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Volumn 25, Issue 10, 2007, Pages 2575-2582

Clinical-scale expansion of a mixed population of bone marrow-derived stem and progenitor cells for potential use in bone tissue regeneration

Author keywords

Bioreactor; Bone marrow; Ex vivo expansion; Osteogenesis

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ENDOGLIN; THY 1 ANTIGEN;

EID: 35348826637     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0204     Document Type: Article
Times cited : (86)

References (54)
  • 1
    • 0024377022 scopus 로고
    • Morbidity at bone graft donor sites
    • Younger EM, Chapman MW. Morbidity at bone graft donor sites. J Orthop Trauma 1989;3:192-195.
    • (1989) J Orthop Trauma , vol.3 , pp. 192-195
    • Younger, E.M.1    Chapman, M.W.2
  • 3
    • 0012119202 scopus 로고
    • Recherches experimentales sur les proprietes physiologiques de la moelle des os
    • Goujon E. Recherches experimentales sur les proprietes physiologiques de la moelle des os. Journal de L'Anat et de La Physiol 1869;6:399-412.
    • (1869) Journal de L'Anat et de La Physiol , vol.6 , pp. 399-412
    • Goujon, E.1
  • 4
    • 35348905629 scopus 로고
    • Uber transplantation von knochenmark
    • Baikow A. Uber transplantation von knochenmark. Centalbl F D Med Wiss 1870;8:371-373.
    • (1870) Centalbl F D Med Wiss , vol.8 , pp. 371-373
    • Baikow, A.1
  • 5
    • 0024252149 scopus 로고
    • Stromal stem cells: Marrow-derived osteogenic precursors
    • Owen M, Friedenstein AJ. Stromal stem cells: Marrow-derived osteogenic precursors. Ciba Foundation Symposium 1988;136:42-60.
    • (1988) Ciba Foundation Symposium , vol.136 , pp. 42-60
    • Owen, M.1    Friedenstein, A.J.2
  • 6
    • 0026228558 scopus 로고
    • Mesenchymal stem cells
    • Caplan AI. Mesenchymal stem cells. J Orthop Res 1991;9:641-650.
    • (1991) J Orthop Res , vol.9 , pp. 641-650
    • Caplan, A.I.1
  • 7
    • 0032898767 scopus 로고    scopus 로고
    • A quadripotential mesenchymal progenitor cell isolated from the marrow of an adult mouse
    • Dennis JE, Merriam A, Awadallah A et al. A quadripotential mesenchymal progenitor cell isolated from the marrow of an adult mouse. J Bone Miner Res 1999;14:700-709.
    • (1999) J Bone Miner Res , vol.14 , pp. 700-709
    • Dennis, J.E.1    Merriam, A.2    Awadallah, A.3
  • 8
    • 0036244446 scopus 로고    scopus 로고
    • Origin and differentiation of human and murine stroma
    • Dennis JE, Charbord P. Origin and differentiation of human and murine stroma. STEM CELLS 2002;20:205-214.
    • (2002) STEM CELLS , vol.20 , pp. 205-214
    • Dennis, J.E.1    Charbord, P.2
  • 9
    • 0030007687 scopus 로고    scopus 로고
    • Differentiation potential of conditionally immortalized mesenchymal progenitor cells from adult marrow of a H-2KbtsA58 transgenic mouse
    • Dennis JE, Caplan AI. Differentiation potential of conditionally immortalized mesenchymal progenitor cells from adult marrow of a H-2KbtsA58 transgenic mouse. J Cell Physiol 1996;167:523-538.
    • (1996) J Cell Physiol , vol.167 , pp. 523-538
    • Dennis, J.E.1    Caplan, A.I.2
  • 10
    • 0017103248 scopus 로고
    • Precursor cells of mechanocytes
    • Friedenstein AJ. Precursor cells of mechanocytes. Int Rev Cytol 1976;47:327-359.
    • (1976) Int Rev Cytol , vol.47 , pp. 327-359
    • Friedenstein, A.J.1
  • 11
    • 35348914443 scopus 로고    scopus 로고
    • Friedenstein AJ. Determined and inducible osteogenic precursor cells. In: Elliott K, Fitzsimons D, eds. Hard Tissue Growth, Repair and Remineralization. 11. North-Holland, Amsterdam: Elsevier-Exerpta Medica, 1973:169-185.
    • Friedenstein AJ. Determined and inducible osteogenic precursor cells. In: Elliott K, Fitzsimons D, eds. Hard Tissue Growth, Repair and Remineralization. Vol 11. North-Holland, Amsterdam: Elsevier-Exerpta Medica, 1973:169-185.
