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Volumn 35, Issue 4, 2008, Pages 286-294

Clinical protocols for the isolation and expansion of mesenchymal stromal cells

Author keywords

Clinical scale expansion; Good Manufacturing Practice (GMP); Mesenchymal stromal cells, multipotent

Indexed keywords

ENDOTOXIN; PYROGEN;

EID: 58549115920     PISSN: 16603796     EISSN: None     Source Type: Journal    
DOI: 10.1159/000141567     Document Type: Review
Times cited : (72)

References (92)
  • 1
    • 0028881201 scopus 로고
    • Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): Implications for therapeutic use
    • Lazarus HM, Haynesworth SE, Gerson SL, Rosenthal NS, Caplan AI: Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplant 1995;16:557-564.
    • (1995) Bone Marrow Transplant , vol.16 , pp. 557-564
    • Lazarus, H.M.1    Haynesworth, S.E.2    Gerson, S.L.3    Rosenthal, N.S.4    Caplan, A.I.5
  • 2
    • 0037173116 scopus 로고    scopus 로고
    • Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
    • Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, Muul L, Hofmann T: Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci U S A 2002;99:8932-8937.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8932-8937
    • Horwitz, E.M.1    Gordon, P.L.2    Koo, W.K.3    Marx, J.C.4    Neel, M.D.5    McNall, R.Y.6    Muul, L.7    Hofmann, T.8
  • 4
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • Le Blanc K, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M, Ringden O: Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004;363:1439-1441.
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3    Gotherstrom, C.4    Hassan, M.5    Uzunel, M.6    Ringden, O.7
  • 5
    • 33745437684 scopus 로고    scopus 로고
    • Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    • Kern S, Eichler H, Stoeve J, Kluter H, Bieback K: Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006;24:1294-1301.
    • (2006) Stem Cells , vol.24 , pp. 1294-1301
    • Kern, S.1    Eichler, H.2    Stoeve, J.3    Kluter, H.4    Bieback, K.5
  • 6
    • 40549111612 scopus 로고    scopus 로고
    • Comparing mesenchymal stromal cells from different human tissues: Bone marrow, adipose tissue and umbilical cord blood
    • Bieback K, Kern S, Kocaomer A, Ferlik K, Bugert P: Comparing mesenchymal stromal cells from different human tissues: bone marrow, adipose tissue and umbilical cord blood. Biomed Mater Eng 2008;18(suppl 1):S71-76.
    • (2008) Biomed Mater Eng , vol.18 , Issue.SUPPL. 1
    • Bieback, K.1    Kern, S.2    Kocaomer, A.3    Ferlik, K.4    Bugert, P.5
  • 9
    • 49649096100 scopus 로고    scopus 로고
    • Phenotypic characterization of mesenchymal stem cells from various tissues
    • Rojewski M, Weber B, Schrezenmeier H: Phenotypic characterization of mesenchymal stem cells from various tissues. Transfus Med Hemother 2008;35:168-184.
    • (2008) Transfus Med Hemother , vol.35 , pp. 168-184
    • Rojewski, M.1    Weber, B.2    Schrezenmeier, H.3
  • 10
    • 49649098557 scopus 로고    scopus 로고
    • Basic biology of mesenchymal stem cells
    • Bieback K: Basic biology of mesenchymal stem cells. Transfus Med Hemother 2008;35:151-152.
    • (2008) Transfus Med Hemother , vol.35 , pp. 151-152
    • Bieback, K.1
  • 11
    • 49649102082 scopus 로고    scopus 로고
    • Characteristics of mesenchymal stem cells - new stars in regenerative medicine or unrecognized old fellows in autologous regeneration?
    • Schaefer R, Northoff H: Characteristics of mesenchymal stem cells - new stars in regenerative medicine or unrecognized old fellows in autologous regeneration? Transfus Med Hemother 2008;35:154-159.
    • (2008) Transfus Med Hemother , vol.35 , pp. 154-159
    • Schaefer, R.1    Northoff, H.2
  • 14
    • 34848863384 scopus 로고    scopus 로고
    • Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    • Caplan AI: Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 2007;213:341-347.
    • (2007) J Cell Physiol , vol.213 , pp. 341-347
    • Caplan, A.I.1
  • 15
    • 34249290435 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treating GVHD: In-vivo fate and optimal dose
    • Subbanna PK: Mesenchymal stem cells for treating GVHD: in-vivo fate and optimal dose. Med Hypotheses 2007;69:469-470.
