Linear combinations of docking affinities explain quantitative differences in RTK signaling

Molecular Systems Biology

Volumn 5, Issue , 2009, Pages

  Gordus, Andrew ^a,c   Krall, Jordan A ^a   Beyer, Elsa M ^a   Kaushansky, Alexis ^a   Wolf Yadlin, Alejandro ^a   Sevecka, Mark ^a   Chang, Bryan H ^a   Rush, John ^b   MacBeath, Gavin ^a  

^a HARVARD UNIVERSITY   (United States)

^b CELL SIGNALING TECHNOLOGY   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Partial least squares regression; Protein microarray; PTB domain; Receptor tyrosine kinase; SH2 domain

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C RECEPTOR; PROTEIN SHC; PROTEIN TYROSINE KINASE; SHC1 PROTEIN, HUMAN;

ARTICLE; IMMUNOBLOTTING; MATHEMATICAL MODEL; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RECEPTOR AFFINITY; BINDING SITE; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BINDING SITES; PHOSPHORYLATION; RECEPTOR PROTEIN-TYROSINE KINASES; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 58549118075     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2008.72     Document Type: Article

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