  • 12
    • 84990622726 scopus 로고
    • Bone marrow osteogenic stem cells: In vitro cultivation and transplantation in diffusion chambers
    • Friedenstein AJ, Chailakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: In vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet 1987;20:263-272.
    • (1987) Cell Tissue Kinet , vol.20 , pp. 263-272
    • Friedenstein, A.J.1    Chailakhyan, R.K.2    Gerasimov, U.V.3
  • 13
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger M, Mackay A, Beck S et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.1    Mackay, A.2    Beck, S.3
  • 14
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Jiang Y, Jahagirdar B, Reinhard L et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418:41-49.
    • (2002) Nature , vol.418 , pp. 41-49
    • Jiang, Y.1    Jahagirdar, B.2    Reinhard, L.3
  • 15
    • 0026318653 scopus 로고
    • Autogeneic bone marrow and porous biphasic calcium phosphate ceramic for segmental bone defects in the canine ulna
    • Grundel R, Chapman M, Yee T et al. Autogeneic bone marrow and porous biphasic calcium phosphate ceramic for segmental bone defects in the canine ulna. Clin Orthop 1991;266:244-258.
    • (1991) Clin Orthop , vol.266 , pp. 244-258
    • Grundel, R.1    Chapman, M.2    Yee, T.3
  • 16
    • 0029659155 scopus 로고    scopus 로고
    • Qualitative and quantitative analysis of orthotopic bone regeneration by marrow
    • Werntz J, Lane J, Burstein A et al. Qualitative and quantitative analysis of orthotopic bone regeneration by marrow. J Orthop Res 1996;14:85-93.
    • (1996) J Orthop Res , vol.14 , pp. 85-93
    • Werntz, J.1    Lane, J.2    Burstein, A.3
  • 17
    • 0037314714 scopus 로고    scopus 로고
    • Spine fusion using cell matrix composites enriched in bone marrow-derived cells
    • Muschler GF, Hiromori N, Matsukura Y et al. Spine fusion using cell matrix composites enriched in bone marrow-derived cells. Clin Orthop Relat Res 2003;407:102-118.
    • (2003) Clin Orthop Relat Res , vol.407 , pp. 102-118
    • Muschler, G.F.1    Hiromori, N.2    Matsukura, Y.3
  • 18
    • 0031868140 scopus 로고    scopus 로고
    • The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects
    • Bruder SP, Kraus KH, Goldberg V et al. The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am 1998;80:985-996.
    • (1998) J Bone Joint Surg Am , vol.80 , pp. 985-996
    • Bruder, S.P.1    Kraus, K.H.2    Goldberg, V.3
  • 19
    • 0030947661 scopus 로고    scopus 로고
    • Culture-expanded, bone marrow derived mesenchymal stem cells can regenerate a critical-sized segmental bone defect
    • Kadiyala S, Jaiswal N, Bruder SP. Culture-expanded, bone marrow derived mesenchymal stem cells can regenerate a critical-sized segmental bone defect. Tissue Eng 1997;3:173-185.
    • (1997) Tissue Eng , vol.3 , pp. 173-185
    • Kadiyala, S.1    Jaiswal, N.2    Bruder, S.P.3
  • 20
    • 0032029899 scopus 로고    scopus 로고
    • Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells
    • Bruder SP, Kurth AA, Shea M et al. Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells. J Orthop Res 1998;16:155-162.
    • (1998) J Orthop Res , vol.16 , pp. 155-162
    • Bruder, S.P.1    Kurth, A.A.2    Shea, M.3
  • 21
    • 0026053037 scopus 로고
    • Rapid medium perfusion rate significantly increases the productivity and longevity of human bone marrow cultures
    • Schwartz R, Palsson B, Emerson S. Rapid medium perfusion rate significantly increases the productivity and longevity of human bone marrow cultures. Proc Natl Acad Sci U S A 1991;88:6760-6764.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 6760-6764
    • Schwartz, R.1    Palsson, B.2    Emerson, S.3
  • 22
    • 0026316479 scopus 로고
    • In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors
    • Schwartz R, Emerson S, Clarke M et al. In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors. Blood 1991;78:3155-3161.
    • (1991) Blood , vol.78 , pp. 3155-3161
    • Schwartz, R.1    Emerson, S.2    Clarke, M.3
  • 23
    • 0025782921 scopus 로고
    • Culture perfusion schedules influence the metabolic activity and granulocyte-macrophage colony-stimulating factor production rates of human bone marrow stromal cells
    • Caldwell J, Palsson BO, Locey B et al. Culture perfusion schedules influence the metabolic activity and granulocyte-macrophage colony-stimulating factor production rates of human bone marrow stromal cells. J Cell Physiol 1991;147:344-353.