    • (2007) Med Hypotheses , vol.69 , pp. 469-470
    • Subbanna, P.K.1
  • 17
    • 0034846746 scopus 로고    scopus 로고
    • Bone marrow aspiration
    • Bain BJ: Bone marrow aspiration. J Clin Pathol 2001;54:657-663.
    • (2001) J Clin Pathol , vol.54 , pp. 657-663
    • Bain, B.J.1
  • 18
    • 39149093357 scopus 로고    scopus 로고
    • Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies
    • Stolzing A, Jones E, McGonagle D, Scutt A: Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev 2008;129:163-173.
    • (2008) Mech Ageing Dev , vol.129 , pp. 163-173
    • Stolzing, A.1    Jones, E.2    McGonagle, D.3    Scutt, A.4
  • 19
    • 0030702126 scopus 로고    scopus 로고
    • Aspiration to obtain osteoblast progenitor cells from human bone marrow: The influence of aspiration volume
    • Muschler GF, Boehm C, Easley K: Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume. J Bone Joint Surg Am 1997;79:1699-1709.
    • (1997) J Bone Joint Surg Am , vol.79 , pp. 1699-1709
    • Muschler, G.F.1    Boehm, C.2    Easley, K.3
  • 20
    • 37749033958 scopus 로고    scopus 로고
    • Human mesenchymal stem cells: From basic biology to clinical applications
    • Abdallah BM, Kassem M: Human mesenchymal stem cells: from basic biology to clinical applications. Gene Ther 2008;15:109-116.
    • (2008) Gene Ther , vol.15 , pp. 109-116
    • Abdallah, B.M.1    Kassem, M.2
  • 21
    • 33749512390 scopus 로고    scopus 로고
    • A new technique for the isolation and surface immobilization of mesenchymal stem cells from whole bone marrow using high-specific DNA aptamers
    • Guo KT, Schaefer R, Paul A, Gerber A, Ziemer G, Wendel HP: A new technique for the isolation and surface immobilization of mesenchymal stem cells from whole bone marrow using high-specific DNA aptamers. Stem Cells 2006;24:2220-2231.
    • (2006) Stem Cells , vol.24 , pp. 2220-2231
    • Guo, K.T.1    Schaefer, R.2    Paul, A.3    Gerber, A.4    Ziemer, G.5    Wendel, H.P.6
  • 22
    • 34248138967 scopus 로고    scopus 로고
    • Simultaneous isolation of human BM hematopoietic, endothelial and mesenchymal progenitor cells by flow sorting based on aldehyde dehydrogenase activity: Implications for cell therapy
    • Gentry T, Foster S, Winstead L, Deibert E, Fiordalisi M, Balber A: Simultaneous isolation of human BM hematopoietic, endothelial and mesenchymal progenitor cells by flow sorting based on aldehyde dehydrogenase activity: implications for cell therapy. Cytotherapy 2007;9:259-274.
    • (2007) Cytotherapy , vol.9 , pp. 259-274
    • Gentry, T.1    Foster, S.2    Winstead, L.3    Deibert, E.4    Fiordalisi, M.5    Balber, A.6
  • 24
    • 0019472556 scopus 로고
    • Three-step isolation of human blood monocytes using discontinuous density gradients of Percoll
    • Fluks AJ: Three-step isolation of human blood monocytes using discontinuous density gradients of Percoll. J Immunol Methods 1981;41:225-233.
    • (1981) J Immunol Methods , vol.41 , pp. 225-233
    • Fluks, A.J.1
  • 26
    • 43549095030 scopus 로고    scopus 로고
    • Separation of adult bone marrow mononuclear cells using the automated closed separation system Sepax
    • Aktas M, Radke TF, Strauer BE, Wernet P, Kogler G: Separation of adult bone marrow mononuclear cells using the automated closed separation system Sepax. Cytotherapy 2008;10:203-211.
    • (2008) Cytotherapy , vol.10 , pp. 203-211
    • Aktas, M.1    Radke, T.F.2    Strauer, B.E.3    Wernet, P.4    Kogler, G.5
  • 27
    • 0033977382 scopus 로고    scopus 로고
    • Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy
    • Koc ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, Lazarus HM: Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 2000;18:307-316.
