Fed-batch optimization of α-amylase and protease-producing Bacillus subtilis using Markov chain methods

Biotechnology and Bioengineering

Volumn 86, Issue 6, 2004, Pages 706-717

  Skolpap, Wanwisa ^a,b   Scharer, J M ^a   Douglas, P L ^a   Moo Young, M ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b THAMMASAT UNIVERSITY   (Thailand)

Author keywords

Bacillus subtilis; Fed batch culture; Modeling; Optimization problem; Parameter estimation

Indexed keywords

ALGORITHMS; CELL CULTURE; ENZYME KINETICS; GENETIC ENGINEERING; MARKOV PROCESSES; MATHEMATICAL MODELS; OPTIMIZATION; STOICHIOMETRY;

BACILLUS SUBTILIS; PROTEASES;

BACTERIA;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL METABOLISM; CULTURE OPTIMIZATION; ENZYME SYNTHESIS; FED BATCH REACTOR; MICROBIAL BIOMASS; NONHUMAN; PROBABILITY;

ALGORITHMS; ALPHA-AMYLASE; BACILLUS SUBTILIS; BIOMASS; BIOREACTORS; CELL CULTURE TECHNIQUES; CHROMATOGRAPHY, GAS; CULTURE MEDIA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; FEASIBILITY STUDIES; MARKOV CHAINS; MODELS, STATISTICAL; MONTE CARLO METHOD; REPRODUCIBILITY OF RESULTS;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS);

EID: 2542424678     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20079     Document Type: Article

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