CagA antigen of helicobacter pylori and coronary instability: Insight from a clinico-pathological study and a meta-analysis of 4241 cases

Atherosclerosis

Volumn 202, Issue 2, 2009, Pages 535-542

  Franceschi, Francesco ^a   Niccoli, Giampaolo ^a   Ferrante, Giuseppe ^a   Gasbarrini, Antonio ^a   Baldi, Alfonso ^b   Candelli, Marcello ^a   Feroce, Florinda ^b   Saulnier, Nathalie ^a   Conte, Micaela ^a   Roccarina, Davide ^a   Lanza, Gaetano A ^a   Gasbarrini, Giovanni ^a   Gentiloni, Silveri Nicolò ^a   Crea, Filippo ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Acute coronary syndromes; Helicobacter pylori; Infection; Meta analysis

Indexed keywords

ACETYLSALICYLIC ACID; BACTERIAL ANTIGEN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CAGA PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MONOCLONAL ANTIBODY; PROTEIN ANTIBODY;

ACUTE CORONARY SYNDROME; ADULT; ANTIBODY TITER; ARTICLE; ATHERECTOMY; ATHEROSCLEROTIC PLAQUE; BACTERIAL STRAIN; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY ATHEROSCLEROSIS; FEMALE; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PATIENT ASSESSMENT; PRIORITY JOURNAL; SEROLOGY; STABLE ANGINA PECTORIS; UNSTABLE ANGINA PECTORIS;

AGED; ANGINA, UNSTABLE; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CORONARY ARTERY DISEASE; CORONARY VESSELS; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; SEROEPIDEMIOLOGIC STUDIES;

EID: 58549111583     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.04.051     Document Type: Article

References (38)