    • (2000) J Clin Oncol , vol.18 , pp. 307-316
    • Koc, O.N.1    Gerson, S.L.2    Cooper, B.W.3    Dyhouse, S.M.4    Haynesworth, S.E.5    Caplan, A.I.6    Lazarus, H.M.7
  • 28
    • 0036456669 scopus 로고    scopus 로고
    • Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality
    • Sekiya I, Larson BL, Smith JR, Pochampally R, Cui JG, Prockop DJ: Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 2002;20:530-541.
    • (2002) Stem Cells , vol.20 , pp. 530-541
    • Sekiya, I.1    Larson, B.L.2    Smith, J.R.3    Pochampally, R.4    Cui, J.G.5    Prockop, D.J.6
  • 30
    • 34147107634 scopus 로고    scopus 로고
    • Concise review: Adipose tissue-derived stromal cells - basic and clinical implications for novel cell-based therapies
    • Schaffler A, Buchler C: Concise review: adipose tissue-derived stromal cells - basic and clinical implications for novel cell-based therapies. Stem Cells 2007;25:818-827.
    • (2007) Stem Cells , vol.25 , pp. 818-827
    • Schaffler, A.1    Buchler, C.2
  • 31
    • 33748267902 scopus 로고    scopus 로고
    • Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery
    • Moseley TA, Zhu M, Hedrick MH: Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery. Plast Reconstr Surg 2006;118(suppl 3):121S-128S.
    • (2006) Plast Reconstr Surg , vol.118 , Issue.SUPPL. 3
    • Moseley, T.A.1    Zhu, M.2    Hedrick, M.H.3
  • 32
    • 34248332602 scopus 로고    scopus 로고
    • Adipose-derived stem cells for regenerative medicine
    • Gimble JM, Katz AJ, Bunnell BA: Adipose-derived stem cells for regenerative medicine. Circ Res 2007;100:1249-1260.
    • (2007) Circ Res , vol.100 , pp. 1249-1260
    • Gimble, J.M.1    Katz, A.J.2    Bunnell, B.A.3
  • 36
    • 0035140834 scopus 로고    scopus 로고
    • A novel device for the simple and efficient refinement of liposuctioned tissue
    • Katz AJ, Hedrick MH, Llull R, Futrell JW: A novel device for the simple and efficient refinement of liposuctioned tissue. Plast Reconstr Surg 2001;107:595-597.
    • (2001) Plast Reconstr Surg , vol.107 , pp. 595-597
    • Katz, A.J.1    Hedrick, M.H.2    Llull, R.3    Futrell, J.W.4
  • 37
    • 58549110800 scopus 로고    scopus 로고
    • The Bedside Celution™ system for isolation of adipose derived regenerative cells
    • Duckers HJ, Pinkernell K, Milstein AM, Hedrick MH: The Bedside Celution™ system for isolation of adipose derived regenerative cells. EuroIntervention 2006;2:395-398.
    • (2006) EuroIntervention , vol.2 , pp. 395-398
    • Duckers, H.J.1    Pinkernell, K.2    Milstein, A.M.3    Hedrick, M.H.4
  • 38
    • 34249320533 scopus 로고    scopus 로고
    • Tissue engineering applications to vascular bypass graft development: The use of adipose-derived stem cells
    • DiMuzio P, Tulenko T: Tissue engineering applications to vascular bypass graft development: the use of adipose-derived stem cells. J Vasc Surg 2007;45(suppl A):A99-103.
    • (2007) J Vasc Surg , vol.45 , Issue.SUPPL. A
    • DiMuzio, P.1    Tulenko, T.2
  • 40
    • 33745266607 scopus 로고    scopus 로고
    • Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells
    • Sotiropoulou PA, Perez SA, Salagianni M, Baxevanis CN, Papamichail M: Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. Stem Cells 2006;24:462-471.
    • (2006) Stem Cells , vol.24 , pp. 462-471
    • Sotiropoulou, P.A.1    Perez, S.A.2    Salagianni, M.3    Baxevanis, C.N.4    Papamichail, M.5
  • 41
    • 3543003475 scopus 로고    scopus 로고
    • Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood
    • Bieback K, Kern S, Kluter H, Eichler H: Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. Stem Cells 2004;22:625-634.
