In vivo acute treatment with trimethyltin chloride causes neuronal degeneration in the murine olfactory bulb and anterior olfactory nucleus by different cascades in each region. J Neurosci Res. 2008;86: 1635-1646.
10. Dragunow M, Preston K. The role of inducible transcription factors in apoptotic nerve cell death. Brain Res Brain Res Rev. 1995;21:1-28.
11. Kitayama T, Ogita K, Yoneda Y. Sustained potentiation of AP1 DNA binding is not always associated with neuronal death following systemic administration of kainic acid in murine hippocampus. Neurochem Int. 1999;35:453-462.
12. Curran T, Franza BR Jr. Fos and Jun: the AP-1 connection. Cell. 1988;55:395-397.
13. Herdegen T, Skene P, Bähr M. The c-Jun transcription factor-bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci. 1997;20:227-231.
14. Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR. Phosphorylation of c-jun mediated by MAP kinases. Nature. 1991;353:670-674.
15. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell. 2000;103:239-252.
16. Luo Y, Umegaki H, Wang X, Abe R, Roth GS. Dopamine induces apoptosis through an oxidation-involved SAPK.JNK activation pathway. J Biol Chem. 1998;273: 3756-3764.
17. Schwarzschild MA, Cole RL, Hyman SE. Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J Neurosci. 199;17: 3455-3466.
18. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 1995;270:1326-1331.
19. Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, et al. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 1997;389: 865-870.
20. Harada J, Sugimoto M. An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons. Jpn J Pharmacol. 1999;79:369-378.
21. Dérijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, et al. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science. 1995; 267:682-685.
22. Moriguchi T, Toyoshima F, Masuyama N, Hanafusa H, Gotoh Y, Nishida E. A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses. EMBO J. 1997;16:7045-7053.
23. Yan M, Dai T, Deak JC, Kyriakis JM, Zon LI, Woodgett JR, et al. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature. 1994;372:798-800.
24. Ogita K, Nitta Y, Watanabe M, Nakatani Y, Nishiyama N, Sugiyama C, et al. In vivo activation of c-Jun N-terminal kinase signaling cascade prior to granule cell death induced by trimethyltin in the dentate gyrus of mice. Neuropharmacology. 2004;47:619-630.
25. di Porzio U, Daguet MC, Glowinski J, Prochiantz A. Effect of striatal cells on in vitro maturation of mesencephalic dopaminergic neurones grown in serum-free conditions. Nature. 1980;288:370-373.
26. Azuma Y, Ogita K, Yoneda Y. Constitutive expression of cytoplasmic activator protein-1 with DNA binding activity and responsiveness to ionotropic glutamate signals in the murine hippocampus. Neuroscience. 1990;92:1295-1308.
27. Patel M, Ardelt BK, Yim GK, Isom GE. Interaction of trimethyltin with hippocampal glutamate. Neurotoxicology. 1990;11:601-608.
28. Sugiyama C, Kuramoto N, Seko K, Yoneda Y, Ogita K. Decreased level of mitochondrial RNA by glutamate in cultured cortical neurons. Neuroreport. 2007;18:827-830.
29. Nishina H, Wada T, Katada T. Physiological roles of SAPK/JNK signaling pathway. J Biochem. 2004;136:123-126.
30. Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 1996;15:2760-2770.
31. Naalsund LU, Allen CN, Fonnum F. Changes in neurobiological parameters in the hippocampus after exposure to trimethyltin. Neurotoxicology. 1985;6:145-158.
32. Nakatsu Y, Kotake Y, Komasaka K, Hakozaki H, Taguchi R, Kume T, et al. Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons. Toxicol Sci. 2006;89:235-242.
33. Viviani B, Rossi AD, Chow SC, Nicotera P. Organotin compounds induce calcium overload and apoptosis in PC12 cells. Neurotoxicology. 1995;16:19-25.
34. Thompson TA, Lewis JM, Dejneka NS, Severs WB, Polavarapu R, Billingsley ML. Induction of apoptosis by organotin compounds in vitro: neuronal protection with antisense oligonucleotides directed against stannin. J Pharmacol Exp Ther. 1996;276:1201-1216.
35. Gunasekar PG, Mickova V, Kotyzova D, Li L, Borowitz JL, Eybl V, et al. Role of astrocytes in trimethyltin neurotoxicity. J Biochem Mol Toxicol. 2001;15:256-262.
36. Maier WE, Bartenbach MJ, Brown HW, Tilson HA, Harry GJ. Induction of tumor necrosis factor alpha in cultured glial cells by trimethyltin. Neurochem Int. 1997;30:385-392.
37. Harry GJ, Tyler K, d'Hellencourt CL, Tilson HA, Maier WE. Morphological alterations and elevations in tumor necrosis factor-alpha, interleukin (IL)-1alpha, and IL-6 in mixed glia cultures following exposure to trimethyltin: modulation by proinflammatory cytokine recombinant proteins and neutralizing antibodies. Toxicol Appl Pharmacol. 2002;180:205-218.
38. Reali C, Scintu F, Pillai R, Donato R, Michetti F, Sogos V. S100b counteracts effects of the neurotoxicant trimethyltin on astro-cytes and microglia. J Neurosci Res. 2005;81:677-686.
39. Lawler S, Fleming Y, Goedert M, Cohen P. Synergistic activation of SAPK1 /JNK by two MAP kinase kinases in vitro. Curr Biol. 1998;8:1387-1390.
40. Yoneda Y, Kuramoto N, Kitayama T, Hinoi E. Consolidation of transient ionotropic glutamate signals through nuclear transcription factors in the brain. Prog Neurobiol. 200;63:697-719.
41. Raghupathi R. Cell death mechanisms following traumatic brain injury. Brain Pathol. 2004;14:215-222.
42. +-induced dopaminergic neuronal cell death: role of caspases, ROS, and JNK. J Neurosci Res. 1999;57:86-94.
43. Ramachandiran S, Huang Q, Dong J, Lau SS, Monks TJ. Mitogen-activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial cells. Chem Res Toxicol. 2002;15:1635-1642.
44. 2. J Biol Chem. 2001;276:11783-11790.
45. Sakon S, Xue X, Takekawa M, Sasazuki T, Okazuki T, Kojima Y, et al. NF-κB inhibits TNF-induced accumulation of ROS that mediated prolonged MAPK activation and necrotic cell death. EMBO J. 2003;22:3898-3909.
46. Jenner P, Olanow CW. Understanding cell death in Parkinson's disease. Ann Neurol. 1998;44:72-84.
47. Shivakumar BR, Kolluri SV, Ravindranath V. Glutathione and protein thiol homeostasis in brain during reperfusion after cerebral ischemia. J Pharmacol Exp Ther. 1995;274:1167-1173.