1. Liuzzo G., Biasucci L.M., Gallimore J.R., et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med 331 (1994) 417-424
2. Crea F., Biasucci L.M., Buffon A., et al. Role of inflammation in the pathogenesis of unstable coronary artery disease. Am J Cardiol 80 (1997) 10E-16E
3. Biasucci L.M., Liuzzo G., Grillo R.L., et al. Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. Circulation 99 (1999) 855-860
4. Spagnoli L.G., Bonanno E., Mauriello A., et al. Multicentric inflammation in epicardial coronary arteries of patients dying of acute myocardial infarction. J Am Coll Cardiol 40 (2002) 1579-1588
5. Tousoulis D., Davies G., Stefanadis C., Toutouzas P., and Ambrose J.A. Inflammatory and thrombotic mechanisms in coronary atherosclerosis. Heart 89 (2003) 993-997
6. Paoletti R., Gotto Jr. A.M., and Hajjar D.P. Inflammation in atherosclerosis and implications for therapy. Circulation 109 (2004) III20-III26
7. Ott S.J., El Mokhtari N.E., Musfeldt M., et al. Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease. Circulation 113 (2006) 929-937
8. Liu R., Yamamoto M., Moroi M., et al. Chlamydia pneumoniae immunoreactivity in coronary artery plaques of patients with acute coronary syndromes and its relation with serology. Am Heart J 150 (2005) 681-688
9. Choussat R., Montalescot G., Collet J., et al. Effect of prior exposure to Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non-Q-wave acute myocardial infarction. Am J Cardiol 86 (2000) 379-384
10. Marshall B.J., Barrett L.J., Prakash C., McCallum R.W., and Guerrant R.L. Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect of acid. Gastroenterology 99 (1990) 697-702
11. Gasbarrini G., Malfertheiner P., Deltenre M., et al. New concepts concerning management of Helicobacter pylori infection: 2 years after the Maastricht Consensus Report. Ital J Gastroenterol Hepatol 30 (1998) S244-S247
12. Crabtree J.E., Kersulyte D., Li S.D., Lindley I.J., and Berg D.E. Modulation of Helicobacter pylori induced interleukin-8 synthesis in gastric epithelial cells mediated by cag PAI encoded VirD4 homologue. J Clin Pathol 52 (1999) 653-657
13. Mendall M.A., Goggin P.M., Molineaux N., et al. Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J 71 (1994) 437-439
14. Danesh J., and Peto R. Risk factors for coronary heart disease and infection with Helicobacter pylori: meta-analysis of 18 studies. BMJ 316 (1998) 1130-1132
15. Kusters J.G., and Kuipers E.J. Helicobacter and atherosclerosis. Am Heart J 138 (1999) S523-S527
16. Ridker P.M., Danesh J., Youngman L., et al. A prospective study of Helicobacter pylori seropositivity and the risk for future myocardial infarction among socioeconomically similar U.S. men. Ann Intern Med 135 (2001) 184-188
17. Pasceri V., Patti G., Cammarota G., et al. Virulent strains of Helicobacter pylori and vascular diseases: a meta-analysis. Am Heart J 151 (2006) 1215-1222
18. Preusch M.R., Grau A.J., Buggle F., et al. Association between cerebral ischemia and cytotoxin-associated gene-A-bearing strains of Helicobacter pylori. Stroke 35 (2004) 1800-1804
19. Franceschi F., Sepulveda A.R., Gasbarrini A., et al. Cross-reactivity of anti-CagA antibodies with vascular wall antigens: possible pathogenic link between Helicobacter pylori infection and atherosclerosis. Circulation 106 (2002) 430-434
20. Rosner B. Fundamentals of biostatistics. fourth ed. (1995), Wadsworth Publishing Company, Belmont, CA
21. Altman D.G., and Bland J.M. Interaction revisited: the difference between two estimates. BMJ 326 (2003) 219
22. Egger M., Smith G.D., Schneider M., and Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 315 (1997) 629-634
23. Begg C.B., and Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 50 (1994) 1088-1101
24. Aceti A., Are R., Sabino G., et al. Helicobacter pylori active infection in patients with acute coronary heart disease. J Infect 49 (2004) 8-12
25. Gunn M., Stephens J.C., Thompson J.R., Rathbone B.J., and Samani N.J. Significant association of CagA positive Helicobacter pylori strains with risk of premature myocardial infarction. Heart 84 (2000) 267-271
26. Howard A.N., Williams N.R., Rajput-Williams J., Dickinson R.J., and Palmer C.R. Infection and myocardial infarction. Helicobacter 4 (1999) 140-141
27. Murray L.J., Bamford K.B., Kee F., et al. Infection with virulent strains of Helicobacter pylori is not associated with ischaemic heart disease: evidence from a population-based case-control study of myocardial infarction. Atherosclerosis 149 (2000) 379-385
28. Pasceri V., Cammarota G., Patti G., et al. Association of virulent Helicobacter pylori strains with ischemic heart disease. Circulation 97 (1998) 1675-1679
29. Pellicano R., Parravicini P.P., Bigi R., et al. Infection by Helicobacter pylori and acute myocardial infarction. Do cytotoxic strains make a difference?. New Microbiol 25 (2002) 315-321
30. Singh R.K., McMahon A.D., Patel H., et al. Prospective analysis of the association of infection with CagA bearing strains of Helicobacter pylori and coronary heart disease. Heart 88 (2002) 43-46
31. Stone A.F., Risley P., Markus H.S., et al. Ischemic heart disease and Cag A strains of Helicobacter pylori in the Caerphilly heart disease study. Heart 86 (2001) 506-509
32. Whincup P., Danesh J., Walker M., et al. Prospective study of potentially virulent strains of Helicobacter pylori and coronary heart disease in middle-aged men. Circulation 101 (2000) 1647-1652
33. Hanson G.K., Holm J., and Jonasson L. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Path 135 (1989) 169-175
34. De Palma R., Del Galdo F., Abbate G., et al. Patients with acute coronary syndrome show oligoclonal T-cell recruitment within unstable plaque: evidence for a local, intracoronary immunologic mechanism. Circulation 113 (2006) 640-646
35. Liuzzo G., Goronzy J.J., Yang H., et al. Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation 101 (2000) 2883-2888
36. Andraws R., Berger J.S., and Brown D.L. Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials. JAMA 293 (2005) 2641-2647
37. Tatemichi M., Hamada G.S., Nishimoto I.N., et al. Ethnic difference in serology of Helicobacter pylori CagA between Japanese and non-Japanese Brazilians for non-cardia gastric cancer. Cancer Sci 94 (2003) 64-69
38. Elitsur Y., Neace C., Werthammer M.C., and Triest W.E. Prevalence of CagA, VacA antibodies in symptomatic and asymptomatic children with Helicobacter pylori infection. Helicobacter 4 (1999) 100-105