Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons

Steroids

Volumn 74, Issue 2, 2009, Pages 256-263

  Stastna, Eva ^a,b   Chodounska, Hana ^a   Pouzar, Vladimir ^a   Kapras, Vojtech ^a   Borovska, Jirina ^a,c   Cais, Ondrej ^c   Vyklicky Jr , Ladislav ^c  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

NMDA receptor; Patch clamp recording; Pregnane derivatives; Structure activity relationship

Indexed keywords

20 OXO 5ALPHA PREGNAN 3ALPHA YL HEMISUCCINATE; 20 OXO 5ALPHA PREGNAN 3ALPHA YL SULFATE PYRIDINIUM SALT; 20 OXO 5ALPHA PREGNAN 3ALPHA,7ALPHA DIYL 3 HEMISUCCINATE 7 ACETATE; 20 OXO 5ALPHA PREGNANE 3ALPHA,7ALPHA DIYL 3 SULFATE 7 ACETATE PYRIDINIUM SALT; 20 OXO 5ALPHA PREGNANE 3ALPHA,7ALPHA DIYL 3 SULFATE 7 NICOTINATE PYRIDINIUM SALT; 20 OXO 5BETA PREGNAN 3ALPH,7ALPHA DIYL 3 SULFATE 7 ACETATE PYRIDINIUM SALT; 20 OXO 5BETA PREGNAN 3ALPHA YL SULFATE PYRIDINIUM SALT; 20 OXO 5BETA PREGNANE 3ALPHA,7ALPHA DIYL 3 HEMISUCCINATE 7 ACETATE; 20 OXO 5BETA PREGNANE 3ALPHA,7ALPHA DIYL 3 SULFATE 7 NICOTINATE PYRIDINIUM SALT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; PREGNANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; BRAIN NERVE CELL; DRUG STRUCTURE; HIPPOCAMPUS; NERVE CELL CULTURE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SYNTHESIS; VOLTAGE CLAMP;

ANIMALS; CELLS, CULTURED; ELECTRIC CONDUCTIVITY; HIPPOCAMPUS; INHIBITORY CONCENTRATION 50; NEURONS; PATCH-CLAMP TECHNIQUES; PREGNANES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

RATTUS;

EID: 58549110612     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2008.11.011     Document Type: Article

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