    • (2004) Stem Cells , vol.22 , pp. 625-634
    • Bieback, K.1    Kern, S.2    Kluter, H.3    Eichler, H.4
  • 42
    • 0031012411 scopus 로고    scopus 로고
    • Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro
    • Jaiswal N, Haynesworth SE, Caplan AI, Bruder SP: Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 1997;64:295-312.
    • (1997) J Cell Biochem , vol.64 , pp. 295-312
    • Jaiswal, N.1    Haynesworth, S.E.2    Caplan, A.I.3    Bruder, S.P.4
  • 44
    • 0036196461 scopus 로고    scopus 로고
    • Human marrow-derived mesenchymal progenitor cells: Isolation, culture expansion, and analysis of differentiation
    • Caterson EJ, Nesti LJ, Danielson KG, Tuan RS: Human marrow-derived mesenchymal progenitor cells: isolation, culture expansion, and analysis of differentiation. Mol Biotechnol 2002;20:245-256.
    • (2002) Mol Biotechnol , vol.20 , pp. 245-256
    • Caterson, E.J.1    Nesti, L.J.2    Danielson, K.G.3    Tuan, R.S.4
  • 45
    • 0032611299 scopus 로고    scopus 로고
    • Bovine sera used in the manufacture of biologicals: Current concerns and policies of the U.S. Food and Drug Administration regarding the transmissible spongiform encephalopathies
    • Asher DM: Bovine sera used in the manufacture of biologicals: current concerns and policies of the U.S. Food and Drug Administration regarding the transmissible spongiform encephalopathies. Dev Biol Stand 1999;99:41-44.
    • (1999) Dev Biol Stand , vol.99 , pp. 41-44
    • Asher, D.M.1
  • 46
    • 58549109564 scopus 로고    scopus 로고
    • Note for guidance on the use of bovine serum in the manufacture of human biological medicinal products. EMEA CPMP/BWP/1793/02;2003
    • Note for guidance on the use of bovine serum in the manufacture of human biological medicinal products. EMEA CPMP/BWP/1793/02;2003.
  • 47
    • 58549101063 scopus 로고    scopus 로고
    • Note for guidance on minimising the risk of transmitting animal spongiform encephalopathy agents via human and veterinary medicinal products. EMEA/410/01 rev2;2004
    • Note for guidance on minimising the risk of transmitting animal spongiform encephalopathy agents via human and veterinary medicinal products. EMEA/410/01 rev2;2004.
  • 48
    • 13844267152 scopus 로고    scopus 로고
    • Human embryonic stem cells express an immunogenic nonhuman sialic acid
    • Martin MJ, Muotri A, Gage F, Varki A: Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat Med 2005;11:228-232.
    • (2005) Nat Med , vol.11 , pp. 228-232
    • Martin, M.J.1    Muotri, A.2    Gage, F.3    Varki, A.4
  • 51
    • 36348946918 scopus 로고    scopus 로고
    • No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients
    • Sundin M, Ringden O, Sundberg B, Nava S, Gotherstrom C, Le Blanc K: No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients. Haematologica 2007;92:1208-1215.
    • (2007) Haematologica , vol.92 , pp. 1208-1215
    • Sundin, M.1    Ringden, O.2    Sundberg, B.3    Nava, S.4    Gotherstrom, C.5    Le Blanc, K.6
  • 52
    • 34547162587 scopus 로고    scopus 로고
    • Concise review: No breakthroughs for human mesenchymal and embryonic stem cell culture: conditioned medium, feeder layer, or feeder-free; medium with fetal calf serum, human serum, or enriched plasma; serum-free, serum replacement nonconditioned medium, or ad hoc formula? All that glitters is not gold!
    • Mannello F, Tonti GA: Concise review: no breakthroughs for human mesenchymal and embryonic stem cell culture: conditioned medium, feeder layer, or feeder-free; medium with fetal calf serum, human serum, or enriched plasma; serum-free, serum replacement nonconditioned medium, or ad hoc formula? All that glitters is not gold! Stem Cells 2007;25:1603-1609.
    • (2007) Stem Cells , vol.25 , pp. 1603-1609
    • Mannello, F.1    Tonti, G.A.2
  • 53
    • 0036780996 scopus 로고    scopus 로고
    • Platelets stimulate proliferation of bone cells: Involvement of platelet-derived growth factor, microparticles and membranes
    • Gruber R, Varga F, Fischer MB, Watzek G: Platelets stimulate proliferation of bone cells: involvement of platelet-derived growth factor, microparticles and membranes. Clin Oral Implants Res 2002;13:529-535.