    • (1991) J Cell Physiol , vol.147 , pp. 344-353
    • Caldwell, J.1    Palsson, B.O.2    Locey, B.3
  • 24
    • 35348845310 scopus 로고    scopus 로고
    • Enhanced yield and antigen presenting function of human dendritic cells produced under perfusion culture conditions in a unique clinical-scale bioreactor system
    • March 12, Taos, New Mexico
    • Smith D, Gorgas G, Hastie K et al. Enhanced yield and antigen presenting function of human dendritic cells produced under perfusion culture conditions in a unique clinical-scale bioreactor system. Keystone Symposia: Dendritic Cells: Interfaces with Immunobiology and Medicine; March 12, 2001; Taos, New Mexico.
    • (2001) Keystone Symposia: Dendritic Cells: Interfaces with Immunobiology and Medicine
    • Smith, D.1    Gorgas, G.2    Hastie, K.3
  • 25
    • 33748618182 scopus 로고    scopus 로고
    • Continuous medium perfusion during ex vivo expansion of human CD8+ T-cells produces high density cultures and enhances proliferation potential and lymphokine release
    • Armstrong R, Smith D, Mandalam R et al. Continuous medium perfusion during ex vivo expansion of human CD8+ T-cells produces high density cultures and enhances proliferation potential and lymphokine release. Exp Hematol 1997;25:886a.
    • (1997) Exp Hematol , vol.25
    • Armstrong, R.1    Smith, D.2    Mandalam, R.3
  • 26
    • 0002223624 scopus 로고    scopus 로고
    • Ex vivo hematopoietic cell expansion for bone marrow transplantation
    • Schindhelm K, Nordon R, eds, San Diego: Academic Press
    • Mandalam R, Koller M, Smith A. Ex vivo hematopoietic cell expansion for bone marrow transplantation. In: Schindhelm K, Nordon R, eds. Ex Vivo Cell Therapy. San Diego: Academic Press, 1999:273-291.
    • (1999) Ex Vivo Cell Therapy , pp. 273-291
    • Mandalam, R.1    Koller, M.2    Smith, A.3
  • 27
    • 17944364269 scopus 로고    scopus 로고
    • A phase II trial evaluating the safety and effectiveness of the AastromReplicell System for augmentation of low-dose blood stem cell transplantation
    • Pecora A, Stiff P, LeMaistre C et al. A phase II trial evaluating the safety and effectiveness of the AastromReplicell System for augmentation of low-dose blood stem cell transplantation. Bone Marrow Transplant 2001;28:295-303.
    • (2001) Bone Marrow Transplant , vol.28 , pp. 295-303
    • Pecora, A.1    Stiff, P.2    LeMaistre, C.3
  • 28
    • 0034654025 scopus 로고    scopus 로고
    • Autologous transplantation of ex vivo expanded bone marrow cells grown from small aliquots after high-dose chemotherapy for breast cancer
    • Stiff P, Chen B, Franklin W et al. Autologous transplantation of ex vivo expanded bone marrow cells grown from small aliquots after high-dose chemotherapy for breast cancer. Blood 2000;95:2169-2174.
    • (2000) Blood , vol.95 , pp. 2169-2174
    • Stiff, P.1    Chen, B.2    Franklin, W.3
  • 29
    • 0032144033 scopus 로고    scopus 로고
    • In vivo osteogenesis assay: A rapid method for quantitative analysis
    • Dennis JE, Konstantakos EK, Arm D et al. In vivo osteogenesis assay: A rapid method for quantitative analysis. Biomaterials 1998;19:1323-1328.
    • (1998) Biomaterials , vol.19 , pp. 1323-1328
    • Dennis, J.E.1    Konstantakos, E.K.2    Arm, D.3
  • 30
    • 0025204146 scopus 로고
    • Expression of aminopeptidase N (CD13) in mesenchymal tumors
    • Mechtersheimer G, Moller P. Expression of aminopeptidase N (CD13) in mesenchymal tumors. Am J Pathol 1990;137:1215-1222.
    • (1990) Am J Pathol , vol.137 , pp. 1215-1222
    • Mechtersheimer, G.1    Moller, P.2
  • 31
    • 0036901021 scopus 로고    scopus 로고
    • Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells
    • Jones EA, Kinsey SE, English A et al. Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum 2002;46:3349-3360.
