3-Aminoxypropionate-based linker system for cyclization activation in prodrug design

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 941-944

  Ge, Yiyu ^a   Wu, Xinghua ^a   Zhang, Dazhi ^a   Hu, Longqin ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Cancer chemotherapy; Cyclization activation; Drug design; FUDR; Hydroxylamine; Prodrug; Proteolysis; Targeted activation

Indexed keywords

3 AMINOXYPROPIONATE; CHYMOTRYPSIN A; PRODRUG; PROPIONIC ACID DERIVATIVE; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG DESIGN; DRUG RELEASE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; PROTEIN DEGRADATION;

ANTINEOPLASTIC AGENTS; CHEMISTRY, ORGANIC; CHEMISTRY, PHARMACEUTICAL; CHYMOTRYPSIN; CYCLIZATION; DRUG DESIGN; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROXYLAMINE; KINETICS; MODELS, CHEMICAL; NEOPLASMS; PRODRUGS; PROPIONATES;

EID: 58549117671     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.11.097     Document Type: Article

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