    • (2002) Clin Oral Implants Res , vol.13 , pp. 529-535
    • Gruber, R.1    Varga, F.2    Fischer, M.B.3    Watzek, G.4
  • 56
    • 16644395948 scopus 로고    scopus 로고
    • Effects of platelet growth factors on human mesenchymal stem cells and human endothelial cells in vitro
    • Kilian O, Flesch I, Wenisch S, Taborski B, Jork A, Schnettler R, Jonuleit T: Effects of platelet growth factors on human mesenchymal stem cells and human endothelial cells in vitro. Eur J Med Res 2004;9:337-344.
    • (2004) Eur J Med Res , vol.9 , pp. 337-344
    • Kilian, O.1    Flesch, I.2    Wenisch, S.3    Taborski, B.4    Jork, A.5    Schnettler, R.6    Jonuleit, T.7
  • 59
    • 34247602975 scopus 로고    scopus 로고
    • Human AB serum and thrombin-activated platelet-rich plasma are suitable alternatives to fetal calf serum for the expansion of mesenchymal stem cells from adipose tissue
    • Kocaoemer A, Kern S, Kluter H, Bieback K: Human AB serum and thrombin-activated platelet-rich plasma are suitable alternatives to fetal calf serum for the expansion of mesenchymal stem cells from adipose tissue. Stem Cells 2007;25:1270-1278.
    • (2007) Stem Cells , vol.25 , pp. 1270-1278
    • Kocaoemer, A.1    Kern, S.2    Kluter, H.3    Bieback, K.4
  • 62
    • 37349080893 scopus 로고    scopus 로고
    • Generation of immunosuppressive mesenchymal stem cells in allogeneic human serum
    • Le Blanc K, Samuelsson H, Lonnies L, Sundin M, Ringden O: Generation of immunosuppressive mesenchymal stem cells in allogeneic human serum. Transplantation 2007;84:1055-1059.
    • (2007) Transplantation , vol.84 , pp. 1055-1059
    • Le Blanc, K.1    Samuelsson, H.2    Lonnies, L.3    Sundin, M.4    Ringden, O.5
  • 63
    • 27144541524 scopus 로고    scopus 로고
    • In vitro expansion of human mesenchymal stem cells: Choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability
    • Shahdadfar A, Fronsdal K, Haug T, Reinholt FP, Brinchmann JE: In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability. Stem Cells 2005;23:1357-1366.
    • (2005) Stem Cells , vol.23 , pp. 1357-1366
    • Shahdadfar, A.1    Fronsdal, K.2    Haug, T.3    Reinholt, F.P.4    Brinchmann, J.E.5
  • 64
    • 33749524824 scopus 로고    scopus 로고
    • Enhanced engraftment of mesenchymal stem cells in a cutaneous wound model by culture in allogenic species-specific serum and administration in fibrin constructs
    • Gregory CA, Reyes E, Whitney MJ, Spees JL: Enhanced engraftment of mesenchymal stem cells in a cutaneous wound model by culture in allogenic species-specific serum and administration in fibrin constructs. Stem Cells 2006;24:2232-2243.
    • (2006) Stem Cells , vol.24 , pp. 2232-2243
    • Gregory, C.A.1    Reyes, E.2    Whitney, M.J.3    Spees, J.L.4
  • 65
    • 20344363684 scopus 로고    scopus 로고
    • Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation
    • Kratchmarova I, Blagoev B, Haack-Sorensen M, Kassem M, Mann M: Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science 2005;308:1472-1477.
    • (2005) Science , vol.308 , pp. 1472-1477
    • Kratchmarova, I.1    Blagoev, B.2    Haack-Sorensen, M.3    Kassem, M.4    Mann, M.5
  • 66
    • 47649121002 scopus 로고    scopus 로고
    • Ng F, Boucher S, Koh S, Sastry KS, Chase L, Lakshmipathy U, Choong C, Yang Z, Vemuri MC, Rao MS, Tanavde V: PDGF, TGF-b and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSC into adipogenic, chondrogenic and osteogenic lineages. Blood 2008(Epub ahead of print).