    • (2002) Arthritis Rheum , vol.46 , pp. 3349-3360
    • Jones, E.A.1    Kinsey, S.E.2    English, A.3
  • 32
    • 0033824164 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Biology and potential clinical uses
    • Deans RJ, Moseley AB. Mesenchymal stem cells: Biology and potential clinical uses. Exp Hematol 2000;28:875-884.
    • (2000) Exp Hematol , vol.28 , pp. 875-884
    • Deans, R.J.1    Moseley, A.B.2
  • 33
    • 0036355088 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Will they have a role in the clinic?
    • Devine SM. Mesenchymal stem cells: Will they have a role in the clinic? J Cell Biochem Suppl 2002;38:73-79.
    • (2002) J Cell Biochem Suppl , vol.38 , pp. 73-79
    • Devine, S.M.1
  • 34
    • 84989485234 scopus 로고
    • The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells
    • Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 1970;3:393-403.
    • (1970) Cell Tissue Kinet , vol.3 , pp. 393-403
    • Friedenstein, A.J.1    Chailakhjan, R.K.2    Lalykina, K.S.3
  • 35
    • 0026525255 scopus 로고
    • Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies
    • Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone 1992;13:69-80.
    • (1992) Bone , vol.13 , pp. 69-80
    • Haynesworth, S.E.1    Baber, M.A.2    Caplan, A.I.3
  • 36
    • 0033547347 scopus 로고    scopus 로고
    • The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105)
    • Barry F, Boynton R, Haynesworth S et al. The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun 1999;265:134-139.
    • (1999) Biochem Biophys Res Commun , vol.265 , pp. 134-139
    • Barry, F.1    Boynton, R.2    Haynesworth, S.3
  • 37
    • 0030826763 scopus 로고    scopus 로고
    • Monoclonal antibodies reactive with human osteogenic cell surface antigens
    • Bruder SB, Horowitz MD, Mosca JD et al. Monoclonal antibodies reactive with human osteogenic cell surface antigens. Bone 1997;21:225-235.
    • (1997) Bone , vol.21 , pp. 225-235
    • Bruder, S.B.1    Horowitz, M.D.2    Mosca, J.D.3
  • 38
    • 0031954963 scopus 로고    scopus 로고
    • Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte cell adhesion molecule and is involved in osteogenic differentiation
    • Bruder S, Ricalton N, Boynton R et al. Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte cell adhesion molecule and is involved in osteogenic differentiation. J Bone Miner Res 1998;13:655-663.
    • (1998) J Bone Miner Res , vol.13 , pp. 655-663
    • Bruder, S.1    Ricalton, N.2    Boynton, R.3
  • 39
    • 10744224947 scopus 로고    scopus 로고
    • + subset colocated with mesenchymal progenitors in human normal bone marrow hematon units is enriched in colony-forming unit megakaryocytes and ling-term culture-initiating cells
    • + subset colocated with mesenchymal progenitors in human normal bone marrow hematon units is enriched in colony-forming unit megakaryocytes and ling-term culture-initiating cells. Exp Hematol 2003;31:1275-1283.
    • (2003) Exp Hematol , vol.31 , pp. 1275-1283
    • Boiret, N.1    Rapatel, C.2    Boisgard, S.3
  • 40
    • 0026351805 scopus 로고
    • Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix. An experimental study in dogs
    • Tiedeman JJ, Connolly JF, Strates BS et al. Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix. An experimental study in dogs. Clin Orthop Relat Res 1991;268:294-302.
    • (1991) Clin Orthop Relat Res , vol.268 , pp. 294-302
    • Tiedeman, J.J.1    Connolly, J.F.2    Strates, B.S.3
  • 41
    • 0026356843 scopus 로고
    • Autologous marrow injection as a substitute for operative grafting of tibial nonunions
    • Connolly JF, Guse R, Tiedeman J et al. Autologous marrow injection as a substitute for operative grafting of tibial nonunions. Clin Orthop Relat Res 1991;266:259-270.
    • (1991) Clin Orthop Relat Res , vol.266 , pp. 259-270
    • Connolly, J.F.1    Guse, R.2    Tiedeman, J.3
  • 42
    • 21444445838 scopus 로고    scopus 로고
    • Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells
    • Hernigou P, Poignard A, Beaujean F et al. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg 2005;87:1430-1437.
