Multicentric inflammation in epicardial coronary arteries of patients dying of acute myocardial infarction

Journal of the American College of Cardiology

Volumn 40, Issue 9, 2002, Pages 1579-1588

  Spagnoli, Luigi Giusto ^a   Bonanno, Elena ^a   Mauriello, Alessandro ^a   Palmieri, Giampiero ^a   Partenzi, Antonietta ^a   Sangiorgi, Giuseppe ^a   Crea, Filippo ^b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; CD3 ANTIGEN; CD68 ANTIGEN; HLA ANTIBODY; HLA DR ANTIGEN; MONOCLONAL ANTIBODY;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; AUTOPSY; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CORONARY ARTERY DISEASE; EPICARDIUM; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INFLAMMATION; INFLAMMATORY CELL; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; T LYMPHOCYTE;

AGED; CORONARY ARTERIOSCLEROSIS; CORONARY VESSELS; FEMALE; FLOW CYTOMETRY; HLA-DR ANTIGENS; HUMANS; IMMUNOPHENOTYPING; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; MYOCARDIAL INFARCTION; T-LYMPHOCYTES;

EID: 0037032291     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(02)02376-8     Document Type: Article

References (18)

1. Fuster V, Badimon L, Badimon J, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med 1992;326:242-50.
2. Davies M, Thomas A. Thrombosis and acute coronary artery lesions in sudden cardiac ischemic death. N Engl J Med 1984;310:1137-40.
3. Roberts WC, Potkin BN, Solus DE, Reddy SG. Mode of death, frequency of healed and acute myocardial infarction, number of major epicardial coronary arteries severely narrowed by atherosclerotic plaque, and heart weight in fatal atherosclerotic coronary artery disease: Analysis of 889 patients studied at necropsy. J Am Coll Cardiol 1990;15:196-203.
4. Goldstein JA, Demetriou D, Grines CL, Pica M, Shoukfeh M, O'Neill WW. Multiple complex coronary plaques in patients with acute myocardial infarction. N Engl J Med 2000;343:915-22.
5. Van der Wal A, Becker A, Van der Loos C, Das PK. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 1994;89:36-44.
6. Bonanno E, Mauriello A, Partenzi A, Anemona L, Spagnoli LG. Flow cytometry analysis of atherosclerotic plaque cells from human carotids: A validation study. Cytometry 2000;39:158-65.
7. Anderson KR, Popple A, Parker DJ, Sayer R, Trickey RJ, Davies MJ. An experimental assessment of macroscopic enzyme techniques for the autopsy demonstration of myocardial infarction. J Pathol 1979;127: 93-8.
8. Fishbein MC, Maclean D, Maroko PR. The histopathologic evolution of myocardial infarction. Chest 1978;73:843-9.
9. Ross R. Atherosclerosis - An inflammatory disease. N Engl J Med 1999;340:115-26.
10. Hansson G, Holm J, Jonasson L. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol 1989;135:169-75.
11. Crea F, Biasucci LM, Buffon A, et al. Role of inflammation in the pathogenesis of unstable coronary artery disease. Am J Cardiol 1997;80:10E-16E.
12. Liuzzo G, Goronzy JJ, Yang H, et al. Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation 2000; 101:2883-8.
13. Neri Serneri GG, Prisco D, Martini F, et al. Acute T-cell activation is detectable in unstable angina. Circulation 1997;95:1806-12.
14. Caligiuri G, Paulsson G, Nicoletti A, Maseri A, Hansson GK. Evidence for antigen-driven T-cell response in unstable angina. Circulation 2000;102:1114-9.
15. Weyand CM, Brandes JC, Schmidt D, Fulbright JW, Goronzy JJ. Functional properties of CD4+/CD28-T cells in the aging immune system. Mech Ageing Dev 1998;102:131-47.
16. Buffon A, Biasucci LM, Liuzzo G, D'Onofrio G, Crea F, Maseri A Widespread coronary inflammation in unstable angina. N Engl J Med 2002;347:5-12.
17. Uren NG, Crake T, Lefroy DC, de Silva R, Davies GJ, Maseri A. Reduced coronary vasodilator function in infarcted and normal myocardium after myocardial infarction. N Engl J Med 1994;331: 222-7.
18. Azar RR, Rinfret S, Theroux P, et al. A randomised placebo-controlled trial to assess the efficacy of anti-inflammatory therapy with Methylprednisolone in UNstable Angina (MUNA trial). Eur Heart J 2000;21:2026-32.