    • Ng F, Boucher S, Koh S, Sastry KS, Chase L, Lakshmipathy U, Choong C, Yang Z, Vemuri MC, Rao MS, Tanavde V: PDGF, TGF-b and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSC into adipogenic, chondrogenic and osteogenic lineages. Blood 2008(Epub ahead of print).
  • 68
    • 33749622440 scopus 로고    scopus 로고
    • Comparative generation and characterization of pluripotent unrestricted somatic stem cells with mesenchymal stem cells from human cord blood
    • Kogler G, Sensken S, Wernet P: Comparative generation and characterization of pluripotent unrestricted somatic stem cells with mesenchymal stem cells from human cord blood. Exp Hematol 2006;34:1589-1595.
    • (2006) Exp Hematol , vol.34 , pp. 1589-1595
    • Kogler, G.1    Sensken, S.2    Wernet, P.3
  • 69
    • 2342642106 scopus 로고    scopus 로고
    • Effects of Wnt signaling on proliferation and differentiation of human mesenchymal stem cells
    • De Boer J, Wang HJ, Van Blitterswijk C: Effects of Wnt signaling on proliferation and differentiation of human mesenchymal stem cells. Tissue Eng 2004;10:393-401.
    • (2004) Tissue Eng , vol.10 , pp. 393-401
    • De Boer, J.1    Wang, H.J.2    Van Blitterswijk, C.3
  • 70
    • 33747595991 scopus 로고    scopus 로고
    • Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro
    • Ebert R, Ulmer M, Zeck S, Meissner-Weigl J, Schneider D, Stopper H, Schupp N, Kassem M, Jakob F: Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro. Stem Cells 2006;24:1226-1235.
    • (2006) Stem Cells , vol.24 , pp. 1226-1235
    • Ebert, R.1    Ulmer, M.2    Zeck, S.3    Meissner-Weigl, J.4    Schneider, D.5    Stopper, H.6    Schupp, N.7    Kassem, M.8    Jakob, F.9
  • 71
    • 33646039757 scopus 로고    scopus 로고
    • Glucose-induced replicative senescence in mesenchymal stem cells
    • Stolzing A, Coleman N, Scutt A: Glucose-induced replicative senescence in mesenchymal stem cells. Rejuvenation Res 2006;9:31-35.
    • (2006) Rejuvenation Res , vol.9 , pp. 31-35
    • Stolzing, A.1    Coleman, N.2    Scutt, A.3
  • 73
    • 40549137738 scopus 로고    scopus 로고
    • Clinical grade production of mesenchymal stem cells
    • Sensebe L: Clinical grade production of mesenchymal stem cells. Biomed Mater Eng 2008;18(suppl 1):S3-10.
    • (2008) Biomed Mater Eng , vol.18 , Issue.SUPPL. 1
    • Sensebe, L.1
  • 76
    • 35348826637 scopus 로고    scopus 로고
    • Clinical-scale expansion of a mixed population of bone-marrow-derived stem and progenitor cells for potential use in bone-tissue regeneration
    • Dennis JE, Esterly K, Awadallah A, Parrish CR, Poynter GM, Goltry KL: Clinical-scale expansion of a mixed population of bone-marrow-derived stem and progenitor cells for potential use in bone-tissue regeneration. Stem Cells 2007;25:2575-2582.
    • (2007) Stem Cells , vol.25 , pp. 2575-2582
    • Dennis, J.E.1    Esterly, K.2    Awadallah, A.3    Parrish, C.R.4    Poynter, G.M.5    Goltry, K.L.6
  • 77
    • 36749085402 scopus 로고    scopus 로고
    • A non-contact suspension culture approach to the culture of osteogenic cells derived from a CD49elow subpopulation of human bone marrow-derived cells
    • Baksh D, Zandstra PW, Davies JE: A non-contact suspension culture approach to the culture of osteogenic cells derived from a CD49elow subpopulation of human bone marrow-derived cells. Biotechnol Bioeng 2007;98:1195-1208.
    • (2007) Biotechnol Bioeng , vol.98 , pp. 1195-1208
    • Baksh, D.1    Zandstra, P.W.2    Davies, J.E.3
  • 78
    • 0042668340 scopus 로고    scopus 로고
    • Adult human bone marrow-derived mesenchymal progenitor cells are capable of adhesion-independent survival and expansion
    • Baksh D, Davies JE, Zandstra PW: Adult human bone marrow-derived mesenchymal progenitor cells are capable of adhesion-independent survival and expansion. Exp Hematol 2003;31:723-732.