    • (2005) J Bone Joint Surg , vol.87 , pp. 1430-1437
    • Hernigou, P.1    Poignard, A.2    Beaujean, F.3
  • 43
    • 0031931205 scopus 로고    scopus 로고
    • MUC18, a member of the immunoglobulin superfamily, is expressed on bone marow fibroblasts and a subset of hematological malignancies
    • Filshie RIA, Zannettino ACW, Makrynilola V et al. MUC18, a member of the immunoglobulin superfamily, is expressed on bone marow fibroblasts and a subset of hematological malignancies. Leukemia 1998;12:414-421.
    • (1998) Leukemia , vol.12 , pp. 414-421
    • Filshie, R.I.A.1    Zannettino, A.C.W.2    Makrynilola, V.3
  • 45
    • 0028102611 scopus 로고
    • + fraction of adult human bone marrow contains the osteogenic precursors
    • + fraction of adult human bone marrow contains the osteogenic precursors. Blood 1994;84:4164-4173.
    • (1994) Blood , vol.84 , pp. 4164-4173
    • Gronthos, S.1    Graves, S.E.2    Ohta, S.3
  • 46
    • 0025741349 scopus 로고
    • Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1
    • Simmons PJ, Torok-Storb B. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood 1991;78:55-62.
    • (1991) Blood , vol.78 , pp. 55-62
    • Simmons, P.J.1    Torok-Storb, B.2
  • 47
    • 0028964614 scopus 로고
    • Bone progenitor cell deficits and the age-associated decline in bone repair capacity
    • Quarto R, Thomas D, Liang CT. Bone progenitor cell deficits and the age-associated decline in bone repair capacity. Calcif Tissue Int 1995;56:123-129.
    • (1995) Calcif Tissue Int , vol.56 , pp. 123-129
    • Quarto, R.1    Thomas, D.2    Liang, C.T.3
  • 49
    • 0028943407 scopus 로고
    • The isolation and culture of cells from explants of human trabecular bone
    • Gundle R, Beresford JN. The isolation and culture of cells from explants of human trabecular bone. Calcif Tissue Int 1995;56:S8-S10.
    • (1995) Calcif Tissue Int , vol.56
    • Gundle, R.1    Beresford, J.N.2
  • 50
    • 0033485750 scopus 로고    scopus 로고
    • Donor variation in the growth properties and osteogenic potential of human marrow stromal cells
    • Phinney D, Kopen G, Righter W et al. Donor variation in the growth properties and osteogenic potential of human marrow stromal cells. J Cell Biochem 1999;75:424-436.
    • (1999) J Cell Biochem , vol.75 , pp. 424-436
    • Phinney, D.1    Kopen, G.2    Righter, W.3
  • 51
    • 0035144210 scopus 로고    scopus 로고
    • High concentrations of dexamethasone suppress the proliferation but not the differentiation or further maturation of osteoblast precursors in vitro: Relevance to glucocorticoid- induced osteoporosis
    • Walsh S, Jordan GR, Jefferiss C et al. High concentrations of dexamethasone suppress the proliferation but not the differentiation or further maturation of osteoblast precursors in vitro: Relevance to glucocorticoid- induced osteoporosis. Rheumatology 2001;40:74-83.
    • (2001) Rheumatology , vol.40 , pp. 74-83
    • Walsh, S.1    Jordan, G.R.2    Jefferiss, C.3
  • 52
    • 0141887410 scopus 로고    scopus 로고
    • STRO-1, HOP-26 (CD63), CD49a and SB-10 (CD166) as markers of primitive human marrow sroma cells and their more differentiated progeny: A comparative investigation in vitro
    • Stewart K, Monk P, Walsh S et al. STRO-1, HOP-26 (CD63), CD49a and SB-10 (CD166) as markers of primitive human marrow sroma cells and their more differentiated progeny: A comparative investigation in vitro. Cell Tissue Res 2003;313:281-290.
    • (2003) Cell Tissue Res , vol.313 , pp. 281-290
    • Stewart, K.1    Monk, P.2    Walsh, S.3
  • 53
    • 0029867151 scopus 로고    scopus 로고
    • Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: Effects of dexamethasone and IL-1 alpha
    • Haynesworth SE, Baber MA, Caplan AI. Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: Effects of dexamethasone and IL-1 alpha. J Cell Physiol 1996;166:585-592.
    • (1996) J Cell Physiol , vol.166 , pp. 585-592
    • Haynesworth, S.E.1    Baber, M.A.2    Caplan, A.I.3
  • 54
    • 0031194017 scopus 로고    scopus 로고
    • Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation
    • Majors A, Boehm CA, Nitto H et al. Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation. J Orthop Res 1997;15:546-557.
    • (1997) J Orthop Res , vol.15 , pp. 546-557
    • Majors, A.1    Boehm, C.A.2    Nitto, H.3


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