    • (2003) Exp Hematol , vol.31 , pp. 723-732
    • Baksh, D.1    Davies, J.E.2    Zandstra, P.W.3
  • 79
    • 33749188522 scopus 로고    scopus 로고
    • Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells
    • Chen X, Xu H, Wan C, McCaigue M, Li G: Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells. Stem Cells 2006;24:2052-2059.
    • (2006) Stem Cells , vol.24 , pp. 2052-2059
    • Chen, X.1    Xu, H.2    Wan, C.3    McCaigue, M.4    Li, G.5
  • 80
    • 33845947864 scopus 로고    scopus 로고
    • Three-dimensional flow perfusion culture system for stem cell proliferation inside the critical-size beta-tricalcium phosphate scaffold
    • Xie Y, Hardouin P, Zhu Z, Tang T, Dai K, Lu J: Three-dimensional flow perfusion culture system for stem cell proliferation inside the critical-size beta-tricalcium phosphate scaffold. Tissue Eng 2006;12:3535-3543.
    • (2006) Tissue Eng , vol.12 , pp. 3535-3543
    • Xie, Y.1    Hardouin, P.2    Zhu, Z.3    Tang, T.4    Dai, K.5    Lu, J.6
  • 81
    • 23244434168 scopus 로고    scopus 로고
    • Effects of oxygen transport on 3-d human mesenchymal stem cell metabolic activity in perfusion and static cultures: Experiments and mathematical model
    • Zhao F, Pathi P, Grayson W, Xing Q, Locke BR, Ma T: Effects of oxygen transport on 3-d human mesenchymal stem cell metabolic activity in perfusion and static cultures: experiments and mathematical model. Biotechnol Prog 2005;21:1269-1280.
    • (2005) Biotechnol Prog , vol.21 , pp. 1269-1280
    • Zhao, F.1    Pathi, P.2    Grayson, W.3    Xing, Q.4    Locke, B.R.5    Ma, T.6
  • 85
    • 58549102047 scopus 로고    scopus 로고
    • Guideline on validation of the Limulus amebocyte lysate test as an end-product endotoxin test for human and animal parenteral drugs, biological products, and medical devices. 1987, sections I-IV
    • Guideline on validation of the Limulus amebocyte lysate test as an end-product endotoxin test for human and animal parenteral drugs, biological products, and medical devices. 1987, sections I-IV: http://www.fda.gov/cber/ gdlns/lal.pdf.
  • 86
    • 0015145780 scopus 로고
    • Fibroblast colony formation from monolayer cultures of blood cells
    • Luria EA, Panasyuk AF, Friedenstein AY: Fibroblast colony formation from monolayer cultures of blood cells. Transfusion 1971;11:345-349.
    • (1971) Transfusion , vol.11 , pp. 345-349
    • Luria, E.A.1    Panasyuk, A.F.2    Friedenstein, A.Y.3
  • 88
    • 3142663241 scopus 로고    scopus 로고
    • Mesenchymal stem cells and their potential as cardiac therapeutics
    • Pittenger MF, Martin BJ: Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 2004;95:9-20.
    • (2004) Circ Res , vol.95 , pp. 9-20
    • Pittenger, M.F.1    Martin, B.J.2
  • 90
    • 0042740515 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex
    • Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringden O: Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 2003;57:11-20.
    • (2003) Scand J Immunol , vol.57 , pp. 11-20
    • Le Blanc, K.1    Tammik, L.2    Sundberg, B.3    Haynesworth, S.E.4    Ringden, O.5
  • 92
    • 33750951074 scopus 로고    scopus 로고
    • Co-culture of umbilical cord blood CD34+ cells with human mesenchymal stem cells
    • Zhang Y, Chai C, Jiang XS, Teoh SH, Leong KW: Co-culture of umbilical cord blood CD34+ cells with human mesenchymal stem cells. Tissue Eng 2006;12:2161-2170.
    • (2006) Tissue Eng , vol.12 , pp. 2161-2170
    • Zhang, Y.1    Chai, C.2    Jiang, X.S.3    Teoh, S.H.4    Leong, K.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.